Working Paper Hypothesis Version 1 This version is not peer-reviewed

Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19

Version 1 : Received: 15 April 2020 / Approved: 16 April 2020 / Online: 16 April 2020 (09:15:49 CEST)

How to cite: Zhao, Y.; Gu, Y.; Liu, Y.; Li, S.; Wang, Y.; Bu, L.; Liu, Q.; Lv, H.; Wan, F.; Wu, L.; Ning, Z. Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19. Preprints 2020, 2020040268 Zhao, Y.; Gu, Y.; Liu, Y.; Li, S.; Wang, Y.; Bu, L.; Liu, Q.; Lv, H.; Wan, F.; Wu, L.; Ning, Z. Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19. Preprints 2020, 2020040268

Abstract

The rapid spread of the coronavirus disease 2019 (COVID-19) is a serious threat to public health systems globally and is subsequently, a cause of anxiety and panic within human society. Understanding the mechanisms and reducing the chances of having severe symptoms from COVID-19 will play an essential role in treating the disease, and become an urgent task to calm the panic. However, the COVID-19 test developed to identify virus carriers is unable to predict symptom development in individuals upon infection. Experiences from other plagues in human history and COVID-19 statistics suggest that genetic factors may determine the compliance with the virus, i.e., severe, mild, and asymptomatic. Here, a hypothesis is put forward based on the epidemiological characteristics and traits of COVID-19, and our gene expression analysis. It proposes that COVID-19 inactivation in the blood by blocking virus entry into other internal organs for reproduction through the blood circulation after lung cell invasion prevents severe symptoms. Additionally, we investigated a genetic connection between candidate genes and severe COVID-19 symptoms through the utilization of strategies combining hypothesis and data-driven approaches. A list of genes and important SNPs that require further investigation to aid the screening of individuals who may suffer severe illness if exposed to the virus is present. Those individuals should be intensively safeguarded and prioritised for treatment. Concurrently to further research on the COVID-19 pathogenesis, our results also offer a new research strategy for pandemic prevention and health maintenance.

Subject Areas

COVID-19; severe symptoms; inactivation; genetic diversity

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.