High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma

Mattia Perazzi; Roberto Piffero; Rosalba Minisini; Silvia Gaia; Emanuela Rolle; Gian Paolo Caviglia; Michela Emma Burlone; Giulia Francesca Manfredi; Stelvio Tonello; Mattia Bellan; Patrizia Carucci; Mario Pirisi

doi:10.20944/preprints202311.0389.v1

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preprints.org > medicine and pharmacology > gastroenterology and hepatology > doi: 10.20944/preprints202311.0389.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma

Giulia Francesca Manfredi

Version 1 : Received: 6 November 2023 / Approved: 7 November 2023 / Online: 7 November 2023 (10:36:58 CET)

How to cite: Perazzi, M.; Piffero, R.; Minisini, R.; Gaia, S.; Rolle, E.; Caviglia, G.P.; Burlone, M.E.; Manfredi, G.F.; Tonello, S.; Bellan, M.; Carucci, P.; Pirisi, M. High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma. Preprints 2023, 2023110389. https://doi.org/10.20944/preprints202311.0389.v1 Perazzi, M.; Piffero, R.; Minisini, R.; Gaia, S.; Rolle, E.; Caviglia, G.P.; Burlone, M.E.; Manfredi, G.F.; Tonello, S.; Bellan, M.; Carucci, P.; Pirisi, M. High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma. Preprints 2023, 2023110389. https://doi.org/10.20944/preprints202311.0389.v1

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MDPI and ACS Style

Perazzi, M.; Piffero, R.; Minisini, R.; Gaia, S.; Rolle, E.; Caviglia, G.P.; Burlone, M.E.; Manfredi, G.F.; Tonello, S.; Bellan, M.; Carucci, P.; Pirisi, M. High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma. Preprints 2023, 2023110389. https://doi.org/10.20944/preprints202311.0389.v1

APA Style

Perazzi, M., Piffero, R., Minisini, R., Gaia, S., Rolle, E., Caviglia, G.P., Burlone, M.E., Manfredi, G.F., Tonello, S., Bellan, M., Carucci, P., & Pirisi, M. (2023). High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma. Preprints. https://doi.org/10.20944/preprints202311.0389.v1

Chicago/Turabian Style

Perazzi, M., Patrizia Carucci and Mario Pirisi. 2023 "High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma" Preprints. https://doi.org/10.20944/preprints202311.0389.v1

Abstract

Background High Mobility Group Box-1 (HMGB-1) is implicated in the pathogenesis of thrombosis and cancer. In the present study, we aimed to evaluate its potential role as a diagnostic biomarker of portal vein thrombosis (PVT) among patients with hepatocellular carcinoma (HCC). Methods The study population included N=100 prospectively recruited patients with a novel diagnosis of HCC. We compared circulating HMGB-1 levels between 34 healthy controls, HCC patients with PVT (N=22), and HCC patients without PVT (N=78). Results HCC patients without PVT showed significantly higher median HMGB-1 serum levels (8.2 [5.5-13.1] ng/ml) than those observed in the case of HCC with PVT (5.5 [4.4-8.5] ng/ml; p=0.012) and in healthy controls (4.1 [3.1-8.2] ng/ml; p<0.001). Among HCC patients, at univariate analysis, the presence of PVT was associated with higher median age (p=0.036), larger major cancer node diameter (p<0.001), and lower HMGB-1 serum level (p=0.012). At multivariate analysis, the presence of PVT maintained a positive association with major node diameter p=0.001) and an inverse association with serum HMGB-1 levels (p=0.003). Conclusions These findings indicate that serum HMGB-1 bears an inverse association with PVT complicating HCC at the time of diagnosis and suggest that serum HMGB-1 depletion may mark PVT development in cirrhotic patients with HCC.

Keywords

High Mobility Group Box-1 (HMGB-1); portal vein thrombosis (PVT); hepatocellular carcinoma (HCC)

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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