Preprint Review Version 1 This version is not peer-reviewed

Recent Developments in Using Drosophila as a Model for Human Genetic Disease

Version 1 : Received: 12 June 2018 / Approved: 12 June 2018 / Online: 12 June 2018 (12:36:08 CEST)

A peer-reviewed article of this Preprint also exists.

Oriel, C.; Lasko, P. Recent Developments in Using Drosophila as a Model for Human Genetic Disease. Int. J. Mol. Sci. 2018, 19, 2041. Oriel, C.; Lasko, P. Recent Developments in Using Drosophila as a Model for Human Genetic Disease. Int. J. Mol. Sci. 2018, 19, 2041.

Journal reference: Int. J. Mol. Sci. 2018, 19, 2041
DOI: 10.3390/ijms19072041

Abstract

Many insights into human disease have been built on experimental results in Drosophila, and research in fruit flies is often justified on the basis of its predictive value for questions related to human health. Additionally, there is now a growing recognition of the value of Drosophila for the study of rare human genetic diseases, either as a means of validating the causative nature of a candidate genetic variant found in patients, or as a means of obtaining functional information about a novel disease-linked gene when there is little known about it. For these reasons, funders in the US, Europe, and Canada have launched targeted programs to link human geneticists working on discovering new rare disease loci with researchers who work on the counterpart genes in Drosophila and other model organisms. Several of these initiatives are described here, as are a number of output publications that validate this new approach.

Subject Areas

rare disease; functional genomics; genetic variant validation

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