Preprint Article Version 1 This version is not peer-reviewed

Proteomics Computational Analyses Suggest That the Envelope Glycoproteins of Segmented Flavi-Like Jingmen Group Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains

Version 1 : Received: 7 February 2020 / Approved: 9 February 2020 / Online: 9 February 2020 (17:29:14 CET)

How to cite: Garry, C.E.; Garry, R.F. Proteomics Computational Analyses Suggest That the Envelope Glycoproteins of Segmented Flavi-Like Jingmen Group Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains. Preprints 2020, 2020020114 (doi: 10.20944/preprints202002.0114.v1). Garry, C.E.; Garry, R.F. Proteomics Computational Analyses Suggest That the Envelope Glycoproteins of Segmented Flavi-Like Jingmen Group Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains. Preprints 2020, 2020020114 (doi: 10.20944/preprints202002.0114.v1).

Abstract

Jingmen viruses are newly described segmented flavi-like viruses that have a worldwide distribution in ticks and have been associated with febrile illnesses in humans. Computational analyses were used to predict that Jingmen flavi-like virus glycoproteins have structural features of class II viral fusion proteins, including an ectodomain consisting of beta-sheets and short alpha-helices, a fusion peptide with interfacial hydrophobicity and a three domain architecture. Jingmen flavi-like virus glycoproteins have a sequence enriched in serine, threonine and proline at the amino terminus, which is a feature of mucin-like domains. Several of the serines and threonines are predicted be modified by the addition of O-linked glycans. Some of the glycoproteins are predicted to have an additional mucin-like domain located prior to the transmembrane anchor, whereas others are predicted to have a stem consisting of two alpha-helices. The flavivirus envelope protein and Jingmen flavi-virus glycoproteins may have diverged from a common class II precursor glycoprotein with a mucin-like domain or domains acquired after divergence.

Subject Areas

Jingmen tick virus; Alongshan virus; flavi-like viruses; class II viral fusion proteins; O-liked glycans; mucin-like domain; virus evolution

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