Preprint Article Version 1 This version is not peer-reviewed

Explore the Potential Mechanism of Bufadienolides-Like Chemicals on Breast Cancer through Bioinformatics Analysis

Version 1 : Received: 29 November 2018 / Approved: 30 November 2018 / Online: 30 November 2018 (10:14:58 CET)

A peer-reviewed article of this Preprint also exists.

Zhang, Y.; Tang, X.; Pang, Y.; Huang, L.; Wang, D.; Yuan, C.; Hu, X.; Qu, L. The Potential Mechanism of Bufadienolide-Like Chemicals on Breast Cancer via Bioinformatics Analysis. Cancers 2019, 11, 91. Zhang, Y.; Tang, X.; Pang, Y.; Huang, L.; Wang, D.; Yuan, C.; Hu, X.; Qu, L. The Potential Mechanism of Bufadienolide-Like Chemicals on Breast Cancer via Bioinformatics Analysis. Cancers 2019, 11, 91.

Journal reference: Cancers 2019, 11, 91
DOI: 10.3390/cancers11010091

Abstract

Bufadienolides-like chemicals, which mostly composed the active ingredient of Chansu, had been widely discovered to possess anti-inflammatory, tumor-suppressing and antipain activity, but the mechanisms of action were not clearly illuminated. In this research, in order to explore the potential mechanism of bufadienolides-like chemicals on breast cancer, a serious of bioinformatics analysis, included (1) differentially expressed genes identification combined with gene set variation analysis, (2) tissue specific co-expression network construction, (3) differentially regulated sub-networks detection with disease phenome, (4) hub gene selection and it’s relation to survival probability, and (5) similar small molecule detection were performed with gene expression profiles of bufadienolides-like chemicals. Results indicated bufadienolides-like chemicals had the most same target with valproic, estradiol and etc, could disturbed the pathways in RNA splicing, apoptotic process, cell migration, extracellular matrix organization, adherens junction organization, synaptic transmission, Wnt signaling, AK-STAT signaling, BMP signaling pathway and unfolded protein response, and had the potential ability to be used as anticancer, hormones and vasoprotectives agents.

Subject Areas

bufadienolides-like chemicals; molecular mechanism; anti-cancer; bioinformatics

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