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Preprint ARTICLE | doi:10.20944/preprints202404.1771.v1

Exploring Predictive Factors for Heart Failure Progression in Hypertensive Patients Based on Medical diagnosis Data from the MIMIC-IV Database

Jinmyung Jung, Doyoon Kim, Inkyung Hwang

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: heart failure; hypertension; predictive factors; MIMIC-IV database; data mining; XGBoost modeling; chi-square test

Online: 26 April 2024 (20:12:01 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1689.v1

Nephrotic Range Proteinuria and Restrictive Heart Failure in a Patient with Secondary Amyloidosis: A Case Report

Simoni Shah, Hetansh Shah, Manas Parikh, Dev Desai, Vismit Gami

Subject: Other, Medicine And Pharmacology Keywords: amyloidosis; Congo red stain; nephrotic syndrome; heart failure

Online: 25 April 2024 (16:11:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1524.v1

Computational Modeling of Sodium Ion Channel-Based Glucose Sensing Biophysics to Study Abnormal Electrical Activities in Cardiac Atrial Cell

CHITARANJAN MAHAPATRA, Kirubanandan Shanmugam

Subject: Biophysics, Biology And Life Sciences Keywords: glucose sensor; ion channel; heart failure; computational modeling; sinoatrial node; action potential

Online: 23 April 2024 (13:48:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1122.v1

Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation

Sarah Mende, Syed Ahmed, Lise DeShea, Edgardo Szyld, Birju A. Shah

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: electrocardiogram; heart rate; neonatal resuscitation

Online: 17 April 2024 (08:33:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1054.v1

Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu, Octavian-Marius Cretu, Daniel Florin Lighezan, Minodora Andor, Ioana Citu, Dragoș Cozma, Brenda-Cristiana Bernad, Adrian-Pavel Trifa, Diana Lighezan, Elena-Silvia Bernad, Dragos Catalin Jianu, Cristian Oancea, Ioan-Radu Lala, Sergiu-Florin Arnautu, Mirela-Cleopatra Tomescu

Subject: Biology And Life Sciences, Life Sciences Keywords: dilated cardiomyopathy; genetics; heart failure; genotype - specific therapy

Online: 16 April 2024 (15:53:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0901.v1

Impact of Withdrawal of SGLT2 Inhibitors on Clinical Outcomes in Patients with Heart Failure

Masaki Nakagaito, Teruhiko Imamura, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; SGLT2 inhibitor; hospitalization; medical cost

Online: 15 April 2024 (11:36:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0913.v1

Statins for Heart Failure with Preserved Ejection Fraction: Current Evidence and Perspectives

Artem Ovchinnikov, Alexandra Potekhina, Tatiana Arefieva, Anastasiia Filatova, Fail Ageev, and Evgeny Belyavskiy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: statins; heart failure with preserved ejection fraction; inflammation; diastolic dysfunction; prognosis

Online: 15 April 2024 (07:25:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0842.v1

Prognostic Value and Limits of Heart Rate and QT-Corrected in A Large Population

Paolo Giovanardi, Cecilia Vernia, Sara Roversi, Enrico Tincani, Giuseppe Spadafora, Federico Silipo, Claudio Giberti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: electrocardiogram; QT corrected; Bazett; heart rate; all-cause death; mortality

Online: 12 April 2024 (09:54:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0788.v1

The Lipid-Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-fat and High Linoleic Acid Consumption

Academic Editor: Mary T Newport, Fabian M Dayrit

Subject: Public Health And Healthcare, Health Policy And Services Keywords: lipid-heart hypothesis; Ancel Keys; saturated fat; trans-fat; polyunsaturated fat; cholesterol; heart disease; dietary guidelines

Online: 11 April 2024 (10:20:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0573.v1

Within-week variation of training load in Turkish elite soccer players by players positions (a GPS technology study)

Hakan BAYRAKTAR, Erkan GÜNAY, Erhan Çene, Egemen Mancı, Zeki Akyıldız

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Soccer; TRIMP; Workload; Players; Heart Rate; GPS; Microcycles.

Online: 8 April 2024 (15:01:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0470.v1

From Detection to Action: A Retrospective Analysis on the Impact of Screening for Congenital Heart Disease in the NICU

Ioana Roșca, Daniela-Eugenia Popescu, Ana Maria Cristina Jura, Alina Turenschi, Cristina Filip, Alexandru Dinulescu, Andreea Teodora Constantin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; neonatology; prenatal diagnosis; parent support; neonatal intensive care unit; pulse oximetry; screening; echocardiography

Online: 7 April 2024 (10:34:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0029.v1

Apolipoprotein E Gene Variation in Pakistani Type 2 Diabetic Subjects with and without Cardiovascular Complications

Shehwar Nadeem, Tahir Maqbool, Javed Anver Qureshi, Awais Altaf, Sadia Naz, Muzmmal Mateen Azhar, Inam Ullah

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Apolipoprotein E; polymorphisms; Ischemic heart disease; stroke

Online: 1 April 2024 (10:26:55 CEST)

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Background Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM). Type 2 diabetes mellitus (T2DM) is a major public health concern worldwide, including in Pakistan. Cardiovascular problems linked with T2DM have a significant impact on people and society. The study's goal is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, lipid profiles, and cardiovascular complications such as ischemic heart disease (IHD) and stroke. Methods: This study was carried out on 260 subjects, divided into control D1: Diabetics without cardiovascular issues. D2: Diabetics with heart disease. D3: Diabetics with stroke. D4: Diabetics with both heart disease and stroke. Anthropometric parameters (age, BMI) and risk factors (smoking, diabetes duration, hypertension) were assessed in all groups. Serum levels of TC, TG, LDL, HDL, VLDL, creatinine, BSF, and HbA1c were measured. Apolipoprotein E gene polymorphism was determined using PCR-RFLP. Results: Hypertension, BMI, and dyslipidemia, defined as elevated levels of total cholesterol, triglycerides, LDL, HDL, and VLDL, as well as uncontrolled hyperglycemia (elevated fasting blood sugar and glycated hemoglobin) in T2DM, were linked to vascular complications such as IHD and stroke. Hypertension was prevalent in 75.4% of the population, with greater rates among the elderly. Stage 2 hypertension was more prevalent in all age groups. Apolipoprotein E gene polymorphism was discovered, with genotypes 3/3, 4/4, 2/3, and 3/4 being the most prevalent. Genotype 3/4 was more common in diabetics who had IHD/stroke or both problems, whereas genotype 2/3 was linked to DM and stroke. Conclusion: It is concluded that BMI, hypertension, hyperglycemia, atherosclerosis, and dyslipidemia are linked with cardiovascular complications of type 2 diabetes. Apolipoprotein E gene polymorphism is associated with cardiovascular disease in diabetic patients by affecting the lipid profile.

Preprint REVIEW | doi:10.20944/preprints202403.1790.v1

Novel Medical Treatments and Devices for the Management of Heart Failure with Reduced Ejection Fraction

Michele Alfieri, Filippo Bruscoli, Luca Di Vito, Federico Di Giusto, Giancarla Scalone, Procolo Marchese, Domenico Delfino, Simona Silenzi, Milena Martoni, Federico Guerra, Pierfrancesco Grossi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: heart failure; reduced ejection fraction; SGLT2 inhibitors; vericiguat; CardioMEMS; Cardiac Contractility Modulation; Left bundle branch area pacing; Wearable cardioverter defibrillators; Ultrafiltration

Online: 28 March 2024 (17:15:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1471.v2

Pivotal Role of Artificial Intelligence in Cardiovascular Health: Highlights from the Late Breaking Trials at the AHA Scientific Sessions 2023

Sashwath Srikanth, Avilash Mondal, Sanjana Aggarwal, Naga Ruthvika Alle, Olufemi Odugbemi, Rupak Desai

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: artificial intelligence; machine learning; coronary artery diease; heart failure; risk stratification; screening

Online: 26 March 2024 (10:23:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1376.v1

Prognostic significance of Lung ultrasound for Heart Failure Patient Management in Primary Care. A Systematic Review

Anna Panisello-Tafalla, Marcos Haro Montoya, Rosa Caballol-Angelats, Maylin Montelongo-Sol, Yoenia Rodriguez-Carralero, Jorgina Lucas-Noll, Josep Lluis Clua-Espuny

Subject: Public Health And Healthcare, Primary Health Care Keywords: Lung ultrasound; Heart Failure; B-lines; prognosis; mortality; hospital admissions; Primary care.

Online: 22 March 2024 (11:38:10 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202403.1326.v1

The Psychophysiological Interrelationship between Working Conditions and Stress of Harvester and Forwarder Drivers – a Study Protocol

Vera Foisner, Christoph Haas, Katharina Göttlicher, Arnulf Hartl, Christoph Huber

Subject: Biology And Life Sciences, Forestry Keywords: emotion recognition; eye tracking; forwarder; galvanic skin response; harvester; heart rate variability; psychophysiology; strain; stress; traction aid winches

Online: 22 March 2024 (04:52:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1233.v1

Effect of Sleep Duration on Autonomic Nervous System Regulation in Patients with Plausible Alzheimer: A Cross-Sectional Pilot Study

Chuen-Ru Liu, Chih-Yuan Yang, Dipanshu Sharma, Tun-Hao Chen, Xian-Qing Huang, Tsui-Mei Hung, Terry B. J. Kuo, Jwo-Huei Jou

Subject: Public Health And Healthcare, Nursing Keywords: Alzheimer’ s disease; autonomic nervous system regulation; dementia severity; heart rate variability; sleep duration

Online: 20 March 2024 (14:30:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1090.v1

Influence of desert dust on the development of premature coronary disease

Alberto Dominguez-Rodriguez, Néstor Báez-Ferrer, Pablo Avanzas, Sergio Rodríguez, Pedro Abreu-González, Elisa Trujillo-Martin, Guillermo Burillo-Putze, Daniel Hernández-Vaquero

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Desert dust; acute coronary syndrome; premature coronary heart disease; air pollution

Online: 19 March 2024 (05:20:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1067.v1

Effects of Stress and Anxiety on Pregnant Women's Cardiovascular Health: A Narrative Review

Brenda-Cristiana Bernad, Mirela-Cleopatra Tomescu, Lavinia Hogea, Dana Emilia Velimirovici, Minodora Andor, Diana Lungeanu, Virgil Enătescu, Adina-Ioana Bucur, Ana Lascu, Rata Andreea Luciana, Elena Silvia Bernad, Vlad Nicoraș, Diana-Aurora Arnautu

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: pregnancy; fetus; stress; anxiety; cardiovascular diseases; heart disease risk factors; psychological; mental health

Online: 19 March 2024 (05:10:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0867.v1

Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician

Ageliki A Karatza, Sotirios Fouzas, Despoina Gkentzi, Eirini Kostopoulou, Nikoleta Oikonomou, Gabriel Dimitriou, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; acquired heart disease; children; diagnostic errors; missed diagnosis; delayed diagnosis; primary care pediatrician

Online: 17 March 2024 (16:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0671.v1

Subclinical Echocardiographic Parameters and Biomarker Approach to Characterise the Pathophysiology of Carcinoid Syndrome

Ileana Nitu, Ionela Baciu, Simona Găloiu, Iulia Burcea, Catalina Poiana

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: carcinoid heart disease; global longitudinal strain; systolic velocities, NT-proBNP; serotonin, 5- hydroxyindolacetic acid

Online: 12 March 2024 (10:17:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0615.v1

TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis

Wan-Chung Hu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Treg; TGFβ ; Scleroderma; heart failure; liver cirrhosis; uremia; pulmonary fibrosis

Online: 11 March 2024 (13:20:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0565.v1

Heart-Cutting Bidimensional Liquid Chromatography for the Simultaneous Analysis of Veterinary Drugs Residues and Nucleotides Monophosphate in Sheep’s Milk

Noelia Caballero-Casero, Diego García-Gómez, José Luis Pérez Pavón, Encarnación Rodríguez-Gonzalo

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Two-dimensional liquid chromatography; heart-cutting 2D-LC; veterinary drug residue; nucleotides monophosphate; sheep’s milk

Online: 11 March 2024 (08:59:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0531.v1

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-ischemic Hypertensive Heart Disease

Nikolaos PE Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael Myrianthefs

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertensive heart disease; echocardiography; prognosis; speckle tracking

Online: 8 March 2024 (16:49:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0391.v1

Carbohydrate Antigen 125 (CA 125): Novel Biomarker in Acute Heart Failure

Mihai Cristian Marinescu, Violeta Diana Oprea, Sorina Nicoleta Munteanu, Aurel Nechita, Dana Tutunaru, Luiza-Camelia Nechita, Aurelia Romila

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: acute heart failure; CA 125; NTpro BNP

Online: 8 March 2024 (01:55:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0386.v1

Advanced Detection of Cardiac Beat Intervals in Functional Near-Infrared Spectroscopy(fNIRS) through Signal Integration Reconstruction

Kyoung soo Kim, Taehoon Kim, Jihyun Cha

Subject: Computer Science And Mathematics, Signal Processing Keywords: Heartbeat; fNIRS; RR-interval; heart rate; HRV; Cardiac beat interval; algorithm

Online: 8 March 2024 (01:52:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0277.v1

Compartmentalized Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve

Meghan Martin, Chih-Ying Chen, Timothy McCowan, Sarah Wells

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart valves; extracellular matrix; remodeling; elastin; cardiac development; collagen; valvulogenesis

Online: 5 March 2024 (15:05:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1997.v2

The congestion “Pandemic” in Acute Heart Failure Patients

Daniela Mocan, Radu Ioan Lala, Maria Puschita, Luminita Pilat, Dan Alexandru Darabantiu, Adina Pop Moldovan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; congestion; volume overload; volume redistribution; biomarkers

Online: 5 March 2024 (05:55:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0181.v1

Biomarkers of Response to Adjunctive Yoga-Based Interventions in Depression: A Scoping Review

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: major depressive disorder; yoga; adjunctive treatment; hypothalamic-pituitary-adrenal axis; heart rate variability; interleukin-6; brain-derived neurotrophic factor

Online: 4 March 2024 (15:54:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0061.v1

Unraveling the Complexity: From Molecular Subtypes to Therapeutic Strategies in Heart Failure with Preserved Ejection Fraction and Atrial Fibrillation

Behzad Fahimi, Somayeh Beikmohammadi, Parsa Rostami

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Atrial Fibrillation; Heart Failure with Preserved Ejection Fraction (HFpEF); Cardiac Amyloidosis; Molecular Imaging; Catheter Ablation; SGLT2 Inhibitors

Online: 1 March 2024 (14:46:58 CET)

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fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). Join us on a journey that unravels the mysteries of molecular intricacies, delves into advanced imaging techniques, and sheds light on therapeutic pathways. Unveiling the role of cardiac amyloidosis, particularly sub-clinical isolated cardiac amyloidosis (ICA), the narrative unfolds the heightened risk of AF in the elderly. State-of-the-art imaging techniques like cardiac magnetic resonance (CMR) and molecular imaging step into the spotlight, unraveling diagnostic and prognostic nuances of AF and HFpEF. Embarking on the molecular voyage, the article navigates through next-generation sequencing and comprehensive genomic profiling, shedding light on genetic alterations shaping the AF-HFpEF landscape. This molecular compass lays the groundwork for personalized medicine, illuminating pathways to identify therapeutic bullseyes and biomarkers. In the realm of medical strategies, the discussion homes in on the promising notes struck by SGLT2 inhibitors, particularly dapagliflozin, orchestrating a reduction in AF burden. Characters like spironolactone and dronedarone make appearances, each weaving a distinct tale, revealing their potential roles in steering the ship for AF- HFpEF patients. The subplot involving obesity in HFpEF unfolds, with the LEGACY study portraying the benefits of weight reduction. The pivotal intervention of catheter ablation emerges as the hero, boasting positive outcomes in reducing hospitalization rates and overall mortality for AF-HFpEF patients. However, cautionary tales echo about its impact on left atrial function, adding layers of complexity that beckon careful consideration and monitoring. Amidst the narrative, critical discussions unfold about the limitations of current research, echoing the need to define acute heart failure, refine imaging techniques, and tailor management strategies. The narrative passionately advocates for a personalized touch in addressing AF-HFpEF, recognizing the unique blend of clinical and molecular personas. In essence, this review paints a vivid mural of AF-HFpEF, skillfully bridging the realms of molecular intricacies and the artistry of clinical management.

Preprint ARTICLE | doi:10.20944/preprints202402.1757.v1

Use of a Simple Stair-Climbing Test to Assess Cardiopulmonary Fitness in Clinical Practice. An Overview of the Published Liter-Ature Aiming for a Future Goal

Johanna Wander, Maurice Pablo Mall, Anne Lentz, Meike Schrader, Nikolaus Alexander Haas, Simone Katrin Dold

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Stair Climbing Test; Cardiorespiratory Fitness; Exercise Test, Children; Congenital Heart Disease

Online: 29 February 2024 (14:34:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1504.v1

The Development and Testing of the Hippocratic Heart Failure Self-care Scale

Hero Brokalaki, ANASTASIA A CHATZIEFSTRATIOU, Nikolaos V. Fotos, Athina Patelarou, Konstantinos Giakoumidakis

Subject: Public Health And Healthcare, Primary Health Care Keywords: self-care; self-management; heart failure; validation; scale development

Online: 27 February 2024 (12:39:05 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202402.1536.v1

User Manual for Coping Strategies Inventory Short Form (CSI-SF) -The Jackson Heart Study

Clifton Addison, Brenda Jenkins, Monique White

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Jackson Heart Study; Coping; Validity; Reliability; CSI-SF Manual; African Americans

Online: 27 February 2024 (12:37:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1417.v1

Harnessing the Synergy of SGLT2 Inhibitors and Continuous Ketone Monitoring (CKM) in Managing Heart Failure Among Patients with Type 1 Diabetes

Nicola Tecce, Giorgio De Alteriis, Giulia de Alteriis, Ludovica Verde, Mario Felice Tecce, Annamaria Colao, Giovanna Muscogiuri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: heart failure; type 1 diabetes; diabetic cardiomyopathy; hospitalization; HFpEF; HFrEF; SGLT2-i; sodium-glucose cotransporter-2 inhibitors; diabetic ketoacidosis; epidemiologic studies; patient education; continuous monitoring of ketone levels; ketonemia

Online: 26 February 2024 (11:54:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1313.v1

Hearables: In-ear Multimodal Data Fusion for Robust Heart Rate Estimation

Marek Zylinski, Amir Nassibi, Edoardo Occhipinti, Adil Malik, Matteo Bermond, Harry J. Davies, Danilo P. Mandic

Subject: Engineering, Bioengineering Keywords: Data fusion method; Heart rate tracing; Hearables; Wearables

Online: 22 February 2024 (12:21:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1191.v1

Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes

Andrii Kamenshchyk, Igor Belenuchev, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: myocardial hypertrophy; children; gene expression signaling pathways; pharmacological modulation; heart

Online: 21 February 2024 (04:42:02 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202402.1065.v1

Cardiac Arrest and Complete Heart Block: Complications after Electrical Cardioversion for Unstable Supraventricular Tachycardia in the Emergency Department

Adina Maria Marza, Claudiu Barsac, Dumitru Sutoi, Alexandru Cristian Cindrea, Alexandra Herlo, Cosmin Iosif Trebuian, Alina Petrica

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: supraventricular tachycardia, cardioversion, unstable patient, complete heart block, ineffective pacing, cardiac arrest, advanced life support.

Online: 19 February 2024 (14:52:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1067.v1

Non‐Invasive Heart Failure Evaluation with Wearable Signals and Machine Learning Algorithms

Odeh Adeyi Victor, Yifan Chen, Wenyan Wang, Xiaorong Ding

Subject: Engineering, Bioengineering Keywords: Heart Failure, Photoplethysmogram, Echocardiogram, Machine Learning

Online: 19 February 2024 (12:55:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1025.v1

Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study

Luana Nosetti, Marco Zaffanello, Carolina Lombardi, Alessandra Gerosa, Giorgio Piacentini, Abramo Michele, Massimo Agosti

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: children; congenital heart disease; Electrocardiogram; Infant; long QT syndrome; neonatal screening; sudden infant death syndrome.

Online: 19 February 2024 (08:22:38 CET)

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(1) Background: Sudden Infant Death Syndrome (SIDS) represents unexplained and sudden deaths during the sleep of infants under one year of age, despite thorough investigation. Screening for prolonged QTc or Long QT Syndrome (LQTS) should be conducted on all newborns to reduce the incidence of SIDS. Neonatal electrocardiogram (ECG) could identify congenital heart defects (CHD) early, especially those not detected at birth. Infants with prolonged QT intervals typically undergo genetic analysis for Long QT Syndrome; (2) Methods: The study involved infants aged 20-40 days, born clinically healthy, with initial ECG screening. Infants with prenatal diagnoses or signs/symptoms of CHD identified immediately after birth, as well as those who underwent ECG or echocardiogram for other clinical or historical indications, were excluded from the study. The data were analyzed using SPSS version 22.0; (3) Results: Of the 42,200 infants involved, 2,245 were enrolled, with 39.9% being males. Subsequently, 164 children (37.8% males) with prolonged QT intervals underwent further diagnostic investigations. Genetic mutations were identified in 11 out of 18 tested children. The most common mutations were LQT1 (54.5%), LQT2 (36.4%), and LQT3 (1 patient). Medications used included propranolol (39.8%), nadolol (22.2%), inderal (11.1%), metoprolol (11.1%), and no treatment (16.7%). The most common abnormalities were focal right bundle branch block (54.5%), left axis deviation (9.2%), and nonspecific ventricular repolarization abnormalities (7.1%). Multiple anomalies were found in 0.47% of children with focal right bundle branch block. Structural abnormalities were associated with specific features in 267 patients (11.9%), primarily isolated patent foramen ovale (PFO) at 61.4%; (4) Conclusions: The screening has proven effective in early diagnosing Long QT Syndrome and other cardiac rhythm anomalies, with additional benefits in detecting mutations and/or QTc prolongations in family members. Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening.

Preprint ARTICLE | doi:10.20944/preprints202402.0619.v1

Embodimetrics: A Principal Component Analysis of the Combined Assessment of Cardiac, Cognitive and Mobility Parameters

Andrea Chellini, Katia Salmaso, Michele Di Domenico, Nicola Gerbi, Marco Donati, Marco Iosa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: embodiment; heart rate variability; stroop task; motor control

Online: 12 February 2024 (13:19:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0620.v1

Prognostic Significance of Heart Failure in Acute Pulmonary Embolism: A Comprehensive Assessment of 30-Day Outcomes

Mariam Farid-Zahran Osuna, Manuel Méndez-Bailón, José María Pedrajas, Rubén Alonso-Beato, Francisco Galeano-Valle, Vanesa Sendín Martín, Javier Marco-Martínez, Pablo Demelo-Rodríguez

Subject: Medicine And Pharmacology, Hematology Keywords: heart failure; venous thromboembolism; pulmonary embolism; mortality; bleeding; comorbidity; left ventricular ejection fraction (LVEF)

Online: 12 February 2024 (08:51:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0456.v1

The Potential Use of Soluble TREM Like Transcript – 1, a Platelet-Specific Receptor, for Early Detection of Anthracyclines Induced Congestive Heart Failure (CHF) in Leukemia Patients

Siobhan Branfield, Susan LaGrand, Ian Cleary, Angelia Gibson, Anthony Valance Washington

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Keywords: keyword triggering receptor expressed in myeloid cells-like transcript (TLT-1); blood platelets; cardiovascular diseases; left ventricular ejection fraction (LVEF); biomarker; anthracyclines, Troponin I, cardiotoxicity, congestive heart failure (CHF)

Online: 7 February 2024 (17:08:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0458.v2

The Influence of Pericardial Fat on Left Ventricular Diastolic Function

Hugo Duarte, Carlos Alcafache, Patricia Coelho, Francisco Rodrigues

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Pericardium [A07.541.795]; Echocardiography [E01.370.350.130.750]; Ventricular Dysfunction, Left [C14.280.945.900]; Heart Failure, Diastolic [C14.280.434.611]; Abdominal Circumference [SP6.270.233.111.178].

Online: 7 February 2024 (14:52:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1922.v1

Statistical and Diagnostic Properties of pRR30, pRR3.25% and Asymmetrical Entropy Descriptors in Atrial Fibrillation Detection

Bartosz Biczuk, Szymon Buś, Sebastian Żurek, Jarosław Piskorski, Przemysław Guzik

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: atrial fibrillation; cardiac arrhythmia; electrocardiography; heart rate variability; entropy

Online: 26 January 2024 (13:50:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1671.v1

Predictive Analytics in Heart Failure Prediction: A Systematic Review

Qisthi Alhazmi Hidayaturrohman, Eisuke Hanada

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: heart failure; predictive analytics; machine learning; readmission; mortality

Online: 24 January 2024 (02:47:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1618.v1

Improving Estimation of Heart Rate and Heart Variability with Real-Time Palm Images Based on Independent Component Analysis and Particle Swarm Optimization

Te-Jen Su, Jui-Chuan Cheng, Wei-Hong Lin, Wen-Rong Yang, Ya-Chung Hung, Shih-Ming Wang, Li-chin Tseng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Independent Component Analysis; Heart Rate Variability; Heart Rate; Particle Swarm Optimization Algorithm

Online: 23 January 2024 (09:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1478.v1

Colour M-mode Velocity Propagation to Predict Early Left Ventricular Diastolic Performance in Acute Decompensated Heart Failure with Preserved Ejection Fraction

A Andrianto, Ivan Satria Pratama, Agus Subagjo, Fahrun Nisa’i Fatimah, Muhammad Ramadhan, Ricardo Adrian Nugraha

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; HFpEF; Colour M– Mode Velocity Propagation; diastolic dysfunction

Online: 19 January 2024 (14:41:50 CET)

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This study aimed to determine the correlation of colour M-mode velocity propagation in the assessment of left ventricular diastolic function among acute decompensated heart failure patients with preserved ejection fraction (HFpEF). This research is an observational analytical study using a cross–sectional study design conducted from April to June 2022. The subjects of this study were patients diagnosed with acute HFpEF and treated at Dr. Soetomo General Academic Hospital, Surabaya. Patients with heart rhythm disturbances, moderate to severe valvular heart disease, and congenital heart defects were excluded from this study. Patients were measured for diastolic function including mitral valve early mitral inflow velocity (MV E Velocity), mitral peak velocity of early filling (E’) (E' Septal and E' Lateral), left atrial volume index (LAVI), The maximal tricuspid regurgitation velocity (TR V Max), Vp, the ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (E/E'), the ratio between early and late ventricular filling velocity (E/A) and E/Vp Ratio. N-terminal-pro hormone B-type natriuretic peptide (NT–ProBNP) examination was also performed on study subjects as an additional diagnosis of acute heart failure. There were 33 patients who met the inclusion and exclusion criteria and were included in our study. There were 26 patients (78.8%) with grade I diastolic dysfunction, 4 patients (12.1%) with grade II diastolic dysfunction, and 3 patients (9.1%) with grade III diastolic dysfunction. There is a strong positive correlation between Vp with parameters E' Septal (p = < 0.001; r = 0.636) and E' Lateral (p = < 0.001; r = 0.650). Vp is negatively correlated with the ratio E/E' (p = 0.029; r = –0.37). The PCWP estimate with E/Vp ratio had a strong correlation with the NT–Pro BNP value > 300 pg/ml in acute HFpEF patients (p = < 0.001; r = 0.726) compared to the PCWP estimate with E/E' (p = < 0.001; r = 0.549). There is no correlation between Vp value and degree of diastolic dysfunction in patients with acute HFpEF.

Preprint CASE REPORT | doi:10.20944/preprints202401.1490.v1

Liver-Kidney-Heart Axis – A Clinical Challenge

Dina Fernandes Neto, Iago Blanco, María Melendo Viu, David Dobarro Perez, Andrés Iñiguez Romo

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type-5 cardio-renal syndrome; heart failure; cirrhosis; Liver-Kidney-Heart axis

Online: 19 January 2024 (13:11:37 CET)

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Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome. A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states. With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.

Preprint REVIEW | doi:10.20944/preprints202307.0500.v2

Cardiovascular Response to Exercise in Vertebrates: Update

Antonio López-Román, Raquel Gómez-Lucas, Elena Jiménez-Herranz, Francisco Javier Calderón-Montero, Juan José Ramos-Álvarez

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: ; vertebrates; arterial pressure; cardiac output; exercise; heart rate; stroke volume ;

Online: 17 January 2024 (13:19:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1295.v1

Autonomic Function in Obese Children and Adolescents: Systematic Review and Meta-Analysis

Georgios E. Papadopoulos, Foteini Balomenou, Xenofon M Sakellariou, Christos Tassopoulos, Dimitrios N Nikas, Vasileios Giapros, Theofilos M Kolettis

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: obesity; heart rate variability; autonomic nervous system; sympathetic activity; vagal activity; children; adolescents

Online: 17 January 2024 (10:16:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1181.v1

Hemodialysis Efficiency Predictor in End Stage Kidney Disease Using Real-Time Heart Rate Variability

Sung Il Im, Ye Na Kim, Hyun Su Kim, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, YeonSoon Jung, Hark Rim, Sung Pil Cho, Jung Hwan Park, Ho Sik Shin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: predictors of hemodialysis; heart rate variability

Online: 16 January 2024 (13:55:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1118.v1

Lessons from the Thioredoxin-1 Knockout Mouse Models

Tetiana Shcholok, Eftekhar Eftekharpour

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Redox balance, thiol antioxidants, transgenic models, brain, heart, glutaredoxin, thioredoxin reductase

Online: 15 January 2024 (10:39:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1004.v1

Predicting Long-Term Childhood Survival of Newborns with Congenital Heart Defects: A Population-Based, Prospective Cohort Study (EPICARD)

Makan Rahshenas, Nathalie Lelong, Damien BONNET, Lucile Houyel, Babak Choodari-Oskooei, Mithat Gonen, Francois Goffinet, Babak KHOSHNOOD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart defects; mortality; prediction; long-term; childhood

Online: 12 January 2024 (11:37:40 CET)

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Introduction: Congenital heart defects (CHD) are the most frequent group of major congenital anomalies, accounting for almost 1% of all births. They comprise a very heterogeneous group of birth defects in terms of their severity, clinical management, epidemiology and embryologic origins. Taking this heterogeneity into account is an important imperative to provide reliable prognostic information to patients and their caregivers, as well as to compare results between centers or to assess alternative diagnostic and treatment strategies. The Anatomic and Clinical Classification of CHD (ACC-CHD) aims to facilitate both the CHD coding process and data analysis in clinical and epidemiological studies. Objectives: 1) To describe the long-term childhood survival of newborns with CHD and 2) To develop and validate predictive models of infant mortality based on the ACC-CHD. Materials and Methods: This study is based on data from a population-based, prospective cohort study: Epidemiological Study of Children with Congenital Heart Defects (EPICARD). The final study population comprised 1881 newborns with CHD after excluding cases that were associated with chromosomal and other anomalies. Statistical analysis included non-parametric survival analysis and flexible parametric survival models. The predictive performance of models was assessed by Harrell’s C index and the Royston-Sauerbrei R2 with internal validation by bootstrap. Results: The overall 8-year survival rate for newborns with isolated CHD was 0.96 [0.93- 0.95]. There was a substantial difference between the survival rate of the categories of ACC-CHD. The highest and lowest 8-year survival rates were 0.995 [0.989-0.997] and 0.34 [0.21-0.50] for “interatrial communication abnormalities and ventricular septal defects” and "functionally univentricular heart", respectively. Model discrimination as measured by Harrell’s C was 87% and 89% for the model with ACC-CHD alone and the full model, which included other known predictors of infant mortality, respectively. The predictive performance as measured by R2 was 45% and 50%, for the ACC-CHD alone and the full model. These measures were essentially the same after internal validation by bootstrap. Conclusion: The ACC-CHD classification provided the basis of a highly discriminant survival model with good predictive ability for the 8-year survival of newborns with CHD. Prediction of individual outcomes remains an important clinical and statistical challenge.

Preprint ARTICLE | doi:10.20944/preprints202401.0941.v1

Prediction of Stress in Radiation Therapy: Integrating Artificial Intelligence with Biological Signals

Sangwoon Jeong, Hongryull Pyo, Won Park, Youngyih Han

Subject: Medicine And Pharmacology, Other Keywords: radiation oncology; artificial intelligence; biological signals; physiological stress; heart rate variability; machine learning

Online: 11 January 2024 (14:52:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0731.v1

Multimodality Imaging in Right Heart Tumors: A Practical Algorithm towards an Appropriate Diagnosis

Mariana Floria, Alexandru Burlacu, Paula Cristina Morariu, Alexandru-Florinel Oancea, Diana Elena Iov, Genoveva Livia Baroi, Celina Silvia Stafie, Viorel Scripcariu, Daniela Maria Tanase

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: right heart; tumor; multimodality; imaging; echocardiography; computer-tomography; cardiac magnetic resonance; positron emission tomography

Online: 10 January 2024 (04:23:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0237.v1

In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease

Francesco Nappi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart disease; first heart field; second heart field; whole exome sequencing; whole genome sequencing; loss-of-function variant; copy number variants; gene variants; deletion; de novo mutations

Online: 3 January 2024 (11:57:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0220.v1

The Role of Artificial Intelligence and Machine Learning in Prediction of Right Heart Failure After LVAD Implantation: Comprehensive Review

Ozlem Balcioglu, Cemre Ozgocmen, Dilber Uzun Ozsahin, Tahir Yagdi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: left ventricular assist device; right heart failure; right ventricle failure; artificial intelligence; machine learning

Online: 3 January 2024 (09:44:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2128.v1

The Structure of the Cardiac Mitochondria Respirasome Is Adapted for the β‐Oxidation of Fatty Acids

Alexander V. Panov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heart mitochondria; β -oxidation of fatty acids; respiratory chain; respirasome; ubiquinone; ubiquinol; oxidative phosphorylation; tricarboxylic acid cycle

Online: 28 December 2023 (07:14:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2153.v1

Different Mechanisms in Doxorubicin-induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

Hien C. Nguyen, Jefferson C. Frisbee, Krishna K. Singh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BRCA2; BRCA1; doxorubicin; breast cancer; heart failure

Online: 28 December 2023 (05:10:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1697.v1

Interplay of Angiotensin Peptides, Vasopressin and Insulin in the Heart: Altered Interactions in Obesity and Diabetes Mellitus

Ewa Szczepańska-Sadowska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Angiotensin; diabetes mellitus; heart failure; hypertension; hypoxia; insulin; obesity; vasopressin

Online: 22 December 2023 (08:12:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1675.v1

Personality Traits, Machiavellianism Intelligence, Irrational Beliefs among Chronically Ill Older People and COVID-19 Outbreak

Kanwal Shahbaz, David Lim, Ayesha Shahbaz

Subject: Public Health And Healthcare, Health Policy And Services Keywords: personality characteristics; Machiavellian intelligence; irrational belief; chronically ill older people; systemic lu-pus erythematosus; complicated diabetes; glomerulonephritis and chronic heart failure; Covid-19

Online: 21 December 2023 (15:29:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1507.v1

Clinical Utility of Baseline Brain Natriuretic Peptide Levels on Health Status Outcomes after Catheter Ablation for Atrial Fibrillation in Individuals without Heart Failure

Shin Kashimura, Nobuhiro Ikemura, Shun Kohsaka, Yoshinori Katsumata, Takehiro Kimura, Daisuke Shinmura, Kotaro Fukumoto, Koji Negishi, Ikuko Ueda, Seiji Takatsuki, Masaki Ieda

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; brain natriuretic peptide; catheter ablation; non–heart failure; quality of life

Online: 20 December 2023 (10:56:19 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.1376.v1

Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds

IVAN VITO FERRARI

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart fatty acid-binding protein; Morusin; molecular docking; FABP3; Resistomycin; pkCSM

Online: 19 December 2023 (09:45:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1407.v1

Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells by WNT Switch Method

Isaiah K Mensah, Martin L Emerson, Hern J Tan, Humaira Gowher

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cardiomyocytes; mesoderm; mouse embryonic stem cells; heart; in vitro differentiation; wnt signaling

Online: 19 December 2023 (07:09:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1152.v1

A Technical Comparative Heart Disease Prediction Framework Using Boosting Ensemble Techniques

Najmu Nissa, Sanjay Jamwal, Mehdi Neshat

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Heart Disease; Diagnosis, Machine Learning; Boosting; Ensemble learning; Comparative framework

Online: 18 December 2023 (02:45:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0960.v1

The Prognostic Role of Global Longitudinal Strain and NT-proBNP in Heart Failure Patients Receiving Cardiac Resynchronization Therapy

Nikolaos PE Kadoglou, Sjoerd Bouwmeester, Anouk GW De Lepper, Marloes De Kleijn, Ingeborg HF Herold, Arthur Bouwman, Ioannis Korakianitis, Tim Simmers, Frank ALE Bracke, Patrick Houthuizen

Subject: Biology And Life Sciences, Life Sciences Keywords: cardiac resynchronization therapy-CRT; global longitudinal strain-GLS; natriuretic peptides; heart failure

Online: 13 December 2023 (11:00:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0633.v1

A Complete Pipeline for Heart Rate Extraction from Infant ECG

Harry T. Mason, Astrid Priscilla Martinez-Cedillo, Quoc C. Vuong, M. Carmen Garcia-de-Soria, Stephen Smith, Elena Geangu, Marina I. Knight

Subject: Computer Science And Mathematics, Signal Processing Keywords: ECG; Infant ECG; Heart Rate; R-Peaks; Open-Source; Naturalistic; Longform

Online: 8 December 2023 (14:39:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0329.v1

Clinical Review of Hypertensive Acute Heart Failure

Ratko Lasica, Lazar Djukanovic, Jovanka Vukmirovic, Marija Zdravkovic, Arsen Ristic, Milika Asanin, Dragan Simic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypertension; acute heart failure; congestion; diagnosis; modern therapy

Online: 6 December 2023 (07:06:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0262.v1

Long-Term Functional Limitations on Cardiopulmonary Exercise Testing in Emotions-Triggered Takotsubo Syndrome

Jean Pierre Jabbour, Luca Arcari, Luca Cacciotti, Damiano Magrì, Tommaso Recchioni, Livia Valeri, Enrico Maggio, Carmine Dario Vizza, Roberto Badagliacca, Silvia Papa

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiopulmonary exercise test; Takotsubo syndrome; Long-term functional limitations; Heart failure

Online: 5 December 2023 (14:40:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0273.v1

Optimized Cuffless Blood Pressure Measurement Using ECG, PPG and Linear Regression

Francesca Boschi, Valeria Figini, Guido Pagana, Monica Visintin

Subject: Engineering, Bioengineering Keywords: ECG; PPG; Pulse transit Time; Heart rate; Blood pressure; Denoising; Regression analysis

Online: 5 December 2023 (14:23:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1913.v1

Hand-Held Echocardiography by Advanced Practice Providers in Patients with Congestive Heart Failure

Maria-Cecilia Tagle-Cornell, Barbara S. Novais, Songnan Wen, Justin Shipman, Deepa Mandale, Drew Flom, Sandeep Sahnan, Lindsey Kriz, Michelle Alland, Christen Bird, Tasneem Z. Naqvi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Congestive heart failure; echocardiography; hand-held echocardiogram; heart failure; images, advanced practice providers

Online: 29 November 2023 (23:04:44 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.1692.v1

One-Year Real-World Experience with Mavacamten and its Physiologic Effects on Obstructive Hypertrophic Cardiomyopathy

Daniel Kim, Emily Chu, Emily Keamy-Minor, Ishan Paranjpe, Wilson Tang, Jack O'Sullivan, Yaanik Desai, Michael Liu, Elise Munsey, Kimberly Hecker, Isabella Cuenco, Beth Kao, Ellen Bacolor, Colleen Bonnett, Andrea Linder, Kathleen Lacar, Nancy Robles, Cynthia Lamendola, Allysonne Smith, Joshua Knowles, Marco Perez, Masataka Kawana, Karim Sallam, Chad Weldy, Matthew Wheeler, Victoria Parikh, Heidi Salisbury, Euan Ashley

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mavacamten; cardiac myosin inhibitor; hypertrophic cardiomyopathy; heart failure

Online: 27 November 2023 (11:50:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1314.v1

Cardiac Targeting Peptide: From Discovery to Applications

Daniella Sahagun, Maliha Zahid

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cell penetrating peptides; protein transduction domains; cardiac targeting peptide; heart failure; atrial fibrillation

Online: 21 November 2023 (10:43:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1228.v1

Varvara Aleksandrovna Ryabkova, Artemiy Vladimirovich Rubinskiy, Valeriy Nikolaevich Marchenko, Vasiliy Ivanovich Trofimov, Leonid Pavlovich Churilov

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; COVID-19; Post-COVID; heart rate variability; autonomic dysfunction

Online: 20 November 2023 (07:51:21 CET)

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Background There is a considerable overlap between clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) . Many of their common symptoms can be linked to dysregulation of the autonomic nervous system (dysautonomia). This study aimed to objectively assess autonomic function in patients with PCC and in patients with ME/CFS whose disease was not related to COVID-19. Methods Synchronous recordings of an electrocardiogram, continuous dynamics of blood pressure in the digital artery using the Penaz method and ultrasound pneumotachography with the spirography function were obtained with spiroarteriocardiorhythmography method in 34 patients diagnosed with ME/CFS, in whom the onset of the disease was not associated with COVID-19, 29 patients meeting PCC definition and 32 healthy controls. Heart rate variability (HRV), systolic and diastolic blood pressure variability (RV), respiration variability were assessed at rest and in tests with fixed respiratory rates. At rest, indicators of baroreflex regulation were additionally determined (baroreflex effectiveness index and baroreflex sensitivity). Results The total power, power of very low frequency, low-frequency and high-frequency of RR interval variability at rest as well as baroreflex effectiveness index in up-ramps of arterial blood pressure and baroreflex sensitivity were significantly lower both in PCC and ME/CFS patients compared to HC. Several diagnostic prediction models for ME/CFS were developed based on HRV parameters. During slow breathing HRV parameters return to normal in PCC, but not in ME/CFS. Correlation analysis revealed a close relationship of HRV, RV parameters and baroreflex sensitivity with fatigue, but not with HADS depressive/anxiety symptoms in ME/CFS and PCC. Conclusion A similar pattern of HRV and baroreflex failure with signs of a pathological acceleration of age-dependant dysautonomia was identified in ME/CFS and PCC. The clinical, diagnostic and therapeutic implications of these findings are discussed, in light of previously described relationship between inflammation, vascular pathology, atherosclerotic cardiovascular disease and autonomic dysfunction.

Preprint ARTICLE | doi:10.20944/preprints202311.1198.v1

Pirfenidone Prevents the Onset of Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy

Tatiana Araújo Silva, Diane Thomas, Jair Lage Siqueira-Neto, Claudia Magalhaes Calvet

Subject: Biology And Life Sciences, Parasitology Keywords: Heart fibrosis; Chagas disease; Pirfenidone

Online: 20 November 2023 (07:34:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1143.v1

Coronary Microvascular Dysfunction and Hypertension: A Bond More Important Than We Think

Marija Zdravkovic, Viseslav Popadic, Slobodan Klasnja, Andrea Klasnja, Tatjana Ivankovic, Ratko Lasica, Dragan Lovic, Drasko Gostiljac, Zorana Vasiljevic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary microvascular dysfunction; hypertension; hypertensive heart disease; myocardial fibrosis; heart failure

Online: 17 November 2023 (15:28:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0971.v1

Modelling and Simulation of the Combined Use of IABP and Impella as a Rescue Procedure in Cardiogenic Shock. An Alternative for non-Transplant Centres?

Beatrice De Lazzari, Massimo Capoccia, Roberto Badagliacca, Claudio De Lazzari

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Lumped-parameter model, CARDIOSIM©; IABP; Impella; cardiovascular system; heart failure; clinician; numerical simulator; e-learning

Online: 15 November 2023 (07:09:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0836.v1

Congestion in Heart Failure: From the Secret of a Mummy to Today's Novel Diagnostic and Therapeutic Approaches. A Comprehensive Review

Ioannis Alevroudis, Serafeim-Chrysovalantis Kotoulas, Stergios Tzikas, Vassilios Vassilikos

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Acute Decompensated Heart failure; fluid overload; loop diuretics; diuretic resistance; mineralocorticoid; SGLT2 inhibitors; ultrafiltration; Carbonic Anhydrase Inhibitor

Online: 14 November 2023 (07:52:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0744.v1

Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)

Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O’Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno

Subject: Engineering, Bioengineering Keywords: NIRS; Frailty; active stand; Frailty Phenotype; Frailty Index; Clinical Frailty Scale; cardiovascular; cerebrovascular; neurocardiovascular; statistical parametric mapping; SPM; blood pressure; heart rate; brain oxygenation; TSI

Online: 13 November 2023 (10:50:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0477.v1

Clinical Impact of Digitalis Therapy in a Large Multicenter Cohort of CRT‐Recipients

Julia W Erath, Nikolett Vigh, Balázs Muk, Carsten W Israel, Badder Kattih, Dávid Pilecky, Gabor Z Duray, Mate Vamos

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: digitalis; digoxin; digitoxin; cardiac‐resynchronization‐therapy; CRT‐D; defibrillator; congestive heart failure; mortality; CRT response

Online: 7 November 2023 (14:18:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0159.v1

Utility of Point-of-Care Ultrasound in Predicting Acute Heart Failure In-Hospital Worsening in Acutely Decompensated Oldest-Old Patients

Tessa Mazzarone, Virginia Morelli, Andrea Giusti, Maria Giovanna Bianco, Lorenzo Maccioni, Cristina Cargiolli, Daniela Guarino, Agostino Virdis, Chukwuma Okoye

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Heart Failure; older adults; ultrasound; outcomes; pleural effusion

Online: 2 November 2023 (10:31:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1945.v1

EHMFFL: Ensemble Heuristic-Metaheuristic Feature Fusion Learning Algorithm for Heart Disease Diagnosis

Mohammad Shokouhifar, Mohamad Hasanvand, Elaheh Moharamkhani, Frank Werner

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: heart disease diagnosis; ensemble learning; feature selection; heuristics; metaheuristics; Pearson correlation coefficient (PCC); grey wolf optimizer (GWO)

Online: 30 October 2023 (16:15:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1359.v1

Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation

Székely Andrea MD PhD, Pállinger Éva MD PhD, Töreki Evelin MD, Ifju Mandula, Barta Bálint András MD, Szécsi Balázs MD, Losoncz Eszter MD, Dohy Zsófia MD, Barabás Imre János MD PhD, Kosztin Annamária MD PhD, Buzas I Edit MD PhD, Radovits Tamás MD PhD, Merkely Béla MD PhD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: organ recipient; heart transplantation; primary graft dysfunction; interleukin; apolipoprotein

Online: 20 October 2023 (13:40:14 CEST)

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End-stage heart failure (ESHF) leads to hypoperfusion and edema formation in the whole body and is accompanied by neurohormonal and immunological alterations. Orthotopic heart transplantation (HTX) has been used as a beneficial option for ESHF. Due to the shortage of donor hearts, the ideal matching and timing of donors and recipients has become more important. Our aim was to explore the relationship between the clinical outcome of HTX and the cytokine and apolipoprotein profiles of the recipient pericardial fluid obtained at transplantation after opening the pericardial sac. The clinical data and the interleukin, adipokine and lipoprotein levels in the pericardial fluid of twenty recipients were investigated. Outcome variables included primer graft dysfunction (PGD), need for posttransplantation mechanical cardiac support (MCS), International Society for Heart and Lung Transplantation grade ≥ 2R rejection and mortality. Recipient risk scores were also investigated. Leptin levels were significantly lower in patients with PGD than in those without PGD (median: 6.36 [IQR: 5.55-6.62]; versus 7.54 [IQR=6.71-10.44]; p = 0.029). Higher ApoCII levels (median: 14.91 [IQR: 11.55-21.30] versus 10.31 [IQR=10.02-13.07]; p = 0.042) and ApoCIII levels (median: 60.32 [IQR: 43.00-81.66] versus 22.84 [IQR=15.84-33.39]; p=0.005) were found in patients (n=5) who died in the first 5 years after HTX. In patients who had rejection (n=4) in the first month after transplantation, the levels of adiponectin (median: 74.48 [IQR: 35.51-131.70] versus 29.96 [IQR: 19.86-42.28]; p=0.039), ApoCII (median: 20.11 [IQR: 13.06-23.54] versus 10.32 [IQR: 10.02-12.84]; p=0.007) and ApoCIII (median: 70.97 [IQR: 34.72-82.22] versus 26.33 [IQR: 17.18-40.17; p=0.029) were higher than those in the nonrejection group. Moreover, the pericardial thyroxine (T4) levels (median: 3.96 [IQR: 3.49-4.46] versus 4.69 [IQR: 4.23-5.77]; p=0.022) were lower in patients with rejection than in patients who did not develop rejection. Our results indicate that apolipoproteins can facilitate the monitoring of rejection and could be a useful tool in the forecast of early and late complications.

Preprint ARTICLE | doi:10.20944/preprints202310.1332.v1

Hippo Signaling Mediates TGFβ-Dependent Transcriptional In-Puts in Cardiac Cushion Mesenchymal Cells to Regulate Extracel-Lular Matrix Remodeling

Mrinmay Chakrabarti, Ahad Chattha, Abhijith Nair, Kai Jiao, Jay D Potts, Lianming Wang, Scotty Branch, Shea Harrelson, Saeed Khan, Mohamad Azhar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Transforming growth factor beta; YAP; SMAD3; Heart Valve; Extracellular matrix

Online: 20 October 2023 (12:22:01 CEST)

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Abstract: The transforming growth factor beta (TGFβ) and Hippo signaling pathways are evolutionarily conserved pathways that play a critical role in cardiac fibroblasts during embryonic development, tissue repair, and fibrosis. TGFβ and Hippo signaling is also important for cardiac cushion remodeling and septation during embryonic development. Loss of TGFβ2 in mice causes cardiac cushion remodeling defects resulting in congenital heart disease. In this study, we used in vitro molecular and pharmacologic approaches in the cushion mesenchymal cell line (tsA58-AVM) and investigated if Hippo pathway acts as a mediator of TGFβ2 signaling. Immunofluorescence staining showed that TGFβ2 induced nuclear translocation of activated SMAD3 in the cushion mesenchymal cells. In addition, the results indicated increased nuclear localization of Yes associated protein 1 (YAP1) following a similar treatment of TGFβ2. In collagen lattice formation assays, TGFβ2 treatment of cushion cells resulted in an enhanced collagen contraction compared to the untreated cushion cells. Interestingly, verteporfin, a YAP1 inhibitor, significantly blocked the ability of cushion cells to contract collagen gel in absence or presence of by exogenously added TGFβ2. To confirm the molecular mechanisms of verteporfin induced inhibition of TGFβ2-dependent extra-cellular matrix (ECM) reorganization we performed gene expression analysis of key mesenchymal genes involved in ECM remodeling in heart development and disease. Our results confirmed that verteporfin significantly decreased the expression of α-smooth muscle actin (Acta2), collagen 1a1 (Col1a1), Ccn1 (i.e., Cyr61), and Ccn2 (i.e., Ctgf). Western blot analysis indicated that verteporfin treatment significantly blocked TGFβ2-induced activation of SMAD2/3 in cushion mesenchymal cells. Collectively, these results indicate that TGFβ2 regulation of cushion mesenchymal cell be-havior and ECM remodeling is mediated by YAP1. Thus, TGFβ2 and Hippo pathway integration represents an important step in understanding the etiology of congenital heart disease.

Preprint ARTICLE | doi:10.20944/preprints202310.0971.v1

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; electrocardiography (ECG); Chronic Chagas Cardiomyopathy; Chagas heart disease

Online: 16 October 2023 (12:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0903.v1

Effects of Acute and Chronic Gabapentin Treatment on Cardiovascular Function of Rats

Ved Pendyala, Sarah Pribil, Vicki Schaal, Kanika Sharma, Sankarasubramanian Jagadesan, Li Yu, Vikas Kumar, Chittibabu Guda, Lie Gao

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Gabapentin; Arterial Blood Pressure; Heart Rate; Left Ventricular Function; Proteomics; Bioinformatics; Calmodulin;

Online: 13 October 2023 (12:41:55 CEST)

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Gabapentin (GBP), a GABA analogue, is primarily used as an anticonvulsant to treat partial seizures and neuropathic pain. While a majority of the side effects are associated with the nervous system, emerging evidence suggests a high risk for heart diseases in the patients taking GBP. In the present study, we used a preclinical model of rats to investigate (1) the acute cardiovascular responses to GBP (bolus i.v. injection, 50 mg/kg) and (2) the effects of chronic GBP treatment (i.p. 100 mg/kg/day x 7 days) on cardiovascular function and the myocardial proteome. Under isoflurane-anesthesia, rat blood pressure (BP), heart rate (HR), and left ventricular (LV) hemodynamics were measured using Millar pressure transducers. The LV myocardium and brain cortex were analyzed by proteomics, bioinformatics, and western blot to explore the molecular mechanisms underlying GBP-induced cardiac dysfunction. In experiment (1), we found that i.v. GBP significantly decreased BP, HR, maximal LV pressure, and maximal and minimal dP/dt, whereas it increased IRP-AdP/dt, Tau, systolic, diastolic, and cycle durations (*p < 0.05 and **p < 0.01 vs baseline; n = 4/group). In experiment (2), we found that chronic GBP treatment resulted in hypotension, bradycardia, and LV systolic dysfunction, with no change in plasma norepinephrine. In the myocardium, we identified 109 differentially expressed proteins involved in calcium pathways, cholesterol metabolism, and galactose metabolism. Particularly, we found that calmodulin, a key protein of intracellular calcium signaling, was significantly upregulated by GBP in the heart but not in the brain. In summary, we found that acute and chronic GBP treatments suppressed cardiovascular function in rats, which is attributed to abnormal calcium signaling in cardiomyocytes. These data reveal a novel side effect of GBP independent of the nervous system, providing important translational evidence to suggest that GBP can evoke adverse cardiovascular events by depression of myocardial function.

Preprint ARTICLE | doi:10.20944/preprints202310.0466.v1

Prevalence and Intensity of Sarcocystis Infections in Alpine Chamois (Rupicapra r. rupicapra) in Germany

Steffen Rehbein, Martin Visser

Subject: Biology And Life Sciences, Parasitology Keywords: Sarcocystis; chamois; heart; diaphragm; Germany

Online: 9 October 2023 (07:36:37 CEST)

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Chamois are mountain ungulates (Subfamily Caprinae) which inhabit several medium and high altitude mountain ranges from southern Europe to the Near East. The first findings of Sarcocystis cysts in the musculature of chamois were reported in the 1970s. However, only limited work on the epidemiology of sarcocystosis and identification of the species of Sarcocystis in chamois has been done in the past. The present work was part of a comprehensive study on the parasites of chamois in Germany aiming to provide, for the first time, data on the prevalence and intensity of Sarcocystis infection in native Alpine chamois using histology examination of heart and/or diaphragm tissue samples collected from 216 chamois (40 kids and 176 chamois ranging of one up to 18 years of age). Sarcocysts were detected in either heart or diaphragm of 167/216 chamois (77.3%) with 131 of 183 heart samples and 127 of 215 diaphragm samples testing sarcocyst positive. Of the 181 chamois with both heart and diaphragm available (34 kids and animals up to 18 years of age), sarcocysts were detected in heart and/or diaphragm of 142 animals translating in an overall 78.5% prevalence of Sarcocystis infection (95%CI 72.5% - 84.4%). Sarcocysts were more frequently recorded in heart vs. diaphragm (72.4% vs. 56.4%; p=0.0021), and diaphragm positivity was associated with heart positivity (p=0.0001). Sarcocyst positivity (heart and/or diaphragm) was significantly (p<0.001) lower in kids than in the older chamois (27.1% vs. 88.6%, respectively) but prevalence did not differ between the sexes, regardless of the chamois’ age (p>0.3). Intensity of infection was generally low (<10 sarcocysts per cm² muscle cut) in both heart positive and diaphragm positive animals (94.7% and 93.7%, respectively) with heart yielding higher sarcocyst counts than diaphragm (p<0.001). Both heart and diaphragm sarcocyst counts were significantly (p<0.001) lower in kids than in the older chamois. Sarcocystis infection was demonstrated to be prevalent in chamois in Germany but intensity is apparently low. Further studies are desired to identify the species of Sarcocystis parasitizing the chamois using both phenotypic and molecular characteristics.

Preprint REVIEW | doi:10.20944/preprints202307.1818.v3

Is modern medicine in need of an overhydration marker in kidney failure? The accuracy of available fluid overload markers and the potential of the new ones.

Barbara Emilia Nikitiuk, Alicja Rydzewska-Rosołowska, Katarzyna Kakareko, Irena Głowińska, Tomasz Hryszko

Subject: Medicine And Pharmacology, Internal Medicine Keywords: fluid status; overhydration; hydration status; renal failure; kidney failure; heart failure; Ca-125; NT-pro-BNP; VEXUS; BIS

Online: 5 October 2023 (14:28:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0293.v1

A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis

Faizus Sazzad, KR Ramanathan, Irwan Shah Moideen, Abdulrahman El Gohary, John C Stevens, Theo Kofidis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: personalized; individualized; open heart surgery; implantation; systematic review

Online: 5 October 2023 (13:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1894.v1

Personality Changes Associated with Organ Transplants

Brian Carter, Laveeen Khoshnaw, Megan Simmons, Lisa Hines, Brandon Wolfe, Mitchell Liester

Subject: Medicine And Pharmacology, Transplantation Keywords: Personality change; organ transplant; heart transplant; temperament; emotions; preferences

Online: 27 September 2023 (11:08:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1743.v1

Aggravation of Health Problems Subsequent to COVID-19 Lockdown

Fatma Nese Efil, Sania Qureshi, Nezihal Gokbulut, Evren Hınçal, Amanullah Soomro

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Covid-19; mathematical modeling; cancer; diabetes; heart diseases; sensitivity analysis

Online: 26 September 2023 (10:40:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1483.v1

Radiation Exposure Assessment in Coronary Angiography CT Scan: Establishing Diagnostic Reference Level for Northeast Assam Population

Arnabjyoti Deva Sarma, Jibon Sharma, Manash Pratim Sarma, Mrinal Kanti Singha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: radiology; computed tomography; coronary angiography; phantom; heart

Online: 22 September 2023 (05:16:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1385.v1

Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and mRNA Vaccine Injury Syndromes

Anthony M Kyriakopoulos, Greg Nigh, Peter A McCullough, Stephanie Seneff

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Lutein; post-COVID syndrome; mRNA vaccination injury syndrome; inflammatory response; reactive oxygen species; reactive nitrogen species; arrhythmogenic heart phenotype; antioxidant defense; bioavailability; extra virgin olive oil

Online: 20 September 2023 (10:07:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0116.v2

Assessing the Impact of Hemodynamic Monitoring with CardioMEMS on Heart Failure Patients: A Cost-Benefit Analysis

Pau Codina, Jose Angel Vicente Gómez, Guillem Hernández Guillamet, Laura Ricou Ríos, Andrea Carrete, Victoria Vilalta, Oriol Estrada, Jordi Ara, Josep Lupón, Antoni Bayés-Genís, Francesc López Seguí

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cost-effectiveness evaluation; heart failure; telemonitoring; pulmonary artery pressure; hemodynamic monitoring

Online: 19 September 2023 (05:23:15 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202309.1187.v1

Preliminary Study on the Immunohistochemical Expression of Galectin-3 in Hypertrophic Hearts

Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: galectin-3; cardiac hypertrophy; immunohistochemical expression; heart transplantation; heart disease; cardiorenal syndrome

Online: 19 September 2023 (03:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0396.v1

Cardiac Laterality: Surgical Results of Right Atrial Isomerism

Diego B. Ortega-Zhindón, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José A. García-Montes, Juan Calderón-Colmenero, Jorge L. Cervantes-Salazar

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: heterotaxy syndrome; atrial isomerism; heart surgery; congenital heart disease.

Online: 7 September 2023 (03:33:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0327.v1

Update on Myocarditis: From Etiology and Clinical Picture to Modern Diagnostics and Methods of Treatment

Ratko Lasica, Lazar Djukanovic, Lidija Savic, Gordana Krljanac, Marija Zdravkovic, Marko Ristic, Andjelka Lasica, Milika Asanin, Arsen Ristic

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: acute myocarditis; chronic inflammatory cardiomyopahty; heart failure; cardiac magnetic resonance; endomyocardial biopsy

Online: 6 September 2023 (02:42:23 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.0330.v1

Right to Left Shunt Evaluation in Cardiac Patent Foramen Ovale Using Bubble Contrast Transcranial Color Coded Doppler: Focused on Cryptogenic Stroke Case

Myeong-Hoon Ji, Youl-Hun Seoung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Heart; Patent foramen ovale; Right to left shunt; Bubble contrast; Transcranial color coded doppler

Online: 5 September 2023 (14:49:24 CEST)

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