Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dietary antiplatelets: a new perspective on the health benefits of the water-soluble tomato concentrate Fruitflow®

Version 1 : Received: 31 March 2021 / Approved: 2 April 2021 / Online: 2 April 2021 (08:12:22 CEST)

How to cite: O’Kennedy, N.; Duss, R.; Duttaroy, A.K. Dietary antiplatelets: a new perspective on the health benefits of the water-soluble tomato concentrate Fruitflow®. Preprints 2021, 2021040039 (doi: 10.20944/preprints202104.0039.v1). O’Kennedy, N.; Duss, R.; Duttaroy, A.K. Dietary antiplatelets: a new perspective on the health benefits of the water-soluble tomato concentrate Fruitflow®. Preprints 2021, 2021040039 (doi: 10.20944/preprints202104.0039.v1).

Abstract

Understanding platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause too strong a platelet suppression to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. Here we review potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women’s health, erectile dysfunction, and the allergic response give an indication of how wide-ranging the utility of dietary antiplatelets can possibly be.

Keywords

Platelet function, platelet activation, platelet hyperactivity, platelet-leukocyte aggregates, inflammation, immunothrombosis, particulate air pollution, dietary antiplatelet, water-soluble tomato extract; Fruitflow; Tomato

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