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Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated With the Presence of Lymph Node Metastases, Vascular Invasion and Lower Overall Survival
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Version 1
: Received: 20 October 2022 / Approved: 21 October 2022 / Online: 21 October 2022 (10:17:46 CEST)
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CIMB | Free Full-Text | Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overal
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<title>CIMB | Free Full-Text | Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overal
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Megalin (LRP2) is a rapidly recycling multiligand endocytic receptor, primarily expressed in polarized epithelial cells. Despite megalin could promote tumor growth and invasiveness through several mechanisms, it has been understudied in the field of molecular oncology so far. The present study aimed to evaluate the impact of megalin expression in oral squamous cell carcinoma (OSCC) on disease progression. Megalin expression was evaluated immunohistochemically in 63 OSCC specimens. Data obtained were retrospectively compared with patients’ clinicopathological features and survival. The proportion of megalin-expressing cells in primary OSCC tissue was significantly associated with metastatic spreading to lymph nodes, vascular invasion and lower overall survival rate. Results obtained by the study suggest that megalin can be considered as a novel molecule involved in OSCC pathogenesis, but also useful as a potential biomarker for cancer progression.
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megalin; oral squamous cell carcinoma; lymph node metastases; vascular invasion; overall survival
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Medicine and Pharmacology, Oncology and Oncogenics
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This is an open access article distributed under the <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution License</a> which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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