Working PaperConcept PaperVersion 1This version is not peer-reviewed
The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype
Version 1
: Received: 5 January 2021 / Approved: 6 January 2021 / Online: 6 January 2021 (15:06:41 CET)
How to cite:
Auboeuf, D. The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype. Preprints2021, 2021010126
Auboeuf, D. The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype . Preprints 2021, 2021010126
Cite as:
Auboeuf, D. The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype. Preprints2021, 2021010126
Auboeuf, D. The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype . Preprints 2021, 2021010126
Abstract
The physics–biology continuum relies on the fact that life emerged from prebiotic molecules. Here, I argue that life emerged from the physical coupling between the synthesis of nucleic acids and the synthesis of amino acid polymers. Owing to this physical coupling, amino acid polymers (or proto-phenotypes) maintained the physicochemical parameter equilibria (proto-homeostasis) in the immediate environment of their encoding nucleic acids (or proto-genomes). This protected the proto-genome physicochemical integrity (i.e., atomic composition) from environmental physicochemical stresses, and therefore increased the probability of reproducing the proto-genome without variation. From there, genomes evolved depending on the biological activities they generated in response to environmental fluctuations. Thus, a genome generating an internal environment whose physicochemical parameters guarantee homeostasis and genome integrity has a higher probability to be reproduced without variation and therefore to reproduce the same phenotype in offspring. Otherwise, the genome is modified by the imbalances of the internal physicochemical parameters it generates, until new emerging biological activities maintain homeostasis. In sum, evolution depends on feedforward and feedback loops between genome and phenotype, since the internal physicochemical conditions that a genome generates in response to environmental fluctuations in turn either guarantee the stability or direct the variation of the genome.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
