Version 1
: Received: 17 December 2023 / Approved: 18 December 2023 / Online: 19 December 2023 (09:45:41 CET)
How to cite:
FERRARI, I. V. Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds. Preprints2023, 2023121376. https://doi.org/10.20944/preprints202312.1376.v1
FERRARI, I. V. Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds. Preprints 2023, 2023121376. https://doi.org/10.20944/preprints202312.1376.v1
FERRARI, I. V. Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds. Preprints2023, 2023121376. https://doi.org/10.20944/preprints202312.1376.v1
APA Style
FERRARI, I. V. (2023). Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds. Preprints. https://doi.org/10.20944/preprints202312.1376.v1
Chicago/Turabian Style
FERRARI, I. V. 2023 "Exploring FABP3 as a Potential Biomarker for Cardiac and Cerebral Injury Post-Stroke: Insights from Molecular Docking Studies with Natural Compounds" Preprints. https://doi.org/10.20944/preprints202312.1376.v1
Abstract
Investigations are currently in progress to assess the potential of elevated FABP3 levels as biomarkers for assessing cardiac and cerebral injury post-stroke. Ongoing research endeavors are concentrated on elucidating the specific mechanisms by which FABPs, particularly FABP3, contribute to the complex processes involved in ischemic stroke.This study employs molecular docking techniques within a Virtual Screening framework to examine the interaction between various natural substances and the active site of human heart fatty acid-binding protein (PDB Code 4TKH). Utilizing Pyrx and Autodock Vina, the research aims to pinpoint compounds demonstrating robust binding interactions, characterized by high binding energy scores (kcal/mol) and the formation of multiple chemical bonds. The anticipated outcomes have the potential to yield valuable insights into the molecular interactions influencing human heart fatty acid-binding protein, suggesting possible implications for therapeutic interventions using these natural substances.From the docking and predicted toxicity results, Resistomycin has demonstrated superior characteristics compared to Morusin.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
