Version 1
: Received: 21 April 2023 / Approved: 23 April 2023 / Online: 23 April 2023 (12:29:17 CEST)
How to cite:
Reyes-Gibby, C. C.; San Valentin, E. M. D.; Yeung, S.-C. J. Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients Through Omics Studies. Preprints2023, 2023040798. https://doi.org/10.20944/preprints202304.0798.v1
Reyes-Gibby, C. C.; San Valentin, E. M. D.; Yeung, S.-C. J. Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients Through Omics Studies. Preprints 2023, 2023040798. https://doi.org/10.20944/preprints202304.0798.v1
Reyes-Gibby, C. C.; San Valentin, E. M. D.; Yeung, S.-C. J. Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients Through Omics Studies. Preprints2023, 2023040798. https://doi.org/10.20944/preprints202304.0798.v1
APA Style
Reyes-Gibby, C. C., San Valentin, E. M. D., & Yeung, S. C. J. (2023). Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients Through Omics Studies. Preprints. https://doi.org/10.20944/preprints202304.0798.v1
Chicago/Turabian Style
Reyes-Gibby, C. C., Erin Marie D. San Valentin and Sai-ching J Yeung. 2023 "Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients Through Omics Studies" Preprints. https://doi.org/10.20944/preprints202304.0798.v1
Abstract
Oral mucositis (OM) is inflammation of the mouth caused by damage to the mucous membranes that line the mouth and throat. It is a side effect of cancer treatment, particularly in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy, chemotherapy, and/or immunotherapy with immune checkpoint inhibitors. The etiology and pathogenic mechanisms of OM is complex and multifaceted, involving cytotoxicity (cell death), inflammation, infection, change in microbiome, and immune-mediated cytotoxicity. We summarize the literature about attempts to use various omics methodologies (genomics, transcriptomics, microbiomics and metabolomics) to elucidate the biological pathways associated with the development or the severity of OM. Integrating different omics into multi-omics approaches carries the potential to discover links among host factors (genomics), host responses (transcriptomics, metabolomics), and local environment (microbiomics).
Keywords
Head and neck cancer; oral mucositis; pain; genomics; transcriptomics; microbiomics
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
