Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review

Version 1 : Received: 9 January 2023 / Approved: 11 January 2023 / Online: 11 January 2023 (10:34:57 CET)

How to cite: Garcia-Quiñones, J.A.; Sanchez-Dominguez, C.N.; Serna-Rodríguez, M.F.; Marino-Martinez, I.A.; Rivas-Estilla, A.M.; Pérez-Maya, A.A. Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review. Preprints 2023, 2023010197. https://doi.org/10.20944/preprints202301.0197.v1 Garcia-Quiñones, J.A.; Sanchez-Dominguez, C.N.; Serna-Rodríguez, M.F.; Marino-Martinez, I.A.; Rivas-Estilla, A.M.; Pérez-Maya, A.A. Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review. Preprints 2023, 2023010197. https://doi.org/10.20944/preprints202301.0197.v1

Abstract

Suicide is defined as the action of harming oneself with the intention of dying. It is estimated that worldwide one suicide occurs every 40 seconds, making it a major health problem. Studies in families have suggested that suicide has a genetic component, around the world studies have been carried out in search of genetic variants associated with suicidal behavior, these variants could be useful as potential biomarkers to identify people at risk of suicide. In this area in Mexico, some studies of variants in genes related to neurotransmission and other important pathways have been carried out and a possible association of variants located in genes has been suggested: SLC6A4, SAT-1, TPH-2, ANKK1, GSHR, SCARA50, RGS10, STK33, COMT, and FKBP5. This systematic review shows the genetic studies on the Mexican population. This article contributes by compiling the existing information on genetic variants and genes associated with suicidal behavior, said variants in the future could be used as potential biomarkers to identify people at risk of suicide.

Keywords

Biomarkers; Genetic; Suicidal behavior; Suicide; Mexican; Genomic.

Subject

Social Sciences, Behavior Sciences

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