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Preprint ARTICLE | doi:10.20944/preprints202310.1072.v1

Aero-Structural Design Optimization of Wind Turbine Blades

Sagidolla Batay, Aigerim Baidullayeva, Yong Zhao, Dongming Wei

Subject: Engineering, Energy And Fuel Technology Keywords: DAFoam; OpenMDAO; TACS; aero-structural optimization; multidisciplinary design optimization

Online: 17 October 2023 (10:36:02 CEST)

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Wind energy is becoming increasingly important as a renewable energy source due to its environmental and economic benefits. Wind turbines are key components in wind energy systems, and their performance is critical for efficient power generation. Wind turbine blades are the most critical components as they interact with the wind, and their design has a significant impact on the overall system performance. Therefore, it is essential to optimize the design of wind turbine blades to enhance their efficiency and reduce their costs. This paper presents an aero-structural optimization approach for wind turbine blade design. The optimization aims to maximize the torque generated by the blade while minimizing its mass. The optimization is implemented using DAFoam software for CFD simulation, TACS for FEM simulation, and Mphys under the OpenMDAO framework for fluid-structure interaction between the CFD and FEM. The optimization results show a 6.78% increase in torque and a 4.22% decrease in mass, which demonstrates the effectiveness of the proposed approach. Aerodynamic optimization focuses on maximizing the blade's torque by modifying the blade's shape. The optimization results show that the optimized blade generates more torque than the original blade design. Additionally, structural optimization aims to minimize the blade's mass while maintaining its structural integrity. This is achieved by adjusting the thickness of the blade's cross-section. The proposed aero-structural optimization approach presents an effective solution for the design optimization of wind turbine blades. The approach considers the interaction between the aerodynamic and structural aspects of the blade and optimizes them simultaneously. This leads to an optimized design that is efficient and cost-effective, which is crucial for the widespread adoption of wind energy systems. The results of this study highlight the importance of considering the interaction between the aerodynamic and structural aspects of wind turbine blades and the effectiveness of the proposed optimization approach in enhancing their performance.

Preprint ARTICLE | doi:10.20944/preprints202310.0902.v1

Spatial Cognition and 3-Dimensional Vertical Urban Design Guidelines - Cognitive Measurement and Modelling for Human Centre Design

Hee Sun Choi, Gerhard Bruyns, Wang Zhang, Sky David Cheng, Saijal Sharma

Subject: Social Sciences, Urban Studies And Planning Keywords: Vertical Urbanism; Human Centric Design; Spatial Cognition and Psychology

Online: 16 October 2023 (08:22:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0844.v1

Effect of Soil Anisotropy on Ground Motion Characteristics

Yuhong Xie, Zhou Cao, Jian Yu

Subject: Engineering, Civil Engineering Keywords: soil anisotropy; ground motion characteristics; standard design response spectrum

Online: 13 October 2023 (08:31:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1882.v1

Application of fSP3 towards Non-Systemic Drug Discovery

Miles Benardout, Adam Le Gresley, Amr El Shaer, Stephen P. Wren

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: fSP3; drug design; bioavailability; non-systemic drugs; druglikeness; cheminformatics

Online: 29 August 2023 (03:25:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0858.v1

Analysis of Compressive Strength of Anhydrite Binder Using Full Factorial Design

Dalia Nizevičienė, Nora Kybartienė, Vacius Jusas

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: factorial design; FGD gypsum; anhydrite binder; compressive strength; activators

Online: 11 August 2023 (02:58:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1898.v1

The Impact of Pulp Temperature on the Water Chemistry and Flotation Performance

Ozlem Bicak, Ertuna Cakir, Seda Ozcelik, Zafir Ekmekci

Subject: Engineering, Mining And Mineral Processing Keywords: Flotation; sulfide ores; water chemistry, temperature; statistical experimental design

Online: 27 July 2023 (09:52:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1972.v1

Designing Effective Instructional Feedback Using Diagnostic and Visualization System: Evidence from a High School Biology Class

Lin Ma, Xuedi Zhang, Zhifeng Wang, Heng Luo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: instructional feedback; feedback design; cognitive diagnosis; visualization; high school

Online: 28 June 2023 (09:47:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0414.v1

Study of Like and Dislike of the Historical Urban Landscape of Ibarra, Ecuador

Morella Briceño-Avila, Ernesto Antonio Ponsot-Balaguer, Alfonso Rondón-González

Subject: Arts And Humanities, Other Keywords: local knowledge; social cohesion; urban design; historical landscape; Ecuador

Online: 6 June 2023 (08:19:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1573.v1

Sunlight Degradation and Mineralization of Food Dye Photoinduced by Homogenous Photo Fenton Fe(III) and Fe(II) /Complex: Surface Response Modeling

Mohammed Kebir, Imen kahina Benramdhan, Nasrallah Noureddine, Hichem Tahraoui, Bait Nadia, Benaissa Houssine, Aomeraoui Rachid, Jie Zhang, Aymen Amin ASSADI, Lotfi Mouni, Abdeltif Amrane

Subject: Engineering, Chemical Engineering Keywords: Complex; Degradation; food dye; mineralization; Box Benhken surface design.

Online: 23 May 2023 (04:52:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1320.v1

Job Crafting and Work-Life Balance in a Mature Organization

Jarosław Stanisław Kardas

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: job crafting; work-life balance; job design; mature organization

Online: 18 May 2023 (10:03:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1052.v1

Sorafenib in Molecularly Selected Cancer Patients: Final Analysis of the MOST-Plus Sorafenib Cohort

Olivier Trédan, Maud Toulmonde, Christophe Le Tourneau, Laure Montane, Antoine Italiano, Isabelle Ray-Coquard, Christelle De La Fouchardière, François Bertucci, Anthony Gonçalves, Carlos Gomez-Roca, Benoit You, Valéry Attignon, Sandrine Boyault, Philippe Cassier, Armelle Dufresne, Séverine Tabone-Eglinger, Alain Viari, Emilie Sohier, Maud Kamal, Gwenaelle Garin, Jean-Yves Blay, David Pérol

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: personalized medicine; biologically-driven trial; sorafenib; randomised discontinuation design

Online: 15 May 2023 (14:22:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0724.v1

Gellan Gum/Alginate Microparticles As Drug Delivery Vehicles: Doe Production Optimization and Drug Delivery

Henrique Carrêlo, Maria Teresa Cidade, João Paulo Borges, Paula Soares

Subject: Chemistry And Materials Science, Biomaterials Keywords: Microparticles; Gellan Gum; Alginate; Design of Experiments; Coaxial airflow

Online: 10 May 2023 (09:53:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0535.v1

Design Path for a Social Robot for Emotional Communication for Children with Autism Spectrum Disorder (ASD)

Sandra Cano, Jaime Díaz-Arancibia, Jeferson Arango-López, Julia Elena Libreros, Matías García

Subject: Computer Science And Mathematics, Robotics Keywords: Human-Robot Interaction; Autism Spectrum Disorder; User-Centered Design

Online: 8 May 2023 (11:57:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0466.v1

Design and Performance Analysis of a Torsional Soft Actuator Based on Superelastic Materials

Zhengyun Xu, Haiqiang Liu, Weihua Feng, Huaming Yang, Xin Nie, Rougang Zhou

Subject: Engineering, Mechanical Engineering Keywords: soft actuator; modular design; machine vision; flexible clamping technology

Online: 8 May 2023 (08:21:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0065.v1

Development of Design Method for Casing and Tubing Strings under Complex Alternating Loads

Jianjun Wang, Dening Li, Xu Du, Hongjie Li, Shangyu Yang

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: oil and gas well; tubing; casing; pipe string design

Online: 2 May 2023 (07:22:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1232.v1

Application of Concurrent Design Strategy on the Design of Multifunction Hydrotherapy Bucket

Shih-Wen Hsiao, Chu-Hsuan Lee

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Concurrent design; Morphological diagram method; PUGH method; TRIZ theory

Online: 29 April 2023 (09:43:33 CEST)

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With the improvement in medical quality, cold mechanical rehabilitation equipment can no longer meet the psychological needs of the physically handicapped. Therefore, design for behaviour change should be viewed as a strategy for enabling lifestyle changes as soon as possible. Although how to use equipment to assist physically disabled people in hydrotherapy rehabilitation is the primary design goal, the psychological feelings of users are also one of the focuses of this study. Besides, coupled with the large-scale spread of the Coronavirus Disease (COVID-19) in the past two years. People's living habits are also forced to change, many activities that people are used to doing outdoors are being slowly completed at home. During the epidemic, it is very dangerous and inconvenient for users who need to go to institutional rehabilitation regularly. Hence, it is urgent to change past usage habits and places. In this study, a personal multi-functional hydrotherapy bucket is designed. In addition to not having to use a public spa with other people to reduce the risk of contracting the Coronavirus Disease, it can be easily placed at home by reducing its size. According to market research, it is known that the current domestic hydrotherapy buckets on the market usually only have a single function. The large medical hydrotherapy pools are not only rare in Taiwan, but this kind of equipment also takes up a lot of space. Various factors have resulted in a relatively low market share of hydrotherapy pools compared to other rehabilitation equipment. In order to take into account, the physical and psychological needs of the physically disabled, this research focus on the design of a multi-functional but small-sized hydrotherapy bucket. Taking the convenience of entering and leaving the bucket as the starting point to improve the shortcomings of the existing products, on the other hand, because most users are inconvenient to move, safety is also the focus of the design to reduce the occurrence of accidents and injuries. This study is based on the systematic design methodology of concurrent design to obtain product design results. Firstly, conduct market research and select products from different manufacturers for analysis and comparison. Through functional analysis and sorting out the problem points, the TRIZ theory and the morphological diagram method are used to find the solution to the problem. Finally, the best design scheme is obtained by the PUGH method. Besides, construct a 3D model to present the design concept that meets the design goals. The research results are hoped to be used as a reference for designing and developing related products, thereby increasing the home's multifunctional hydrotherapy buckets' market share.

Preprint ARTICLE | doi:10.20944/preprints202304.1089.v1

Effects of Footpad Slope, Movement Direction and Contact Part of Foot on Foot-based Interactions

Sang-Won Kim, Seung-Kweon Hong

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: foot movement; foot interface design; foot touchpad; movement direction.

Online: 28 April 2023 (03:18:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0147.v1

A Maturity Model for the Scientific Review of Clinical Trial Designs and Their Informativeness

Shawn Dolley, Thea Norman, Doug McNair, Dan Hartman

Subject: Public Health And Healthcare, Health Policy And Services Keywords: clinical trial; informativeness; design review; trial methods maturity model

Online: 10 April 2023 (04:56:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0186.v1

Experimental Evaluation on Fatigue Strength of Lattice Structures of AlSi10Mg Fabricated by AM for an Innovative Aerospace Anti-Ice System

Carlo Giovanni Ferro, Sara Varetti, Paolo Maggiore

Subject: Engineering, Mechanical Engineering Keywords: Additive Manufacturing; Lattice Structures; Fatigue Strength; Aerospace System Design

Online: 10 March 2023 (08:02:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0029.v1

Research on Optimal Circuit Design and Charging Strategy of DC/DC Charger

Haodong Shen, Rong Yan, Junnan Zhou, Lin Pan

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC/DC Charger; circuit design; charging strategy; working loss

Online: 3 January 2023 (09:37:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0157.v1

Engineering Self-Adaptive Capabilities in Wireless Sensors Based on Control Algorithms and Model-Based Design Methodologies

Raúl Mario Del Toro Matamoros, Andrei Pruteanu, Rodolfo Elias Haber Guerra

Subject: Engineering, Control And Systems Engineering Keywords: self-adaption; wireless sensors; model-based design; control engineering

Online: 8 December 2022 (10:24:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0190.v1

Optimization of Bleaching Crude Palm Oil with Activated Snail Shell using Central Composite Design [CCD]

Modupe Ojewumi, Ezeocha Roosevelt

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: adsorbent; palm oil; central composite design; bleaching; snail shell

Online: 13 May 2022 (10:40:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0492.v2

Design, Modelling and Tests of a Barycenter Offset Locomotion Mechanism for Cylindrical Robots

Océane Patiny

Subject: Engineering, Automotive Engineering Keywords: Education Robotics; Mechanism Design; Motion Control; Barycenter Offset Robot

Online: 1 March 2022 (06:46:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0093.v1

Detecting Usability and User Experience Issues in Stroke Caregiving Apps: An Analysis of User Reviews

Elton Henry Lobo, Mohamed Abdelrazek, Anne Frølich, Lene Juel Rasmussen, Patricia M. Livingston, Sheikh Mohammed Shariful Islam, Finn Kensing, John Grundy

Subject: Computer Science And Mathematics, Information Systems Keywords: mHealth; App; Stroke; Caregiver; Usability; User Experience; Needs; Design

Online: 7 February 2022 (15:17:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0064.v1

Study Designs for Evaluation of Combination Treatment: Focus On Individual Patient Benefit

Martin C. Michel, David Staskin

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: combination treatment; monotherapy; clinical trial design; benefit/risk assessment

Online: 6 January 2022 (10:14:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0622.v1

An Extensible and Modular Design and Implementation of Monte Carlo Tree Search for the JVM

Larkin Liu, Jun Tao Luo

Subject: Computer Science And Mathematics, Information Systems Keywords: Monte Carlo Tree Search, Software Design, Markov Decision Process

Online: 28 July 2021 (10:29:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0397.v1

Sustainable Infrastructure 4.0 - Value Chain Integration through Federated Digital Platforms

Konrad Nübel, Michael Bühler, Thorsten Jelinek

Subject: Engineering, Automotive Engineering Keywords: Sustainable Infrastructure; Governance; Design; Protocols; Implementation; Value Chain; Digitalization

Online: 19 July 2021 (09:11:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0266.v1

Cultural Heritage through Design Thinking

Diana Andreescu

Subject: Social Sciences, Anthropology Keywords: design thinking; innovation; creativity; experience; empathy; thinking; consumer; health

Online: 12 May 2021 (11:14:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0387.v1

Design of Breakwaters to Minimize Greenwater Loading on Bow Structures of Fixed Floating Vessels

Lim Jun An, Mohammed Abdul Hannan

Subject: Engineering, Marine Engineering Keywords: Bow structures; Breakwater design; CFD; Greenwater; Wave structure interaction

Online: 17 July 2020 (15:09:16 CEST)

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Working Paper ARTICLE

On the Theory and Design of Cold Resistors

Jiaao Song, Laszlo B. Kish

Subject: Engineering, Electrical And Electronic Engineering Keywords: thermal noise; negative feedback; low-noise resistors; theory; design

Online: 31 May 2020 (19:02:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0020.v2

Experimental and Numerical Evaluation of Residual Displacement and Ductility in Ratcheting and Shakedown of an Aluminum Beam

Simone Palladino, Luca Esposito, Paolo Ferla, Elena Totaro, Renato Zona, Vincenzo Minutolo

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: shakedown; plasticity; limit design; ratcheting; experimental comparison; residual displacement; ductility assessment

Online: 19 May 2020 (04:29:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0234.v1

A Statistical Study on the Development of Metronidazole-alginate-chitosan Nanocomposite Formulations using Full Factorial Designs

Hazem Sabbagh, Samer Hussein Al Ali, Mohd Zobir Hussein, Zead Abudayeh, Rami Ayoub, Suha Abudoleh

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Full Factorial Design; Optimization; metronidazole; nanocomposites; sodium alginate; Chitosan

Online: 21 January 2020 (09:58:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0409.v1

FEM Based Preliminary Design Optimization in Case of Large Power Transformers

Tamás Orosz, David Pánek, Pavel Karban

Subject: Engineering, Electrical And Electronic Engineering Keywords: design optimization; evolutionary computation; finite element analysis; power transformers

Online: 31 December 2019 (10:42:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0178.v1

Footwear Design Strategies for Thai Footwear Industry to Be Excellence in World Market

Adul Adulyanukosol, Thanin Silpcharu

Subject: Business, Economics And Management, Business And Management Keywords: strategies; design; footwear industry; structural equation model; competitive edge

Online: 13 December 2019 (05:27:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0220.v1

How Size Matters: Diversity for Fragment Library Design

Yun Shi, Mark von Itzstein

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: diversity; fragment-based drug discovery; library design; library size

Online: 19 July 2019 (07:54:41 CEST)

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Working Paper ARTICLE

Factorial Structure and Psychometric Analysis of the Persian Version of Perceived Competence Scale for Diabetes (PCSD-P)

Habibeh Matin, Haidar Nadrian, Parvin Sarbakhsh, Abdolreza Shaghaghi

Subject: Social Sciences, Cognitive Science Keywords: Validation; Questionnaire Design; Self-Perception; Diabetes Mellitus; Self Care.

Online: 25 March 2019 (10:00:07 CET)

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Background: Level of perceived competence as a basic psychological need could trigger achievement of diabetes self-management goals. Due to lack of a specific data collection tool to measure level of self-competence among Persian speaking patients with diabetes this study was conducted for cross-cultural adaptation and psychometric assessment of the Persian version of Perceived Competence Scale for Diabetes (PCSD-P). Methods: Standard translation/back-translation procedure was carried out to prepare a preliminary draft of the PCSD-P. Content and face validity of the early draft were checked by an expert panel including 15 scholars in the field of health education and promotion as well as nursing education with experience of working and research on diabetes. The final drafted questionnaire was completed by 177 randomly selected patients with type 2 diabetes. Based on the collected data structural validity of the contrived version was appraised using exploratory and confirmatory factor analysis (EFA, CFA). Cronbach's alpha and Intraclass Correlation coefficients (ICC) were used to check the scale’s reliability and internal consistency. ; (3) Results: The estimated measures of Content Validity Index (CVI= 0.95) and Content Validity Ratio (CVR= 0.8) were in the range of acceptable recommended limits. The EFA analysis results demonstrated a single factor solution according to the items’ loadings for the component. The model fit indices i.e. RMSEA= 0.000, CFI=1, TLI=1, GFI= 0.998, NFI= 0.999 RFI= 0.995 confirmed consistency of the hypothesized one-factor solution. Values of the internal consistency and reliability coefficients were also in the vicinity of acceptable range (α= 0.892, ICC=0. 886, P= 0.001). Conclusions: The study findings revealed good internal validity and applicability of the PCSD-P to measure degree of self-competence among Persian speaking type 2 diabetes patients to manage the chronic disease. Due to unrepresentativeness of the study sample future cross-cultural test of PCSD-P on diverse and broader Persian speaking populations is recommended.

Preprint ARTICLE | doi:10.20944/preprints201903.0159.v1

Optimizing Conditions for Scandium Extraction from Bauxite Residue Using Taguchi Methodology

Theopisti Lymperopoulou, Paraskevas Georgiou, Lamprini-Areti Tsakanika, Konstantinos Hatzilyberis, Maria Ochsenkuehn-Petropoulou

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Taguchi method; experimental design; optimization; scandium; extraction; sulfuric acid

Online: 15 March 2019 (09:34:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0513.v1

Learning Transportation Sustainability through Human Powered Vehicle Design - A Ten-Year Experience at Politecnico di Torino

Paolo Baldissera, Cristiana Delprete

Subject: Engineering, Control And Systems Engineering Keywords: project based learning; human powered vehicles; sustainable transportation design

Online: 23 October 2018 (03:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0315.v1

Elevating Art Thinking to a Fine Art

Peter Robbins

Subject: Arts And Humanities, Humanities Keywords: Design thinking, Art thinking, Creativity, Strategy, Fine Art, Printmaking

Online: 17 August 2018 (15:51:17 CEST)

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This article uses a contemporary and revelatory case study to explore the relationship between three conversations in the innovation literature: design thinking, creativity in strategy and, the emerging area of art-thinking. Businesses are increasingly operating in a VUCA environment where they need to design better experiences for their customers and better outcomes for their firm and the Arts are no exception. Innovation, or more correctly growth through innovation, is a top priority for business and although there is no single, unifying blueprint for success at innovation, design thinking is the process that is receiving most attention and getting most traction. Design thinking teaches businesses to think with the creativity and intuition of a designer; to show a deep understanding of; and have empathy with the user. But design thinking has limitations. By placing the consumer at the very heart of the innovation process, design thinking can often lead to more incremental than radical ideas. Now there is a new perspective emerging, art-thinking, in which the objective is not to design a journey from current scenario; A to improved position: B. Art thinking requires the creation of B and spends more time in the open ended, problem space, staking out possibilities and looking for uncontested space. In Dublin, we examine a case of the oldest, largest and most prestigious fine art gallery and studio where most of the country’s best-known and successful visual artists both make, exhibit and sell their art. Graphic Studio Dublin is primarily a printmaking studio, established by artists over 60 years ago. It has facilities for woodblock, lino-print, silkscreen, intaglio and carborundum etching spread over four floors of a centrally located studio where the artists have access 24/7. But two years ago it found itself on the brink of collapse having borrowed heavily to invest in new facilities during the period of Ireland’s economic collapse. Its loans were sold to a vulture-fund who were about to foreclose in a move that would have seen a generation of Irish Artists displaced. A new board of directors was empaneled and they introduced some art thinking principles to bring the organisation back from the brink. They used an art-thinking mindset and design thinking tools to restore the fortunes of this venerable, artist-led institution and it worked.

Preprint ARTICLE | doi:10.20944/preprints201805.0228.v1

Design PV Tracking System According to Efficiency in Function of Orientation

José Ruelas, Benjamin Pusch, Flavio Muños, Juan Delfin, Francisco Javier Ochoa Estrella

Subject: Engineering, Energy And Fuel Technology Keywords: PV solar tracker; design methodology; efficiency function of orientation

Online: 16 May 2018 (09:51:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0077.v1

A Methodology for Design and Analysis of Sensor Fusion with Real Data in UAV Platforms

Jesús García, Jose Manuel Molina, Jorge Trincado

Subject: Engineering, Electrical And Electronic Engineering Keywords: UAVs sensor fusion; EKF; real data analysis; system design

Online: 9 January 2018 (07:47:45 CET)

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Preprint REVIEW | doi:10.20944/preprints201712.0145.v1

Architect and the Paradigms of Sustainable Development: A Review of Dilemmas

Wojciech Bonenberg, Oleg Kapliński

Subject: Engineering, Civil Engineering Keywords: architect; sustainable architecture; paradigms of design; knowledge; society; Poland

Online: 20 December 2017 (10:22:12 CET)

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Preprint REVIEW | doi:10.20944/preprints201705.0003.v3

Introducing Sustainability in Value Models to Support Design Decision Making: A Systematic Review

Marco Bertoni

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: sustainability; value modeling; decision support; value driven design; review

Online: 12 June 2017 (13:51:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0026.v1

Propose of Mix Design Method for CO₂ Reduction Concrete Using the Regression Analysis

Tae Hyoung Kim

Subject: Engineering, Civil Engineering Keywords: concrete; sustainability; regression analysis mix design; CO2 emission; cost

Online: 3 August 2016 (06:05:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1555.v1

Reporting on the Development of a Web-Based Design Management Prototype Dashboard Achieved through a Design Science Research (DSR) Approach

Barry Gledson, Kay Rogage, Anna Thompson, Hazel Ponton

Subject: Engineering, Architecture, Building And Construction Keywords: Design Management; Design Science Research (DSR); digital innovations in construction; impact of digital technologies on construction processes; Information management; Information technology; Innovation

Online: 20 December 2023 (11:56:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1654.v1

Drag on Passenger Cars: Computational Fluid Dynamics Analysis of 2D Body Design Using ANSYS Fluent

Ava Martoma, Zbigniew Kabala

Subject: Engineering, Civil Engineering Keywords: drag coefficient; drag force; computational fluid dynamics (CFD); optimal car design; Toyota Corolla; Kia Soul; Hyundai Elantra; gas mileage; environmental design

Online: 21 December 2023 (14:17:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0060.v1

Structural Optimization in Building Information Modeling (BIM) Projects Using Visual Programming, Evolutionary Algorithms, and Sustainability Assessment Tools

Feyzullah Yavan, Reza Maalek, Vedat Toğan

Subject: Engineering, Architecture, Building And Construction Keywords: Structural Optimization; Genetic Algorithm; Parametric Design; Visual Programming; Generative Modeling

Online: 2 April 2024 (12:41:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1746.v1

The Development of an Oral Health Nursing Tool in Patients with a Psychotic Disorder: A Human-Centered Design with a Feasibility Test

Sonja Kuipers, Stynke Castelein, Linda Kronenberg, Job van ’t Veer, Nynke Boonstra

Subject: Social Sciences, Other Keywords: oral health; nursing; mental health; psychotic disorder; human-centered design

Online: 28 March 2024 (15:37:34 CET)

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Patients with a psychotic disorder frequently report oral health problems, while mental health nurses (MHNs) seem not to be fully aware of these problems and the risk factors. Therefore, this study aims to develop supportive tools for MHNs regarding oral health to increase sensitization among MHNs and to provide MHNs with knowledge to recognize (potential) oral health problems in patients with a psychotic disorder. We used a human-centered design in which the user, MHNs as well as experts by experience, were placed in the centre of the research process. Problems and needs in MHNs working with patients with a psychotic disorder were addressed. To identify key issues of problem as well as the needs in terms of resources, we started with focus groups (n = 9). We analysed the data thematically based on context of patients and MHNs in practice regarding oral health, preferred oral health tools focused on MHN, and intended outcomes of tools. A Multi Criteria Decision Matrix was developed and analysed (n = 9) to identify the most optimal and viable solution based on established criteria and issues that are prevalent in the work of MHNs. Most promising result was the development of a brochure with an awareness screener. The brochure with awareness screener was developed as a low-fidelity prototype for MHNs regarding oral health in patients with a psychotic disorder, based on the latest scientific evidence. After testing it, the feasibility was tested through semi-structured interviews (n=19). MHNs and experts by experience were satisfied with the tool and provided recommendations for adjustments to the content. Significant augmentations to the brochure include a clinical lesson and a toothbrush with toothpaste for patients. We can conclude that a brochure with an awareness screener is feasible for MHNs. Future steps aiming to further refine and optimize care processes for oral health tools in MHNs, should take refining eligibility criteria for psychiatric populations and the language level of the target group of a tool into account.

Preprint ARTICLE | doi:10.20944/preprints202403.1781.v1

Batch To Continuous: From Laboratory Recycle Trickle Bed Test Reactor Data to Full Scale Plant Preliminary Design—A Case Study Based on the Hydrogenation of Resorcinol

Steve D. Pollington, Bal S Kalirai, E. Hugh Stitt

Subject: Engineering, Chemical Engineering Keywords: flow chemistry; hydrogenation; resorcinol; continuous; recycle trickle-bed; process design

Online: 28 March 2024 (15:00:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0199.v1

Nest Design and Breeding Success: Replicability of Methodologies and Research Findings in Avian Model Species

Marcel Lambrechts, Charles Deeming

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Nest design; Breeding success; Nest-box; Cavity-nesting birds; Replicability

Online: 5 March 2024 (09:12:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1655.v1

A Two-Stage Twisted Blade μ-Vertical Axis Wind Turbine – An Enhanced Savonius Rotor Design

Andrés Pérez-Terrazo, Martin Moreno, Iván Trejo-Zúñiga, J. Alberto López

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: VAWT; Energy Harvesting; Two-Stage Design; Renewable Energy; Wind Technology

Online: 2 March 2024 (17:13:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1132.v1

Development and Properties of Recycled Biomass Fly Ashes Modified Mortars

Julien Hubert, Sophie Grigoletto, Frédéric Michel, Zengfeng Zhao, Luc Courard

Subject: Engineering, Civil Engineering Keywords: biomass fly ashes; cement; masonry mortar; rendering mortar; design; properties

Online: 21 February 2024 (03:43:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0011.v1

Comparative Analysis of Strap-Induced Pressure at the Toe Hold Area: Assessing the Impact of Rolled Inner Seam Flip Flops in Healthy Volunteers

Shreya Rao, Howard Maibach

Subject: Public Health And Healthcare, Other Keywords: Foot ulcers; Dorsal foot; Flip-flops; Strap design; Pressure distribution

Online: 3 January 2024 (03:43:57 CET)

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Abstract:Background: Foot ulcers, especially dorsal foot ulcers caused by straps in footwear, can lead to discomfort, pain, and severe complications, particularly in individuals with diabetes and leprosy. While plantar foot pressure measurements have been extensively studied, research on the impact of strap-induced pressure on the dorsal foot aspect remains limited.Research question: The main research question of this prospective study is: Does the implementation of a rolled inner seam strap design (RIS) in flip-flops result in reduced pressure at the toehold area compared to traditional strap designs (Control) in healthy volunteers?Methods: We studied healthy female volunteers, with 10 feet (5 left and 5 right) per arm of the study. Two types of flip-flops, RIS and Control, were compared in a standardized 5-step walk trial on a hardwood floor. Pressure at the toehold was measured using Pressure Sensitive Switches with portable, accurate, ultra-thin pressure sensors. Paired t-tests compared the maximum pressure at the toehold between RIS and Control flip-flops (p < 0.05).Results: The study revealed a statistically significant difference in pressure at the toehold between the RIS and Control flip-flops (p = 0.0014). The mean difference of -40.90 grams (95% CI: -61.22 to -20.58) indicated that the RIS exerted significantly lower pressure than the Control flip flops. The RIS group had a mean pressure of 29.30 grams. The Control group had a mean pressure of 70.20 grams at the toehold area.Significance: The findings of this study have significant clinical implications for individuals at risk of foot ulcers, particularly those with neuropathic conditions such as diabetes and leprosy. The implementation of the RIS design in flip-flops may offer a practical and cost-effective solution to reduce strap-induced pressure and mitigate the risk of strap-related foot ulcers, especially in resource-limited settings where comprehensive foot care is lacking.

Preprint ARTICLE | doi:10.20944/preprints202312.2303.v1

Parameter optimization of Friction Pendulum Bearings Based on the Adaptive Genetic Algorithm Considering the Overall Evolutionary Status

Guanghua Yin, Minglei Ma, Peng Jia, Xinxu Ma

Subject: Engineering, Civil Engineering Keywords: parameter optimization; adaptive genetic algorithm; seismic design; friction pendulum bearing

Online: 29 December 2023 (12:39:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1975.v1

Fail-Safe Topology Optimization Using Damage Scenarios Filtering

Wuhe Sun, Yong Zhang, Yunfei Liu, Kai Cheng, Fei Cheng

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: topology optimization; fail-safe design; dage scenarios filtering; snsitivity analysis

Online: 26 December 2023 (09:47:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1880.v1

Performance Evaluation of Balcony Designs for Mitigating Ground Level Noise

Long Bin Tan, Linus Yinn Leng Ang, Heow Pueh Lee, Kian Meng Lim

Subject: Engineering, Mechanical Engineering Keywords: balcony design; noise mitigation; outdoor noise; Helmholtz resonator; jagged ledge

Online: 25 December 2023 (15:59:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1506.v1

A Comprehensive Strategy for Stepwise Design of a Lab Prototype for the Removal of Emerging Contaminants in Water Using Cyclodextrin Polymers as Adsorbent Material

Antonio Tomás Hernández Cegarra, Teresa Gómez Morte, José Antonio Pellicer, Nuria Vela, María Isabel Rodríguez-López, Estrella Núñez-Delicado, José Antonio Gabaldón Hernández

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: β-Cyclodextrins; porous adsorbent; adsorption kinetics; pilot design; furosemide; hydrochlorothiazide.

Online: 20 December 2023 (08:58:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0893.v1

Characterizing the Digital Twin in Structural Mechanics

Rebecca Richstein, Kai-Uwe Schröder

Subject: Engineering, Mechanical Engineering Keywords: Archetypes, Design, Digital Twin, Structural Health Monitoring, Structural Mechanics, Taxonomy

Online: 12 December 2023 (12:09:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0738.v1

Optimization of a Low-cost Corona-DBD Plasma Wastewater Treatment System through CCD/RSM with Mechanistic and Efficiency Analysis

Yiting Xiao, Yang Tian, Yuanhang Zhan, And Jun Zhu

Subject: Environmental And Earth Sciences, Pollution Keywords: Water purification; non-thermal plasma; reactor design; advanced purification systems

Online: 11 December 2023 (16:38:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1572.v1

Insights Beyond Functionality: Empowering Digital Mental Health User Experiences Through Participatory Engagement and Evaluation

Harold Ngabo-Woods

Subject: Social Sciences, Psychiatry And Mental Health Keywords: Mental Health; Digital Health; Interaction; User Experience; Participatory Design; Telehealth

Online: 26 November 2023 (05:35:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0927.v1

The Effect of Model Similarity on Exercise Self-Efficacy Among Adults Recovering from a Stroke: A Mixed-Method Single Case Experimental Research Design

Olivia Pastore, François Jarry, Jammy Zou, Jennifer R. Tomasone, Luc J. Martin, Véronique Pagé, Shane Sweet

Subject: Social Sciences, Psychology Keywords: mixed-method; modelling; peers; single-case design; self-efficacy; stroke

Online: 14 November 2023 (15:21:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1734.v1

Rehabilitation Chair Design Based on Functional Technology Matrix and Multi-Level Evaluation Methods

Xinyan Yang, Zhongfeng Zhang

Subject: Public Health And Healthcare, Other Keywords: product design; rehabilitation chair; AHP; entropy weighting; grey relational analysis

Online: 26 September 2023 (13:40:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0830.v1

Improving Borehole Design and Upgrading Its Hydraulic Properties: Case Studies from Unconsolidated Aquifers in Israel

Joseph Guttman, Zigmund Barenblat

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Borehole design; drilling methods enhancements; pumping tests, drilling enhancements ranking

Online: 13 September 2023 (07:59:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0103.v1

Parametric Optimisation of Hypersonic Re-entry Capsules with Air-Duct Systems

Mansour Al Qubeissi, Feras Shaban, Khalid M. Almohammadi, Raja Mazuir R.A. Shah

Subject: Engineering, Aerospace Engineering Keywords: Design; Fluid dynamics; Hypersonic flow; Modelling; Optimisation; Re-entry capsule

Online: 5 September 2023 (10:24:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1765.v1

Minimum Cost Design for Rectangular Isolated Footings Taking into Account That the Column Is Located in Any Part of the Footing

Arnulfo Luévanos-Rojas

Subject: Engineering, Civil Engineering Keywords: minimum cost design; minimum area; moments; bending shear; punching shear

Online: 25 August 2023 (07:08:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0467.v1

Digital Platforms That Do Well and Do Good. Platform Architecture for Sustainability

Andrea Carolina Soto R.

Subject: Business, Economics And Management, Business And Management Keywords: Digital platforms; sustainability; business model design; business models for sustainability

Online: 7 August 2023 (10:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0282.v1

Impact of Fixed Cost Increase on the Optimization of Two-Stage Sustainable Supply Chain Network

Ahmed Mostafa, Kamal Moustafa, Raafat Elshaer

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Supply chain; Network design; Two-Stage; Fixed cost; Sensitivity analysis

Online: 3 August 2023 (09:57:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1143.v1

Using Wash’Em to design handwashing programmes for crisis-affected populations in Zimbabwe: A Process Evaluation

Astrid Hasund Thorseth, Jennifer Lamb, Constancia Vimbayi Mavodza, Mandikudza Tembo, Anesu Petra Mushangari, Eddington Zinyandu, Thomas Heath, Sian White

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Handwashing; Programme Design; Behaviour Change; Hygiene, Humanitarian Crises; Process Evaluation

Online: 18 July 2023 (05:47:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0158.v1

A Goal-Directed Trajectory Planning using Active Inference in UAV-Assisted Wireless Networks

Ali Krayani, Khalid Khan, Lucio Marcenaro, Mario Marchese, Carlo Regazzoni

Subject: Engineering, Telecommunications Keywords: UAVs; Wireless Networks; Trajectory Design; AI-enabled Radios; Active Inference

Online: 4 July 2023 (07:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1854.v1

How Buildings Relate Classifying Architectural Interactions

Marco Enia, Flavio Martella

Subject: Arts And Humanities, Architecture Keywords: Architectural relations; Design theory; Architectural theory; Architectural relations; Relational architecture

Online: 26 May 2023 (04:45:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0660.v2

Signal Design, Detection, and Identification Technology for Ground-Penetrating Communication Based on Ground Electrode Current Field

Jingang He, Zhong Su, Zhan Xu, Yaxing Zha, Xiaowen Wen, Xin Zhou

Subject: Computer Science And Mathematics, Information Systems Keywords: current field; ground-penetrating communication; signal design; detection and identification

Online: 25 May 2023 (05:08:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1608.v1

Greenery-Covered Towers: Examining Innovative Design Approaches

Kheir Al-Kodmany

Subject: Arts And Humanities, Architecture Keywords: high-rise buildings; vegetation; advantages; disadvantages; biophilic design; sustainability; greenwashing

Online: 23 May 2023 (08:06:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1098.v1

The European DEMO HCPB Breeding Blanket: Design Status at the End of Pre-Concept Design Phase

Guangming Zhou, Francisco Alberto Hernández, Pavel Pereslavtsev, Béla Kiss, Anoop Retheesh, Luis Maqueda, Jin Hun Park

Subject: Engineering, Energy And Fuel Technology Keywords: European DEMO; Helium Cooled Pebble Bed; Tritium Breeding Blanket; Design

Online: 28 April 2023 (03:46:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0059.v1

Exploring the Unbinding Mechanism of Drugs from SERT via Molecular Dynamics Simulation and its Implication in Antidepressants

Xin-Guan Tan, Xue-Feng Liu, Xin Li, Ming-Hui Pang, Yu-Qing Wang, Yun-Jie Zhao

Subject: Biology And Life Sciences, Biophysics Keywords: hSERT; comprehensive molecular dynamics (MD) simulation; drug design; MM/GBSA

Online: 3 February 2023 (06:16:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0107.v2

A Systematic Assessment for the Co-Design of Green Infrastructure Prototypes - A Case Study in Urban Costa Rica

Fernando Chapa, María Perez Rubi, Jochen Hack

Subject: Environmental And Earth Sciences, Environmental Science Keywords: green infrastructure; transdisciplinary; water systems; Costa Rica; co-design; prototype

Online: 27 December 2022 (01:55:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0078.v1

Assessment of Needs and Expectations of Expectant and New Parents as a Fundamental Step in Co-design of a mHealth Application Supporting the First 1000 Days of Life

Laura Brunelli, Sofia Bussolaro, Raffaella Dobrina, Chiara De Vita, Elena Mazzolini, Giuseppa Verardi, Maura Degrassi, Maria Piazza, Andrea Cassone, Anja Starec, Giuseppe Ricci, Sara Zanchiello, Tamara Stampalija

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: mHealth; pregnancy; app; first 1000 days; co-design; expectant parents

Online: 5 December 2022 (14:43:03 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202210.0350.v1

Experimental Natural Frequency Analysis of Moderately Thick Plates Made of Glass/Polyester Composite and Carbon

Musaddiq Al Ali

Subject: Engineering, Mechanical Engineering Keywords: composite preparation; random fiber design; natural frequency; moderate thick plates

Online: 24 October 2022 (07:09:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0034.v1

Working from Home, Telework, and Psychological Wellbeing? A Systematic Review

Joseph Crawford

Subject: Business, Economics And Management, Business And Management Keywords: remote work; telework; systematic literature review; work design; workforce planning

Online: 2 September 2022 (05:54:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0388.v1

Design and Implementation of a Time-Restricted Feeding Intervention in a Randomized, Controlled Feeding Study

Karen White, Beiwen Wu, Scott J. Pilla, Jeanne Charleston, May Thu Thu Maw, Lawrence J. Appel, Jeanne M Clark, Nisa M Maruthur

Subject: Biology And Life Sciences, Food Science And Technology Keywords: time-restricted feeding; controlled feeding study; study design; nutrition interventions

Online: 22 August 2022 (19:16:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0143.v1

Immunoinformatic Guided Rational Design of a Next Generation Multi Epitope Based Peptide Vaccine against Marburg Virus Disease Combined with Molecular Docking Studies

Mujahed Mustafa, Shaza Shantier

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Marburg virus disease (MVD); Vaccine design; Immunoinformatic; Molecular Docking Study.

Online: 10 May 2022 (14:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0139.v1

Functionally Graded Material Fabricated by Powder-based Laser Directed Energy Deposition: From Conventional to Complex Concentrated Alloys

Kun Li, Xin Wang, Wei Xiong

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Directed energy deposition; functionally graded materials; precipitation; high-throughput design

Online: 15 April 2022 (08:31:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0113.v1

Solar Radiation in Architectural Projects as a Key Design Factor for the Recovery of Alzheimer’s Outpatients

Jose-Manuel Almodovar-Melendo, Santiago Quesada-García, Pablo Valero, Joseph Cabeza-Lainez

Subject: Arts And Humanities, Architecture Keywords: Alzheimer's disease; daylighting simulation; radiative exchanges; design strategies; healthy architecture

Online: 12 April 2022 (12:24:36 CEST)

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The beneficial effects of solar radiation on human health are well documented. One necessary mechanism triggers the production of vitamin D whose insufficiency has been linked to a variety of disorders like diabetes, hypertension and more recently amyloidosis and Alzheimer disease. However, there are few architectural designs capable on ensuring adequate provision of solar radiation inside buildings. Conventional fenestration is not sufficient to provide for significant doses of sunlight even to prevent seasonal affective disorder (SAD). In this paper we discuss the effect of new design alternatives for skylights, especially in the refurbishment of obsolete facilities. After such complex retrofit is executed, we have analyzed the performance of a building in warm and sunny climates as is the case of southern Spain. It has been considered as a priority the study of the factors that relate sunlight and energy, as well as, to a certain extent, other aspects like ventilation and insulation. Many architectural designs are presented as correct if the thermal requirements alone are met, even at the risk of later energy waste in lighting devices and visual or physical discomfort. On the other hand, large glazed areas allow more daylight into a space, but they may also allow excessive heat gains or losses which increase the air-conditioning cooling or heating load. To avoid these problems, we have considered the combined effect of daylight and energy from the beginning of the skylight design-process. A daylighting software based on configuration factors that we have apply in former researches to study the problems of direct sun over architectural structures have been used. This question cannot be treated adequately with conventional programs for overcast skies. The skylights have already been constructed and on-site measurements in the offices have been taken to complement the computer simulations data. The results show that it is possible to achieve energy saving and high radiation levels in winter without increasing heat loads during the summer. All this is considered beneficial to improve the condition of users with cognitive diseases as Alzheimer’s disease by virtue of adapted spaces.

Preprint ARTICLE | doi:10.20944/preprints202202.0102.v1

Ecosystem Thinking and Methods in Design Morphology

Song Qiu, Weizi Xu, Xiao Zhang, Qiang Cui, Siyu Jin

Subject: Arts And Humanities, Architecture Keywords: Design Morphology; Ecosystem Thinking and Methods; Ecological Environment; Form Community

Online: 7 February 2022 (16:31:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0267.v1

A single-case design investigation for measuring the efficacy of Gestalt therapy to treat depression in older adults with dementia in Italy and in Mexico: a research protocol

Alessandra Merizzi, Rosanna Biasi, José Fernando Álvarez Zamudio, Margherita Spagnuolo Lobb, Sara Santini

Subject: Social Sciences, Psychology Keywords: Gestalt therapy; dementia; depression; single-case experimental design; psychosocial interventions

Online: 19 January 2022 (09:32:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0100.v1

A Switched Capacitor Memristor Emulator using Stochastic Computing

Carola de Benito, Oscar Camps, Mohamad Moner Al Chawa, Stavros G. Stavrinides, Rodrigo Picos

Subject: Engineering, Electrical And Electronic Engineering Keywords: memristor; emulator; analog design; switched capacitor; stochastic computing; mixed signal

Online: 7 December 2021 (11:41:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0376.v1

Pumping Schedule Optimization in Acid Fracturing Treatment by Unified Fracture Design

Rahman Lotfi, Mostafa Hosseini*, Davood Aftabi, Alireza Baghbanan, Guanshui Xu

Subject: Engineering, Energy And Fuel Technology Keywords: Acid fracturing; UFD; Optimization; Fracture geometry; Acid type; Design parameters

Online: 26 October 2021 (12:01:51 CEST)

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Working Paper SHORT NOTE

The Tripping Point – Minimum Planting Widths for Small-Stature Trees in Dense Urban Developments

Andrew K. Koeser, Richard J. Hauer, Deborah R. Hilbert, Robert J. Northrop, Hunter Thorn, Drew C. McLean, Allyson B. Salisbury

Subject: Biology And Life Sciences, Forestry Keywords: ecosystem disservices; green infrastructure; site design; tree selection; urban forestry

Online: 31 August 2021 (11:42:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0270.v1

Computer-aided Design of Peptidomimetic Inhibitors of falcipain-3: QSAR and Pharmacophore Models

Boris D. Bekono, Akori Esmel, Brice Dali, Fidele Ntie-Kang, Melalie Keita, Luc Calvin Owono Owono, Eugene Megnassan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: drug design; falcipain; malaria; peptidomimetics; Plasmodium falciparum; virtual screening; pharmacophore.

Online: 12 July 2021 (14:48:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0379.v1

Design of Experimental Approach Biosensor for the Development and Validation of UV Spectrophotometry Method for Determination of Thiamine in Biological Samples and Tablet Formulation

Hemraj Sharma, Hari Prasad Sapkota, Sushant Aryal, Nim Bahadur Dangi, Gaber El-Saber BATIHA, Niranjan Koirala

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: thiamine; PDAB reagent; UV Spectrophotometry; Design of experiment; pharmaceutical samples

Online: 14 June 2021 (16:04:21 CEST)

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Preprint ESSAY | doi:10.20944/preprints202102.0247.v1

Using Pathway Modeling to Evaluate and Improve Student-Centered Teaching Practices in Co-Taught College Science Courses

Xinnian Chen, John Redden, Aiyana Bobrownicki, Julia Gill, Mark Graham

Subject: Business, Economics And Management, Accounting And Taxation Keywords: course pathway modeling; student-centered classroom; course evaluation; course design

Online: 10 February 2021 (09:01:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0586.v1

Optimization of the Obtaining of Cellulose Nanocrystals from Agave Tequilana Weber Var. Azul Bagasse by Acid Hydrolysis

Manuel Alberto Gallardo-Sánchez, Tania Diaz-Vidal, Alejandra Berenice Navarro-Hermosillo, Edgar Benjamín Figueroa Ochoa, Rogelio Ramirez Casillas, José Anzaldo Hernández, Luis Carlos Rosales-Rivera, J. Felix Armando Soltero Martínez, Salvador García Enriquez, Emma Rebeca Macías-Balleza

Subject: Chemistry And Materials Science, Biomaterials Keywords: Agave tequilana; bagasse; cellulose nanocrystals; acrylic hydrolysis; AFM; factorial design

Online: 28 January 2021 (13:21:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0332.v1

An Egocentric Network Contact Tracing Experiment

Andrew Pilny, C. Joseph Huber

Subject: Social Sciences, Media Studies Keywords: contact tracing; ego networks; experimental design; social networks; field theory

Online: 14 December 2020 (13:06:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0031.v1

Optimising Embodied Energy and Thermal Performance of Thermal Insulation in Building Envelopes Via an Automated Building Information Modelling (BIM) Tool

Zixuan Chen, Ahmed W A Hammad, Imriyas Kamardeen, Ali Akbarnezhad

Subject: Engineering, Automotive Engineering Keywords: BIM; Insulation Design; Building Envelope; Multi-objective; Optimisation; Pareto-front

Online: 2 November 2020 (11:26:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0325.v1

A Bibliometric Analysis of Research on Membrane Coated Electrodes in the 2001-2019 Period: Potential Application to CO2 Capture and Utilization

Clara Casado-Coterillo, Aitor Marcos-Madrazo, Aurora Garea, Angel Irabien

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Keywords; CO2; conversion; bibliometrics; electrode design; CO2RR; membrane; flow cell

Online: 15 September 2020 (04:45:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0139.v1

The Roles of Different Design Techniques in Learning Tactical Scenes of Play through Dynamic Visualizations: A Brief Review

Ghazi Rekik, Yosra Belkhir, Mohamed Jarraya, Mohamed Amine Bouzid, Yung-Sheng Chen, Cheng-Deng Kuo

Subject: Social Sciences, Cognitive Science Keywords: Cognitive load theory; dynamic visualizations; design techniques; learning; team sports

Online: 5 September 2020 (10:41:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0047.v1

Investigation of Interfacial Microstructure and Tensile Strength of Ultrasonic Welding Joints on Nonwoven Fabrics

Hai T. Nguyen, Quang Le, Loc Nguyen, Ngo Huu Manh, Nguyen Van Anh

Subject: Engineering, Mechanical Engineering Keywords: horn design; ultrasonic welding; nonwoven fabric; micro-structure; tensile strength

Online: 5 June 2020 (14:01:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0376.v1

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, Robert D. Finn, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, René Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, Maria J. Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric Nawrocki, Áine Niamh O'Toole, Nancy Palacios-Ontiveros, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David L. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz

Subject: Biology And Life Sciences, Virology Keywords: virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools

Online: 23 May 2020 (11:01:11 CEST)

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Working Paper REVIEW

Sequencing Enabling Design and Learning in Synthetic Biology

Pierre-Aurelien Gilliot, Thomas E. Gorochowski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: sequencing; omics; synthetic biology; systems biology; machine learning; biological design

Online: 23 April 2020 (03:47:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0087.v1

While We Wait for a Vaccine Against SARS-CoV-2, Why Not Think About Available Drugs?

Francisco J. Barrantes

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Coronavirus; COVID-19; SARS-CoV-2; design drugs; ACE2; prophylaxis

Online: 7 April 2020 (11:02:13 CEST)

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At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, but full validation of this and other current developments is likely to take many more months to reach completion. The ongoing pandemic constitutes a major health burden of world proportions that is also having a devastating impact on whole economies worldwide, the knock-on effects of which could be catastrophic especially in poorer countries. Alternative measures to ameliorate the impact and hamper or minimally slow down disease progression are urgently called for. This review discusses past and currently evolving data on the etiological agent of the current pandemic, SARS-CoV-2, and its host cell receptors with a view to disclosing alternative drugs for palliative or therapeutic approaches. Firstly, SARS-CoV-2 exhibits marked tropism for cells that harbor the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) at their plasmalemma, predominantly in cells lining the oral cavity, upper respiratory tract, and bronchoalveolar cells, making these epithelial mucosae the most likely viral receptor cell targets and entry routes. Secondly, the crystal structures of several coronavirus spike proteins in complex with their cell host target receptors, and of SARS-Cov-2 in complex with an inhibitor, are now available at atomic resolution through X-ray diffraction and cryo-electron microscopy studies. Thirdly, viral entry of other viruses has been successfully blocked by inhibiting viral endogenous proteases or clathrin/dynamin-dependent endocytosis, the same internalization pathway followed by ACE2 and some viruses. Fourthly, the target cell-surface receptor molecules and SARS-CoV-2 possess other putative sites for drugs potentially modulating receptor activity or virus processing. A multi-pronged pharmacological approach attacking more than one flank of the viral-receptor interactions is worth considering as a front-line strategy.

Preprint ARTICLE | doi:10.20944/preprints202001.0271.v1

Evaluation of Process Parameters for Fiber Alignment of Electrospun Tubular Nanofibrous Matrices: A DoE Approach

Rossella Dorati, Enrica Chiesa, Silvia Pisani, Ida Genta, Tiziana Modena, Giovanna Bruni, Chiara Maria Brambilla, Marco Benazzo, Bice Conti

Subject: Chemistry And Materials Science, Biomaterials Keywords: Nanomaterials; Electrospun nanofibers; biodegradable 3D scaffolds; Electrospinning; Design of Experiments.

Online: 23 January 2020 (16:23:33 CET)

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