Version 1
: Received: 23 October 2019 / Approved: 25 October 2019 / Online: 25 October 2019 (04:16:43 CEST)
How to cite:
Reis, N.A.D.; Rodrigues, R.A.P.; Tavares, D.M.D.S.; Fhon, J.R.S.; Virtuoso Júnior, J.S. Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge. Preprints2019, 2019100283. https://doi.org/10.20944/preprints201910.0283.v1
Reis, N.A.D.; Rodrigues, R.A.P.; Tavares, D.M.D.S.; Fhon, J.R.S.; Virtuoso Júnior, J.S. Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge. Preprints 2019, 2019100283. https://doi.org/10.20944/preprints201910.0283.v1
Reis, N.A.D.; Rodrigues, R.A.P.; Tavares, D.M.D.S.; Fhon, J.R.S.; Virtuoso Júnior, J.S. Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge. Preprints2019, 2019100283. https://doi.org/10.20944/preprints201910.0283.v1
APA Style
Reis, N.A.D., Rodrigues, R.A.P., Tavares, D.M.D.S., Fhon, J.R.S., & Virtuoso Júnior, J.S. (2019). Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge. Preprints. https://doi.org/10.20944/preprints201910.0283.v1
Chicago/Turabian Style
Reis, N.A.D., Jack Roberto Silva Fhon and Jair Sindra Virtuoso Júnior. 2019 "Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge" Preprints. https://doi.org/10.20944/preprints201910.0283.v1
Abstract
C-reactive protein (CRP) and leukocytes are blood biomarkers involved in "Inflamm-Aging", which is a risk factor for the onset and progression of age-related diseases. Studies show that higher serum concentrations of these biomarkers are associated with functional disability, increased risk of low muscle strength, decreased muscle mass and mortality in the elderly. The objective was to estimate the predictive power and discriminating criteria of C-reactive protein and leukocyte concentrations for the risk of adverse health factors in the elderly within 30 days after hospital discharge (HD). Prospective cohort study using exploratory methods and blood biomarkers with 135 older adults admitted to medical and surgical clinics at a government hospital. The elderly were monitored at home after 30 days of HD for adverse health factors (rehospitalization, falls, amount of medication consumed, disability in basic and instrumental activities of daily living and mortality). CRP> 2.4; ≥ 0.7 and> 24.7 mg / dL and leukocytes ≥ 6.410; ≥ 8.690 and> 8.310 mm³ were discriminant for rehospitalization, falls and mortality within 30 days after HD, respectively. The cut-off points described may be used as a reference in the screening of hospitalized elderly vulnerable to adverse health events after hospital discharge.
Keywords
chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health
Subject
Medicine and Pharmacology, Hematology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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