Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Version 1 : Received: 9 December 2021 / Approved: 13 December 2021 / Online: 13 December 2021 (13:33:11 CET)
Version 2 : Received: 8 January 2022 / Approved: 11 January 2022 / Online: 11 January 2022 (12:54:23 CET)

A peer-reviewed article of this Preprint also exists.

Fome, A.D.; Sangeda, R.Z.; Balandya, E.; Mgaya, J.; Soka, D.; Tluway, F.; Masamu, U.; Nkya, S.; Makani, J.; Mmbando, B.P. Hematological and Biochemical Reference Ranges for the Population with Sickle Cell Disease at Steady State in Tanzania. Hemato 2022, 3, 82-97. Fome, A.D.; Sangeda, R.Z.; Balandya, E.; Mgaya, J.; Soka, D.; Tluway, F.; Masamu, U.; Nkya, S.; Makani, J.; Mmbando, B.P. Hematological and Biochemical Reference Ranges for the Population with Sickle Cell Disease at Steady State in Tanzania. Hemato 2022, 3, 82-97.

Journal reference: Hemato 2022, 3, 7
DOI: 10.3390/hemato3010007

Abstract

Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management and evaluation of interventions. This study was conducted at Muhimbili National Hospital (MNH) in Dar es Salaam, to establish laboratory reference ranges in SCD at steady-state. Patients were grouped into five age groups with respects to their sex. Aggregate functions were used to handle repeated measures within the indi-vidual level in each age group. A nonparametric approach was used to smooth the curves and a parametric approach was used to determine SCD normal ranges. Comparison between males and females and against the general population was documented. Data from 4,422 patients collected from 2004-2015 were analyzed. The majority of the patients (35.41%) were children aged between 5-11 years. There were no significant differences (p≥0.05) in mean corpuscular hemoglobin concentration (MCHC), lymphocytes, basophils and bilirubin direct observed between males and females. Significant differences (p<0.05) were observed in all selected parameters across age groups except neutrophils and MCHC in adults, as well as platelets and alkaline phosphatase in infants when SCD estimates were compared to the general population. Laboratory reference ranges in SCD at steady-state were different from those of the general population and varied with sex and age. The established reference ranges for SCD at steady-state will be a helpful in the management and monitoring of the progress of SCD.

Keywords

Hematological parameters; biochemical parameters; reference ranges; sickle cell disease; Tanzania; steady-state.

Subject

MEDICINE & PHARMACOLOGY, General Medical Research

Comments (1)

Comment 1
Received: 11 January 2022
Commenter: Anna Fome
Commenter's Conflict of Interests: Author
Comment: Modified texts are highlighted in yellow
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