Santos, I.B.; Garrido-Maraver, J.; Gonçalves, C.; Oliveira, B.I.; Tavares, Á.A. Role of MOB4 in Cell Proliferation and Neurogenesis. BioChem2023, 3, 182-196.
Santos, I.B.; Garrido-Maraver, J.; Gonçalves, C.; Oliveira, B.I.; Tavares, Á.A. Role of MOB4 in Cell Proliferation and Neurogenesis. BioChem 2023, 3, 182-196.
Santos, I.B.; Garrido-Maraver, J.; Gonçalves, C.; Oliveira, B.I.; Tavares, Á.A. Role of MOB4 in Cell Proliferation and Neurogenesis. BioChem2023, 3, 182-196.
Santos, I.B.; Garrido-Maraver, J.; Gonçalves, C.; Oliveira, B.I.; Tavares, Á.A. Role of MOB4 in Cell Proliferation and Neurogenesis. BioChem 2023, 3, 182-196.
Abstract
Signaling modules that integrate the diverse extra- and intracellular inputs to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signalling pathways. Here we review recent advances unraveling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and simultaneously is involved in synapse formation and neural development. In addition, the gene is often overexpressed in a wide range of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and development of tissues and individuals.
Keywords
Mob4,; Cell proliferation, neurogenesis, spermatogenesis, Hippo pathway, STRIPAK, MOB-like protein
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
