Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

An Immune Escape of Oral Squamous Cell Carcinoma Might Be Different in the Originating-Epithelium, Keratinized or Non-keratinized

Yoshiaki Kistukawa
,
Chonji Fukumoto
ORCID logo ,
Toshiki Hyodo
,
Yuske Komiyama
,
Ryo Shiraishi
,
Aya Koike
,
Shuma Yagisawa
,
Yosuke Kunitomi
,
Tomonori Hasegawa
,
Wataru Kotani
,
Kazuyuki Ishida
ORCID logo ,
Takahiro Wakui
* ,
Hitoshi Kawamata
*
Version 1 : Received: 6 March 2024 / Approved: 7 March 2024 / Online: 7 March 2024 (07:49:57 CET)

A peer-reviewed article of this Preprint also exists.

Kitsukawa, Y.; Fukumoto, C.; Hyodo, T.; Komiyama, Y.; Shiraishi, R.; Koike, A.; Yagisawa, S.; Kunitomi, Y.; Hasegawa, T.; Kotani, W.; Ishida, K.; Wakui, T.; Kawamata, H. Difference between Keratinized- and Non-Keratinized-Originating Epithelium in the Process of Immune Escape of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci. 2024, 25, 3821. Kitsukawa, Y.; Fukumoto, C.; Hyodo, T.; Komiyama, Y.; Shiraishi, R.; Koike, A.; Yagisawa, S.; Kunitomi, Y.; Hasegawa, T.; Kotani, W.; Ishida, K.; Wakui, T.; Kawamata, H. Difference between Keratinized- and Non-Keratinized-Originating Epithelium in the Process of Immune Escape of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci. 2024, 25, 3821.

Abstract

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand 1 (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases including oral cancer. Cancer cells usually escape from immune system and acquire proliferative capacity and invasive/metastatic potential. We have focused on the two immune checkpoints, PD-1/PD-L1 and CD47/SIRPα in the tumor microenvironment of oral squamous cell carcinoma (OSCC), and performed a retrospective analysis of the expression of seven immune-related factors (PD-L1, PD-1, CD4, CD8, CD47, CD56 and CD11c), and examined their correlation with clinicopathological status. As a result, there were no significant findings relating seven immune-related factors and several clinicopathological statuses. However, the immune-checkpoint related factors (PD-1, PD-L1, CD47) were highly expressed in non-keratinized epithelium-originated tumors when compared to those in keratinized epithelium-originated tumors. It is of interest that immunoediting via immune checkpoint-related factors was facilitated in non-keratinized sites. Several researchers reported that keratinization of oral mucosal epithelia affected the immune response, but our present finding is the first study to show a difference of the tumor immunity in the originating-epithelium of OSCC, keratinized or non-keratinized. Tumor immunity, an immune escape status of OSCC might be different in the originating-epithelium, keratinized or non-keratinized.

Keywords

immune escape; tumor immunity; immune checkpoint; oral squamous cell carcinoma; programmed death receptor-1 (PD-1); programmed cell death 1-ligand 1 (PD-L1); CD47

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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