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Preprint REVIEW | doi:10.20944/preprints202110.0079.v1

Engineering of Synthetic Transcriptional Switches in Yeast

Masahiro Tominaga, Akihiko Kondo, Jun Ishii

Subject: Life Sciences, Biotechnology Keywords: genetic switch; yeast; synthetic transcription factor; synthetic promoter; directed evolution

Online: 5 October 2021 (11:19:46 CEST)

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Working Paper REVIEW

The Boggarts of Biology: How Non-Genetic Changes Influence the Genotype

Laasya Samhita

Subject: Biology, Anatomy & Morphology Keywords: Non-genetic change; translation errors; phenotypic variability; adaptation; evolution

Online: 6 October 2020 (15:16:03 CEST)

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Working Paper ARTICLE

A Decision Support Tool for Multi-Objectives Teaching Assignment Problem

Tung Son Ngo, Ngoc Anh Bui, Jaafar Jafreezal

Subject: Keywords: Timetabling; Task Assignment; MOP; Combinatory Optimization; Compromise Programming; Genetic Algorithm

Online: 31 August 2020 (07:57:53 CEST)

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Working Paper CONCEPT PAPER

The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype

Didier Auboeuf

Subject: Life Sciences, Biochemistry Keywords: evolution; darwinism; genetic code; RNA; homoestasis; physics

Online: 6 January 2021 (15:06:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0671.v1

Long-Term Pedigree Analysis: An Effective Tool for Managing Congenital Malformations in Cattle

Jindřich Čítek, Libor Večerek, Soňa Šlosárková, Petr Fleischer, Daniela Schröffelová, Josef Kučera

Subject: Life Sciences, Genetics Keywords: genetic health; surveillance program; aplasia genitalis; atresia ani et recti; hernia cerebralis

Online: 26 March 2021 (15:09:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0340.v1

Prevalence, Phylogroups, Antimicrobial Susceptibility and GE-Netic Diversity of Escherichia coli Isolates From Food Products

Babak Pakbin, Samaneh Allahyari, Zahra Amani, Wolfram Manuel Bruck, Razzagh Mahmoudi, Amir Peymani

Subject: Life Sciences, Microbiology Keywords: Escherichia coli; Antimicrobial resistance; Food samples; Phylogenetic group; Genetic diversity

Online: 16 August 2021 (13:35:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0354.v1

High-throughput Genome Editing Tools for Lactic Acid Bacteria: Opportunities for Food, Feed, Pharma and Biotech

Rosa Aragão Börner, Vijayalakshmi Kandasamy, Amalie Melton Axelsen, Alex Toftgaard Nielsen, Elleke F Bosma

Subject: Life Sciences, Microbiology Keywords: Genetic tool development, Food fermentation, Biotherapeutics, Phytotherapeutics, Synthetic biology, GMO regulation

Online: 18 September 2018 (14:22:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0154.v1

Integrated Genetic and Omics Approaches for the Regulation of Nutritional Activities in Rice (Oryza sativa L.)

Muhammad Junaid Zaghum, Kashir Ali, Sheng Teng

Subject: Biology, Agricultural Sciences & Agronomy Keywords: Genome selection; Rice breeding; Genetic analysis; Omics assisted markers; Nutritional quality; Genomics and pangenomics; Biofortification

Online: 8 August 2022 (10:53:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0256.v1

Development of Evolutionary Systems based on Quantum Petri Nets

Tiberiu Stefan Letia, Elenita Maria Durla-Pasca, Dahlia Al-Janabi, Octavian Petru Cuibus

Subject: Mathematics & Computer Science, Artificial Intelligence & Robotics Keywords: quantum computing; genetic algorithms; Petri nets; Quantum Petri nets; software development; analysis and verification

Online: 19 September 2022 (03:41:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0042.v1

Utilizing Genomic Selection for Wheat Population Development and Improvement

Lance F. Merrick, Andrew W. Herr, Karansher S. Sandhu, Dennis N. Lozada, Arron H. Carter

Subject: Life Sciences, Genetics Keywords: plant breeding; two-part strategy; recurrent selection; population improvement; product development; optimization; genetic gain; cross-prediction

Online: 2 February 2022 (18:07:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0077.v1

Genetics of Externalizing Behavior and Structural Brain Development in Adolescence

Jalmar Teeuw, Marieke Klein, Nina Roth Mota, Rachel M. Brouwer, Dennis van 't Ent, Zyneb Al-Hassaan, Barbara Franke, Dorret I. Boomsma, Hilleke E. Hulshoff Pol

Subject: Behavioral Sciences, Behavioral Neuroscience Keywords: externalizing behavior; adolescence; gray matter volume; white matter integrity; heritability; genetic correlation; longitudinal; magnetic resonance imaging

Online: 4 February 2022 (15:07:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0297.v1

Development of a Transformation Method for Metschnikowia borealis and Other CUG-Serine Yeasts

Zachary Gordon, Maximillian P. M. Soltysiak, Christopher Leichthammer, Jasmine A. Therrien, Rebecca S. Meaney, Carolyn Lauzon, Matthew Adams, Dong Kyung Lee, Preetam Janakirama, Marc-Andre Lachance, Bogumil J. Karas

Subject: Life Sciences, Biotechnology Keywords: genome engineering; synthetic biology; yeasts; Metschnikowia; genetic tools; DNA delivery; CUG-Ser

Online: 13 November 2018 (05:17:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0105.v1

Development of Therapies for Rare Genetic Disorders of GPX4: Roadmap and Opportunities

Dorian Cheff, Alysson Muotri, Brent Stockwell, Edward Schmidt, Qitao Ran, Reena Kartha, Simon Johnson, Plavi Mittal, Elias Arnér, Kristen Wigby, Matthew Hall, Sanath Ramesh

Subject: Medicine & Pharmacology, Allergology Keywords: Sedaghatian-type Spondylometaphyseal Dysplasia; SSMD; glutathione peroxidase 4; GPX4; rare genetic disorder; therapy development; roadmap; ultra-rare disease

Online: 5 April 2021 (11:57:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0292.v1

Meier-Gorlin Syndrome: Clinical Misdiagnosis as Jeune Syndrome, Genetic Testing and Functional Analysis of ORC6 Mutations and the Development of a Prenatal Test

Maria S. Nazarenko, Iuliia V. Viakhireva, Mikhail Y. Skoblov, Elena V. Soloveva, Aleksei A. Sleptcov, Ludmila P. Nazarenko

Subject: Life Sciences, Genetics Keywords: Meier-Gorlin syndrome; Jeune syndrome; ORC6; exon skipping variant; prenatal genetic testing

Online: 23 May 2022 (10:18:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0160.v1

Functional T Cell Reactivity to Melanocyte Antigens is Lost During Development of Malignant Melanoma, but is Restored with Successful Immunotherapy

Paul Lehmann

Subject: Keywords: melanoma; genetic whole cell therapeutic melanoma vaccine (AGI-101H); CD8+ T cells; melanoma antigens; ELISPOT

Online: 7 December 2020 (13:53:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0583.v1

A Systematic Review on Extreme Phenotype Strategies to Search for Rare Variants in Genetic Studies of Complex Disorders

Sana Amanat, Teresa Requena, Jose Antonio Lopez-Escamez

Subject: Life Sciences, Genetics Keywords: genetic association studies; extreme phenotype; genetic epidemiology; tinnitus

Online: 24 July 2020 (13:43:00 CEST)

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Working Paper ARTICLE

Operationalising Forensic Genetic Genealogy in an Australian Context

Nathan Scudder, Runa Daniel, Jennifer Raymond, Alison Sears

Subject: Life Sciences, Genetics Keywords: forensic genetic genealogy; investigative genetic genealogy; DNA; forensic DNA

Online: 1 August 2020 (16:29:22 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202011.0387.v1

Genetic Music: When Genes Code for Melodies Instead of Proteins

Marga Consortium, Blanca A. Gutierrez, Iván Aitor Lucas del-Amo, Beatriz Alejos Bermudez, Cristina Gonzalez Moran, Veronica Noval Gutierrez, Borja Sanchez

Subject: Arts & Humanities, Anthropology & Ethnography Keywords: genetic music; genetic code; music composition; steam disciplines; notch1 gene

Online: 13 November 2020 (15:34:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0047.v1

Genetic Structure and Eco-Geographical Differentiation of Wild Sheep Fescue (Festuca ovina L.) in Xinjiang, Northwest China

Chenglin Zhang, Jianbo Zhang, Yan Fan, Ming Sun, Wendan Wu, Wenda Zhao, Xiaopeng Yang, Linkai Huang, Yan Peng, Xiao Ma, Xinquan Zhang

Subject: Life Sciences, Genetics Keywords: Festuca ovina L.; AFLP, genetic diversity; genetic barriers; environmental factors

Online: 18 July 2017 (10:05:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0738.v1

Utility of Whole-Exome Sequencing in Pediatric and Medical Diagnosis

Mohd Fareed, Varun Sharma, Hemender Singh

Subject: Life Sciences, Biochemistry Keywords: Next generation sequencing; Genetic disorders; Genomic medicine; Genetic counseling; Rare diseases

Online: 29 December 2020 (16:47:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0144.v1

Genetic Environments of Plasmid-Mediated bla_CTXM-15beta-lactamase gene in Enterobacteriaceae from Africa

Babafela Awosile, Michael Agbaje

Subject: Life Sciences, Biochemistry Keywords: Antimicrobial resistance; blaCTX-M-15; genetic environment; mobile genetic elements; Africa

Online: 7 December 2020 (12:49:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0710.v1

Genetic Algorithm Based Feature Selection Technique for Optimal Intrusion Detection

Sydney Mambwe Kasongo

Subject: Engineering, Automotive Engineering Keywords: Intrusion Detection; Genetic Algorithm

Online: 29 June 2021 (13:30:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0276.v1

Genetic Variation of Traits in Natural Enemies Relevant for Biological Control: A Systematic Review

Kim B. Ferguson, Sophie R. Chattington, Wouter N. Plouvier, Bart A. Pannebakker

Subject: Biology, Entomology Keywords: genetic improvement; genetic variation; heritability; systematic review; biocontrol agent; life history traits

Online: 24 January 2020 (10:39:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0099.v1

Genetic Parameters of Growth Traits and Quantitative Genetic Metrics for Selection and Conservation of Mecheri Sheep of Tamil Nadu

B. Balasundaram, A.K. Thiruvenkadan, N. Murali, J. Muralidharan, D. Cauveri, Sunday O. Peters

Subject: Biology, Animal Sciences & Zoology Keywords: Genetic parameters, (Co)variance components, Mecheri sheep, Animal models, Maternal genetic influence, Inbreeding

Online: 6 December 2022 (10:03:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0509.v1

Genetic Variation of Native Perilla Germplasms Collected from South Korea Using SSR Markers and Morphological Characteristics

Jun Seok Oh, Kyu Jin Sa, Hyeon Park, Do Yoon Hyun, Sookyeong Lee, Ju-Hee Rhee, Ju Kyong Lee

Subject: Biology, Anatomy & Morphology Keywords: Perilla crop; genetic resources; morphological traits; principal component analysis; SSR marker; genetic variation

Online: 22 July 2021 (08:04:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology, Anatomy & Morphology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0021.v1

Protein 0^th-Order Structure: The Key for Creating Entirely New Gene/Protein

Kenji Ikehara

Subject: Life Sciences, Molecular Biology Keywords: protein 0th-order structure; origin of gene; origin of protein; origin of genetic code; GNC primeval genetic code hypothesis; SNS primitive genetic code hypothesis

Online: 3 December 2019 (11:10:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0234.v1

History of Advances in Genetic Engineering of Viruses Prior to COVID-19 Pandemic

Mikhail Teppone

Subject: Life Sciences, Virology Keywords: reassortant virus; recombinant virus; chimeric virus; genetic engineering; reverse genetic; SARS-CoV-2; COVID-19

Online: 13 December 2022 (08:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0075.v1

Deep Network Optimization Using a Genetic Algorithm for Recognizing Hand Gestures via EMG Signals

Kasra Sehat, Seyed Mohammadreza Shokouhyan, Nada K. Abdallah, Kinda Khalaf

Subject: Engineering, Biomedical & Chemical Engineering Keywords: EMG; optimization; genetic algorithm; deep learning

Online: 4 January 2023 (09:21:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0414.v1

Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

Deiviane Calegar, Beatriz Nunes, Kerla Monteiro, Polyanna Bacelar, Brenda Evangelista, Mayron Moraes, Jurecir Silva, Jéssica Santos, Márcio Bóia, Lauren Jaeger, Filipe Anibal Carvalho-Costa

Subject: Medicine & Pharmacology, Other Keywords: Giardia duodenalis; Assemblages; Epidemiology; Genetic diversity

Online: 27 January 2022 (11:18:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0533.v1

Unlocking the Complete Chloroplast Genome of a Native Tree Species from the Amazon Basin, Capirona (Calycophyllum spruceanum Benth., Rubiaceae), and Its Comparative Analysis with Other Ixoroideae Species

Carla L. Saldaña, Pedro Rodriguez-Grados, Julio C. Chávez-Galarza, Shefferson Feijoo, Juan Carlos Guerrero Abad, Héctor V. Vásquez, Jorge L. Maicelo, Jorge H. Jhoncon, Carlos I. Arbizu

Subject: Life Sciences, Genetics Keywords: chloroplast; genetic resources; genomics capirona; phylogenomics

Online: 29 November 2021 (12:32:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0692.v1

Use of Genetic Algorithms to Optimize Efficiency in Small-Scale Structures

Aaron Chew

Subject: Engineering, Civil Engineering Keywords: Genetic algorithms, structures, algorithms, generative design

Online: 29 March 2021 (12:50:16 CEST)

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Working Paper ARTICLE

Evaluation of the Gene Flow From East to West among Various Populations of Rajasthan, India

R.K. Kumawat, Pankaj Shrivastava, Shivani Dixit, Divya Shrivastava, G.K. Mathur, Gyaneshwer Chaubey

Subject: Life Sciences, Genetics Keywords: Genetic affinity; STR; Rajasthan; Heterozygosity; Polymorphic

Online: 21 June 2020 (14:12:03 CEST)

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Working Paper REVIEW

Physicochemical Foundations of Life that Direct Evolution. Why Chance and Natural Selection cannot Explain Evolution

Didier Auboeuf

Subject: Life Sciences, Other Keywords: evolution; genetic code; RNA; protein; physicochemistry

Online: 28 November 2019 (09:38:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Life Sciences, Other Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0201.v1

The Critical Needs and Challenges for Genetic Architecture Studies in Africa

Alicia R. Martin, Solomon Teferra, Marlo Möller, Eileen G. Hoal, Mark J. Daly

Subject: Life Sciences, Genetics Keywords: genetic architecture; Africa; GWAS; health disparities

Online: 13 June 2018 (11:17:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0197.v1

Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review

Juan Angel Garcia-Quiñones, Celia Nohemi Sanchez-Dominguez, María Fernanda Serna-Rodríguez, Ivan Alberto Marino-Martinez, Ana María Rivas-Estilla, Antonio Alí Pérez-Maya

Subject: Behavioral Sciences, Behavioral Neuroscience Keywords: Biomarkers; Genetic; Suicidal behavior; Suicide; Mexican; Genomic.

Online: 11 January 2023 (10:34:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0430.v1

Optimization of Water Distribution Networks Using Genetic Algorithm based SOP–WDN Program

Uchit Sangroula, Kuk-Heon Han, Kang-Min Koo, Kapil Gnawali, Kyung-Taek Yum

Subject: Engineering, Civil Engineering Keywords: Water distribution networks; Optimization; Genetic Algorithm; EPANET

Online: 28 January 2022 (08:53:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0400.v1

The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients

Marica Meroni, Miriam Longo, Erika Paolini, Anna Alisi, Luca Miele, Emilia Rita De Caro, Giuseppina Pisano, Marco Maggioni, Giorgio Soardo, Luca Vittorio Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni

Subject: Medicine & Pharmacology, Allergology Keywords: Lipid metabolism; NAFLD; genetic variants; PSRC1; HCC

Online: 15 March 2021 (16:30:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0003.v2

Non-Homologous end Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population

Raquel Gago-Fuentes, Valentyn Oksenych

Subject: Life Sciences, Biochemistry Keywords: DNA repair; NHEJ; synthetic lethality; genetic interaction

Online: 15 December 2020 (10:41:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0653.v1

DetR DB: A Database of Ionizing Radiation Resistance Determinants

Alina Ryabova, Olga Kozlova, Azat Kadirov, Oleg Gusev, Elena Shagimardanova

Subject: Life Sciences, Biochemistry Keywords: ionizing radiation; radiation resistance; genetic mechanisms; microorganisms

Online: 26 September 2020 (17:24:56 CEST)

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Working Paper HYPOTHESIS

Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19

Yiqiang Zhao, Yunchun Gu, Yongji Liu, Sa Li, Yuzhan Wang, Lina Bu, Qi Liu, Hongyi Lv, Fang Wan, Lida Wu, Zemin Ning

Subject: Life Sciences, Genetics Keywords: COVID-19; severe symptoms; inactivation; genetic diversity

Online: 16 April 2020 (09:15:49 CEST)

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Working Paper ARTICLE

Assessment of Genetic Diversity of Dioscorea praehensilis (Berth.) Collected from Central Region, Ghana Using Simple Sequence Repeat (SSR) Markers

Adeyinka S. Adewumi, Kingsley J. Taah, Paul A. Asare, Michael O. Adu, Paterne A. Agre

Subject: Life Sciences, Genetics Keywords: genetic diversity; Dioscorea praehensilis; SSR markers; Ghana

Online: 8 March 2020 (14:55:19 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201912.0176.v1

A Framework for Maximising the Capture of Genetic Diversity in Sampling for ex situ Conservation

Linda Neaves

Subject: Biology, Other Keywords: conservation; genetic diversity; decision-making; ex situ

Online: 12 December 2019 (12:43:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0046.v1

Stimulation of Replication Template-Switching by DNA-Protein Crosslinks

Laura T. Laranjo, Julie A. Klaric, Susan T. Lovett

Subject: Life Sciences, Genetics Keywords: DNA replication, DNA repair, genetic recombination, mutagenesis

Online: 2 November 2018 (10:19:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0089.v1

The Importance of a Multidisciplinary Approach in the Management of a Patient with Type I Gaucher Disease

Miguel-Ángel Torralba-Cabeza, Susana Olivera-González, José-Luis Sierra-Monzón

Subject: Medicine & Pharmacology, Other Keywords: multidisciplinary; Gaucher; genotype/phenotype correlation; genetic counselling

Online: 5 July 2018 (08:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0329.v1

Ethical, Legal and Social Implications of Susceptibility Genetic Testing for Late-Onset Neurodegenerative Diseases

Amaranta Manrique de Lara, Elisa Núñez-Acosta, Garbiñe Saruwatari-Zavala, Liliana Soto-Gómez, Miguel E. Rentería

Subject: Life Sciences, Genetics Keywords: Alzheimer’s disease; Parkinson’s disease; Genetic testing; bioethics

Online: 21 June 2018 (04:38:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0191.v1

Recent Developments in Using Drosophila as a Model for Human Genetic Disease

Christine Oriel, Paul Lasko

Subject: Life Sciences, Genetics Keywords: rare disease; functional genomics; genetic variant validation

Online: 12 June 2018 (12:36:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0215.v1

Estimation of Genetic Parameters and Prediction of Genotypic Values in Common Beans Using Mixed Models

Jessica Delfini, Vania Moda Cirino, Claudete de Fátima Ruas, Paulo Mauricio Ruas, José dos Santos Neto, Leandro Simões Azeredo Gonçalves

Subject: Life Sciences, Genetics Keywords: Phaseolus vulgaris L.; REML/BLUP; genetic diversity

Online: 26 March 2018 (10:35:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0005.v1

Improved Forms for Controlling the Acrobot with Motors of Atypical Size Using Artificial Intelligence Techniques

Gonzalo Mier, Javier de Lope

Subject: Engineering, Control & Systems Engineering Keywords: Acrobot; Artificial Intelligence; SARSA; PWM; Genetic Algorithm

Online: 4 July 2017 (16:12:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0453.v1

Genetics of Resistance to Leaf Rust in Wheat: An Overview in A Genome-Wide Level

Xiaopeng Ren, Chuyuan Wang, Zhuang Ren, Jing Wang, Peipei Zhang, Shuqing Zhao, Mengyu Li, Meng Yuan, Xiumei Yu, Zaifeng Li, Shisheng Chen, Xiaodong Wang

Subject: Biology, Agricultural Sciences & Agronomy Keywords: wheat; resistance; leaf rust; genetic loci; genome-wide

Online: 23 December 2022 (08:11:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0427.v1

Composition and Patterns of Taxa Assemblages in the Western Channel Assessed by 18S Sequencing, Microscopy and Flow Cytometry

Stern Rowena, Kathryn Picard, Jessica Clarke, Charlotte Walker, Claudia Martins, Clare Marshall, Ana Amorim, Malcolm Woodward, Claire Widdicombe, Glen Tarran, Martin Edwards

Subject: Earth Sciences, Environmental Sciences Keywords: Plankton; Monitoring; Harmful algae; microscopic; genetic; Western Channel

Online: 22 December 2022 (11:34:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0210.v1

Impact of Drought on Maize Yield and Exploration of In-Situ Maize Crop Genetic Resources for Drought Tolerance.

G MAHENDRA SINGH, Gokul Gosavi, Srinathareddy S, Shiv Shankar Patel, Pawan Singh Solanki, Feng Zhang, Jianchu Xu, V K Mishra, Sandeep Sharma

Subject: Biology, Agricultural Sciences & Agronomy Keywords: Maize; drought; landrace; climate-change; crop genetic resources

Online: 13 December 2022 (01:07:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0244.v1

Screening Aromatic Rice Genotypes by RAPD Markers for Breeding Salinity Stress Tolerant Rice Variety

Md Abdul Azim, Md Mahbubur Rahman, Dipali Rani Gupta, Aniruddha Sarker, Tofazzal Islam

Subject: Life Sciences, Molecular Biology Keywords: aromatic rice; salt screening; RAPD marker; genetic diversity

Online: 14 November 2022 (07:43:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0106.v1

Chloroplast Genetics Engineering: from Bench to Blast Application of Chloroplast Genetic-Engineering in Basic Research

Bo Wang

Subject: Life Sciences, Genetics Keywords: Keywords: chloroplast genetic engineering; Homologus recombination; ORF; photosynthesis

Online: 7 November 2022 (04:31:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0332.v1

Getting the Full Picture of Plankton in the Western Channel

Stern Rowena, Kathryn Picard, Jessica Clarke, Charlotte Walker, Claudia Martins, Clare Marshall, Ana Amorim, Malcolm Woodward, Claire Widdicombe, Glen Tarran, Martin Edwards

Subject: Biology, Ecology Keywords: Plankton; Monitoring; Harmful algae; microscopic; genetic; Western Channel

Online: 22 July 2022 (03:33:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0331.v1

Visualizing the Complexity of Proteins in Living Cells With Genetic Code Expansion

Kanokpol Aphicho, Narongyot Kittipanukul, Chayasith Uttamapinant

Subject: Life Sciences, Biochemistry Keywords: Genetic code expansion; unnatural amino acid; fluorescence imaging

Online: 21 December 2021 (12:42:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0334.v1

An Improved Nesting Algorithm for Irregular Patterns

German Martinez-Martinez, Jose-Luis Sanchez-Romero, Antonio Jimeno-Morenilla, Higinio Mora-Mora

Subject: Mathematics & Computer Science, Information Technology & Data Management Keywords: Nesting; cutting; irregular pattern; genetic algorithm; smart manufacturing

Online: 22 October 2021 (15:41:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0606.v1

Inheritance of Qualitative Morphological Traits and Variation of Quantitative Agronomic Traits of Enset (Ensete Ventricosum (Welw.) Cheesman) Clones Obtained From Wolaita Zone, Southern Ethiopia

Mesfin Kebede Gessese, Abraham Bosha

Subject: Biology, Anatomy & Morphology Keywords: Chi-squared; Genetic ratios; Progenies; Selfing; Variability analysis

Online: 25 May 2021 (10:34:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0305.v1

Distance Only Brings You Closer: Application of ISSR Markers to Analyze Molecular Relationships in Roses (Rosa spp.) - The Symbol of Love

Tanay Joshi, Santosh Kumar, Lalit Arya, Amritbir Riar

Subject: Life Sciences, Biochemistry Keywords: ISSR; Rosa spp.; DNA fingerprinting; genotypes; genetic diversity

Online: 13 May 2021 (14:01:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0461.v1

Germplasm Conservation: Instrumental in Agricultural Biodiversity-A Review

Veerala Priyanka, Rahul Kumar, Inderpreet Dhaliwal, Prashant Kaushik

Subject: Life Sciences, Genetics Keywords: Germplasm; Genetic plant resources; Preservation; Propagation; in vitro

Online: 19 April 2021 (11:28:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0470.v1

Assessing a Smart Technology versus a Mathematical model to Estimate the Transverse Shear Stress Distribution in a Rectangular Channel

Babak Lashkar-Ara, Niloofar Kalantari, Zohreh Sheikh Khozani, Amir Mosavi

Subject: Engineering, Civil Engineering Keywords: Smooth rectangular channel; Tsallis entropy; Genetic Programming (GP)

Online: 22 February 2021 (13:09:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0303.v1

Fuzzy Genetic Algorithm Approach for Verification of Reachability and Detection of Deadlock in Graph Transformation Systems

Nahid Salimi, Vahid Rafe, Hamed Tabrizchi, Amir Mosavi

Subject: Mathematics & Computer Science, Algebra & Number Theory Keywords: fuzzy genetic algorithm; reachability property; deadlock; model checking

Online: 14 October 2020 (10:58:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0028.v1

Genetic Algorithm: Reviews, Implementations, and Applications

Tanweer Alam, Shamimul Qamar, Amit Dixit, Mohamed Benaida

Subject: Keywords: genetic algorithm; search techniques; random tests; evolution; applications

Online: 4 June 2020 (07:44:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0119.v1

Mining and Characterizing the SSR Markers for Black Rice Using the Illumina Sequencing Platform

Dhananjay Kumar, Prasanta Kumar Das, Chandra Singha, Bidyut Kumar Sarmah

Subject: Life Sciences, Biotechnology Keywords: black rice; transcriptome sequencing; genic SSRs; genetic diversity

Online: 7 March 2020 (09:03:34 CET)

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Working Paper ARTICLE

Optimized Surge Arrester Allocation Based on Genetic Algorithm and ATP Simulation in Electric Distribution Systems

Gabriel Rocha, Raphael Barradas, João Rodrigo Muniz, Ubiratan Bezerra, Igor Araújo, Daniel Costa, Abner Silva, Marcus Nunes, Jucileno Silva

Subject: Engineering, Electrical & Electronic Engineering Keywords: transient analysis; surge arrester allocation; genetic algorithm; ATP

Online: 1 September 2019 (09:59:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0010.v1

Kalina-Flash Cycle Performance Analysis and Parametric Optimization

Raveendra Nath R, C. Vijaya Bhaskar Reddy, K.Hemachandra Reddy

Subject: Engineering, Mechanical Engineering Keywords: genetic algorithm; Kalina cycle; energy efficiency; Exergy efficiency;

Online: 1 August 2019 (06:13:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0321.v1

Whole Genome Diversity, Population Structure and Linkage Disequilibrium Analysis of Chickpea (Cicer arietinum L.) Genotypes Using Genome-Wide DArTseq-Based SNP Markers

Somayeh Farahani, Mojdeh Maleki, Rahim Mehrabi, Homayoun Kanouni, Reza Talebi

Subject: Life Sciences, Genetics Keywords: chickpea; genetic diversity; linkage disequilibrium; DArTseq-SNP markers

Online: 29 April 2019 (07:56:52 CEST)

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Characterization of genetic diversity, population structure and linkage disequilibrium is prerequisite for proper management of breeding programs and conservation of genetic resources. In this study, 186 chickpea genotypes including advanced “Kabuli” breeding lines and Iranian landrace “Desi” chickpea genotypes were genotyped using DArTseq-Based SNP markers. Out of 3339 SNPs, 1152 markers with known chromosomal position were selected for genome diversity analysis. The number of mapped SNP markers varied from 52 (LG8) to 378 (LG4), with an average of 144 SNPs per linkage group. The chromosome size that covered by SNPs varied from 16236.36 kbp (LG8) to 67923.99 kbp (LG5), while LG4 showed higher number of SNPs, with an average of 6.56 SNPs per Mbp. Polymorphism information content (PIC) value of SNP markers ranged from 0.05 to 0.50, with an average of 0.32, while the markers on LG4, LG6 and LG8 showed higher mean PIC value than average. Un-weighted Neighbor Joining cluster analysis and Bayesian-based model population structure grouped chickpea genotypes into four distinct clusters. Principal component analysis (PCoA) and Discriminant Analysis of Principal Component (DAPC) results were consistent with that of the cluster and population structure analysis. Linkage disequilibrium (LD) was extensive and LD decay in chickpea germplasm was relatively low. A few markers showed r²≥0.8, while 2961 pairs of markers showed complete LD (r²=1) and a huge LD block was observed on LG4. High genetic diversity and low kinship value between pairs of genotypes suggesting the presence of a high genetic diversity among studied chickpea genotypes. This study also demonstrated the efficiency of DArTseq-based SNP genotyping for large scale genome analysis in chickpea. The genotypic markers provided in this study are useful for various association mapping studies when combined with phenotypic data of different traits such as seed yield, abiotic and biotic stresses and therefore can be efficiently used in breeding programs to improve chickpea.

Preprint ARTICLE | doi:10.20944/preprints201811.0603.v1

Adjuvant Potential of CD24 on Immunogenicity and Lethal Challenge Protection of a DNA vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus

Touraj Aligholipour Farzani, Alireza Hanifehnezhad, Katalin Foldes, Koray Ergunay, Erkan Yilmaz, Hiba Hashim Mohamed Ali, Aykut Ozkul

Subject: Medicine & Pharmacology, Other Keywords: CCHFV, CD24, nucleocapsid, genetic adjuvant, immunogenicity, IFNAR-/- mice

Online: 27 November 2018 (12:15:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0164.v1

Thermal and Electrical Parameter Identification of a Proton Exchange Membrane Fuel Cell Using Genetic Algorithm

H. Eduardo Ariza, Antonio Correcher, Carlos Sánchez, Ángel Navarro-Pérez, Emilio García

Subject: Engineering, Electrical & Electronic Engineering Keywords: PEM fuel cell; identification; genetic algorithm; model; LabVIEW

Online: 10 July 2018 (10:12:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0089.v1

Conservation of Crop Genetic Resources in Italy with a Focus on Vegetables and a Case Study of a Neglected Race of Brassica oleracea

Karl Hammer, Vincenzo Montesano, Paolo Direnzo, Gaetano Laghetti

Subject: Biology, Agricultural Sciences & Agronomy Keywords: agrobiodiversity; vegetables; plant genetic resources; Italy; safeguarding; landraces

Online: 4 May 2018 (09:34:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0199.v1

Optimisation of Multipurpose Reservoir Operation by coupling SWAT and Genetic Algorithm for Optimal Operating Policy (Case Study: Ganga River basin)

Jatin Anand, A K Gosain, R Khosa

Subject: Engineering, Civil Engineering Keywords: Reservoir operation; SWAT; Genetic Algorithm; Urbanisation; Ganga River

Online: 23 March 2018 (15:07:22 CET)

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Reservoirs are recognized as one of the most efficient infrastructure components in integrated water resources management and development. At present, with the ongoing advancement of social economy and requirement of water, the water resources shortage problem has worsened, and the operation of reservoirs, in terms of consumption of flood water, has become significantly important. Reservoirs perform both regulation of flood and integrated water resources management, in which the flood limited water level is considered as the most important parameter for trade-off between regulation of flood and conservation. To achieve optimal operating policies for reservoirs, large numbers of simulation and optimization models have been developed in the course of recent decades, which vary notably in their applications and working. Since each model has their own limitations, the determination of fitting model for derivation of reservoir operating policies is challenging and most often there is always a scope for further improvement as the selection of model depends on availability of data. Subsequently, assessment and evaluation associated with the operation of reservoir stays conventional. In the present study, the Soil and Water Assessment Tool (SWAT) models and a Genetic Algorithm model has been developed and applied to two reservoirs in Ganga River basin, India to derive the optimal operational policies. The objective function is set to minimize the annual sum of squared deviation form desired irrigation release and desired storage volume. The decision variables are release for irrigation and other demands (industrial and municipal demands), from the reservoir. As a result, a simulation-based optimization model was recommended for optimal reservoir operation, such as allocation of water, flood regulation, hydropower generation, irrigation demands and navigation and e-flows using a definite combination of decision variables. Since the rule curves are derived through random search it is found that the releases are same as that of demand requirements. Hence based on simulated result, in the present case study it is concluded that GA-derived policies are promising and competitive and can be effectively used operation of the reservoir.

Preprint ARTICLE | doi:10.20944/preprints201705.0109.v1

The Genetic Structure of Turnip mosaic Virus Population Reveals the Rapid Expansion of a New Emergent Lineage in China

Xiangdong Li, Tiansheng Zhu, Xiao Yin, Chengling Zhang, Jia Chen, Yanping Tian, Jinliang Liu

Subject: Biology, Plant Sciences Keywords: Turnip mosaic virus; Potyvirus; Genetic structure; Population; China

Online: 15 May 2017 (11:38:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0519.v1

Genetic Risk Scores and Missing Heritability in Ovarian Cancer

James P Brody, Yasaman Fatapour

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: ovarian cancer; machine learning; germ line; genetic risk scores

Online: 28 January 2023 (06:58:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0263.v1

Phenotypic Variations, Environmental Effects and Genetic Basis Analysis of Grain Elemental Concentrations in Rice (Oryza sativa L.) for Improving Human Nutrition

Yheni Dwiningsih, Jawaher Alkahtani

Subject: Life Sciences, Biotechnology Keywords: rice; nutrient elements; toxic elements; phenotypic variance; genetic basis

Online: 19 September 2022 (05:31:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0029.v1

Variability of Genetic Characters Associated with Probiotic Functions in Lacticaseibacillus Species

Franca Rossi, Carmela Amadoro, Maria Pallotta, Giampaolo Colavita

Subject: Life Sciences, Microbiology Keywords: Lacticaseibacillus species; probiotic potential; genetic traits; presence in genomes

Online: 6 April 2022 (04:54:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0399.v1

BiGAMi: Bi-Objective Genetic Algorithm Fitness Function for Feature Selection on Microbiome Datasets

Mike Lenske, Francesca Bottacini, Haithem Afli, Bruno G. N. Andrade

Subject: Mathematics & Computer Science, Artificial Intelligence & Robotics Keywords: microbiome; genetic algorithm; feature selection; human health; machine learning

Online: 31 March 2022 (08:00:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0295.v1

Genetic Diversity of Schistosoma Haematobium in Sub-Saharan Africa: A Systematic Review

Rabecca Tembo, Panji Nkhoma, Mildred Zulu, Florence Mwaba, John Yabe, Hikabasa Halwiindi, Moses Kamwela, King S. Nalubamba, Chummy S. Sikasunge, Andrew M. Phiri

Subject: Life Sciences, Other Keywords: Urinary schistosomiasis; Schistosoma haematobium; sub-Saharan Africa; Genetic Diversity

Online: 22 March 2022 (04:25:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0514.v1

Advances and Milestones of Radish Breeding: An Update

Anand Kumar, Prashant Kaushik

Subject: Keywords: radish; breeding; interspecific hybridization; molecular breeding; genomics; genetic engineering

Online: 26 August 2021 (16:46:36 CEST)

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Working Paper ARTICLE

Revisiting the Implications of Positive Germline Testing Results Using Multi-Gene Panels in a Cohort of Individuals With Personal and/or Family History of Breast Cancer

Georgios N. Tsaousis, Eirini Papadopoulou, Konstantinos Agiannitopoulos, Georgia Pepe, Nikolaos Tsoulos, Ioannis Boukovinas, Theofanis Floros, Rodoniki Iosifidou, Ourania Katopodi, Anna Koumarianou, Christos Markopoulos, Konstantinos Papazisis, Vasileios Venizelos, Achilleas Kapsimalis, Grigorios Xepapadakis, Amanda Psyrri, Eugeniu Banu, Dan Tudor Eniu, Alexandru Blidaru, Dana Lucia Stanculeanu, Andrei Ungureanu, Vahit Ozmen, Sualp Tansan, Mehmet Tekinel, Suayib Yalcin, George Nasioulas

Subject: Medicine & Pharmacology, Allergology Keywords: germline testing; NGS; breast cancer; genetic counselling; risk assessment

Online: 7 July 2021 (13:14:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0162.v1

Genetic Diversity and Population Structure of Capirona (Calycophyllum spruceanum Benth.) from the Peruvian Amazon Assessed by RAPD Markers

Carla Saldaña, Johan Cancan, Wilbert Cruz, Mirian Correa, Miriam Ramos, Eloy Cuellar, Carlos Arbizu

Subject: Life Sciences, Biochemistry Keywords: Amazon forest; capirona; molecular markers; genetic diversity; population structure

Online: 7 June 2021 (10:06:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0465.v1

Genetic Diversity and Population Structure of a Rhodes Grass (Chloris gayana) Collection

Alemayehu Teressa Negawo, Meki S. Muktar, Yilikal Assefa, Jean Hanson, Alieu M. Sartie, Ermias Habte, Chris S. Jones

Subject: Life Sciences, Biochemistry Keywords: DArTSeq markers; genetic diversity; Rhodes grass (Chloris gayana); subset

Online: 20 May 2021 (09:46:57 CEST)

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Working Paper ARTICLE

Utilization of a Wheat50K SNP Microarray-Derived High-Density Genetic Map for QTL Mapping of Plant Height and Grain Traits in Wheat

Yun Dong Lv, Zhang Chuan Liang, Rui Yv, Juntao Jian, Hui Jian Wu, Peng Xiao Song, Xin Jian Yao, Bo Peng Song, Yuan Ze Zhang, Dejun Han, Jie Dao Sun

Subject: Biology, Anatomy & Morphology Keywords: wheat; plant height; grain traits; Wheat50K; genetic map; QTL

Online: 22 April 2021 (10:20:48 CEST)

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Plant height is significantly correlated with grain traits, which is a component of wheat yield. The purpose of this study is to investigate the main QTLs that control plant height and grain-related traits in multiple environments. In this study, we constructed a high-density genetic linkage map using the Wheat50K SNP Array to map quantitative trait loci (QTLs) for these traits in 198 recombinant inbred lines (RILs). The two ends of the chromosome were identified as re-combination-rich areas in all chromosomes except chromosome 1B. The middle area of the chro-mosomes was identified as the recombination-barren area. Both the genetic map and the physical map showed a significant correlation when p=0.001, with a correlation coefficient between 0.63 and 0.99. However, there was almost no recombination between 1RS and 1BS. In terms of plant height, 1RS contributed to the reduction of plant height by 3.43cm. In terms of grain length, 1RS contributed to the elongation of grain by 0.11mm. A total of 43 QTLs were identified, including 8 QTLs for Plant height(PH), 11 QTLs thousand grain weight(TGW), 15 QTLs for grain length(GL),and 9 QTLs for grain width(GW), which explained 1.36%–33.08% of the phenotypic variation. Seven were environment-stable QTLs, including two loci Qph.nwafu-4B and Qph.nwafu-4D that determined plant height. The explanation rates of phenotypic variation were 7.39%-12.26% and 20.11%-27.08%, respectively. One QTL, Qtgw.nwafu-4B, which influenced TGW, showed an explanation rate of 3.43%-6.85% for phenotypic variation, two co-segregating KASP markers were developed, the physical locations corresponding to KASP_AX-109316968 and KASP_AX-109519968 were 25.888344 MB and 25.847691 MB. Another QTL, Qgw.nwafu-4D, which determined grain width, had an explanation rate of 3.43%-6.85%. Three loci that affected the grain length were Qgl.nwafu-5A, Qgl.nwafu-5D.2 and Qgl.nwafu-6B, illustrating the explana-tion rates of phenotypic variation as 6.72%-9.59%, 5.62%-7.75%, and 6.68%-10.73%, respectively. Two QTL clusters were identified on chromosomes 4B and 4D.

Preprint ARTICLE | doi:10.20944/preprints202104.0300.v1

Exploring Fusarium Head Blight Resistance In a Winter Triticale Germplasm Collection

Sydney Wallace, Bhavit Chhabra, Yanhong Dong, Xuefeng Ma, Gary Coleman, Vijay Tiwari, Nidhi Rawat

Subject: Biology, Anatomy & Morphology Keywords: Fusarium head blight; deoxynivalenol; triticale; genetic resistance; disease evaluation

Online: 12 April 2021 (12:49:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0209.v1

Genomic Mapping in Detection of Vascular Disorders

Sameer Quazi, Arnaud Capuzzo, Javid Ahmad Malik

Subject: Life Sciences, Biochemistry Keywords: Genetic Mapping; Vascular system; Embryogenesis; Vascular disorder; PIk3CA gene

Online: 8 March 2021 (10:43:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0209.v1

Contrasting Epidemiology and Genetic Variation of Plasmodium vivax Infecting Duffy Negatives across Africa

Eugenia Lo, Gianluca Russo, Kareen Pestana, Daniel Kepple, Beka Raya Abargero, Ghyslaine Bruna Djeunang Dongho, Karthigayan Gunalan, Louis H Miller, Muzamil Mahdi Abdel Hamid, Delenasaw Yewhalaw, Giacomo Maria Paganotti

Subject: Biology, Anatomy & Morphology Keywords: Plasmodium vivax; Duffy Negatives; Africa; Molecular epidemiology; Genetic relatedness

Online: 8 December 2020 (20:30:36 CET)

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Working Paper REVIEW

Integrating Conflicting Cancer Theories by Recognizing the Roles of Epigenetic and Genetic Alterations in the Immediate-Cancer-Causing Genes that Establish Cellular Immortality and Autonomy

Shengming Zhu, Jiangang Wang, Haiyan Zhou, Yan Zhao, Yan He, Lucas Zellmer, Zhiguo Luo, Sixi Wei, Fei Deng, Hai Huang, Dezhong Joshua Liao

Subject: Medicine & Pharmacology, Allergology Keywords: Mutation; Epigenetic; Genetic; Neoplastic transformation; Stem cell; Tumor classification

Online: 30 November 2020 (08:26:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0149.v1

Advances in Melon Breeding (Cucumis melo L.): An Update

Hari Kesh, Prashant Kaushik

Subject: Biology, Anatomy & Morphology Keywords: breeding; diversity; genetic engineering; genomics; male sterility; melon; QTLs

Online: 7 October 2020 (09:22:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0279.v1

The Population Genetics of Ploidy Change in Fungi

Aleeza C. Gerstein, Nathaniel Sharp

Subject: Biology, Other Keywords: selection; mutation; genetic drift; adaptation; ploidy drive; genome instability

Online: 13 September 2020 (11:48:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0145.v1

Leaky Severe Combined Immunodeficiency in Mice Lacking Non-homologous End Joining Factors XLF and MRI

Sergio Castaneda-Zegarra, Qindong Zhang, Amin Alirezaylavasani, Marion Fernandez-Berrocal, Rouan Yao, Valentyn Oksenych

Subject: Life Sciences, Genetics Keywords: NHEJ; Cernunnos; Cyren; pro-B cells; lymphocyte; genetic interaction

Online: 6 September 2020 (15:50:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0079.v1

Performance Comparisons of Bio-micro Genetic Algorithms on Robot Locomotion

Francisco A. Chávez-Estrada, Jacobo Sandoval-Gutierrez, Juan C. Herrera-Lozada, Mauricio Olguín-Carbajal, Daniel L. Martínez-Vázquez, Miguel Hernández-Bolaños, Israel Rivera-Zárate

Subject: Engineering, Control & Systems Engineering Keywords: micro segmented genetic algorithm; multicore embedded system; parallel processing

Online: 5 March 2020 (03:23:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0281.v1

Genetic Algorithm Design of MOF-Based Gas Sensor Arrays for CO₂-in-Air Sensing

Brian A. Day, Christopher E. Wilmer

Subject: Chemistry, Applied Chemistry Keywords: genetic algorithms; MOFs; metal-organic frameworks; molecular modelling; arrays

Online: 21 December 2019 (10:55:20 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0286.v1

Indigenous Pig Genetic Resources in Southern Africa: Progress and Prospects

Tinyiko Edward Halimani, Obvious Mapiye, Tawanda Marandure, Diedre Januarie, Venancio Edward Imbayarwo Chikosi, Kennedy Dzama

Subject: Life Sciences, Genetics Keywords: diversity; conservation; animal genetic resources; indigenous pigs; southern Africa

Online: 24 November 2019 (14:47:39 CET)

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Working Paper ARTICLE

Identifying Genetic Variants and Pathways Associated with Extreme Levels of Fetal Hemoglobin in Sickle Cell Disease in Tanzania

Siana Nkya, Liberata Mwita, Josephine Mgaya, Happiness Kumburu, Marco van Zwetselaar, Stephan Menzel, Gaston K. Mazandu, Raphael Z. Sangeda, Emile R. Chimusa, Julie Makani

Subject: Life Sciences, Genetics Keywords: Sickle cell disease; genetic disorder; fetal hemoglobin; hemoglobinopathy; Tanzania

Online: 20 September 2019 (11:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0144.v1

ISSR-Markers Assisted Genetic Diversity Assessment of Acid Lime [Citrus aurantifolia (Christm.) Swingle] Germplasm of Eastern Nepal

Nabin Narayan Munankarmi, Neesha Rana, Tribikram Bhattarai, Ram Lal Shrestha, Bal Krishna Joshi, Bikash Baral, Sangita Shrestha

Subject: Life Sciences, Molecular Biology Keywords: citrus breeding; diversity; genetic similarity; Lime; molecular markers; PCR

Online: 9 May 2018 (11:05:37 CEST)

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Acid lime [Citrus aurantifolia (Christm.) Swingle] is a fruit crop, enriched with high commercial value and is cultivated in 60 out of 75 districts representing all geographical landscapes of Nepal. Lack of high yielding cultivars is probably one of the main reason for its extremely reduced productivity which warrants a deep understanding of genetic diversity in existing germplasm. Hereby, we aim to access the genetic diversity of acid lime germplasm cultivated at 3-different ecological gradients of eastern Nepal employing PCR-based Inter-Simple Sequence Repeats markers (ISSR). Altogether, 21 polymorphic ISSR markers were used to assess the genetic diversity in 60 acid lime cultivars sampled from different geographical locations. Analysis of binary data matrix was performed on the basis of bands obtained, scoring of the data was done accordingly, and principal coordinate analysis and phenogram were constructed using different computer algorithms. ISSR profiling yielded 234 amplicons, of which 87.18% were found to be polymorphic. The number of amplified fragments ranged from 7-18 with amplicon size ranging from 250-3200 bp. The NTSYS based Cluster analysis using UPGMA algorithm taking Dice Similarity coefficient separated 60 accessions into 2-major and 3-minor clusters. The genetic diversity analysis revealed the highest for Terai and the lowest for High-hill zone. Cluster I comprised of accessions from High-hill and Mid-hill regions revealing the close genetic relationship, whereas cluster II comprised of accessions from all three agro-ecological zones and the exotic varieties. Furthermore, our results revealed the accessions harvested from different geographical gradients were not genetically distinct, but highest diversity was observed in Terai accessions in comparison to the regions belonging to the High and Mid-hills. Thus, our data indicate that the ISSR provides a better option for evaluating the genetic diversity of Nepalese Acid Lime cultivars and furnished significant information, assisting parental selection in current and future breeding programs and germplasm conservation which ultimately may help to provide a technological breakthrough for the farmers of the developing country like Nepal.

Preprint ARTICLE | doi:10.20944/preprints201712.0129.v1

Nonlinear Modeling and Coordinate Optimization of Semi-Active Energy Regenerative Suspension with Electro-Hydraulic Actuator

Farong Kou, Jiafeng Du, Zhe Wang, Dong Li, Jianan Xu

Subject: Engineering, Automotive Engineering Keywords: semi-active suspension; feed energy; parameter optimization; genetic algorithm

Online: 19 December 2017 (06:53:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0081.v1

Electric Power Grids Distribution Generation System For Optimal Location and Sizing – An Case Study Investigation by Various Optimization Algorithms

Ahmet Ali, Sanjeevikumar Padmanaban, Bhekisipho Twala, Tshilidzi Marwala

Subject: Engineering, Electrical & Electronic Engineering Keywords: optimization; simulated annealing; genetic algorithm; power losses; power consumption

Online: 9 May 2017 (10:45:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0015.v1

Design and analysis of the redundancy allocation problem using a greedy technique

Souradeep Nanda, SIDDHARTH SHARMA, Kundnani Piyush, ANAND SHANKER DEB, C. Vijayalakshmi

Subject: Mathematics & Computer Science, Numerical Analysis & Optimization Keywords: Redundancy Allocation Problem, Genetic Algorithm, Simulated Annealing, Greedy Algorithm

Online: 9 July 2016 (05:13:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0494.v1

Genetic Diversity and Population Structure of Anopheles funestus in western Kenya Based on Mitochondrial DNA Marker mtDNA-COII

Isaiah Debrah, Kevin O. Ochwedo, Wilfred O. Otambo, Maxwell G. Machani, Edwin O. Magomere, Shirley A. Onyango, Daibin Zhong, Linda Eva Amoah, Andrew Karanja Githeko, Yaw Asare Afrane, Guiyun Yan

Subject: Life Sciences, Other Keywords: Anopheles funestus; western Kenya; mtDNA-COII; genetic diversity; gene flow

Online: 27 January 2023 (06:46:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0404.v1

Integration of Epidemiological and Genomic Data to Investigate H5N1 HPAI Outbreaks in Northern Italy in 2021-2022

Diletta Fornasiero, Alice Fusaro, Bianca Zecchin, Matteo Mazzucato, Francesca Scolamacchia, Grazia Manca, Calogero Terregino, Tiziano Dorotea, Paolo Mulatti

Subject: Life Sciences, Virology Keywords: HPAI; H5N1; Italy; genetic network; epidemiological investigation; contact tracing; ERGM

Online: 22 December 2022 (01:14:38 CET)

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