Version 1
: Received: 11 January 2020 / Approved: 12 January 2020 / Online: 12 January 2020 (15:01:23 CET)
How to cite:
Ishikawa, M.; Nakayama, K.; Nakamura, K.; Yamashita, H.; Ishibashi, T.; Minamoto, T.; Iida, K.; Razia, S.; Ishikawa, N.; Nakayama, S.; Otsuki, Y.; Kyo, S. High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma. Preprints2020, 2020010122. https://doi.org/10.20944/preprints202001.0122.v1
Ishikawa, M.; Nakayama, K.; Nakamura, K.; Yamashita, H.; Ishibashi, T.; Minamoto, T.; Iida, K.; Razia, S.; Ishikawa, N.; Nakayama, S.; Otsuki, Y.; Kyo, S. High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma. Preprints 2020, 2020010122. https://doi.org/10.20944/preprints202001.0122.v1
Ishikawa, M.; Nakayama, K.; Nakamura, K.; Yamashita, H.; Ishibashi, T.; Minamoto, T.; Iida, K.; Razia, S.; Ishikawa, N.; Nakayama, S.; Otsuki, Y.; Kyo, S. High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma. Preprints2020, 2020010122. https://doi.org/10.20944/preprints202001.0122.v1
APA Style
Ishikawa, M., Nakayama, K., Nakamura, K., Yamashita, H., Ishibashi, T., Minamoto, T., Iida, K., Razia, S., Ishikawa, N., Nakayama, S., Otsuki, Y., & Kyo, S. (2020). High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma. Preprints. https://doi.org/10.20944/preprints202001.0122.v1
Chicago/Turabian Style
Ishikawa, M., Yoshiro Otsuki and Satoru Kyo. 2020 "High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma" Preprints. https://doi.org/10.20944/preprints202001.0122.v1
Abstract
The effectiveness of immunotherapy for cervical adenocarcinoma (CA) has not been demonstrated yet. It may be possible for us to use programmed cell death 1 (PD-1), programmed cell death-ligand 1 (PD-L1), and CD8 as biomarkers of response to immune therapy in CA patients. In the present study, we aimed to investigate whether the expression levels of PD-1, PD-L1, and CD8 can predict the prognosis of CA patients and their response to ICI therapy. The levels of the PD-1, PD-L1, and CD8 proteins were analyzed by immunohistochemical analysis from formalin-fixed, paraffin-embedded tumor samples. The correlation between the expression levels and patient prognosis was analyzed by the Kaplan–Meier method and univariate and multivariate Cox proportional hazard regression model. We observed a significant inverse-correlation between the PD-1 and CD8 expression (p=0.001, chi square test). We also found a significant inverse-correlation between the PD-L1 and CD8 expression (p=0.027). The overall survival was significantly worse in patients with positive PD-1 expression (p=0.027). Similarly, the progression-free survival was also worse (p=0.087). Our results demonstrate that a high level of PD-1 expression is associated with a poor prognosis in CA patients. Further research is necessary to identify the molecular mechanisms that mediate this association.
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