Working Paper Communication Version 1 This version is not peer-reviewed

Tumor Associated Granulomas Preceding the Diagnosis of Systemic Thoracic Sarcoidosis. A Retrospective Study

Version 1 : Received: 10 July 2021 / Approved: 13 July 2021 / Online: 13 July 2021 (10:00:24 CEST)

A peer-reviewed article of this Preprint also exists.

Muñoz-Hernández, P.; Valdivia-Mazeyra, M.; Ancochea, J.; Alonso Pérez, T.; Rajas, O.; Valenzuela, C.; Hernández-Muñiz, S.; Esteban-Peris, A.; Jiménez-Heffernan, J.A. Tumor-Associated Granulomas Preceding a Diagnosis of Thoracic Sarcoidosis: A Retrospective, Single-Center Cohort Study. J. Clin. Med. 2021, 10, 4151. Muñoz-Hernández, P.; Valdivia-Mazeyra, M.; Ancochea, J.; Alonso Pérez, T.; Rajas, O.; Valenzuela, C.; Hernández-Muñiz, S.; Esteban-Peris, A.; Jiménez-Heffernan, J.A. Tumor-Associated Granulomas Preceding a Diagnosis of Thoracic Sarcoidosis: A Retrospective, Single-Center Cohort Study. J. Clin. Med. 2021, 10, 4151.

Journal reference: J. Clin. Med. 2021, 10, 4151
DOI: 10.3390/jcm10184151

Abstract

There is a relationship between systemic sarcoidosis (SS) and malignancy. Sarcoidosis results from an exaggerated immune response in genetically susceptible individuals. In oncologic pa-tients with sarcoidosis, tumoral antigens and antineoplastic treatment are considered potential triggering factors. The observation of a patient with granulomas in a parotid carcinoma that later developed SS led us to review previous tumors of patients with SS. The aim of the study is to see if granulomas were already present in the tumors that preceded sarcoidosis. We identified 196 sarcoidosis patients, 47 of which had a previous tumor. We were able to review 29 cases 12 of which showed tumor associated granulomas (TAGs)(41.4%). This ratio is much higher than that of the normal population. We analyzed five control patients without sarcoidosis for each tumor. In conclusion, we have observed TAGs in patients who later develop SS. In our series, the ratio of TAGs in patients with SS was significantly greater than in the normal population. To prove our findings, we suggest reviewing the history of patients with SS in search of previous tumors. The histology of such tumors should be reviewed in an attempt to identify granulomas.

Keywords

granulomas, neoantigens, neoplasia, sarcoidosis, sarcoid-like reaction, tumoral antigens.

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.