Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and mRNA Vaccine Injury Syndromes

Version 1 : Received: 15 September 2023 / Approved: 20 September 2023 / Online: 20 September 2023 (10:07:58 CEST)

A peer-reviewed article of this Preprint also exists.

Kyriakopoulos, A.M.; Nigh, G.; McCullough, P.A.; Seneff, S. Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and MRNA Vaccine Injury Syndromes. F1000Research 2024, 13, 191, doi:10.12688/f1000research.143517.1. Kyriakopoulos, A.M.; Nigh, G.; McCullough, P.A.; Seneff, S. Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and MRNA Vaccine Injury Syndromes. F1000Research 2024, 13, 191, doi:10.12688/f1000research.143517.1.

Abstract

Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. Elevated concentrations of lutein found in human blood and plasma, due to high dietary intake, are beneficial against eye disease and improve cardiometabolic health. Lutein plays an important protective role against the development of neurological disorders, including Alzheimer’s disease (AD), multiple sclerosis (MS) and Parkinson’s disease (PD). It has also been shown to be beneficial for liver, kidney and respiratory health. Lutein, acting as a very strong antioxidant, can alleviate oxidative stress and downgrade reactive oxygen species (ROS). Oxidative stress is one of the key pathogenic mechanisms in post-COVID and mRNA vaccine injury syndromes. Recent in silico studies suggest that lutein and other naturally derived antioxidants, by docking at the site where the SARS-CoV-2 spike protein (SP) binds to the angiotensin enzyme type 2 (ACE2) receptor, may neutralize the SP-ACE2 interactions. Lutein can be added to a detoxification regimen to aid in clearing Spike protein and relieving symptoms. In agreement with Hippocrates’ dictum to “Let food be thy medicine,” this review establishes dietary lutein as a valuable therapy in the treatment of post-COVID syndrome, mRNA vaccine injury syndromes, and a wide range of other chronic illnesses.

Keywords

Lutein; post-COVID syndrome; mRNA vaccination injury syndrome; inflammatory response; reactive oxygen species; reactive nitrogen species; arrhythmogenic heart phenotype; antioxidant defense; bioavailability; extra virgin olive oil

Subject

Biology and Life Sciences, Food Science and Technology

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