PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis
Version 1
: Received: 10 March 2024 / Approved: 11 March 2024 / Online: 11 March 2024 (13:20:13 CET)
How to cite:
Hu, W. TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis. Preprints2024, 2024030615. https://doi.org/10.20944/preprints202403.0615.v1
Hu, W. TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis. Preprints 2024, 2024030615. https://doi.org/10.20944/preprints202403.0615.v1
Hu, W. TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis. Preprints2024, 2024030615. https://doi.org/10.20944/preprints202403.0615.v1
APA Style
Hu, W. (2024). TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis. Preprints. https://doi.org/10.20944/preprints202403.0615.v1
Chicago/Turabian Style
Hu, W. 2024 "TGFβ Producing Regulatory T Cells Related Tolerable Immunities and Their Relations to Scleroderma and End Organ Failures Including Heart Failure, Liver Cirrhosis, Uremia, and Pulmonary Fibrosis" Preprints. https://doi.org/10.20944/preprints202403.0615.v1
Abstract
Regulatory T cells are key immune cells to initiate tolerable immune responses. TGFβ is the key cytokine of regulatory T cells. TGFβ is also the master cytokine to stimulate tissue fibrosis. Systemic sclerosis is an autoimmune disease related to overt organ fibrosis. Thus, systemic sclerosis is a disease related to regulatory T cell over-representation. Besides, many end stage organ failures including heart failure, liver cirrhosis, uremia, and pulmonary fibrosis also related to tissue fibrosis. Thus, TGFβ producing regulatory T cells are also involved in the pathogenesis of these end stage organ failure. Once we know the significance of TGFβ and it induced tolerable immune reactions in the pathophysiology of end organ failure, we can develop better prevention or therapeutic strategies to combat these detrimental disorders.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
