Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects

Shimul Halder; Sanjida Afrose; Manik Chandra Shill; Nahid Sharmin; Patricia Prova Mollick; Madhabi Lata Shuma; S. M. Abdur Rahman

doi:10.20944/preprints202211.0372.v1

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preprints.org > biology and life sciences > food science and technology > doi: 10.20944/preprints202211.0372.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects

^* ,

Patricia Prova Mollick

Madhabi Lata Shuma

S. M. Abdur Rahman

Version 1 : Received: 18 November 2022 / Approved: 21 November 2022 / Online: 21 November 2022 (04:43:27 CET)

How to cite: Halder, S.; Afrose, S.; Shill, M.C.; Sharmin, N.; Mollick, P.P.; Shuma, M.L.; Rahman, S.M.A. Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects. Preprints 2022, 2022110372. https://doi.org/10.20944/preprints202211.0372.v1 Halder, S.; Afrose, S.; Shill, M.C.; Sharmin, N.; Mollick, P.P.; Shuma, M.L.; Rahman, S.M.A. Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects. Preprints 2022, 2022110372. https://doi.org/10.20944/preprints202211.0372.v1

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MDPI and ACS Style

Halder, S.; Afrose, S.; Shill, M.C.; Sharmin, N.; Mollick, P.P.; Shuma, M.L.; Rahman, S.M.A. Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects. Preprints 2022, 2022110372. https://doi.org/10.20944/preprints202211.0372.v1

APA Style

Halder, S., Afrose, S., Shill, M.C., Sharmin, N., Mollick, P.P., Shuma, M.L., & Rahman, S.M.A. (2022). Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects. Preprints. https://doi.org/10.20944/preprints202211.0372.v1

Chicago/Turabian Style

Halder, S., Madhabi Lata Shuma and S. M. Abdur Rahman. 2022 "Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects" Preprints. https://doi.org/10.20944/preprints202211.0372.v1

Abstract

Nigella sativa's thymoquinone (TQM), a water-insoluble phytonutrient exhibits nephroprotective effects. This study intends to develop a self-micellizing solid dispersion (SMSD) of TQM for better biopharmaceutical and nephroprotective performance. Soluplus®-based SMSD of TQM was created and tested for physicochemical properties, solubility, and pharmacokinetics in rats. Plasma creatinine, blood urea nitrogen (BUN), nephrotoxic indicators, and oxidative stress biomarkers were also tested. During SMSD preparation, TQM was found amorphous, boosting solubility. Minimal band changes between TQM and Soluplus® indicate insignificant drug-carrier interactions. SMSD-TQM generated fine micelles in water, improving TQM's solubility by 97.8% in 60 min. SMSD-TQM was 4.9 times more bioavailable orally in rats than crystalline TQM. In a rat model of acute renal damage by cisplatin (6 mg/kg, i.p.), SMSD-TQM (10 mg-TQM/kg, p.o.) reduced blood creatinine and BUN by 56% and 63.2%, respectively. These findings imply that SMSD-TQM may be a potent dosage option for enhancing TQM's nutrient value.

Keywords

biopharmaceutical; nephroprotective; oral absorption; self-micellizing solid dispersion; thymoquinone.

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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