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Preprint REVIEW | doi:10.20944/preprints202212.0212.v1

The Involvement of Krüppel-like Factors in Cardiovascular Diseases

Michelle Giovanna Santoyo-Suarez, Jimena D. Mares-Montemayor, Gerardo R. Padilla-Rivas, Juan L. Delgado-Gallegos, Adriana G. Quiroz-Reyes, Jorge A. Roacho-Perez, Diego F. Benitez-Chao, Lourdes Garza-Ocañas, Gilberto Arevalo-Martinez, Elsa N. Garza-Treviño, Jose Francisco Islas

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cardiovascular diseases; Krüppel -like factors; Transcription factor regulation

Online: 13 December 2022 (01:13:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0308.v1

CHRDL1 Regulates Stemness in Glioma Stem-Like Cells

Inka Berglar, Stephanie Hehlgans, Franz Rödel, Donat Kögel, Benedikt Linder

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Glioma; Glioblastoma; Glioma stem-like cells; CHRDL1; BMP4

Online: 20 October 2022 (11:20:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0158.v1

Oncological Features of Intravenous Leiomyomatosis: Involvement of Mesenchymal Tumor Stem-Like Cells

Saya Tamura, Takuma Hayashi, Hideki Tokunaga, Nobuo Yaegashi, Kaoru Abiko, Ikuo Konishi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: intravenous leiomyomatosis; leiomyoma; leiomyosarcoma; tumor stem-like cells

Online: 8 September 2021 (20:00:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0691.v1

Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases their Susceptibility to Temozolomide

Julia Gerstmeier, Anna-Lena Possmayer, Süleyman Bozkurt, Marina E. Hoffmann, Ivan Dikic, Christel Herold-Mende, Michael C. Burger, Christian Münch, Donat Kögel, Benedikt Linder

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Calcitriol; Vitamin D3; Glioblastoma; Glioblastoma stem-like cells

Online: 29 June 2021 (08:37:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0625.v1

The Dual Role of Toll-like Receptor10

Motahareh Dargahi, Niloufar Taheri, Zahra Mirsanei, Arezoo Rasti, Reza Jafari

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Toll-Like Receptor; Innate Immunity; Inflammation; Anti-inflammation

Online: 26 May 2021 (08:17:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0629.v1

Explore the Potential Mechanism of Bufadienolides-Like Chemicals on Breast Cancer through Bioinformatics Analysis

Yingbo Zhang, Xiaomin Tang, Yuxin Pang, Luqi Huang, Dan Wang, Chao Yuan, Xuan Hu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bufadienolides-like chemicals; molecular mechanism; anti-cancer; bioinformatics

Online: 30 November 2018 (10:14:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0107.v1

Evidence for the Involvement of Toll-Like Receptor 4 (TLR4)-Mediated Apoptosis in Gynecological Cancers

Jinyoung Won, Youngjeon Lee, Kyu-Tae Chang, Yonggeun Hong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: apoptosis; gynecologic cancer; lipopolysaccharide; proliferation; Toll-like receptor

Online: 20 December 2016 (11:12:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0398.v1

An Immune Escape of Oral Squamous Cell Carcinoma Might Be Different in the Originating-Epithelium, Keratinized or Non-keratinized

Yoshiaki Kistukawa, Chonji Fukumoto, Toshiki Hyodo, Yuske Komiyama, Ryo Shiraishi, Aya Koike, Shuma Yagisawa, Yosuke Kunitomi, Tomonori Hasegawa, Wataru Kotani, Kazuyuki Ishida, Takahiro Wakui, Hitoshi Kawamata

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immune escape; tumor immunity; immune checkpoint; oral squamous cell carcinoma; programmed death receptor-1 (PD-1); programmed cell death 1-ligand 1 (PD-L1); CD47

Online: 7 March 2024 (07:49:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0363.v1

The Virus-induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members are not Required for the Efficient Replication of HSV-1

Andreja Zubković, Ines Žarak, Ivana Ratkaj, Filip Rokić, Maja Badurina, Marina Pribanić Matešić, Ricardo Lebron, Cristina Gómez-Martín, Berislav Lisnić, Vanda Juranic Lisnic, Stipan Jonjić, Dongli Pan, Oliver Vugrek, MIchael Hackenberg, Igor Jurak

Subject: Biology And Life Sciences, Virology Keywords: herpes simplex virus 1; HSV-1; virus-host interaction; miRNA; FoxO

Online: 26 May 2022 (10:34:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0565.v1

Targeting Tat-TAR RNA Interaction for HIV-1 Inhibition

Awadh Alanazi, Andrey Ivanov, Namita Kumari, Xionghao Lin, Songping Wang, Dmytro Kovalskyy, Sergei Nekhai

Subject: Biology And Life Sciences, Virology Keywords: HIV-1 transcription; HIV-1 Tat; TAR RNA; small molecule inhibitors

Online: 23 June 2021 (11:04:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0138.v1

Comparison of Forecasting Ability for Energy Consumption in BRICS: ARIMA (1,1,1) and FGM (1, 1) Models

Atif Maqbool Khan, Magdalena Osinska

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Energy consumption; BRICS; GM (1, 1); Fractional-order; GREY; Forecasting accuracy

Online: 5 April 2021 (13:51:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0796.v1

The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection

Thomas Ray O'Neil, Kevin Hu, Naomi Truong, Sana Arshad, Barbara Shacklett, Anthony Laurence Cunningham, Najla Nasr

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HIV-1; HSV-1/2; CD4; CD8; Vaccines; Infection; Immunity; Keratitis

Online: 31 December 2020 (12:18:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1967.v1

Oncogenic Human Papillomavirus Infection (HPV 16/18) and Associated Factors among Women in East Gojjam Zone, Northwest Ethiopia 2021

mamaru getinet

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: OncoE6TM cervical test; HPV; East Gojjam zone; prevalence; associated factors

Online: 26 December 2023 (10:14:26 CET)

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Background: Human papillomavirus is a common pathogen that infects the skin and mucosal epithelium, is transmitted sexually; causes condylomas or squamous cell carcinomas. Two (16 and 18) of the 150 HPV serotypes are oncogenic types. Studies have been done on the infection by oncogenic human papillomavirus 16/18 and associated factors are found to be very limited in Ethiopia. Objective: This study aimed to assess the prevalence of oncogenic human papillomavirus infection (HPV 16/18) and associated factors among women. Methods: An institutional-based cross-sectional study was conducted among 337 women screened for cervical cancer in two hospitals in East Gojjam Zone from February to April 2021 G.C. Four BSc-qualified nurses who worked in the chosen hospitals collected the data using pretested questionnaire and an HPV test (OncoE6TM Cervical Test) specific to HPV16/18 in cervical swabs. Descriptive analysis was performed to determine the prevalence and a multivariate logistic regression model was used to identify the associated factors of HPV16/18 infection. Finally, statistical significance was declared at P < 0.05.Results: The prevalence of HPV infection was 14.2% (95% CI: 10.7% -18.1%). The mean age of the respondents was 36.7±9.1 years. Women with the age group of 55-65 years (AOR = 7.91, 95% CI: 1.95-32.09), early initiation of sexual intercourse (AOR = 5.36, 95% CI: 1.58-18.13), history of sexually transmitted infection (STI) (AOR = 3.52, 95% CI: 1.27-9.72), human immunodeficiency virus (HIV) positive status (AOR = 6.8, 95% CI: 1.99-23.54), and number of lifetime sexual partners (AOR = 4.37, 95% CI: 1.15-17.3) were important independent factors associated with the presence of oncogenic HPV infection. Conclusion and Recommendation: We found a relatively low prevalence of high-risk HPV infection. Age, early initiation of sexual intercourse at less than 18 years, STI of women, being HIV seropositive, and a number of sexual partners were important factors for high-risk HPV infection. Women aged > 46 years, women with early initiation of sex, a history of STI, being HIV positive, and a history of multiple sexual partners should be encouraged to be screened and vaccinated for HPV infection. Wider-ranging studies are also needed in HPV-infected women in association with the cervical lesion.

Preprint ARTICLE | doi:10.20944/preprints202311.1256.v1

TitleBiological Effects of “Inflammageing” on Human Oral Cells: Insights into a Potential Confounder of Age-Related Diseases

Elli Alexakou, Athina Bakopoulou, Danae A Apatzidou, Aristeidis Kritis, Andigoni Malousi, Vassiliki Anastassiadou

Subject: Biology And Life Sciences, Life Sciences Keywords: inflammageing; senescence; pro-inflammatory stimulus; Senescence Associated Secretory Phenotype (SASP)

Online: 20 November 2023 (16:15:05 CET)

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Objectives: The term "inflammageing” describes the process of inflammation-induced aging that leads living cells to a state of permanent cell cycle arrest due to chronic antigenic irritation. This in vitro study aimed to shed light on the mechanisms of “inflammageing” on human oral cells. Methods: Primary cultures of human gingival fibroblasts (hGFs) were exposed to variable pro-inflammatory stimuli, including lipopolysaccharide (LPS), Tumor Necrosis Factor-alpha (TNFa), and gingival crevicular fluid (GCF) collected from active periodontal pockets of systemically healthy patients. Inflammageing was studied through two experimental models, employing either late-passage (“aged”) cells (p.10) that were exposed to the pro-inflammatory stimuli or early-passage (“young”) cells (p.1) continuously exposed during a period of several passages (up to p.10) to the above-mentioned stimuli. Cells were evaluated for the expression of beta-galactosidase activity (histochemical staining), senescence-associated genes (qPCR analysis), and biomarkers related to a Senescence Associated Secretory Phenotype (SASP), through proteome profile analysis and bioinformatics. Results: A significant increase (p<0.05) of beta-galactosidase-positive cells was observed after exposure to each pro-inflammatory stimulus. The senescence-associated gene expression included upregulation for CCND1 and downregulation for SUSD6, and STAG1, a profile typical for cellular senescence. Overall, pro-inflammatory priming of late-passage cells caused more pronounced effects in terms of senescence, than long-term exposure of early-passage cells to these stimuli. Proteomic analysis showed induction of SASP, evidenced by upregulation of several pro-inflammatory proteins (IL-6, IL-10, IL-16, IP-10, MCP-1, MCP-2, M-CSF, MIP-1a, MIP-1b, TNFb, sTNF-RI, sTNF-RII, TIMP-2) implicated in cellular aging and immune responses. The least potent impact on the induction of SASP was provoked by LPS and the most pronounced by GCF. Conclusion: This study demonstrates that long-term exposure of hGFs to various pro-inflammatory signals induced or accelerated cellular senescence with the most pronounced impact noted for the late-passage cells. The outcome of this analyses provides insights into oral chronic inflammation, as a potential confounder of age-related diseases.

Preprint ARTICLE | doi:10.20944/preprints202304.0151.v1

The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years

Sally EL Tawab, Sabina Nistor, Rene Roux, Sanjiv Manek, Kezia Geitskell, Ahmed Ahmed, Sean Kehoe, Hooman Soleymani majd

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Ovarian clear cell carcinoma; residual disease; recurrence; survival; endometriosis- associated

Online: 10 April 2023 (05:14:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0078.v2

Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders

Claudia Deus, Henrique Tavares, Margarida Beatriz, Sandra Mota, Carla Lopes

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Extracellular vesicles; neurodegenerative disorders; mitochondrial damage-associated molecular patterns; inflammation

Online: 6 July 2022 (09:16:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0096.v1

Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal

Abou Abdallah Malick Diouara, Seynabou Lo, Cheikh Momar Nguer, Assane Senghor, Halimatou Diop Ndiaye, Noël Magloire Manga, Fodé Danfakha, Sidy Diallo, Marie Edouard Faye Dieme, Ousmane Thiam, Babacar Biaye, Ndèye Marie Pascaline Manga, Fatou Thiam, Habibou Sarr, Gora Lo, Momar Ndour, Sébastien Paterne Manga, Nouhou Diaby, Modou Dieng, Idy Diop, Yakhya Dieye, Coumba Toure Kane, Martine Peeters, Ahidjo Ayouba

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis E; Associated risk factors; Pregnant women; Environment; Prevention; Senegal

Online: 7 June 2022 (08:06:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0385.v1

Improved Cognitive Performances in Trace Amine-Associated Receptor 5 (TAAR5) Knock-out Mice

Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R Gainetdinov, Stefano Espinoza

Subject: Social Sciences, Behavior Sciences Keywords: Trace amine-associated receptor 5; cognition; decision-making; switch task

Online: 25 January 2022 (14:49:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0320.v2

Phylogenetic and Expression Analysis of CENH3 and APOLLO Genes in Sexual and Apomictic Boechera Species

Evgeny Bakin, Fatih Sezer, Aslıhan Özbilen, Irem Kilic, Buket Uner, Mike Rayko, Kemal Melih Taskin, Vladimir Brukhin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Boechera; Brassicaceae; CENH3; APOLLO; apomixis associated genes; cell division; apomeiosis

Online: 20 December 2021 (10:40:57 CET)

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Apomictic plants (reproducing via asexual seeds), unlike sexual individuals, avoid meiosis and egg cell fertilization. Consequently, apomixis is very important for fixing maternal genotypes in the next plant generations. Despite the progress in the study of apomixis, molecular and genetic regulation of the latter remains poorly understood. So far APOLLO (Aspartate Glutamate Aspartate Aspartate histidine exonuclease) is one of the very few described genes associated with apomixis in Boechera species. The centromere-specific histone H3 variant encoded by CENH3 gene is essential for cell division. Mutations in CENH3 disrupt chromosome segregation during mitosis and meiosis since the attachment of spindle microtubules to a mutated form of the CENH3 histone fails. This paper presents in silico characteristic of APOLLO and CENH3 genes, which may affect apomixis. Also, we characterize the structure of CENH3, study expression levels of APOLLO and CENH3 in gynoecium/siliques of the natural diploid apomictic and sexual Boechera species at the stages of before and after fertilization. While CENH3 was a single copy gene in all Boechera species, the APOLLO gene have several polymorphic alleles associated with sexual and apomictic reproduction in the Boechera genera. Expression of the APOLLO apo-allele during meiosis was upregulated in gynoecium of apomict B. divaricarpa downregulating after meiosis until 4th day after pollination (DAP). On the 5th DAP, expression in apomictic siliques increased again. In sexual B. stricta gynoecium and siliques APOLLO apo-allele did not express. Expression of the APOLLO sex-allele during and after meiosis in gynoecium of sexual plants was several times higher than that in apomictic gynoecium. However, after pollination the sex-allele was downregulated in sexual siliques to the level of apomicts and increased sharply on the 5th DAP, while in apomictic siliques it almost did not express. At the meiotic stage, the expression level of CENH3 in the gynoecium of apomicts was two times lower than that of the sexual Boechera, decreasing in both species after meiosis and keep remaining very low in siliques of both species for several days after artificial pollination until the 4th DAP, when the expression level raised in sexual B. stricta siliques exceeding 5 times the level in apomictic B. divaricarpa siliques. We also discuss polymorphism and phylogeny of the APOLLO and CENH3 genes.

Preprint REVIEW | doi:10.20944/preprints202004.0331.v1

Coronavirus 2019 Infection in People with Associated Co-Morbidities: Case Fatality and ACE2 Inhibitors Treatment Concerns

Maryam Honardoost, Rokhsareh Aghili, Mohammad E. Khamseh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes

Online: 19 April 2020 (05:42:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0114.v1

Proteomics Computational Analyses Suggest That the Envelope Glycoproteins of Segmented Flavi-Like Jingmen Group Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains

Courtney E. Garry, Robert F. Garry

Subject: Biology And Life Sciences, Virology Keywords: Jingmen tick virus; Alongshan virus; flavi-like viruses; class II viral fusion proteins; O-liked glycans; mucin-like domain; virus evolution

Online: 9 February 2020 (17:29:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1648.v1

Tumor and Tumor-Like Lesions in Red Foxes (Vulpes vulpes) from Croatia

Šimun Naletilić, Ivan-Conrado Šoštarić-Zuckermann, Željko Mihaljević

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Red fox, Vulpes vulpes, tumor, tumor-like lesion, Croatia

Online: 21 December 2023 (11:34:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1038.v1

Magnetic, Antiferroelectric Like Behavior, and Resistance Switching Properties in BiFeO₃-CaMnO₃ Polycrystalline Thin Films

Abdelilah LAHMAR, Jacem Zidani, Jamal Belhadi, Ilham Hamdi Alaoui, Hussam Musleh, Jihad Asaad, Naji Al Dahoudi, Mimoun El Marssi

Subject: Physical Sciences, Applied Physics Keywords: ferromagnetic; Antiferroelectric like; polycrystalline films, BiFeO3-CaMnO3; Resistance switching

Online: 17 October 2023 (07:07:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0153.v1

Isolation of a PRD1-like Phage Uncovers the Carriage of Three Putative Conjugative Plasmids in Clinical Burkholderia Contaminans

Cassandra R Stanton, Steve Petrovski, Steven Batinovic

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Burkholderia cepacia complex; bacteriophage; PRD1-like phage; conjugative plasmid

Online: 10 April 2023 (05:46:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0440.v1

Fisetin Modulates Toll-Like Receptor-Mediated Innate Antiviral Response in Chikungunya Virus-Infected Hepatocellular Carcinoma Huh7 Cells

Rafidah Lani, Boon-Teong Teoh, Sing-Sin Sam, Sazaly Abubakar, Pouya Hassandarvish

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: infectious diseases; chikungunya; antiviral; flavonoids; fisetin; toll-like receptors

Online: 28 September 2022 (12:15:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0199.v1

Using a Toy Model to Improve the Quantization of Gravity and Field Theories

John Klauder

Subject: Physical Sciences, Particle And Field Physics Keywords: Affine quantization; Ashtekar-like variables; gravity and field theories

Online: 13 December 2021 (12:36:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0030.v1

Time-Like Proton Form Factors in Initial State Radiation Process

Dexu Lin, Alaa Dbeyssi, Frank Maas

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: proton; electromagnetic form factors; initial state radiation; time-like

Online: 2 December 2021 (10:27:18 CET)

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Working Paper COMMUNICATION

Tumor Associated Granulomas Preceding the Diagnosis of Systemic Thoracic Sarcoidosis. A Retrospective Study

Patricia Muñoz-Hernández, Mariel Valdivia-Mazeyra, Julio Ancochea, Tamara Alonso-Pérez, Olga Rajas, Claudia Valenzuela, Susana Hernández-Muñiz, Amparo Esteban-Peris, José A. Jiménez-Heffernan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: granulomas, neoantigens, neoplasia, sarcoidosis, sarcoid-like reaction, tumoral antigens.

Online: 13 July 2021 (10:00:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0422.v1

SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2

George Tetz, Victor Tetz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19; SARS; SARS-CoV-2 Prion-like domain

Online: 29 March 2020 (06:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0160.v1

Influenza-Like Illness Caused by the 2019 Novel Coronavirus (2019-nCoV) via the Person-to-Person Transmission

Huimin Zhang, Wei Wang, Ningjun Wu, Wugao Liu, Chunsheng Qu, Xu Jia, Chang Su, Jingke Wang, Youjun Feng

Subject: Biology And Life Sciences, Virology Keywords: influenza-like illness; 2019-nCoV; person-to-person transmission

Online: 10 March 2020 (05:18:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0666.v1

Metagenomic Characterization of the Viral Community of the South Scotia Ridge

Qingwei Yang, Chen Gao, Jiang Yong, Ming Wang, Xinhao Zhou, Hongbing Shao, Zheng Gong, Andrew McMinn

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: virus; South Scotia Ridge; viral community; diversity; Pgvv-like

Online: 29 October 2018 (09:43:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0036.v1

Degradation of Methylene Blue Dye in the Presence of Visible Light Using SiO₂@α-Fe₂O₃ Nanocomposites Deposited on SnS₂ Flowers

Sridharan Balu, Kasimayan Uma, Guan-Ting Pan, Thomas C.-K. Yang, Sayee Kannan Ramaraj

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: photocatalyst; flower-like SnS2; nanocomposites; visible light; methylene blue

Online: 3 April 2018 (10:53:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0039.v1

Benveniste’s Experiments Explained by a Non-Conventional Experimenter Effect

Francis Beauvais

Subject: Biology And Life Sciences, Other Keywords: systems biology; probabilistic modelling; experimenter effect; quantum-like correlations

Online: 6 March 2018 (03:35:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0181.v1

Blood Leukocyte Transcriptional Modules and Differentially Expressed Genes Associated with Disease Severity and Age in COVID-19 Patients

Silvia Yumi Bando, Fernanda Bernardi Bertonha, Sandra E Vieira, Danielle B. L. Oliveira, Vanessa N Chalup, Edison L Durigon, Patricia Palmeira, Ana Cristina P Curi, Caroline S Faria, Leila Antonangelo, Gerhard da P Lauterbach, Fabiane A Regalio, Roberto M Cesar Jr, Carlos Alberto Moreira-Filho

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; disease severity; blood leukocyte transcriptome; WGCNA; transcriptional modules; differentially expressed genes; COVID-19 transcriptional markers

Online: 9 August 2022 (14:59:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0283.v1

Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge

Nayara Araújo dos Reis, Rosalina Aparecida Partezani Rodrigues, Darlene Mara dos Santos Tavares, Jack Roberto Silva Fhon, Jair Sindra Virtuoso Júnior

Subject: Medicine And Pharmacology, Hematology Keywords: chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health

Online: 25 October 2019 (04:16:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1501.v1

Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents

Martina Wimmerová, Uladzimir Bildziukevich, Zdenek Wimmer

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: plant triterpenoid; structure modifier; antiviral activity; HIV-1; HSV-1; maturation inhibitor

Online: 24 October 2023 (07:33:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0547.v1

First Screening of Beta-Lactam Antibiotic Resistance Genes and Bacterial Diversity in the Public Transport System of Quito, Ecuador

Fernanda Gabriela Hernandez-Alomia, Carlos Andrès Bastidas-Caldes, Isabel Ballesteros, Gabriela N. Tenea, Pablo Santiago Jarrin, Carlos Alfonso Molina, Pablo Castillejo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mecA; blaTEM-1; blaOXA-181; blaCTX-M-1; environmental-DNA; antibiotic-resistance

Online: 29 December 2022 (02:05:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0054.v1

Identification of the Sixth Ig-like Domain of VCAM-1 as a Novel Therapeutic Target in Lung Cancer Cell Invasion

Mi Ra Kim, Ji Hye Jang, Chang Sik Park, Taek-Keun Kim, Youn-Jae Kim, Junho Chung, Hyunbo Shim, In Hyun Nam, Jung Min Han, Sukmook Lee

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: human antibody; invasion; lung cancer; therapeutic target; VCAM-1; VCAM-1-D6

Online: 15 February 2017 (10:45:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0456.v1

The Potential Use of Soluble TREM Like Transcript – 1, a Platelet-Specific Receptor, for Early Detection of Anthracyclines Induced Congestive Heart Failure (CHF) in Leukemia Patients

Siobhan Branfield, Susan LaGrand, Ian Cleary, Angelia Gibson, Anthony Valance Washington

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Keywords: keyword triggering receptor expressed in myeloid cells-like transcript (TLT-1); blood platelets; cardiovascular diseases; left ventricular ejection fraction (LVEF); biomarker; anthracyclines, Troponin I, cardiotoxicity, congestive heart failure (CHF)

Online: 7 February 2024 (17:08:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0263.v1

Cancer‐Associated Fibroblast Heterogeneity in Oral Cancer

Julia Arebro, Che-Min Lee, Kevin L Bennewith, Cathie Garnis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer‐associated fibroblast, CAF subtype, oral squamous cell carcinoma, tumor microenvironment

Online: 5 December 2023 (11:11:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1202.v1

The Risk of Death among Patients with Healthcare-Associated Infections and Cardiovascular Diseases Admitted in Intensive Care Unit in Romania

Mihaela Alexandra Budianu, Liviu Moraru, Bogdan Mihai Budianu, Judit Kovacs, Septimiu Voidăzan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: healthcare-associated infections; Intensive Care Unit; cardiovascular diseases, multidrug resistant bacteria

Online: 18 October 2023 (18:26:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1121.v1

Knowledge and Visual Differentiation Ability of the Pressure Injury Classification System and Incontinence-Associated Dermatitis among Hospital Nurses: A Descriptive Study

Seungmi Park, Eun Jung Kim, Son Ja Lee, Eun Jeong Kim, Ji Yeon Lee, Jung Eun Hong

Subject: Public Health And Healthcare, Nursing Keywords: clinical nurses; visual differentiation; diagnostic ability; pressure injury; incontinence-associated dermatitis

Online: 18 October 2023 (10:00:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1794.v1

DNA Promoter Methylation of the ATM, APC, CDO1, RB1, TP53, WIF1 Genes in Patients with Head and Neck Squamous Cell Carcinoma

Segey Kurevlev, Anna Aghjanayan, Leyla Tskhovrebova, Konstantin Gordon, Andrey Polyakov, Mikhail Ratushnyy, Timur Fatkhudinov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA methylation; cancer associated genes; head and neck squamous cell carcinoma

Online: 25 August 2023 (08:33:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0307.v1

The Consistency of the Distribution Function Conditional Estimate and Application on the Consistency and Asymptotic Normality of the Conditional Hazard Function Estimate for High Dimensional Quasi-Associated Data

Hamza Daoudi, Zouaoui Chikr Elmezouar, Fatimah Alshahrani

Subject: Computer Science And Mathematics, Mathematics Keywords: conditional distribution function; asymptotic normality, conditionalhazard function; quasi-associated; functional data

Online: 3 August 2023 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0751.v1

Identification of EGF Receptor and Thrombospondin-1 As En-Dogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells

Kohta Miura, Riko Katsuki, Shusei Yoshida, Ren Ohta, Taku Tamura

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Endoplasmic reticulum-associated degradation (ERAD); EDEM1; ER chaperone; EGF receptor; TSP1

Online: 12 June 2023 (03:58:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0232.v1

The microRNAs in the Antennae of Apolygus lucorum (Hemiptera: Miridae): Expression Properties and Targets Prediction

Adel Khashaveh, Xingkui An, Shuang Shan, Xiaoqian Pang, Yan Li, Xiaowei Fu, Yongjun Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Small RNA sequencing; miRNAs; Target prediction; Chemosensory-associated genes; Apolygus lucorum

Online: 18 February 2022 (10:01:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0573.v1

Epidemiological and Microbiological Aspects of Health Care-associated Infections in Ukraine During the 2009–2019 Period

Yulian Konechnyi, Marta Panas, Iryna Tymchuk, Roksolana Konechna, Olena Borysiuk, Iryna Hubytska, Lesya Zhurakhivska, Olena Korniychuk

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: healthcare-associated infections; HCAIs; hospital acquired infections; nosocomial infections; statistical analysis

Online: 24 September 2020 (08:19:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0003.v6

Farey Sequences and the Riemann Hypothesis

Darrell Cox

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann hypothesis, Farey sequence, Gauss sum associated with a Dirichlet character

Online: 10 August 2016 (11:35:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1353.v1

D1-like and D2-like Dopamine Receptor of Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits

Lidia M Birioukova, Gilles Van Luijtelaar, Inna S Midzyanovskaya

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: dopamine; D1-like dopamine receptors; D2-like dopamine receptors; prefrontal cortex; generalized epilepsy; absence epilepsy; audiogenic epilepsy; animal model; autism spectrum disorder; phenotype

Online: 20 September 2023 (08:51:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0541.v9

A Solution of The Collatz Conjecture Problem

baoyuan duan

Subject: Computer Science And Mathematics, Signal Processing Keywords: Collatz conjecture; (*3+1)/2^k odd sequence; (*3+2^m-1)/2^k odd sequence; (*3+2^m-1)/2^k odd tree; weight function

Online: 21 July 2023 (08:53:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0397.v1

Erythrocytes of Nonalcoholic Steatohepatitis Patients Contain Decreased Arginase-1 and Thrombospondin-1, and Increased Phosphatidylethanolamine Levels

Charalampos Papadopoulos, Konstantinos Mimidis, Ioannis Tentes, Konstantinos Anagnostopoulos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: erythrocyte; non alcoholic steatohepatitis; immunometabolism; thrombospondin-1; arginase-1; phosphatidylethanolamine; metabolic inflammation ;

Online: 17 April 2023 (04:22:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0120.v1

Mathematical Modeling of the Growth Suppression of HER2+ Breast Cancer Colonies Under the Effect of Trastuzumab and PD-1/PD-L1 Inhibitor

Regina Padmanabhan, Hadeel Kheraldine, Ishita Gupta, Nader Meskin, Anas Hamad, Semir Vranic, Ala-Eddin Al Moustafa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; PD-1/PD-L1; Mathematical model; HER2/PD-1 Interaction; Breast cancer

Online: 9 May 2022 (14:06:20 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1070.v1

Prostate Adenocarcinoma with Signet-Ring Cells and Features of Mucin. A Clinical Case and Literature Review

Migle Sakalauskaite, Ausra Garnelyte, Ignas Civilka, Audrius Dulskas, Marius Kincius, Aušvydas Patašius

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Prostate cancer; signet-ring cell-like carcinoma; features of mucin

Online: 16 April 2024 (15:47:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0454.v2

Biased Random Process of Randomly Moving Particles with Fixed Mean and Curl

Baodan Bai, Tao Guo

Subject: Physical Sciences, Mathematical Physics Keywords: Randomly Moving Particles; Biased Motion; Special Relativistic-like Effects; Curl

Online: 17 October 2023 (09:36:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1088.v1

Fetuin-A Modulates Tumor Growth and Invasion in a Basal-Like Triple Negative Breast Cancer Cell Line, MDA-MB-468

Divya Kenchappa, Olga Y Korolkova, Peace Odiase, Michael G. Izban, Amos Sakwe, Josiah Ochieng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Fetuin-A; Triple Negative; Breast Cancer; TLR4; Invasion; Basal-like

Online: 15 September 2023 (16:02:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0940.v1

Investigation of Rock-like Material for Deep Damaged Rock Mass Based on Orthogonal Experimental Method

Hongwei Wang, Fuxiang Xie, Jian Song, Wenke Bao, Zhaoming Yin

Subject: Engineering, Civil Engineering Keywords: damaged rock mass; rock-like material; orthogonal test; mechanical property

Online: 14 July 2023 (05:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0660.v1

Bismuth Decorated Honeycomb-like Carbon Nanoﬁbers: An Active Electrocatalyst for Construction of Sensitive Nitrite Sensor

Fengyi Wang, Ye Li, Chenglu Yan, Qiuting Ma, Xiaofeng Yang, Huaqiao Peng, Huiyong Wang, Juan Du, Baozhan Zheng, Yong Guo

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: nitrite sensor; honeycomb-like carbon nanofibers; Bi nanoparticles; nitrite detection

Online: 21 April 2023 (02:50:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0710.v1

Dermal Exposure to Hazardous Chemicals in Baby Diapers: A Critical Review of the Quantitative Health Risk Assessment Con-Ducted by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES)

Alfred Bernard

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: diaper, dioxin; dioxin-like polychlorobiphenyls; polycyclic aromatic hydrocarbons; formaldehyde; fragrance.

Online: 30 July 2021 (23:52:09 CEST)

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Working Paper ARTICLE

LED Light Improved by an Optical Filter to Visible Solar-Like Light With High Color Rendering

Li-Siang Shen, Hsing-Yu Wu, Li-Jen Hsiao, Chih-Hsuan Shih, Jin-Cherng Hsu

Subject: Physical Sciences, Acoustics Keywords: LED; solar-like light; optical coating; color rendering index; D65

Online: 1 June 2021 (09:46:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0286.v2

Human-Like Arm Motion Generation: A Review

Gianpaolo Gulletta, Wolfram Erlhagen, Estela Bicho

Subject: Computer Science And Mathematics, Robotics Keywords: human-like motion; humanoid robots; arm motion planning; literature review

Online: 10 November 2020 (10:38:49 CET)

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Working Paper ARTICLE

The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice

Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Dendra M. Hillier, Stephen J. Renaud

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: embryogenesis; blastocyst; trophoblast; stem cell; differentiation; placenta; Ovo-like 2

Online: 8 March 2020 (04:11:35 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202002.0107.v1

A Topological Approach to Infinity in Physics

Arturo Tozzi, James F. Peters

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: donut-like; infinity; paths; physical geometry; networks, Alexander horned sphere

Online: 9 February 2020 (15:55:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0060.v1

“Memory of Water” Experiments Explained with No Role Assigned to Water: Pattern Expectation after Classical Conditioning of the Experimenter

Francis Beauvais

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Experimenter effect; “Memory of water”; Quantum-like correlations; Classical conditioning

Online: 3 October 2018 (14:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0088.v1

Mixed of Elzaki Transform and Projected Differential Transform Method for a Nonlinear Wave-Like Equations with Variable Coefficients

Ali Khalouta, Abdelouahab Kadem

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: nonlinear wave-like equations; Elzaki transform; projected differential transform method

Online: 5 August 2018 (10:04:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0136.v1

Early Hyperbaric Oxygen Treatment Attenuates Burn-Induced Neuroinflammation by Inhibiting the Galectin-3-Dependent Toll-Like Receptor-4 Pathway in a Rat Model

Zong-Sheng Wu, Jing-Jou Lo, Sheng-Hua Wu, Chau-Zen Wang, Rong-Fu Chen, Su-Shin Lee, Chee-Yin Chai, Shu-Hung Huang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hyperbaric oxygen; Neuroinflammation; burn; Galectin-3; Toll-like receptor-4

Online: 9 July 2018 (12:03:39 CEST)

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Hyperbaric oxygen (HBO) treatment has been proven to attenuate neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague–Dawley (SD) rats were randomly assigned to the following six groups (n = 6 per group): (1) sham burn with sham HBO treatment, (2) sham burn with HBO treatment, (3) burn with 1-week sham HBO treatment, (4) burn with 2-week sham HBO treatment, (5) burn with 1-week HBO treatment, and (6) burn with 2-week HBO treatment. SD rats that received third-degree burn injury were used as a full-thickness burn injury model. Subsequently, we analyzed the expression of proteins involved in the galectin-3 (Gal-3)-dependent Toll-like receptor-4 (TLR-4) pathway through enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC) analysis, and Western blotting, and a behavior test was also conducted. The behavior test revealed that HBO treatment significantly suppressed mechanical hypersensitivity in the burn with HBO treatment group compared with the burn with sham HBO treatment group (p < 0.05). ELISA results showed that tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) levels in the dorsal horn of the spinal cord and the skin were significantly decreased in the burn with HBO treatment group compared with the burn with sham HBO treatment group (p < 0.05). Western blotting results demonstrated that HBO treatment significantly reduced the expression of Gal-3 and TLR-4 in the dorsal horn of the spinal cord in the burn with HBO treatment group compared with the burn with sham HBO treatment group (p < 0.05). IHC analysis results showed that the expression of Gal-3, TLR-4, CD68, and CD45 in the dorsal horn of the spinal cord was significantly lower in the burn with HBO treatment group than in the burn with sham HBO treatment group (p < 0.05), and the expression of CD68 and macrophage migration inhibitory factor (MIF) in the right hind paw skin was significantly lower. The expression of vimentin and fibroblast growth factor (FGF) in the right hind paw skin was significantly higher after HBO treatment (p < 0.05). This study proved that early HBO treatment relieves neuropathic pain, inhibits the Gal-3-dependent TLR-4 pathway, and suppresses microglia/macrophage activation in a rat model.

Preprint REVIEW | doi:10.20944/preprints201806.0161.v1

The role of miR-29a in the regulation, function, and signaling of liver fibrosis

Ying-Hsien Huang, Ya-Ling Yang, Feng-Sheng Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: miR-29a; cholestasis; apoptosis; ER stress; toll like receptors; epigenetics

Online: 11 June 2018 (14:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0622.v1

Para-Ricci-like Solitons on Almost Paracontact Almost Paracomplex Riemannian Manifolds

Hristo Manev, Mancho Manev

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: para-Ricci-like soliton; $\eta$-Ricci soliton; para-Einstein-like manifold; $\eta$-Einstein manifold; almost paracontact almost paracomplex Riemannian manifold; torse-forming vector field

Online: 25 June 2021 (12:31:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0684.v1

Incretin Hormones and Type 2 Diabetes – Mechanistic Insights and Therapeutic Approaches

Geke Aline Boer, Jens Juul Holst

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GIP; GLP-1; incretins; T2DM

Online: 27 November 2020 (11:24:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0136.v1

Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice

Ana I Sanchez-Garrido, Vanessa Prieto-Vicente, Victor Blanco-Gozalo, Miguel Arevalo, Yaremi Quiros, Daniel Lpopez-Montañes, Francisco J. Lopez-Hernandez, Antonio Rodriguez-Perez, José M Lopez-Novoa

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: apoptosis; cardiotrophin-1; colon; inflammation

Online: 12 October 2019 (03:38:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0389.v1

High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma

Mattia Perazzi, Roberto Piffero, Rosalba Minisini, Silvia Gaia, Emanuela Rolle, Gian Paolo Caviglia, Michela Emma Burlone, Giulia Francesca Manfredi, Stelvio Tonello, Mattia Bellan, Patrizia Carucci, Mario Pirisi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: High Mobility Group Box-1 (HMGB-1); portal vein thrombosis (PVT); hepatocellular carcinoma (HCC)

Online: 7 November 2023 (10:36:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0876.v1

Cellular-Host Interaction of SARS-CoV-2 Gamma Variant

Aline Miranda Scovino, Elizabeth Chen Dahab, Israel Diniz-Lima, Etiele de Senna Silveira, Shana Priscila Coutinho Barroso, Karina Martins-Cardoso, Dirlei Nico, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima, Natalia Valente, Valeria Nacife, Ana Machado, Mia Araújo, Gustavo Fioravanti Vieira, Alex Pauvolid-Corrêa, Marilda Mendonça Siqueira, Alexandre Morrot

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; P.1 variant; B.1 strain; cytokines; COVID-19; macrophages; neutrophils

Online: 13 July 2023 (04:34:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0141.v1

Molecular Characterization and Antibiogram of Acinetobacter Baumannii Clinical Isolates Recovered From the Patients With Ventilator-Associated Pneumonia

Saleem Mohd, Azharuddin Sajid Syed Khaja, Ashfaq Hossain, Fahaad Alenazi, Kamaleldin B. Said, Soha Abdallah Moursi, Homoud Abdulmohsin Almalaq, Hamza Sharif Mohamed, Ehab Rakha

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Acinetobacter baumannii; XDR; IMP-1; VIM-2; NDM-1; VAP; ICU; Hospital-acquired infections

Online: 9 June 2022 (10:58:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0038.v1

Diabetes Induced Renal Complications by Leukocyte Activation of Nuclear Factor κ-B and its Regulated Genes Expression

Noura Darwish, Yousif Elnahas, Fatmah AlQahtany

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: NF-κB; IL-1β; IL-6; VEGF; TNF-α; FN; ICAM-1; VCAM-1

Online: 2 September 2020 (09:46:10 CEST)

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Working Paper REVIEW

Revisiting the Stress Concept in the Context of Solid Tumors Prognostic: A Role for the Stress Granules?

Anais Aulas, Pascal Finetti, Shawn Lyons, François Bertucci, Daniel Birnbaum, Claire Acquaviva, Emilie Mamessier

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: stress granules; G3BP1; G3BP2; Caprin-1; USP10; TIA1; TIAR; cancer prognosis; biomarker; metastasis; resistance; cell death; pro-survival properties

Online: 7 April 2020 (01:56:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0122.v1

High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma

Masako Ishikawa, Kentaro Nakayama, Kohei Nakamura, Hitomi Yamashita, Tomoka Ishibashi, Toshiko Minamoto, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa, Satoru Nakayama, Yoshiro Otsuki, Satoru Kyo

Subject: Physical Sciences, Biophysics Keywords: cervical adenocarcinoma; immune-checkpoint inhibitor; programmed cell death-1(PD-1); programmed cell death-ligand 1(PD-L1); CD8 expression; lymphocyte; survival analysis

Online: 12 January 2020 (15:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0599.v1

Chemo-Enzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and other β2- Agonists

Fredrik Heen Blindheim, Mari Bergan Hansen, Sigvart Evjen, Wei Zhu, Elisabeth Egholm Jacobsen

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: (R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol; (S)-N-(2,6-dichloro-4-(1-hydroxyethyl)phenyl)acetamide; clenbuterol; ketoreductase; chiral chromatography

Online: 25 October 2018 (08:44:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2085.v1

Evaluation of the Antibacterial Activity of New Dermaseptin Derivatives against Acinetobacter baumannii

Houda HADDAD, Radhia MEJRI, Alyne Rodriguez De ARAUJO, Amira Zaïri

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Dermaseptin B2; Dermaseptin S4; analogs; Acinetobacter baumannii; Healthcare-Associated Infections; Antibacterial activity

Online: 27 December 2023 (10:24:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1080.v1

Brief Electrical Stimulation Ameliorates Poor Recovery after Surgical Repair of Injured Peripheral Nerves

Tessa Gordon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: peripheral nerve regeneration; delayed surgical nerve repair; regeneration associated genes; electrical stimulation

Online: 17 October 2023 (11:02:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1231.v1

Molecular Mechanisms of Pentagalloyl Glucose-Mediated Stabilization of Abdominal Aortic Aneurysms

Dan Simionescu, Nishanth Tharayil, Elizabeth Leonard, Wenda Carlyle, Alex Schwarz, Kelvin Ning, Christopher Carsten, Juan Carlos Carrillo Garcia, Alexander Carter, Collin Owens, Agneta Simionescu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aneurysms; polyphenols; diffusion; stabilization; docking simulations; elastin; collagen; elastin-associated microfibrillar proteins

Online: 16 June 2023 (11:04:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1213.v1

Unravelling the Immune Microenvironment in Classic Hodgkin Lymphoma: Prognostic and Therapeutic Implications

Vasileios Georgoulis, Alexandra Papoudou-Bai, Alexandros Makis, Panagiotis Kanavaros, Eleftheria Hatzimichael

Subject: Medicine And Pharmacology, Hematology Keywords: Hodgkin lymphoma; tumor microenvironment; tumor associated macrophages; CD169+ macrophages; immune evasion; immunosuppression

Online: 17 May 2023 (09:37:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0470.v1

Kaposi’s Sarcoma-associated Herpesvirus ORF21 Enhances the Phosphorylation of MEK and the Infectivity of Progeny Virus

Tatsuo Yamaguchi, Tadashi Watanabe, Yuki Iwaisako, Masahiro Fujimuro

Subject: Biology And Life Sciences, Virology Keywords: Kaposi’s sarcoma-associated herpesvirus; MEK; thymidine kinases; lytic replication; infectivity; ORF21; herpesvirus

Online: 25 November 2022 (06:13:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0099.v1

Extracellular Secretomes of Leptospira Interrogans Serovar Icterohemorrhagiae Respond to the In Vivo Mimic of Physiological Osmolarity and Temperature Transition

Tipparat Thiangtrongjit, Onrapak Reamtong, Weerapong Phumratanapraphin, Direk Limmathurotsakul, Surapong Chatpun, Mingkwan Odton, Muthita Vanaporn, Pornpan Pumirat, Usa Boonyuen, Sumate Ampawong, Ngamphol Soonthornworasiri, Poom Adisakwattana, Urai Chaisri, Santi Maneewatchararangsri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Leptospira spp., secretome; virulent-associated secreted proteins; in-vivo mimic mammalian condition

Online: 9 October 2022 (02:07:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0340.v1

Unlocking the Molecular and Biochemical Machinery of Insect Herbivore Resistance: the Key is a Perception of Herbivore-Associated Elicitors

Saiful Malook, Saiqa Maqbool, Muhammad Hafeez, Samantha Chandranath Karunarathna, Nakarin Suwannarach

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: herbivore-associated elicitors; plant defense; secondary metabolites; signaling metabolites; pattern recognition receptors

Online: 25 May 2022 (03:53:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0148.v1

Peptide: N-Glycanase 1 and Its Relationship with Congenital Disorder of Deglycosylation

Xiangguang Miao, Jin Wu, Hongping Chen, Guanting Lu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: N-glycosylation; NGLY1; ER associated degradation process; congenital disorder of deglycosylation; NFE2L1

Online: 10 March 2022 (12:51:22 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202104.0774.v1

Wuhan's Experience in Fighting COVID-19: Achieving Zero Case of COVID-19 Infection among Healthcare Workers

Anhua Wu, liuyi li, Caixia Tan, Xiujun Meng, Xudong Ma, Chunhui Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; infection control; healthcare-associated infections; healthcare workers; SARS-CoV-2

Online: 29 April 2021 (11:35:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0479.v1

Suboptimal Health Status of High School Students in Guangzhou, Shanxi, and Tibet, China: A Cross-Sectional Study

Gehendra Mahara, Jiazhi Liang, Zhirong Zhang, Qi Ge, Jinxin Zhang

Subject: Medicine And Pharmacology, Other Keywords: suboptimal health status; associated factors; high school students; Shanxi; Guangzhou; Tibet; China

Online: 20 September 2020 (14:50:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0501.v1

Novel Circoviruses Detected in Feces of Sonoran Felids

Natalie Payne, Simona Kraberger, Rafaela S Fontenele, Kara Schmidlin, Melissa H Bergeman, Ivonne Cassaigne, Melanie Culver, Arvind Varsani, Koenraad Van Doorslaer

Subject: Biology And Life Sciences, Virology Keywords: circoviridae; circoviruses; bobcat; lynx rufus; Sonoran desert; Sonoran felid associated (Sonfela) circoviruses

Online: 24 August 2020 (03:09:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0445.v1

Oral Tumour Cell Migration and the Effect of the Local Soluble Factors from the Microenvironment on Signalling Pathways. Is It All about the Akt?

Hanan Ahmed, Arpa Ghoshal, Sarah Jones, Ian Ellis, Mohammad Islam

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oral cancer; cancer-associated fibroblasts; metastasis; cell migration; cell invasion; Akt; EGFR

Online: 27 May 2020 (08:25:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0060.v1

Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

Thomas Ziebart, Sebastian Blatt, Junho Jung, Andreas Pabst, Christian Walter, Frank Halling, Paul Heymann, Andreas Neff, Leonardo Righesso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingiva; bisphosphonate; soft tissue; fibroblasts; keratinocytes; bisphosphonate associated osteonecrosis of the jaws

Online: 15 October 2016 (08:03:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0039.v1

Dietary antiplatelets: a new perspective on the health benefits of the water-soluble tomato concentrate Fruitflow®

Niamh O’Kennedy, Ruedi Duss, Asim K Duttaroy

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Platelet function, platelet activation, platelet hyperactivity, platelet-leukocyte aggregates, inflammation, immunothrombosis, particulate air pollution, dietary antiplatelet, water-soluble tomato extract; Fruitflow; Tomato

Online: 2 April 2021 (08:12:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0164.v1

Curvature Properties of Almost Ricci-Like Solitons with Torse-Forming Vertical Potential on Almost Contact B-Metric Manifolds

MANCHO MANEV

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Almost Ricci-like soliton; almost $\eta$-Ricci soliton; almost Einstein-like manifold; almost $\eta$-Einstein manifold; almost contact B-metric manifold; torse-forming vector field

Online: 5 February 2021 (14:05:20 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.1700.v2

Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions

Mitsuhiro Tachibana, Hideki Hamayasu, Akihiko Yokota, Masahiro Matsushita

Subject: Biology And Life Sciences, Life Sciences Keywords: hyperplastic nodule; polypoid lesion; colitis nucleomigrans; colorectal mucosa; tumor-like lesion

Online: 29 March 2024 (17:10:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0913.v1

RNA Interference-Mediated Suppression of Ecdysone Signaling Inhibits Choriogenesis in two Coleoptera species

Xiao-Qing Zhang, Lin Jin, Wen-Chao Guo, Kai-Yun Fu, Guo-Qing Li

Subject: Biology And Life Sciences, Insect Science Keywords: Leptinotarsa decemlineata; Henosepilachna vigintioctopunctata; choriogenesis; ecdysone signal, chitin-like substance; eggshell

Online: 15 March 2024 (11:33:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0735.v1

Fibonacci-Like Sequences Reveal the Genetic Code Symmetries, also When the Amino Acids Are in a Physiological Environment

Tidjani Négadi

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic code; amino acids; Fibonacci-like sequences; hydrogen patterns; atom patterns

Online: 10 January 2024 (08:52:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1473.v1

Role of MOB4 in Cell Proliferation and Neurogenesis

Álvaro A. Tavares, Inês B. Santos, Juan Garrido-Maraver, Bruna I. Oliveira, Carolina Gonçalves

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Mob4,; Cell proliferation, neurogenesis, spermatogenesis, Hippo pathway, STRIPAK, MOB-like protein

Online: 21 August 2023 (12:12:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1408.v1

Fabrication of Cu-doped Diamond-like Carbon Film for Improving Sealing Performance of Hydraulic Cylinder of Shearer

Yufei Shi, Jingyan Ye, Xiang Yu, Ruxue Hao, Zhiyan Zhao, Lei Zhang

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: diamond-like carbon film; Cu doping；sealing performance; hydraulic cylinder; Shearer

Online: 21 August 2023 (12:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0940.v1

Expressions of Insulin-Like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning

Mengying Dou, Md. Abul Kalam Azad, Yating Cheng, Sujuan Ding, Yang Liu, Bo Song, Xiangfeng Kong

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chinese indigenous pig; insulin-like growth factors; receptors; binding protein; weaning

Online: 11 August 2023 (11:08:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0921.v1

Investigating the Biochemical Stability and Kinetic Performances of SiO2@AuNPs Nanocomposite as High Throughput Peroxidase Alternatives

Saeed Reza Hormozi Jangi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: SiO2@AuNPs nanocomposite; intrinsic peroxidase‐like activity; cycling stability; shelf stability

Online: 11 August 2023 (10:16:57 CEST)

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