Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Involvement of Krüppel-like Factors in Cardiovascular Diseases

Michelle Giovanna Santoyo-Suarez
ORCID logo ,
Jimena D. Mares-Montemayor
,
Gerardo R. Padilla-Rivas
,
Juan L. Delgado-Gallegos
,
Adriana G. Quiroz-Reyes
,
Jorge A. Roacho-Perez
,
Diego F. Benitez-Chao
,
Lourdes Garza-Ocañas
,
Gilberto Arevalo-Martinez
,
Elsa N. Garza-Treviño
ORCID logo ,
Jose Francisco Islas
*
Version 1 : Received: 9 December 2022 / Approved: 13 December 2022 / Online: 13 December 2022 (01:13:14 CET)

A peer-reviewed article of this Preprint also exists.

Santoyo-Suarez, M.G.; Mares-Montemayor, J.D.; Padilla-Rivas, G.R.; Delgado-Gallegos, J.L.; Quiroz-Reyes, A.G.; Roacho-Perez, J.A.; Benitez-Chao, D.F.; Garza-Ocañas, L.; Arevalo-Martinez, G.; Garza-Treviño, E.N.; Islas, J.F. The Involvement of Krüppel-like Factors in Cardiovascular Diseases. Life 2023, 13, 420. Santoyo-Suarez, M.G.; Mares-Montemayor, J.D.; Padilla-Rivas, G.R.; Delgado-Gallegos, J.L.; Quiroz-Reyes, A.G.; Roacho-Perez, J.A.; Benitez-Chao, D.F.; Garza-Ocañas, L.; Arevalo-Martinez, G.; Garza-Treviño, E.N.; Islas, J.F. The Involvement of Krüppel-like Factors in Cardiovascular Diseases. Life 2023, 13, 420.

Abstract

KLFs seem to associate with congenital heart disease-linked syndromes, malformations because of autosomal diseases, mutations that relate to protein instability, and/or loss functions such as atheroprotective activities. Ischemic damage also relates to KLF dysregulation because of differentiation of cardiac myofibroblasts or a modified fatty acid oxidation, related to the formation of a dilated cardiomyopathy; myocardial infarctions, left ventricular hypertrophy and diabetic cardiomyopathies. MicroRNA have been involved in certain regulatory loops of KLFs as they may function as critical modulators of vascular smooth muscle cells in atherosclerosis, in heart failure and as markers of endothelial damage in acute myocardial infarction.

Keywords

Cardiovascular diseases; Krüppel -like factors; Transcription factor regulation

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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