Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management and evaluation of interventions. This study was conducted at Muhimbili National Hospital (MNH) in Dar es Salaam, to establish laboratory reference ranges in SCD at steady-state. Patients were grouped into five age groups with respects to their sex. Aggregate functions were used to handle repeated measures within the indi-vidual level in each age group. A nonparametric approach was used to smooth the curves and a parametric approach was used to determine SCD normal ranges. Comparison between males and females and against the general population was documented. Data from 4,422 patients collected from 2004-2015 were analyzed. The majority of the patients (35.41%) were children aged between 5-11 years. There were no significant differences (p≥0.05) in mean corpuscular hemoglobin concentration (MCHC), lymphocytes, basophils and bilirubin direct observed between males and females. Significant differences (p<0.05) were observed in all selected parameters across age groups except neutrophils and MCHC in adults, as well as platelets and alkaline phosphatase in infants when SCD estimates were compared to the general population. Laboratory reference ranges in SCD at steady-state were different from those of the general population and varied with sex and age. The established reference ranges for SCD at steady-state will be a helpful in the management and monitoring of the progress of SCD.

In this paper, Hybrid Automata, which is a formal model for hybrid systems, has been introduced. A summary of its theory is presented and some of its special and important classes are listed and some properties that can be studied and checked for it are mentioned. Finally, the purposes of use, the most widely used areas, and the tools that provide H.A. Support are addressed.

The purpose of this study is to examine the relationship between the institutional investors which can affect financial performance for corporate sustainability on the income smoothing. Therefore, this study focus on the connection between the nature of stock rights and income smoothing in China. For this study, hypotheses were established on the relationship each state-controlled companies, income smoothing, and information equilibrium of individual investors, and empirical analysis was conducted through related variables. The analysis results are summarized in three categories as follows. First, this research finds that state-controlled firms (CONTs) prefer income smoothing activities compared to non-state-controlled firms for the long-term sustainable development of firms using data from 2011 to 2019. Second, this study found out that Institutional investors support the behavior of CONTs to smooth their earnings because this behavior is seen as an attempt by CONTs to convey valuable private information to other investors. Third, we was able to discover that institutional investors' monitoring effect is predominantly driven by pressure-resistant institutional investors. This research complements the lack of empirical research on income smoothing and enable to give a guideline that the type of stock rights is a critical key determinant of participation in income smoothing activities for stable growth and sustainability in the future.

The many-body problem in quantum physics originates from the difficulty of describing the non-trivial correlations encoded in the exponential complexity of the many-body wave function. Motivated by the Giuseppe Carleo's work titled solving the quantum many-body problem with artificial neural networks [Science, 2017, 355: 602], we focus on finding the NNQS approximation of the unknown ground state of a given Hamiltonian $H$ in terms of the best relative error and explore the influences of sum, tensor product, local unitary of Hamiltonians on the best relative error. Besides, we illustrate our method with some examples.

Garnet-type Ta-doped Li7La3Zr2O12 (LLZO) ceramic solid electrolytes with Ga2O3 additive were synthesized via a conventional solid-state reaction process. When the amounts of Ga2O3 additive were below 2 mol %, the sintered sample has a dense structure composed of grains with the averaged size of 5 to 10 μm, while 3 mol % or more Ga2O3 addition causes the significant increase in grain size above several 10 to 100 μm, due to the sintering with large amount of liquid Li-Ga-O phase at high temperature. The highest total (bulk + grain-boundary) ionic conductivity of 1.1 mS cm1 at room temperature was obtained in the sample with 5 mol % Ga2O3 addition. However, in galvanostatic testing of the symmetric cell with Li metal electrodes, this sample was shorted by Li dendrite growth into solid electrolyte at current density below 0.2 mA cm2. The tolerance for Li dendrite growth is maximized in sample sintered with 2 mol % Ga2O3 addition, which was shorted at 0.8 mA cm2 in the symmetric cell. Since the interfacial resistance between Li metal and solid electrolyte was nearly identical among the all samples, the difference in tolerance for Li dendrite growth is mainly attributed to the difference in microstructure of sintered samples depending on the amounts of Ga2O3.

In this paper, we present some new models for anisotropic compact stars within the framework of 5-dimensional Einstein-Gauss-Bonnet (EGB) gravity with a linear and nonlinear equation of state considering a metric potential proposed for Thirukkanesh and Ragel (2012) and generalized for Malaver (2014). The new obtained models satisfy all physical requirements of a physically reasonable stellar object. Variables as energy density, radial pressure and the anisotropy are dependent of the values of the Gauss-Bonnet coupling constant

Background: Social skills deficits are present in 43.3% of major depressed patients and significantly impact health-related quality of life. However, studies concerning social deficits as state-dependent markers of depression are limited. Objective: To delineate the effects of severity of depression, personality characteristics, family support satisfaction and self-esteem on social skills in clinical depression. Methods: We recruited 150 patients with major depressive disorder or persistent depressive disorder and assessed 1) Beck Depression Inventory-II (BDI-II), 2) Social Skill Inventory (SSI), 3) Family Adaptation, Partnership, Growth, Affection, Resolve (APGAR) Questionnaire 4) Rosenberg Self-Esteem Scale (RSES) and 5) Maudsley Personal Inventory (MPI). Results: Social skills deficits were significantly associated with female gender, age < 40 years, depression severity, introvert / neurotic personality, and lowered family support satisfaction and self-esteem. A large part of the variance (47.2%) in social skills deficits was predicted by satisfaction of family support, introvert personality, and low self-esteem. Exploratory Factor Analysis showed that a bifactorial model best fitted the data with a) a general factor loading highly on BDI-II, SSI emotional and social, APGAR, RSES, MPI_introvert and MPI_neurotic scores, and b) a single-group factor loading on both SSI, RSES, and MPI introvert scores. Conclusion: In clinical depression, social skills deficits covary with increasing severity of depression and thus constitute a state marker of depression, and independently from severity of depression covary with introvert personality features. As such, remission of social skills deficits may emerge as a novel objective for the treatment of depression and prevention of new episodes.

Three low band gap copolymers based on isoindigo acceptor units were designed and successfully synthesized by direct arylation polycondensation method. Two of them were benzodithiophene(BDT)-isoindigo copolymers (PBDTI-OD and PBDTI-DT) with 2-octlydodecyl(OD) and 2-decyltetradecyl (DT) substituted isoindigo units, respectively. Thiophene donor and DT-substituted isoindigo acceptor units were copolymerized to synthesize PTI-DT. The copolymers have broad absorption range that extends to over 760 nm with a band gap ~ .5 eV. The photophysical property studies showed the BDT based copolymers have non-polar ground states. Their emission exhibited the population of intramolecular charge transfer (ICT) state in polar solvents and tightly bound excitonic state in non-polar solvents due to self-aggregation. On the contrary, the emission from the thiophene based copolymers was only from the tightly bound excitonic state. The thermal decomposition temperature of the copolymers was above 380 oC. The X-ray diffraction pattern of the three copolymers showed a halo due pi-pi stacking. A second sharper peak was observed in the BDT-based copolymer with longer side chain on the isoindigo unit (PBDTI-DT) and the thiophene based copolymers with PTI-DT exhibiting a better structural order.

It is shown that the representation theory of some finitely presented groups thanks to their $SL_2(\mathbb{C})$ character variety is related to algebraic surfaces. We make use of the Enriques-Kodaira classification of algebraic surfaces and the related topological tools to make such surfaces explicit. We study the connection of $SL_2(\mathbb{C})$ character varieties to topological quantum computing (TQC) as an alternative to the concept of anyons. The Hopf link $H$, whose character variety is a Del Pezzo surface $f_H$ (the trace of the commutator), is the kernel of our view of TQC. Qutrit and two-qubit magic state computing, derived from the trefoil knot in our previous work, may be seen as TQC from the Hopf link. The character variety of some two-generator Bianchi groups as well as that of the fundamental group for the singular fibers $\tilde{E}_6$ and $\tilde{D}_4$ contain $f_H$. A surface birationally equivalent to a $K_3$ surface is another compound of their character varieties.

State legitimacy and effectiveness could be seen by the way to deliver welfare to citizens to mitigate social grievances, that could eventually lead to conflicts (Kivimäki, 2021). Social security systems in Maghreb countries are quite similar in their architecture and aims to provide social insurance to all the workers in the labor market. However, they suffer from the same main problem: the low rate of enrollment of workers. Many workers (employees and self-employed) work informally without any social security coverage. The issue of whether informal jobs are chosen voluntarily by workers or as a strategy of last resort is controversial. Many authors recognize that the informal sector is heterogeneous and it is made up of workers who voluntary choose it and others who are pushed inside because of entry barriers to the formal sector (Günther & Launov, 2012). Using the SAHWA survey and discrete choice models, this article confirms the heterogeneity of the informal labor market in three Maghreb countries: Algeria, Morocco, and Tunisia. Furthermore, this article highlights the profiles of workers who voluntarily choose informality, which is missing from previous studies. Finally, this article proposes policy recommendations in order to extend social security to informal workers and to include them in the formal labour market.

The Forest Stewardship Council initiated a pilot Forest Certification for Ecosystem Services (ForCES) project from 2011 to 2017 to improve and promote sustainable forest management addressing a range of ecosystem services. Three sites in Indonesia were studied in the pilot. Whilst the development of the certification standard was largely by a partnership between the certification standard organization, civil society and research organisations, implementation and monitoring of the impact of this voluntary sustainability standard will entail interaction with state regulations. This study sought to understand how certification and state regulations concerning ecosystem services in Indonesia interplay, particularly in the agenda setting and negotiation stage. Using the conceptual lenses of transition theory and state and non-state market-based governance, the interrelationships between ecosystem services certification and regulations were found to be both complementary, supporting and antagonistic. The majority were complementary. Antagonism occurred where regulations do not accommodate land use issues and due to different contradictory state regulations. The voluntary instruments were developed largely in the absence of state involvement and without any substitution with regulatory standards. Given the increasing proliferation of voluntary market-driven initiatives at farm, forest concession and landscape level, stakeholders developing and managing voluntary standards need to collaborate with national and local governments to create synergy to enable their acceptance, adoption and effectiveness to positively enhance the conservation of ecosystem services through incentivizing market-based instruments.

Hydrogenated amorphous silicon (a-Si:H) can be produced by plasma-enhanced chemical vapour deposition (PECVD) of SiH4 (Silane) mixed with Hydrogen. The resulting material shows outstanding radiation resistance properties and can be deposited on a wide variety of different substrates. These devices have been used to detect many different kinds of radiation namely: MIPs, x-rays, neutrons and ions as well as low energy protons and alphas. However, MIP detection using planar diodes has always been difficult due to the unsatisfactory S/N ratio arising from a combination of high leakage current, high capacitance and a limited charge collection efficiency (50% at best for a 30 µm planar diode). To overcome these limitations the 3D-SiAm collaboration proposes to use a 3D detector geometry. The use of vertical electrodes allows for a small collection distance to be maintained while conserving a large detector thickness for charge generation. The depletion voltage in this configuration can be kept below 400 V with consequent reduction in the leakage current. In this paper, following a detailed description of the fabrication process, the results of the tests performed on the planar p-i-n structures made with ion implantation of the dopants and with carrier selective contacts will be illustrated.

Communication, compression of information, transmission of information through noisy channels, interconnecting different information systems, cryptography, gate construction –– these areas all depend on classical information theory. We show that, in classical terms, semantic aspects of communication are not at all irrelevant to the engineering problem, contrary to Shannon, and affect the message intended to be transmitted. This is revisited and captured by an analogy to trust, in that they are essential to the channel (for proper use), but cannot be transferred (under risk of flaws) through that same channel. Information is also described by, at least, a tri-state system — not by binary logic. The trust analogy semantics can be coded as the Curry-Howard relationship, connecting computer code with structural logic, by way of different categories. Two-state and Boolean logic (aka Shannon semantics) was used classically before, with Shannon theory, but without trust analogy semantics – found to be a sine qua non condition. This is now familiar in classical gate construction with physical systems with, e.g., Verilog and SystemVerilog. The applications to computation and quantum theory are further explored. The most fundamental entity in today`s theory of information is proposed to use at least three logical states, not bits, in all applications, including: cyber-physical systems, devices, in computation, and in quantum theory.

Intratumoral heterogeneity can exist along multiple axes: Cancer Stem Cells (CSCs)/non-CSCs, drug-sensitive/drug-tolerant states and a spectrum of epithelial-hybrid-mesenchymal phenotypes. Further, these diverse cell-states can switch reversibly among one another, thereby posing a major challenge to therapeutic efficacy. Therefore, understanding the origins of phenotypic plasticity and heterogeneity remains an active area of investigation. While genomic components (mutations, chromosomal instability) driving heterogeneity have been well-studied, recent reports highlight the role of non-genetic mechanisms in enabling both phenotypic plasticity and heterogeneity. Here, we discuss various processes underlying phenotypic plasticity such as stochastic gene expression, chromatin reprogramming, asymmetric cell division and the presence of multiple “attractors”. These processes can facilitate a dynamically evolving cell population such that a subpopulation of (drug-tolerant) cells can survive lethal drug exposure and recapitulate population heterogeneity on drug withdrawal, leading to relapse. These drug-tolerant cells can be both pre-existing and also induced by the drug itself through cell-state reprogramming. The dynamics of cell-state transitions both in absence and presence of the drug can be quantified through mathematical models. Such a dynamical systems approach to elucidating patterns of intratumoral heterogeneity by integrating longitudinal experimental data with mathematical models can help design effective combinatorial and/or sequential therapies for better clinical outcomes.

Schizophrenia is widely seen as a disorder of dysconnectivity. Neuroimaging studies have examined both structural and functional connectivity in the disorder, but these modalities have rarely been integrated directly. We scanned 29 patients with schizophrenia and 25 healthy control subjects and acquired resting state fMRI and diffusion tensor imaging. The Functional and Tractographic Connectivity Analysis Toolbox (FATCAT) was used to estimate functional and structural connectivity of the default mode network. Correlations between modalities were investigated, and multimodal connectivity scores (MCS) were created using principal components analysis. Nine of 28 possible region pairs showed consistent (>80%) tracts across participants. Correlations between modalities were found among those with schizophrenia for the prefrontal cortex, posterior cingulate, and lateral temporal lobes with frontal and parietal regions, consistent with frontotemporoparietal network involvement in the disorder. In patients, MCS values correlated with several aspects of the Positive and Negative Syndrome Scale, positively with those involving inwardly directed psychopathology, and negatively with those involving external psychopathology. In this preliminary sample, we found FATCAT to be a useful toolbox to directly integrate and examine connectivity between imaging modalities. A consideration of conjoint structural and functional connectivity can provide important information about the network mechanisms of schizophrenia.

Information-theoretically provable unique true random numbers, which cannot be correlated or controlled by an attacker, can be generated based on quantum measurement of vacuum state and universal-hashing randomness extraction. Quantum entropy in the measurements decides the quality and security of the random number generator (RNG). At the same time, it directly determines the extraction ratio of true randomness from the raw data, in other words, it obviously affects quantum random bits generating rate. In this work, we commit to enhancing quantum entropy content in the vacuum noise based quantum RNG. We have taken into account main factors in this proposal to establish the theoretical model of quantum entropy content, including the effects of classical noise, the optimum dynamical analog-digital convertor (ADC) range, the local gain and the electronic gain of the homodyne system. We demonstrate that by amplifying the vacuum quantum noise, abundant quantum entropy is extractable in the step of post-processing even classical noise excursion, which may be deliberately induced by an eavesdropper, is large. Based on the discussion and the fact that the bandwidth of quantum vacuum noise is infinite, we propose large dynamical range and moderate TIA gain to pursue higher local oscillator (LO) amplification of vacuum quadrature and broader detection bandwidth in homodyne system. High true randomness extraction ratio together with high sampling rate is attainable. Experimentally, an extraction ratio of true randomness of 85.3% is achieved by finite enhancement of the laser power of the LO when classical noise excursions of the raw data is obvious.

Recently, there has been, on the one hand, an increase in the complexity of digital device designs and, on the other hand, an increase in the requirements for the development time and the reliability of the designs. One of the directions of solving this problem is developing new techniques for designing digital devices.This paper proposes a new technique for designing digital devices based on finite state machines with datapath (FSMD), when the functioning of the device is described in the form of an algorithm state machine with datapath (ASMD) charts. The new technique is called ASMD-FSMD. Different digital device design techniques are compared to each other using design examples of a synchronous multiplier on field programmable gate array (FPGA). The efficiency of the ASMD-FSMD technique compared to the traditional approach in terms of area and performance was investigated. The ASMD-FSMD technique, compared to the traditional one, reduces the area from 28.6% to 39.7% and increases the speed for some designs to 17.6%. In addition, using the ASMD-FSMD technique significantly reduces design time and increases design reliability. In conclusion, recommendations for using the ASMD-FSMD technique are made.

In the past few decades, probabilistic interpretations of brain functions have become widespread in cognitive science and neuroscience. In particular, the free energy principle and active inference are increasingly popular theories of cognitive functions that claim to offer a unified understanding of life and cognition within a general mathematical framework derived from information and control theory, and statistical mechanics. However, we argue that if the active inference proposal is to be taken as a general process theory for biological systems, it is necessary to understand how it relates to existing control theoretical approaches routinely used to study and explain biological systems. For example, recently, PID control has been shown to be implemented in simple molecular systems and is becoming a popular mechanistic explanation of behaviours such as chemotaxis in bacteria and amoebae, and robust adaptation in biochemical networks. In this work, we will show how PID controllers can fit a more general theory of life and cognition under the principle of (variational) free energy minimisation when using approximate linear generative models of the world. This more general interpretation provides also a new perspective on traditional problems of PID controllers such as parameter tuning as well as the need to balance performances and robustness conditions of a controller. Specifically, we then show how these problems can be understood in terms of the optimisation of the precisions (inverse variances) modulating different prediction errors in the free energy functional.

The Hertzian contact theory, as well as most of the other classical theories of normal and tangential contact, provides displacements and the distribution of normal and tangential stress components directly in the contact surface. However, other components of the full stress tensor in the material may essentially influence the material behaviour in contact. Of particular interest are principal stresses and the equivalent von Mises stress, as well as the gradient of the hydrostatic pressure. For many engineering and biomechanical problems, it would be important to find these stress characteristics at least in the contact plane. In the present paper, we show that the complete stress state in the contact plane can be easily found for axially symmetric contacts under very general assumptions. We provide simple explicit equations for all stress components and the normal component of the gradient of hydrostatic pressure in the form of one-dimensional integrals.

The induced draft (ID) fan is important auxiliary equipment in the thermal power plant. It is of great significance to monitor the operation of the ID fan for safe and efficient production. In this paper, an adaptive warning model is proposed to detect early faults of ID fans. First, a non-parametric monitoring model is constructed to describe the normal operation states with the multivariate state estimation technique (MSET). Then, an early warning approach is presented to identify abnormal behaviors based on the results of the MSET model. As the performance of the MSET model is heavily influenced by the normal operation data in the historic memory matrix, an adaptive strategy is proposed by using the samples with a high data quality index (DQI) to manage the memory matrix and update the model. The proposed method is applied to a 300 MW coal-fired power plant for early fault detection, and it is compared with the model without an update. Results show that the proposed method can detect the fault earlier and more accurately.

This paper presents the current lexical, morphological, syntactic and rule-based machine translation work for Erzya and Moksha that can and should be used in the development of a roadmap for Mordvin linguistic research. We seek to illustrate and outline initial problem types to be encountered in the construction of an Apertium-based shallow-transfer machine translation system for the Mordvin language forms. We indicate reference points within Mordvin Studies and other parts of Uralic studies, as a point of departure for outlining a linguistic studies with a means for measuring its own progress and developing a roadmap for further studies.

The issues of metallic scrap management and its utilization in manufacturing plants are nowadays intensely considered to address essential sustainability guidelines. Efficient recycling procedure for shop floor metallic scrap is not yet available because of abundance and contamination of nonmetallic constituents. Other ferrous metallic scrap are melted and purified during secondary steelmaking to get products in the form of blooms and billets are obtained. This study illustrates the potential of powder technology (powder metallurgy (PM) and metal injection molding (MIM)) based process for solid-state recycling and attainment of usable products. Industrially downgraded grinding sludge is pulverized and used as a raw material. Results showed properties of sintered parts are significantly improved due to in-situ reduction and densification during sintering. Recyclability Index (RI) was created to compare the effect of process variables on obtained products. Based on RI, recycled ferrous parts have about 70% comparable properties with equivalent pure iron parts. Complex reduction and sintering behavior in MIM, particularly, diffusion and pore volume kinetics limits applicability of MIM with this recycling approach. However, few industrial parts were developed and manufactured by PM based approach to validate the applicability of this novel recycling-cum-manufacturing process for the production of porous parts.

Port state control inspections implemented under the Paris Memorandum of Understanding (MoU) have become known as one of the best instruments for maritime administrations in European Union (EU) Member States to ensure that the ships docked in their ports comply with all maritime safety requirements. This paper focuses on the analysis of all inspections made between 2013 and 2018 in the top ten EU ports incorporated in the Paris MoU (17,880 inspections). The methodology consists of a multivariate statistical information system (STATIS) analysis using the inspected ship’s characteristics as explanatory variables. The variables used describe both the inspected ships (classification society, flag, age and gross tonnage) and the inspection (type of inspection and number of deficiencies), yielding a dataset with more than 600,000 elements in the data matrix. The most important results are that the classifications obtained match the performance lists published annually by the Paris MoU and the classification societies. Therefore, the approach is a potentially valid classification method and would then be useful to maritime authorities as an additional indicator of a ship’s risk profile to decide inspection priorities and as a tool to measure the evolution in the risk profile of flag over time.

One of the earliest hallmarks of plant immune response is production of reactive oxygen spe-cies (ROS) in different subcellular compartments, which regulate plant immunity. A suitable equilibrium, which is crucial to prevent ROS over-accumulation leading to oxidative stress, is maintained by salicylic acid (SA), a chief regulator of ROS. However, ROS are not only acting downstream of SA signaling, but were also proposed to be a central component of a self-amplifying loop that regulates SA signaling as well as the interaction balance between dif-ferent phytohormones. The exact role of this crosstalk, the position where SA interferes with ROS signaling and ROS interferes with SA signaling and the outcome of this regulation depend on the origin of ROS but also on the pathosystem. The precise spatiotemporal regulation of or-ganelle specific ROS and SA levels determine the effectiveness of pathogen arrest and is there-fore crucial for a successful immune response. However, the regulatory interplay behind still remain poorly understood, as up till now, the role of organelle specific ROS and SA in HR-conferred resistance has mostly been studied by altering the level of a single component. In order to address these aspects, a sophisticated combination of research methods for monitoring the spatiotemporal dynamics of key players and transcriptional activity in plants is needed, and will most probably consist of biosensors and precision transcriptomics.

In the context of the COVID-19 epidemic, and on the basis of the Theory of Dynamical Systems, we propose a simple model for the expansion of contagious diseases, with a particular focus on viral respiratory tracts. The infection develops through contacts between contagious and exposed people, with a rate proportional to contact duration and turnover, inversely proportional to the efficiency of protection measures, and balanced by the average immunological response. The obvious initial exponential increase is readily hindered by the size reduction of the exposed population. The system converges towards a stable attractor whose value is expressed in terms of the ratio C/D of contamination vs decay factors. Decreasing this ratio below a critical value leads to a tipping point beyond which the epidemic is over. By contrast, significant values of C/D may bring the system through a bifurcating hierarchy of stable cycles up to a chaotic behaviour.

We present a new analytical method to find the asymptotic stable equilibria states based on the Markov chain technique. We reveal this method on the SIR-type epidemiological model that we developed for viral diseases with long-term immunity memory pandemic. This is a large-scale model containing 15 nonlinear ODE equations, and classical methods have failed to analytically obtain its equilibria. The proposed method is used to conduct a comprehensive analysis by a stochastic representation of the dynamics of the model, followed by finding all asymptotic stable equilibrium states of the model for any values of parameters and initial conditions.

SHANK3 encodes scaffold protein involved in postsynaptic receptor density in glutamatergic synapses, including those in the parvalbumin (PV)+inhibitory neurons – the key players in generation of sensory gamma oscillations, such as 40-Hz auditory steady-state response(ASSR). Here we describe a clinical and neurophysiological phenotype of a 15-years old girl (SH01) with microduplication of 16389 bp in 22q13.33, affecting the SHANK3 gene in comparison to typically developing children (n=32). EEG were recorded during the binaurally presentation of 40-Hz clicks’ trains lasting for 500 ms with inter-trial intervals 500-800 ms. SH01 was diagnosed with mild mental retardation and learning disabilities(F70.88) and had problems with reading and writing, as well as smaller vocabulary than TD peers. Her clinical phenotype generally resembled the phenotype of previously described patients with 22q13.33 microduplication. SH01 had mild autistic symptoms but below the threshold for ASD diagnosis. No seizures or MRI abnormalities were reported. While SH01 had relatively preserved auditory event-related potential(ERP) with slightly attenuated P1, her 40-Hz ASSR was totally absent significantly deviating from TD’s ASSR. Absence of 40-Hz ASSR in patient with microduplication, affected SHANK3 gene, indicates deficient temporal resolution of the auditory system, that might underlie language problems, and represent neurophysiological biomarker of SHANK3 abnormalities.

Nowadays, model checking is applied as an accurate technique to verify software systems. The main problem of model checking techniques is the state space explosion. This problem occurs due to the exponential memory usage by the model checker. In this situation, using meta-heuristic and evolutionary algorithms to search for a state in which a property is satisfied/violated is a promising solution. Recently, different evolutionary algorithms like GA, PSO, etc. are applied to find deadlock state. Even though useful, most of them are concentrated on finding deadlock. This paper proposes a fuzzy algorithm in order to analyze reachability properties in systems specified through GTS with enormous state space. To do so, we first extend the existing PSO algorithm (for checking deadlocks) to analyze reachability properties. Then, to increase the accuracy, we employ a Fuzzy adaptive PSO algorithm to determine which state and path should be explored in each step to find the corresponding reachable state. These two approaches are implemented in an open-source toolset for designing and model checking GTS called GROOVE. Moreover, the experimental results indicate that the hybrid fuzzy approach improves speed and accuracy in comparison with other techniques based on meta-heuristic algorithms such as GA and the hybrid of PSO-GSA in analyzing reachability properties.

In the first part of this talk we review some prerequisites for and essential arguments involved in the construction of the thermal-ground-state estimate for the deconfining phase in the thermodynamics of SU(2) Quantum Yang-Mills theory and how this structure supports its distinct excitations. The second part applies deconfining SU(2) Yang-Mills thermodynamics to the Cosmic Microwave Background in view of (i) a modified temperature-redshift relation with an interesting link to correlation-length criticality in the 3D Ising model, (ii) the implied minimal changes in the dark sector of the cosmological model, and (iii) best-fit parameter values of this model when confronted with the spectra of the angular two-point functions TT, TE, and EE, excluding the low-$l$ physics. The latter, which is treated in an incomplete way because of the omission of radiative effects, is addressed in passing towards future work.

The battle of currents between AC and DC reignited as a result of the development in the field of power electronics. The efficiency of DC distribution systems is highly dependent on the efficiency of distribution converter, which calls for optimized schemes for efficiency enhancement of distribution converters. Modular solid-state transformers play a vital role in DC Distribution Networks and Renewable Energy systems (RES).This paper deals with efficiency-based load distribution for Solid State Transformers (SSTs) in DC distribution networks. Aim is to achieve a set of minimum inputs that are consistent with output while considering constraints and efficiency. As the main feature of modularity is associated with a three-stage structure of SSTs. This modular structure has been optimized using Ant Lion Optimizer (ALO) and validated by applying it EIA (Energy Information Agency) DC Distribution Network which contains SSTs. In the DC distribution grid, modular SSTs provide promising conversion of DC power from medium voltage to lower DC range (400V). The proposed algorithm is simulated in MATLAB and also compared with two other metaheuristic algorithms. The obtained results prove that the proposed method can significantly reduce input requirements for producing the same output while satisfying the specified constraints.

Merchant marine fleet is under inspections by several parties to ensure maritime regulation compliance. One of the major effects on implementation of regulations by International Maritime Organization (IMO) is indeed Port State Control. This article aims to analyze Paris Memoranda of Understanding (MOU) all detention remarks from 2013 to 2019 for EU15 countries (except Luxemburg and Austria) through an approach based on Analytical Hierarchy Process and demonstrate the results on Geographic Information System (GIS) to guide marine industry on detainable Port State Control remarks and country risk profile. While Analytical Hierarchy Process Approach has been used to indicate the ranking of basic maritime regulations from the perspective of the port state control , GIS help us to demonstrate the regional dispersion amongst EU15. The data of the detained vessel taken from the public website of Paris MOU and each report considered as a professional judgement that causes detention. It has been shown that almost all countries top priorities for regulation are Safety of Life at Sea (SOLAS) and Fire Safety Systems (FSS). Consequently, the results of the study can assist Port State Officers, ship crew, ship owners and managers presenting the facts of their inspection and able to improve themselves. The spatial analysis also expected to guide ship owners and managers to focus their vessel’s deficiencies to prevent sub-standardization.

Li3FeN2 material was synthesized by two-step solid-state method from Li3N (adiabatic camera) and FeN2 (tube furnace) powders. Phase investigation of Li3N, FeN2 and Li3FeN2 were carried out. Discharge capacity of Li3FeN2 is 343 mAh g-1, that is about 44.7% of theoretic capacity. The molar heat capacity of Li3FeN2 at constant pressure in the temperature range 298-900 K should be calculated as Cp,m = 77,831 + 0,130 × T – 6,289 × T-2, where T is absolute temperature, . Thermodynamic characteristics of Li3FeN2 were determined as next: entropy S0298 = 116.2 J mol-1 K-1, molar enthalpy of dissolution ΔdHLFN = ˗ 206,537 ± 2,8 kJ mol−1, the standard enthalpy of formation ΔfH0 = ˗ 291.331 ± 5.7 kJ mol−1, entropy S0298 = 113.2 J mol-1 K-1 (Neumann-Kopp rule) and 116.2 J mol-1 K-1 (W.Herz rule), the standard Gibbs free energy of formation ∆f G0298 = ˗276,7 kJ mol-1.

The cyclic lipopeptide produced from Bacillus pumilus strain HY1 was isolated from Korean soybean sauce. The chemical structures of the surfactin isomers were analyzed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS). The five potential surfactin isoforms were detected with protonated masses of m/z 994.7, 1,008.7, 1022.7, 1036.7, and 1,050.7 and different structures in combination with Na+, K+, and Ca2+ ions. ESI-MS/MS analysis revealed that the isolated surfactin possessed the precise amino acid sequence LLVDLL and hydroxyl fatty acids with 12 to 16 carbons. The surfactin content during cheonggukjang fermentation increased from 0.3 to 51.2 mg/kg over 60 h of fermentation. The surfactin extraction of cheonggukjang inhibited the growth of two cancer cell lines. The growth of both MCF-7 and Caco-2 cells was strongly inhibited with 100 μg/μL surfactin. These results suggest that surfactins produced from strain HY1 have anticancer properties.

The space gravitational wave detection and drag free control requires the micro-thruster to have very low thrust noise within 0.1mHz~100mHz, which poses a great challenge to the ground thrust test. The evaluation and decoupling of thermal noise are the difficulties in the application of torsion balance for most thrusters dissipate heat in the experiment. The research has adopted a calibration scheme of micro-Newton thrust torsion balance. On the basis of Lisa Pathfinder's former research and using ideas inspired from PID control and multi time scale (MTS) for reference, the paper proposes to expand the state space of temperature to be applied on thrust prediction based on fine tree regression (FTR), to subtract the thermal noise filtered by transfer function fitted with z-domain vector fitting (ZDVF). The results show that the thrust amplitude thrust density in diurnal temperature fluctuation is decoupled from 24μN/Hz1/2 to 4.9μN/Hz1/2 at 0.11mHz. And the 1μN square wave modulations of electrostatic fins (ESF) is extracted from the simultaneously ambiguous background of temperature for PTC's heating and cooling. The FTR method is well demonstrated in thermal noise decoupling and can guide the design of thermal control and be extended to other physical quantities for noise decoupling.

The change in the value of the breaking energy is discussed here for selected steel grades used in building structures after subjecting the samples made of them to episodes of heating in the steady-state heating regime and then cooling in a simulated fire conditions. These changes were recorded based on the instrumented Charpy impact tests, in relation to the material initial state. The S355J2+N, 1H18N9T steels and also X2CrNiMoN22-5-3 duplex steel were selected for detailed analysis. The fire conditions were modelled experimentally by heating the samples and then keeping them for a specified time at a constant temperature of: 600°C (first series) and 800°C (second series), respectively. Two alternative cooling variants were investigated in the experiment: slow cooling of the samples in the furnace, simulating the natural fire progress, without any external extinguishing action, and cooling them in water mist simulating an extinguishing action by a fire brigade. The temperature of the tested samples was set at the level -20oC and alternatively at the level + 20oC. The conducted analysis is aimed at assessing the risk of sudden, catastrophic fracture of load-bearing structure made of steel degraded as a result of a fire previously occurred with different development scenarios.

For crystal periodic structure prediction, a new and concise approach based on the principles of statistical physics was employed to derive a new form of the equation to determine their period vectors (cell edge vectors), under general external stress. Then the new form is applicable to both classical physics and quantum physics. It also turned out to be the equation of state and the mechanical equilibrium condition for crystals under external stress and temperature. It should be helpful in piezoelectric and piezomagnetic studies, as the period vectors were changed by the external stress. For linear elastic crystals, it is actually also the microscopic but temperature-dependent form of the generalized Hooke's law, then can be used to calculate the corresponding elastic constants of the law, for given temperatures.

This paper reports applying Minimax principle and impulsive differential inequality to derive the existence of multiple stationary solutions and the global stability of a positive stationary solution for a delayed feedback Gilpin-Ayala competition model with impulsive disturbance. The conclusion obtained in this paper reduces the conservatism of the algorithm compared with the known literature, for the impulsive disturbance is not limited to impulsive control.

This paper proposes a Case-Based Reasoning (CBR) system to contribute to reinforce the sustainable performance of an environmental management system. The CBR system aims to support the decision-making process to select environmental management actions aimed at reducing risky trends of the environmental state of a region. The CBR system takes advantage of a set of situation-solution pairs called cases, which are stored in a memory and then retrieved as candidates to solve new problems. Situations in this work are represented by a set of risky trends of the following key environmental variables: CO2 emissions, Air-Quality, Loss of Vegetation Cover, Water Availability, and Solid Waste, whose combination damage the environmental state quality of a region. Meanwhile, solutions are represented by a set of environmental management actions. Similar situations to a given current situation are retrieved from the memory of cases and then their solutions are combined, through an adaptation mechanism, until the solution of the current problem is obtained. We used risky trends derived from real data related to the environmental states of a Mexican region to test the proposed CBR system. The results obtained provided insights into the potential of CBR systems to support the decision-making process to select environmental management actions aimed at reducing risky trends of current environmental states.

As a critical transmitter, the compact 532 nm lasers operating on high repetition and narrow pulse widths have been used widely for airborne or space-borne laser active remote sensing. We developed a free space pumped TEM₀₀ mode sub-nanosecond 532 nm laser that occupied a volume of less than 125 mm × 50 mm × 40 mm (0.25 liters). The fundamental 1064 nm laser consists of a passively Q-switched composite crystal microchip laser and an off-axis, two-pass power amplifier. The pump sources were two single-emitter semiconductor laser diodes (LD) of 808 nm with a maximum continuous wave (CW) power of 10 W each. The average power of fundamental 1064 nm laser was 1.26 W with the laser operating at 16 kHz repetition rates, and 857ps pulse widths. Since the beam distortion would be severe in microchip lasers in terms of the increase in heat load, for obtaining a high beam quality of 532 nm, the beam distortion was compensated by adjusting the distribution of pumping beam in our experiment of fundamental amplification. Furthermore, better than 0.6 W average power, 770 ps, beam quality of M² ＜1.2, and 16 kHz pulse output at 532 nm was obtained by a Type I LiB₃O₅ (LBO) crystal in the critical phase matching (CPM) regime for second harmonic generation (SHG).

The penetration of modern supermarkets is believed to be the cause of the declining role of traditional markets and street vendors in Indonesia. But the competition between state-promoted markets and traditional markets is rarely discussed. This investigation focuses on traditional markets as social institutions, which continuously have developed a variety of strategies in order to remain competitive in the midst of intense rivalry. Firstly, we will outline a theoretical understanding of the traditional markets positioning along the concepts of flexibility and market devices. Secondly, we empirically reflect the strategies of four traditional vegetable markets in the District of Malang, East Java Province, as case studies. We show that the traditional markets build flexibility without governmental support by: (1) specifying commodities, (2) segmenting customers, (3) managing the load time, (4) modifying transportation to operate more efficiently, and (5) minimizing transaction costs by leveraging social capital. We argue that traditional vegetable markets institutionally reduce the potential of transaction costs to be competitive and avoid problems of coordination by building social capital through networks. All in all, market institutions supported by market devices are flexibly capable of adapting to the pressures of both selfishness among actors and competition with other markets.

The use of mixed-state ionic beams in collision dynamics investigations is examined. Using high resolution Auger projectile spectroscopy involving He-like ($1s^2\thinspace^1\!S, 1s2s\thinspace^{3,1}\!S$) mixed-state beams, the spectrum contributions of the $1s2s\thinspace^3\!S$ metastable beam component is effectively separated and clearly identified. This is performed with a technique that exploits two independent spectrum measurements under the same collision conditions, but with ions having quite different metastable fractions, judiciously selected by varying the ion beam charge-stripping conditions. Details of the technique are presented together with characteristic examples. In collisions of 4 MeV B$^{3+}$ with H$_2$ targets, the Auger electron spectrum of the separated $1s2s\thinspace^{3}S$ boron beam component allows for a detailed analysis of the formation of the $1s2s(^3\!S)nl \thinspace^2\!L$ states by direct $nl$ transfer. In addition, the production of hollow $2s2p\thinspace^{1,3}\!P$ doubly- and $2s2p^2\thinspace^2\!D$ triply-excited states, by direct excitation and transfer-excitation processes, respectively, can also be independently studied. In similar mixed-state beam collisions of 15 MeV C$^{4+}$ with H$_2$, He, Ne and Ar targets, the contributions of the $1s^2$, $1s2s\thinspace^{3,1}S$ beam components to the formation of the $2s2p\thinspace^{3,1}\!P$ states by double-excitation, $1s\rightarrow2p$ excitation and transfer-loss processes can be clearly identified, facilitating comparisons with theoretical calculations.

Ensuring a protection scheme in DC distribution is more difficult to achieve against pole-to-ground fault than in AC distribution system because of the absence of zero crossing points and low line impedance. To complement the major obstacle of limiting the fault current, several compositions have been proposed related to mechanical switching and solid-state switching. Among them, solid-state circuit breakers(SSCBs) are considered a possible solution to limit fast fault current. However, they may cause problems in circuit complexity, reliability and cost-related troubles due to the use of multiple power semiconductor devices and additional circuit configuration to commutate current. This paper proposes the SSCB with a coupled inductor(SSCB-CI) which has symmetrical configuration. The circuit is comprised of passive components like commutation capacitors, a CI and damping resistors. Thus, proposed SSCB-CI offers the advantages of simple circuit configuration and fewer utilized power semiconductor devices than another typical SSCBs in LVDC microgrid. For analysis, six operation states are described for the voltage across main switches and fault current. The effectiveness of the SSCB-CI against a short-circuit fault is proved via simulation and experimental results in a lab-scale prototype.

The conformational dependence of the matrix element for spin-orbit coupling and of the electronic coupling for charge separation are determined for an electron donor-acceptor system containing a pyrene acceptor and a dimethylaniline donor. Different kinetic and energetic aspects that play a role in the spin-orbit charge transfer intersystem crossing (SOCT-ISC) mechanism are discussed. This includes parameters related to initial charge separation and the charge recombination pathways using the (Semi-Classical) Marcus Theory for electron transfer. The spin-orbit coupling, which plays a significant role in charge recombination to the triplet state can be probed by (TD-)DFT, using the latter as a tool to understand and predict the SOCT-ISC mechanism. The matrix elements for spin-orbit coupling for acetone and 4-thio-thymine are used for benchmarking. (Time Dependent-) Density Functional Theory (DFT and TD-DFT) calculations are applied using the quantum chemical program Amsterdam Density Functional (ADF).

Cognitive deterioration caused by illness or aging often occurs before symptoms arise, and their timely diagnosis is crucial to reducing its medical, personal, and societal impacts. Brain-Computer Interfaces (BCIs) stimulate and analyze key cerebral rhythms, enabling reliable cognitive assessment that can accelerate diagnosis. The BCI system presented analyzes Steady-State Visually Evoked Potentials (SSVEPs) elicited in subjects of varying age to detect cognitive aging, predict its magnitude, and identify its relationship with SSVEP features (band power and frequency detection accuracy), which were hypothesized to indicate cognitive decline due to aging. The BCI system was tested with subjects of varying age to assess its ability to detect aging-induced cognitive deterioration. Rectangular stimuli flickering at theta, alpha, and beta frequencies were presented to subjects, and frontal and occipital EEG responses were recorded. These were processed to calculate detection accuracy for each subject and calculate SSVEP band power. A neural network was trained using the features to predict cognitive age. The results showed potential cognitive deterioration through age-related variations in SSVEP features. Frequency detection accuracy declined after age group 20–40 and band power, throughout all age groups. SSVEPs generated at theta and alpha frequencies, especially 7.5 Hz, were the best indicators of cognitive deterioration. Here, frequency detection accuracy consistently declined after age group 20-40 from an average of 96.64% to 69.23%. The presented system can be used as an effective diagnosis tool for age related cognitive decline.

Protein-DNA interactions are critical for the successful functioning of all natural systems. The key role in these interactions is played by processes of protein search for specific sites on DNA. Although it has been studied for many years, only recently microscopic aspects of these processes became more clear. In this work, we present a review on current theoretical understanding of the molecular mechanisms of the protein target search. A comprehensive discrete-state stochastic method to explain the dynamics of the protein search phenomena is introduced and explained. Our theoretical approach utilizes a first-passage analysis and it takes into account the most relevant physical-chemical processes. It is able to describe many fascinating features of the protein search, including unusually high effective association rates, high selectivity and specificity, and the robustness in the presence of crowders and sequence heterogeneity.

A mathematical model given by a two - dimensional differential system is introduced in order to understand the transition process from the normal hematopoiesis to the chronic and accelerated acute stages in chronic myeloid leukemia. A previous model of Dingli and Michor is refined by introducing a new parameter in order to differentiate the bone marrow microenvironment sensitivities of normal and mutant stem cells. In the light of the new parameter, the system now has three distinct equilibria corresponding to the normal hematopoietic state, to the chronic state, and to the accelerated acute phase of the disease. A characterization of the three hematopoietic states is obtained based on the stability analysis. Numerical simulations are included to illustrate the theoretical results.

Clausius’ virial theorem set a basis for relating kinetic energy in a body of independent material particles to its potential energy, pointing to their complementary role with respect to the second law of maximum entropy. In action mechanics, expressing the entropy of ideal gases as a capacity factor for sensible heat or enthalpy plus the configurational work to sustain the relative translational, rotational and vibrational action yields algorithms for estimating chemical reaction rates and positions of equilibrium. All properties of state including entropy, work potential as Helmholtz and Gibbs energies and activated transition state reaction rates can be estimated, using easily accessible molecular properties, such as atomic weights, bond lengths, moments of inertia and vibrational frequencies. Understanding how Clausius’ virial theorem balances the internal kinetic energy with field potential energy justifies partitioning between thermal and statistical properties of entropy, yielding a more complete view of the evolutionary nature of the second law of thermodynamics. The ease of performing these operations is illustrated by three important chemical gas phase reactions, the reversible dissociation of the hydrogen molecules, lysis of water to hydrogen and oxygen and the reversible formation of ammonia from nitrogen and hydrogen. Employing the ergal also introduced by Clausius to define the reversible internal work to overcome molecular interactions plus the configurational internal work of negative Gibbs energy as a function of volume or pressure may provide a practical guide for managing risk in industrial processes and climate change at the global scale.

The general coupling between particle transport and ionization-recombination processes in hot plasma is considered on the key concept of equilibrium charge state (CS) transport. A theoretical interpretation of particle and CS transport is gained in terms of a two-dimensional (2D) Markovian stochastic (random) processes, a discrete 2D Fokker-Plank-Kolmogorov equation (in charge and space variables) and generalized 2D coronal equilibrium between atomic processes and particle transport. The basic tool for analysis of CS equilibrium and transport is the equilibrium cell (EC) (two states on charge and two on space), which presents (i) a unit phase volume, (ii) the characteristic scale of local equilibrium, (iii) a comprehensive solution for the simplest nonlinear relations between transport and atomic processes. The approach opens up new perspectives on transport studies: (i) the direct modelling of equilibrium and transport of impurity using the atomic data base, (ii) recovery of the complete recombination rate profile based on knowledge of density profiles and ionization rate profiles, (iii) the local transport analysis, based on the reduction of the equilibrium set to the single EC (in particular, central or edge), (iv) analysis of the reduced transport coefficients (diffusion and convection) on the density profile measurements.

This present work explores the performance of a thermal-magnetic engine of Otto type, considering as a working substance an effective interacting spin model corresponding to the q− state clock model. We obtain all the thermodynamic quantities for the q = 2, 4, 6, 8 cases in a small lattice size (3×3 with free boundary conditions) by using the exact partition function calculated from the energies of all the accessible microstates of the system. The extension to bigger lattices was performed using the mean-field approximation. Our results indicate that the total work extraction of the cycle is highest for the q=4 case, while the performance for the Ising model (q=2) is the lowest of all cases studied. These results are strongly linked with the phase diagram of the working substance and the location of the cycle in the different magnetic phases present, where we find that the transition from a ferromagnetic to a paramagnetic phase extracts more work than one of the Berezinskii–Kosterlitz–Thouless to paramagnetic type. Additionally, as the size of the lattice increases, the extraction work is lower than smaller lattices for all values of q presented in this study.

Measuring the status and trends of biodiversity is critical for making informed decisions about the conservation, management or restoration of species, habitats and ecosystems. Defining the reference state against which status and change are measured is essential. Typically, reference states describe historical conditions, yet historical conditions are challenging to quantify, may be difficult to falsify, and may no longer be an attainable target in a contemporary ecosystem. We have constructed a conceptual framework to help inform thinking and discussion around the philosophical underpinnings of reference states and guide their application. We characterise currently recognised historical reference states and describe them as Pre-Human, Indigenous Cultural, Pre-Intensification and Hybrid-Historical. We extend the conceptual framework to include contemporary reference states as an alternative theoretical perspective. The contemporary reference state framework is a major conceptual shift that focuses on current ecological patterns and identifies areas with higher biodiversity values, regardless of the disturbance history. The specific context for which we design the contemporary conceptual frame is underpinned by an overarching goal—to maximise biodiversity conservation and restoration outcomes in existing ecosystems. The contemporary reference state framework can account for the inherent differences in the diversity of biodiversity values (e.g., species richness, habitat complexity) across spatial scales, communities and ecosystems. In contrast to historical reference states, contemporary references states are measurable and falsifiable. This ‘road map of reference states’ offers perspective needed to define and assess the status and trends in biodiversity and habitats. Our framework for contemporary reference states provides a tractable way for policy-makers and practitioners to navigate biodiversity assessments to maximise conservation and restoration outcomes in contemporary ecosystems. We illustrate how to define a contemporary reference state using an example from south-eastern Australia.

In this paper, we found a new model for compact star with charged anisotropic matter distribution considering an extended version of the Chaplygin equation of state. We specify a particular form of the metric potential Z(x) that allows us to solve the Einstein-Maxwell field equations. The obtained model satisfies all physical properties expected in a realistic star such that the expressions for the radial pressure, energy density, metric coefficients, measure of anisotropy and the mass are fully well defined and are regular in the interior of star. The solution obtained in this work can have multiple applications in astrophysics and cosmology.

Beyond the usual ferromagnetic and paramagnetic phases present in spin systems, the usual q-state clock model, presents an intermediate vortex state when the number of possible orientations q for the system is equal to 5 or larger. Such vortex states give rise to the Berezinskii-Kosterlitz-Thouless (BKT) phase present up to the XY model in the limit q→∞. Based on information theory, we present here an analysis of the classical order parameters plus new short-range parameters defined here. Thus, we show that even using the first nearest neighbors spin-spin correlations only, it is possible to distinguish the two transitions presented by this system for q greater than or equal to 5. Moreover, the appearance at relatively low temperature and disappearance of the BKT phase at a rather fix higher temperature is univocally determined by the short-range interactions recognized by the information content of classical and new parameters.

The redefined vacuum approach, which is frequently employed in the many-body perturbation theory, proved to be a powerful tool for formula derivation. Here, we elaborate this approach within the bound-state QED perturbation theory. In addition to general formulation, we consider the particular example of a single particle (electron or vacancy) excitation with respect to the redefined vacuum. Starting with simple one-electron QED diagrams, we deduce first- and second-order many-electron contributions: screened self-energy, screened vacuum polarization, one-photon exchange, and two-photon exchange. The redefined vacuum approach provides a straightforward and streamlined derivation and facilitates its application to any electronic configuration. Moreover, based on the gauge invariance of the one-electron diagrams, we can identify various gauge-invariant subsets within derived many-electron QED contributions.

With the automotive industry moving towards automated driving, sensing is increasingly important in enabling technology. The virtual sensors allow data fusion from various vehicle sensors and provide a prediction for measurement that is hard or too expensive to measure in another way or in the case of demand on continuous detection. In this paper, virtual sensing is discussed for the case of vehicle suspension control, where information about the relative velocity of the unsprung mass for each vehicle corner is required. The corresponding goal can be identified as a regression task with multi-input sequence input. The hypothesis is that the state-of-art method of Bidirectional Long-Short Term Memory (BiLSMT) can solve it. In this paper, a virtual sensor has been proposed and developed by training a neural network model. The simulations have been performed using an experimentally validated full vehicle model in IPG Carmaker. Simulations provided the reference data which was used for Neural Network (NN) training. The extensive dataset covering 26 scenarios has been used to obtain training, validation and testing data. The Bayesian Search was used to select the best neural network structure using root mean square error as a metric. The best network is made of 167 BiLSTM, 256 fully connected hidden units and 4 output units. Error histograms and spectral analysis of the predicted signal compared to the reference signal are presented. The results demonstrate the good applicability of neural network-based virtual sensors to estimate vehicle unsprung mass relative velocity.

The introduction of electrical vehicle charging infrastructure including EV charger, renewable energy resource at secondary feeder in distribution system has been increased as one of countermeasure for global environmental issues. However, the Electric Vehicle Charging (EVC) infrastructure may act as the peak load in distribution system, which can adversely impact on the voltage stability when the electric vehicle is quickly charged. Therefore, to keep within the limit capacity of secondary feeder and allowable limit for feeder voltage, this paper proposes a stabilization method by the Energy Storage System (ESS) control strategy at secondary feeder in order to be not violated over than lower and upper limit. Also, this paper presents the estimation method to keep the proper standard value of State of Charge (SOC). From the simulation results, the voltage stabilization operation by ESS should make the feeder voltages of the distribution system(secondary feeder) introduced EVC Infra keep better voltage conditions, also estimation method to keep the proper standard value is confirmed that the SOC of ESS when is the standby condition could be exactly kept within the proper reference range.

Helmholtz energy of ice VII-X is determined in a pressure regime extending to 450 GPa at 300 K using local basis functions in the form of b splines. The new representation for the equation of state is embedded in a physics-based inverse theory framework of parameter estimation. Selected pressures as a function of volume from 14 prior experimental studies and two theoretical studies constrain the behavior of Helmholtz energy. Separately measured bulk moduli, not used to construct the representation, are accurately replicated below about 20 GPa and above 60 GPa. In the intermediate range of pressure, the experimentally determined moduli are larger and have greater scatter than values predicted using the Helmholtz representation. Although systematic experimental error in the experimental elastic moduli is possible and likely, the alternative hypothesis is a slow relaxation time associated with changes in proton mobility or the ice VII to X transition. A correlation is observed between anomalies in the pressure derivative of the predicted bulk modulus and previously suggested higher-order phase transitions. Improved determinations of elastic properties at high pressure would allow refinement of the current equation of state. More generally, the current method of data assimilation is broadly applicable to other materials in high-pressure studies.

Mathematical models across the applied sciences often utilize a standard methodological representation called a state variable formulation more commonly referred to as state space form. Recent research in unmanned underwater vehicle motor turbine blade thermal modeling for fatigue-life is generalized here permitting the proposed novel state space from to be applied to electrodynamics, motion mechanics, and many other disciplines. Proposed here is a very compact form inherently representing time variance, with a convenient presentation of dynamic variables applicable to all proper transfer functions, where all the distinct, real poles, zeros and gain of the transfer function appear as explicit components in the state space. The resulting manifestation simplifies utilization of the state space methods broadly across the applied sciences.

Chinese-speaking parents are argued to use less cognitive mental-state-talk than their English-speaking counterparts due to their goals in socializing their children to follow an interdependence script. To extend this research, we investigated bilingual Mandarin-English Singaporean mothers who associate different functions for each language as prescribed by their government: English for school and Mandarin for in-group contexts. English and Mandarin maternal mental-state-talk from bilingual Mandarin-English mothers with their toddlers was examined. Mothers produced more cognitive terms in English than in Mandarin and more desire terms in Mandarin than in English. We show that mental-state-talk differs between bilingual parents’ languages, suggesting that mothers adjust their mental-state-talk to reflect each language’s function.

Room-temperature phosphorescent (RTP) materials have been attracted tremendous interest owing to their unique material characteristics and potential applications for state-of-the-art optoelectronic devices. Recently, we have reported a synthesis and fundamental photophysical properties of new RTP materials based on benzil, i.e., fluorinated monobenzil derivative and fluorinated and non-fluorinated bisbenzil derivative analogues [Yamada, S. et al, Beilstein J. Org. Chem. 2020, 16, 1154–1162.]. To further understand their RTP properties, here we investigated the excited-state dynamics and photostability of the derivatives by means of time-resolved and steady-state photoluminescence spectroscopies. For these derivatives, clear RTP emissions with lifetimes on the microsecond timescale were identified. Among them, the monobenzil derivative was found to be the most efficient RTP material, showing both the longest lifetime and highest amplitude RTP emission. Time-resolved photoluminescence spectra measured at 77 K and density functional theory calculations revealed the existence of a second excited triplet state in the vicinity of the first excited singlet state for the monobenzil derivative, indicative of the presence of a fast intersystem crossing pathway. A discussion of the correlation between the excited state dynamics, emission properties, and conformational flexibility of the three derivatives is presented.

Synthetic chalcomenite-type cupric selenite CuSeO₃∙2H₂O has been studied at room temperature under compression up to pressures of 8 GPa by means of single-crystal X-ray diffraction, Raman spectroscopy, and density-functional theory. According to X-ray diffraction, the orthorhombic phase undergoes an isostructural phase transition at 4.0(5) GPa with the thermodynamic character being first-order. This conclusion is supported by Raman spectroscopy studies which have detected the phase transition at 4.5(2) GPa and by the first-principles computing simulations. The structure solution at different pressures has provided information on the change with pressure of unit-cell parameters as well as on the bond and polyhedral compressibility. A Birch-Murnaghan equation of state has been fitted to the unit-cell volume data. We found that chalcomenite is highly compressible with a bulk modulus of 42 – 49 GPa. The possible mechanism driving changes in the crystal structure is discussed, being the behavior of CuSeO₃∙2H₂O mainly dominated by the large compressibility of the coordination polyhedron of Cu. On top of that, an assignation of Raman modes is proposed based upon density-functional theory and the pressure dependence of Raman modes discussed. Finally, the pressure dependence of phonon frequencies is also reported.

This article will briefly review the progress of h-BN based solid-state metal semiconductor metal (MSM) neutron detectors. In the last decade, several groups have been working on hexagonal boron nitride (h-BN) based solid-state neutron detectors. Recently, the detection efficiency of 59% has been reported. Efficient, low-cost neutron detectors made from readily available materials are essential for various applications. Neutron detectors are widely used to detect fissile materials and nuclear power plants for security applications. The most common and widely used neutron detectors are 3He based, which are sometimes bulky, difficult to transport, have high absorption length, need relatively high bias voltage (>1000 V), and have low Q-value (0.764 MeV). Also, 3He is not readily available material. Thus, there is a strong need to find an alternative detection material. 10B isotope has a high neutron absorption cross-section, and it has been tested as a coating on the semiconducting materials. Due to the two-step process, neutron capture through 10B, and then electron-hole pair generation in a typical semiconducting material, the efficiency of these devices is not up to the mark. The progress in h-BN based detectors requires a review to envision the further improvement in this technology.

Modern development of high-intensity and high-resolution X-ray technology allows detailed studies of the multiphoton absorption and scattering of X-ray photons by deep and subvalent shells of molecular systems on a wide energy range. The interpretation of experimental data requires the improvement of computational methods for obtaining excited and ionized electron states of molecular systems with one or several vacancies. The specificity of solving these problems requires the use of molecular orbitals obtained in one-center representation. Slow convergence of one-center expansions is a significant disadvantage of this approach; it affects the accuracy of the calculation of spectroscopic quantities. We offer a method of including higher harmonics in one-center expansion of a molecular orbital with the use of wave functions of electrons of deep shells of a ligand (off-center atom of a molecule). The method allows one to take into account correctly electron density of a linear molecule near the ligand when describing vacancies created in a molecular core leading to radial relaxation of electron density. The analysis of the parameters of one-center expansion of the ligand functions depending on ligand’s charge is performed. The criteria for the inclusion of higher harmonics of one-center decomposition of the ligand functions in the molecular orbital are determined. The efficiency of the method is demonstrated by the example of diatomic molecules HF, LiF, and BF by estimating energy characteristics of their ground and ionized states.

End-of-life electric vehicle (EV) batteries can be reused to reduce their environmental impact and economic costs. However, the growth of a second-life market is limited by the lack of information on the characteristics and performance of these batteries. As the volume of end-of-life EVs may exceed the amount of batteries needed for stationary applications, investigating the possibility of repurposing them in mobile applications is also necessary. This article presents an experimental test that can be used to collect the data necessary to fill a battery passport. The proposed procedure can facilitate the decision making process regarding the suitability of a battery for reuse at the end of its first life. Once the battery passport has been completed, the performance and characteristics of the battery are compared with the requirements of several mobile applications. Mobile charging stations and forklift trucks were identified as relevant applications for the reuse of high capacity prismatic cells. Finally, a definition of a state of health (SoH) is proposed to track the suitability of the battery during use in the second life application considering not only energy but also power and efficiency of the battery. This SoH shows that even taking into account accelerated ageing data, a repurposed battery can have an extended life of 11 years at 25~°C. It has also been shown that energy fade is the most limiting performance for lifetime and that cell-to-cell variation should be tracked as it has been shown to have a significant impact on battery life.

In this work, we have developed a non-ordinary state-based peridynamic model for multiple crack initiation and propagation due to compression-compression fatigue load. In each loading cycle, the fatigue loading is redistributed among the peridynamic solid body, leading to the progressive fatigue damage initiation and propagation in an autonomous fashion. The proposed fatigue model parameters are firstly validated by 3D numerical benchmark tests, and then it is applied to simulate widespread fatigue damage evolution of the aircraft wing corner box. The modified constitutive damage model has been implemented into the peridynamics framework at finite strain. Furthermore, the criterion algorithm from multiple initiation to propagation is discussed. It is shown that the numerical results obtained from peridynamics simulations are in general agreement with those from the experiment data. The comparison of experimental and numerical results indicates that the proposed non-ordinary state-based peridynamics fatigue model has the ability to capture the multiple crack initiation and propagation and other features of the aluminium alloy material.

The on-state voltage of MOSFETs is a convenient and powerful temperature-sensitive electric parameter (TSEP) to determine the junction temperature, thus enabling device monitoring, protection, diagnostics and prognostics. The main hurdle in the use of the on-state voltage as a TSEP is the per-device characterization procedure, to be carried out in a controlled environment, with high costs. In this paper we compare two novel techniques for MOSFET junction temperature estimation: controlled shoot-through and direct heating by resistive heaters embedded in two Kapton (polyimide) films. Both allow in-place characterization of the TSEP curve with the device mounted in its final circuit and assembly, including the working heat sink. The two methods are also validated against the conventional procedure in a thermal chamber.

The feasibility of a steady-state visual evoked potential (SSVEP) brain-computer interface (BCI) with a single flicker stimulus for multiple-target decoding has been demonstrated in a number of recent studies. The single-flicker BCIs have mainly employed the direction information for encoding the targets, i.e. different targets are placed at different spatial directions relative to the flicker stimulus. The present study explored whether visual eccentricity information can also be used to encode target for the purpose of increasing the number of targets in the single-flicker BCIs. A total number of 16 targets were encoded, placed at eight spatial directions, and two eccentricities (2.5° and 5°) relative to a 12 Hz flicker stimulus. Whereas distinct SSVEP topographies were elicited when participants gazed at targets of different directions, targets of different eccentricities were mainly represented by different signal-to-noise ratios (SNRs). Using a canonical correlation analysis-based classification algorithm, simultaneous decoding of both direction and eccentricity information was achieved, with an average offline 16-class accuracy of 66.8±16.4% averaged over 12 participants and a best individual accuracy of 90.0%. Our results demonstrate a single-flicker BCI with a substantially increased target number towards practical applications.

In this paper, a metal cutting machine position control have been designed and simulated using Matlab/Simulink Toolbox successfully. The open loop response of the system analysis shows that the system needs performance improvement. Static output feedback and full state feedback H₂ controllers have been used to increase the performance of the system. Comparison of the metal cutting machine position using static output feedback and full state feedback H₂ controllers have been done to track a set point position using step and sine wave input signals and a promising results have been analyzed.

The formation of high-melting-point Cu₆Sn₅ interconnections is crucial to overcome the collapse of Sn-based micro-bumps and produce reliable intermetallic interconnections in three-dimensional (3D) package. However, because of the multiple reflows in 3D package manufacturing, Cu₆Sn₅ interconnections will experience the cyclic polymorphic transitions in the solid state. The repeated and abrupt change in the Cu₆Sn₅ lattice due to the cyclic polymorphic transitions can cause extreme strain oscillations, producing damages at the surface and in the interior of the Cu₆Sn₅ matrix. Moreover, because of the polymorphic-transition-induced grain splitting and superstructure phase formation, the reliability of Cu₆Sn₅ interconnections will thus face great challenges in 3D package. In addition, the Cu₆Sn₅ polymorphic transition is structure-dependent, and the η′↔η polymorphic transition will occur at the surface while the η′↔ηs↔η polymorphic transition will occur in the deep matrix. Our results can provide in-depth understandings of structural evolution and damage mechanism of Cu₆Sn₅ interconnections in real 3D package manufacturing.

Conjugated singlet ground state diradicals have received remarkable attention owing to their potential applications in optoelectronic devices. A distinctive character of these systems is the location of the double exciton state, a low lying excited state dominated by the doubly excited H,H→L,L configuration, which may influence optical and other photophysical properties. In this contribution we investigate this specific excited state, for a series of recently synthesized conjugated diradicals, employing time dependent density functional theory based on the unrestricted parallel spin reference configuration in the spin-flip formulation (SF-TDDFT) and standard TD calculations based on the unrestricted antiparallel spin reference configuration (TDUDFT). The quality of the computed results is assessed considering diradical and multiradical descriptors and the excited state wavefunction composition.

We examined special roles of the Central Nervous System (CNS) in an attempt to resolve the puzzle that chronic diseases cannot be cured by medicine. By exploring a skill-learning model, we found that the CNS is able to remember certain information reflecting biochemical and cellular (B&C) processes in the body. From the skill using ability, we found that the CNS is able to control basic B&C processes that drive and power the skill. From the ability to adjust forces and force direction of a physical act, we found that the CNS is able to adjust B&C processes that drive the physical act. From this adjustment capability, we further inferred that the CNS must also store information on the baseline B&C processes. As a whole, we found that the CNS can maintain information on baseline B&C processes, up-regulate or down-regulate the processes, and make comparisons in performing its regulatory functions. We found that chronic diseases are the results of deviated baseline B&C processes. Per the proved hypothesis, the CNS maintains deviated baseline B&C processes, and thus protects the body states of fully developed diseases. We then used the three CNS roles to explain that cancer progresses with increasing malignancy, cancer quickly returns after a surgery, cancer cells repopulate after chemotherapy and radiotherapy, cancer develops drug resistance inevitably, immune cells rebound after suppression, generally poor benefits of cancer drugs such as beta-blockers, etc. We further showed that long-term exercises generally push most, if not all, baseline B&C processes in diametrical opposing directions against the diseased B&C processes, implying that exercises play unique roles in reversing chronic diseases. Finally, we proposed several strategical approaches to resetting the CNS’ state memory as the essential condition for curing chronic diseases.

Background: Sex differences in blood pressure (BP) exist during all reproductive life between women and men whereas a sharper increase in BP occurs after menopause which is associated with increased prevalence of cardiovascular diseases. This study examined cardiovascular and biochemical parameters in perimenopausal women (PW) aiming to investigate the influence of sex on a) office BP and for 24 hours; b) cardiac autonomic modulation; c) redox state by measuring MDA, SOD, and catalase; d) NO_x^- concentration. In addition, aerobic exercise training (AET) was applied for detecting changes in cardiovascular responsiveness during the menopausal transition. Methods: Thirty-one participants were enrolled, healthy PW and age-matched men. Cardiovascular and biochemical biomarkers were evaluated at baseline and after AET (8 weeks of exercise on a treadmill, three sessions/week, duration of 30-40 minutes). Results: At rest, PW presented: a) a lower diastolic BP during daytime; b) a lower absolute and normalized LF component as well as a higher HF normalized component; d) no sex differences for redox biomarkers and NO_x^- concentration. After AET, only PW was responsive in lowering systolic BP that was accompanied by an increase in NO_x^- concentration and SOD activity. Regarding HRV, both groups were responsive to the AET. Conclusions: During the menopausal transition, systolic BP was similar to men whereas cardiac autonomic modulation remained unaltered showing the influence of sex steroids on BP. In Addition, AET was fundamental during the menopause transition by preventing an elevation in BP, minimizing the effects of aging associated with estrogen deficiency on women's cardiovascular health.

The purpose of this paper is to build a new bridge between category theory and a generalized probability theory known as noncommutative probability or quantum probability, which was originated as a mathematical framework for quantum theory, in terms of states as linear functional defined on category algebras. We clarify that category algebras can be considered as generalized matrix algebras and that the notions of state on category as linear functional defined on category algebra turns out to be a conceptual generalization of probability measures on sets as discrete categories. Moreover, by establishing a generalization of famous GNS (Gelfand-Naimark-Segal) construction, we obtain a representation of category algebras of †-categories on certain generalized Hilbert spaces which we call semi-Hilbert modules over rigs.

From experimental studies of protein folding, it is now clear that there are two types of folding behavior, i.e., two-state folding and non-two-state folding, and understanding the relationships between these apparently different folding behaviors is essential for fully elucidating the molecular mechanisms of protein folding. This article describes how the presence of the two types of folding behavior has been confirmed experimentally, and discusses the relationships between the two-state and the non-two-state folding reactions, on the basis of available data on the correlations of the folding rate constant with various structure-based properties, which are determined primarily by the backbone topology of proteins. Finally, a two-stage hierarchical model is proposed as a general mechanism of protein folding. In this model, protein folding occurs in a hierarchical manner, reflecting the hierarchy of the native three-dimensional structure, as embodied in the case of non-two-state folding with an accumulation of the molten globule state as a folding intermediate. The two-state folding is thus merely a simplified version of the hierarchical folding caused either by an alteration in the rate-limiting step of folding or by destabilization of the intermediate.

In the paper is described the control electronics for an industrial pneumatic – hydraulic system based on a low-cost PLC. The developed system is a hydraulic pulse system and it generates series of high pressure hydraulic pulses (max. 200 bar). We describe requirements, an overall concept of the embedded control system, user interface, security features and network connectivity. In the description of the software solution we describe implementation of hierarchical ordered program threads (multithreaded program) and main control state machine. At the conclusion, we describe the calibration method of the system and calibration curves and we present the schematic diagram and a photo of a functional prototype of the system.

Li-rich layered oxide cathode materials have become one of the most promising cathode materials for high-energy-density lithium-ion batteries owning to its high theoretical specific capacity, low cost, high operating voltage and environmental friendliness. Yet they suffer from severe capacity and voltage attenuation during prolong cycling, which blocks their commercial application. To clarify these causes, we synthesize 0.5Li2MnO3·0.5LiNi0.8Co0.1Mn0.1O2 (LL-811) with high-nickel-content cathode material by a solid-sate complexation method, and it manifests a lot slower capacity and voltage attenuation during prolong cycling compared to LL-111 and LL-523 cathode materials. The capacity retention at 1C after 100 cycles reaches to 87.5% and the voltage attenuation after 100 cycles is only 0.460 V. Combining X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscopy (TEM), it indicates that increasing the nickel content not only stabilizes the structure but also alleviates the attenuation of capacity and voltage. Therefore, it provides a new idea for designing of Li-rich layered oxide cathode materials that suppress voltage and capacity attenuation.

To embrace the special theory of relativity with classical thermodynamics correct Lorentz transformations of thermodynamic state functions are formulated. All of these Lorentz transformations of state functions equally support the time dilation phenomenon which is experimentally verified fact. Relativistic Boltzmann constant proves entropy to be the Lorentz variant. Twin paradox thought experiments for heat engines prove heat flux to be Lorentz variant. Lorentz transformation of entropy and heat flux proves temperature Lorentz invariant. All thermodynamic state functions are proved to be Lorentz variant which is shown in accord with Lorentz transformation of thermodynamic work.

A wide variety of applications require high peak laser intensity in conjunction with a narrow spectral linewidth. Typically, injection-locked amplifiers have been employed for this purpose, where a continuous wave oscillator is amplified in a secondary external resonant amplifier cavity using a pulsed pump laser. In contrast, here we demonstrate a setup that combines a CW Ti:sapphire oscillator and pulsed amplifier in a single optical cavity, resulting in a compact system. Dichroic beam combination of blue wavelength semiconductor diodes and the green wavelength of a Nd:YAG laser allowed the simultaneous excitation of the Ti:sapphire crystal by both continuous-wave and pulsed pump sources. A linewidth of &lt;2MHz is achieved in continuous wave operation, while the linewidth increases to about 10MHz in the combined CW + pulsed mode with a pulse duration of 73ns. A peak pulse intensity of 0.2kW is achieved, which should enable efficient single-pass second harmonic generation in a nonlinear crystal.

Although most biological processes are characterized by a strong temporal asymmetry, several popular mathematical models neglect this issue. Maximum entropy methods provide a principled way of addressing time irreversibility, which leverages powerful results and ideas from the3literature of non-equilibrium statistical mechanics. This article provides a comprehensive overview of these issues, with a focus in the case of spike train statistics. We provide a detailed account of the5mathematical foundations and work out examples to illustrate the key concepts and results from non-equilibrium statistical mechanics

All-solid-state lithium batteries (ASSLBs) using argyrodite electrolyte materials have shown promise for applications in electric vehicles (EVs). However, understanding the effects of pro-cessing parameters on the ionic conductivity of these electrolytes is crucial for optimizing battery performance and manufacturing methods. This study investigates the influence of electrolyte op-erating temperature, electrolyte operating pressure, electrolyte pelletization pressure, and electro-lyte pelletizing temperature on the ionic conductivity of Li6PS5Cl0.5Br0.5 argyrodite electrolyte (AmpceraTM, D50=10 µm). A specially designed test cell is employed for the experimental meas-urements, allowing for controlled pelletization and testing within the same tooling. The results demonstrate the significant impact of the four parameters on the ionic conductivity of the argy-rodite electrolyte. The electrolyte operating temperature has a more pronounced effect than oper-ating pressure, and pelletizing temperature exerts a greater influence than pelletizing pressure. This study provides graphs that aid in understanding the interplay between these parameters and achieving desired conductivity values. It also establishes a baseline for the maximum pelletizing temperature before undesirable degradation of electrolyte occurs. By manipulating the pelletizing pressure, operating pressure, and pelletizing temperature, battery engineers can achieve the desired conductivity for specific applications. The findings emphasize the need to consider operating conditions to ensure satisfactory low-temperature performance, particularly for EVs. Overall, this study provides valuable insights into processing and operating conditions for ASSLBs utilizing Li6PS5Cl0.5Br0.5 argyrodite electrolyte.

Li₇La₃Zr₂O₁₂Solid-state reaction was used for Li₇La₃Zr₂O₁₂ material synthesis from Li₂CO₃, La₂O₃ and ZrO₂ powders. Phase investigation by XRD, SEM and EDS methods of Li₇La₃Zr₂O₁₂ were carried out. The molar heat capacity of Li₇La₃Zr₂O₁₂ at constant pressure in the temperature range 298-800 K should be calculated as Cp,m = 518.135+0.599 × T - 8.339 × T−2, where T is absolute temperature, . Thermodynamic characteristics of Li₇La₃Zr₂O₁₂ were determined as next: entropy S0298 = 362.3 J mol-1 K-1, molar enthalpy of dissolution ΔdHLlZO = ˗ 1471.73 ± 29.39 kJ mol−1, the standard enthalpy of formation from elements ΔfH0 = ˗ 9327.65 ± 7.9 kJ mol−1, the standard Gibbs free energy of formation ∆f G0298 = ˗9435.6 kJ mol-1.

Multipartite entanglement is a resource for application in disparate protocols, of computing, communication and cryptography. Nested entanglement provides resource-states for quantum information processing. In this paper, Matryoshka quantum resource-states, which contain nested entanglement patterns, has been studied. A novel scheme for the generation of such quantum states has been proposed using an anisotropic XY spin-spin interaction-based model. The application of the Matryoshka GHZ-Bell states for n-qubit teleportation is reviewed and an extension to more general Matryoshka ExhS-Bell states is posited. An example of Matryoshka ExhS-Bell states is given in the form of the genuinely entangled seven-qubit Xin-Wei Zha state. Generation, characterisation and application of this seven-qubit resource state in theoretical schemes for quantum teleportation of arbitrary one, two and three qubits states, bidirectional teleportation of arbitrary two qubit states and probabilistic circular controlled teleportation are presented.

This research aims to study the ultimate limit state (ULS) behaviour of stiffened panel under longitudinal compression by non-linear finite element method (NLFEM). There are different types of stiffeners being used in shipbuilding i.e. T-bar, flat-bar and angle-bar. However, this research focuses on the ultimate compressive strength behaviour of flat-bar stiffened panel. A total of 420 of reliable scenarios of flat-bar stiffened panel are selected for numerical simulation by ANSYS NLFEM. The ultimate strength behaviours obtained were used as data for the development of closed form shape empirical formulation. Recently, Kim et al. [1] proposed for advanced empirical formulation for T-bar stiffened panel and the applicability of the proposed formulation to flat-bar stiffened panel will be confirmed by this study. The accuracy of the empirical formulation obtained for flat-bar stiffened panel has been validated by FE simulation results of statistical analysis (R2 = 0.9435). The outcome obtained will be useful for ship structural designers in predicting the ultimate strength performance of flat-bar type stiffened panel under longitudinal compression.

With a reduction in the mortality rate of burn patients, patient length of stay (LOS) is increasingly adopted as an outcome measure. Some studies have attempted to identify factors that explain a burn patient's expected LOS. However, few have investigated the association between LOS and a patient's mental and socioeconomic status. There is anecdotal evidence for links between these factors and uncovering these will aid in better addressing the specific physical and emotional needs of burn patients, and facilitate the planning of scarce hospital resources. Here, we employ machine learning (clustering) and statistical models (regression) to investigate whether a segmentation by socioeconomic/mental status can improve the performance and interpretability of an upstream predictive model, relative to a unitary model derived for the full adult population of patients. Although we found no significant difference in the performance of the unitary model and segment-specific models, the interpretation of the segment-specific models reveals a reduced impact of burn severity in LOS prediction with increasing adverse socioeconomic and mental status. Furthermore, the models for the socioeconomic segments highlight an increased influence of living circumstances and source of injury on LOS. These findings suggest that, in addition to ensuring that the physical needs of patients are met, management of their mental status is crucial for delivering an effective care plan.

This review article aims at improving understanding of the theoretical discussion on technonationalism. Reviewing conventional works of the literature proposes protectionist, innovationist, and strategic industrial approaches toward high-tech industries. The findings show that technonationalism is a concept linking technology and national security, seeking geoeconomic interests in the integrated global market to exert state power for economic statecraft. The nature of industry highly relies on the global value chain, and technological innovation in the high-tech sectors occurs mainly in the private sector; thus, this article points out the issue of embracing business interests into the state’s strategic addenda as a critical criterion of technonationalism. Also, technonationalism is a narrowly defined concept with state actors involved in national security affairs and high-tech business actors.

In cosmology, the cosmic curvature $K$ and the cosmological constant $\Lambda$ are two most important parameters, whose values have strong influence on the behavior of the universe. By analyzing the energy-momentum tensor and equations of state of ideal gas, scalar, spinor and vector potential in detail, we find that the total mass density of all matter is always positive, and the initial total pressure is negative. Under these conditions, by qualitatively analyzing the global behavior of the dynamical equation of cosmological model, we get the following results: (i) $K= 1$, namely, the global spatial structure of the universe should be a 3-dimensional sphere $S^3$. (ii) $0\le\Lambda < 10 ^ {-24} {\rm ly} ^ {-2}$, the cosmological constant should be zero or an infinitesimal. (iii) $a(t)>0$, the initial singularity of the universe is unreachable, and the evolution of universe should be cyclic in time. This means that the initial Big Bang is impossible at all. Since the matter components considered are quite complete and the proof is very elementary and strict, these logical conclusions should be quite reliable. Obviously, these conclusions will be much helpful to correct some popular misconceptions and bring great convenience to further research other problems in cosmology such as property of dark matter and dark energy.

The paper presents an analysis of the method of recording the magnetic component of the Earth’s natural pulse electromagnetic field in an urban environment. This method of recording has already proved itself to be a method that allocates the stressed sections of rock mass at mining and, therefore, authors suppose its effectiveness for allocating active tectonic disturbances and forecasting accidents at underground utilities, what will help reduce the potential environmental hazard of these objects.

In this paper, the stability control of the inverted pendulum on a cart with a disturbance forces has been done using observer based and full state feedback H2 controllers. The Lagrangian equation has been used to model the system equation of motions and linearized the system to the unstable upward position. Comparison of the system stability has been simulated by comparing the proposed controllers using Matlab/Scripts and a promising results has been analyzed successfully.

Mental stress state recognition using electroencephalogram (EEG) signals for real-life applications needs a conventional wearable device. This requires an efficient number of EEG channels and an optimal feature set. The main objective of the study is to identify an optimal feature subset that can best discriminate mental stress states while enhancing the overall performance. Thus, multi-domain feature extraction methods were employed, namely, time domain, frequency domain, time-frequency domain, and network connectivity features, to form a large feature vector space. To avoid the computational complexity of high dimensional space, a hybrid feature selection (FS) method of minimum Redundancy Maximum Relevance with Particle Swarm Optimization and Support Vector Machine (mRMR-PSO-SVM) is proposed to remove noise, redundant, and irrelevant features and keep the optimal feature subset. The performance of the proposed method is evaluated and verified using four datasets, namely EDMSS, DEAP, SEED, and EDPMSC. To further consolidate, the effectiveness of the proposed method is compared with that of the state-of-the-art heuristic methods. The proposed model has significantly reduced the features vector space by an average of 70% in comparison to the state-of-the-art methods while significantly increasing overall detection performance.

This paper aims to provide the smart grid research community with an open and accessible general mathematical framework to develop and implement optimal flexibility mechanisms in large-scale network applications. The motivation of this paper is twofold. On the one hand, flexibility mechanisms are currently a hot topic of research, which is aimed to mitigate variation and uncertainty of electricity demand and supply in decentralised grids with a high aggregated share of renewables. On the other hand, a large part of such related research is performed by heuristic methods, which are generally inefficient (such methods do not guarantee optimality) and difficult to extrapolate for different use cases. Alternatively, this paper presents an MPC-based (Model Predictive Control) framework explicitly including a generic flexibility mechanism which is easy to particularise to specific strategies such as Demand Response, Flexible Production and Energy Efficiency Services. The proposed framework is benchmarked with other non-optimal control configurations to better show the advantages it provides. The work of this paper is completed by the implementation of a generic use case which aims to further clarify the use of the framework and thus, to ease its adoption by other researchers in their specific flexibility mechanisms applications.

The description of stellar interiors remains as a big challenge for the nuclear astrophysics community. The consolidated knowledge is restricted to density regions around the saturation of hadronic matter $\rho _{0} = 2.8\times 10^{14} {\rm\ g\ cm^{-3}}$, regimes where our nuclear models are successfully applied. As one moves towards higher densities and extreme conditions up to five to twenty times $\rho_{0}$, little can be said about the microphysics of such obejects. Here, we employ an MCMC strategy in order to access the variability of polytropic three-pircewised models for neutron star equation of states. With a fixed description of the hadronic matter we explore a variety of models for the high density regimes leading to stellar masses up to 2.5 $M_{\odot}$. In addition, we also discuss the use of a Bayesian power regression model with heteroscedastic error. The set of EoS from LIGO was used as inputs and treated as data set for testing case.

Multipartite entanglement is a resource for application in disparate protocols, of computing, communication and cryptography. In this paper, generation, characterisation and application of a genuine genuinely entangled seven-qubit resource state is studied. Theoretical schemes for quantum teleportation of arbitrary one, two and three qubits states, bidirectional teleportation of arbitrary two qubit states and probabilistic circular controlled teleportation as well as three schemes for undertaking tripartite quantum state sharing are presented.

The use of natural stone has a historical and environmental value that makes it strategically valuable for landscape conservation in Europe. Marble, among others, is widely spread on Earth, and it offers high-performance features in architectural applications. However, the complexity of these formations and the rock variability in different ore bodies require detailed studies of the natural and induced stress state, the fracturing degree, and the influence of external factor (such as temperature and/or chemical agents) on the mechanical properties in order to optimize the exploitation processes by reducing extractive waste. This article shows a series of studies conducted by the authors over the last 20 years aimed at making the exploitation of marble blocks in the Carrara basin safer, more efficient, and, therefore, more sustainable. In particular, studies for increasing the knowledge on the natural and the induced stress state through on-site measurements and numerical modeling, studies to improve the quality of the exploited material through improvements of cutting technologies, studies to improve the knowledge of the mechanical behavior of the material under varying loads and temperature conditions and studies to improve the reuse of water materials and their reduction are reported.

Analytical solutions for radiation dominated phase of Quasi Steady State Cosmology in Friedmann-Robertson-Walkar models are obtained. We find that matter density is positive in all the cases (k = 0,-1,1). The nature of Hubble parameter (H) in [0,2] is discussed. The deceleration parameter (q) is marginally less than zero indicating accelerating universe. The scale factor (S) is graphically shown with time. The model represents oscillating universe between the above mentioned limits. Because of bounce in QSSC, the maximum density phase is still matter dominated. The models represent singularity free model. We also find that the models have event horizon i.e. no observer beyond the proper distance rH can communicate each other in FRW mdels for radiation dominated phase in the frame work of QSSC. The FRW models are special classes of Bianchi type I, V, IX space-times with zero, negative and positive curvatures respectively. Initially i.e. at  = 0, the model represents steady model. We have tried to show how a good fit can be obtained to the observations in the framework of QSSC during radiation dominated phase.

This paper studies the integrated design problems of control and guidance with parameter uncertainties, target disturbances, input constraints and actuator faults. Firstly, based on the integrated design idea of the missile guidance and control, the auxiliary variable is used to establish and transform it into a cascade system with input constraints, actuator faults and disturbances of unknown upper bounds. Secondly, the adaptive anti-saturation dynamic surface fault-tolerant controller is designed by using the back-stepping method, adaptive control, auxiliary system and tracking differentiator. By introducing the tracking differentiator and tangent barrier Lyapunov function, the computational explosion problem in the traditional back-stepping method is avoided and the angle of attack can be guaranteed in prospective range, respectively. Finally, the theoretical proof of the designed control strategy is given to ensure that the states of the closed-loop system are bounded. At the same time, the digital simulation of the maneuvering target of different maneuvering forms is carried out, which further illustrate the effectiveness and robustness of the designed control schemes.

Directional modulation (DM), as an emerging promising physical layer security (PLS) technique at the transmitter side with the help of an antenna array, has developed rapidly over decades. In this study, a DM technique using a polarization sensitive array (PSA) to produce the modulation with different polarization states (PSs) at different directions is investigated. PSA can be employed for more effective DM for an additional degree of freedom provided in the polarization domain. The polarization information can be exploited to transmit different data streams simultaneously at the same directions, same frequency, but with fixed different PSs in the desired directions to increase the channel capacity, and with random PSs off the desired directions to enhance PLS. The proposed method has the capability of concurrently projecting independent signals into different specified spatial directions while simultaneously distorting signal constellation in all other directions. Mathematical analysis and design examples for single-beam and multi-beam DM systems are presented. Simulation results demonstrate that the proposed method is more effective for PLS and the channel capacity is significantly improved compared with conventional antenna arrays.

Agriculture has been experiencing a difficult situation because of limiting factors in its production, Natural biostimulants (NBs) have emerged as a novel alternative. This study reviews NBs produced through Solid-State Fermentation (SSF) from organic waste, focusing on the processes and production methods. The aim is to highlight their potential for improving agricultural productivity and promoting sustainable agriculture. Through a literature review, the effects of NBS on crops were examined, as well as the challenges associated with their production and application. The importance of standardizing production processes, optimizing fermentation conditions, and assessing their effects on different crops is emphasized. Furthermore, future research areas are identified, such as enhancing production efficiency and evaluating the effectiveness of SSF-produced NBS in different agricultural systems. In conclusion, SSF-produced NBS offers a promising alternative for sustainable agriculture, but further research and development are needed to maximize its efficacy and enable large-scale implementation.

Quantum computing arrives. Preceded by Mādhava of Sangamagrāma and other Hindu mathematicians, around 1,500 CE, and our previous work, we show at least 4 quantum properties that are indeed universal in some number systems; here we use them to enable quantum computing. Using the sets B={0,1}, B^n, N, Z, Q, and Q*, one has +4 quantum properties that one can trust, as archetypes of easy communication to friends and foes, to ignoranti or cognoscenti, and for quantum consciousness. Therefore, this work applies to computer calculations, apps in cell phones, algebra, atoms, mathematics, physics, and the human mind.

Routing quantum information among different nodes in a network is a fundamental prerequisite for a quantum internet. While single-qubit routing has been largely addressed, many-qubit routing protocols have not been intensively investigated so far. Building on the many-excitation transfer protocol in Ref. , we apply the perturbative transfer scheme to a two-excitation routing protocol on a network where multiple two-receivers block are coupled to a linear chain. We address both the case of switchable and permanent couplings between the receivers and the chain. We find that the protocol allows for efficient two-excitation routing on a fermionic network, although for a spin-12 network only a limited region of the network is suitable for high-quality routing.

Liquid-liquid phase separation (LLPS) of proteins has been found ubiquitously in eukaryotic cells, critical in the controlling of many biological processes through forming a temporary condensed phase with different bimolecular components. TDP-43 is recruited to stress granules in cells and is the main component of TDP-43 granules and proteinaceous amyloid inclusions in patients with amyotrophic lateral sclerosis (ALS). TDP-43 low complexity domain (LCD) is able to demix in solution forming the protein condensed droplets. The molecular interactions regulating its LLPS were investigated at the protein fusion equilibrium stage, where the droplets stopped growing. We found the molecules in the droplet were still liquid-like but with enhanced intermolecular helix-helix interaction in the LCD. The protein would start to aggregate after about 200 minutes of lag time and aggregate slower than at the condition when the protein does not phase separate or the molecules have a reduced intermolecular helical interaction. A structural transition intermediate towards protein aggregation was also discovered involving a decrease of the intermolecular helix-helix interaction and a reduction in the helicity. Therefore, LLPS and the intermolecular helical interaction could help maintain the stability of TDP-43 LCD.

This paper focuses on hyperglycemic hyperosmolar syndrome (HHS), a unique hyperglycemic state requiring divergent diagnosis and treatment approaches from diabetic ketoacidosis (DKA), despite some shared characteristics. We introduce the mnemonic DI-FF-ER-EN-CE-S to encapsulate unique HHS management and complications. 'DI' emphasizes the need to delay and reduce initial insulin therapy until serum glucose decline is managed by fluid resuscitation alone. 'FF' and 'ER' stress the importance of fluid and electrolyte replacement due to severe dehydration and imbalances. 'EN' denotes the potential for encephalopathy and the requirement for a controlled serum osmolality reduction. 'CE' indicates that cerebral edema is rare but necessitates aggressive fluid therapy. 'S' signifies systemic multiorgan failure. We categorize the associated risks into three mnemonic groups: the 3Rs (renal failure, respiratory distress, rhabdomyolysis), the 3Hs (heart failure, hypercoagulation, hyperthermia), and AP (arrhythmias, pancreatitis) to facilitate awareness and screening of HHS.