Preprint Article Version 1 This version is not peer-reviewed

Influenza-Like Illness Caused by the 2019 Novel Coronavirus (2019-nCoV) via the Person-to-Person Transmission

Version 1 : Received: 9 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (05:18:19 CET)

How to cite: Zhang, H.; Wang, W.; Wu, N.; Liu, W.; Qu, C.; Jia, X.; Su, C.; Wang, J.; Feng, Y. Influenza-Like Illness Caused by the 2019 Novel Coronavirus (2019-nCoV) via the Person-to-Person Transmission. Preprints 2020, 2020030160 (doi: 10.20944/preprints202003.0160.v1). Zhang, H.; Wang, W.; Wu, N.; Liu, W.; Qu, C.; Jia, X.; Su, C.; Wang, J.; Feng, Y. Influenza-Like Illness Caused by the 2019 Novel Coronavirus (2019-nCoV) via the Person-to-Person Transmission. Preprints 2020, 2020030160 (doi: 10.20944/preprints202003.0160.v1).

Abstract

The ongoing pandemic of the 2019 novel coronavirus disease (COVID-19) raises a global health crisis, which has resulted in 75,778 confirmed cases with 2130 deaths in China and beyond. Atypical symptom renders it challenging to earlier recognize the 2019-nCoV carrier with the potential ability of equivalent transmission. Therefore, it is needed to gain full spectrum of COVID-19. Here we report clustered COVID-19 cases of person-to-person transmission. The symptoms of typical pneumonia are shared by the two familial members, namely son (Patient 1) and father (Patient 2). Unexpectedly, an influenza-like illness (ILI) is also caused in Patient 3 having close contact with Patient 1 at personal dinner party. Combined with clinical and epidemiological study, chest computed tomography (CT) and molecular diagnosis demonstrate that all the three cases tested positive for COVID-19 with distinct symptoms by human-to-human transmission. To the best of knowledge, it closes in part (if not all), a missing gap of clinical repertoires of COVID-19 outbreaks and underlines the possibility that neglection of cryptic/asymptomatic/mild cold-like syndromes gives biased screen in the earlier stage of COVID-19 cases.

Subject Areas

influenza-like illness; 2019-nCoV; person-to-person transmission

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