Dou, M.; Azad, M.A.K.; Cheng, Y.; Ding, S.; Liu, Y.; Song, B.; Kong, X. Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning. Animals2023, 13, 3011.
Dou, M.; Azad, M.A.K.; Cheng, Y.; Ding, S.; Liu, Y.; Song, B.; Kong, X. Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning. Animals 2023, 13, 3011.
Dou, M.; Azad, M.A.K.; Cheng, Y.; Ding, S.; Liu, Y.; Song, B.; Kong, X. Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning. Animals2023, 13, 3011.
Dou, M.; Azad, M.A.K.; Cheng, Y.; Ding, S.; Liu, Y.; Song, B.; Kong, X. Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning. Animals 2023, 13, 3011.
Abstract
The present study investigated the insulin-like growth factors (IGFs) and their receptors and binding proteins among different pig breeds during weaning. Sixty Duroc (DR), Taoyuan black (TB), and Xiangcun black (XB) piglets (20 piglets per breed) were selected at 21 and 24 days of age (three days of post-weaning) to analyze organ indices, plasma concentrations of IGF and IGF-binding proteins (IGFBPs) using ELISA kits, and gene expression of IGF system-related components in different tissues. The plasma IGFBP-3 level in TB piglets was higher (P > 0.05) than in the XB and DR piglets at 21 days of age. At 21 days of age, compared with the DR piglets, the IGF-1 expression was lower (P < 0.05) in the kidney but was higher (P < 0.05) in the spleen of XB and TB piglets. At 24 days of age, the IGF-1 expression was higher (P < 0.05) in the kidney of TB piglets than in the XB and DR piglets, while IGFBP-3 in the stomach and IGFBP-4 in the liver of XB and TB piglets were lower (P < 0.05) compared with the DR piglets. Weaning down-regulated (P < 0.05) the IGF-1 expression in the jejunum, spleen, and liver of piglets, while up-regulated (P < 0.05) IGFBP-3 expression in the stomach, IGFBP-4 in the liver, IGFBP-5 in the ileum, and IGFBP-6 in the jejunum of DR piglets. Spearman’s correlation analysis showed a negative correlation (P < 0.05) between plasma IGFBP-2 and IGFBP-5 and the organ index of piglets. Collectively, there were significant differences in IGF system components among different pig breeds. The IGF system components were altered during weaning, which might be involved in weaning stress to decrease the growth of piglets.
Keywords
Chinese indigenous pig; insulin-like growth factors; receptors; binding protein; weaning
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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