Version 1
: Received: 20 January 2020 / Approved: 21 January 2020 / Online: 21 January 2020 (09:58:09 CET)
How to cite:
Sabbagh, H.; Al Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S. A Statistical Study on the Development of Metronidazole-alginate-chitosan Nanocomposite Formulations using Full Factorial Designs. Preprints2020, 2020010234. https://doi.org/10.20944/preprints202001.0234.v1
Sabbagh, H.; Al Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S. A Statistical Study on the Development of Metronidazole-alginate-chitosan Nanocomposite Formulations using Full Factorial Designs. Preprints 2020, 2020010234. https://doi.org/10.20944/preprints202001.0234.v1
Sabbagh, H.; Al Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S. A Statistical Study on the Development of Metronidazole-alginate-chitosan Nanocomposite Formulations using Full Factorial Designs. Preprints2020, 2020010234. https://doi.org/10.20944/preprints202001.0234.v1
APA Style
Sabbagh, H., Al Ali, S.H., Hussein, M.Z., Abudayeh, Z., Ayoub, R., & Abudoleh, S. (2020). A Statistical Study on the Development of Metronidazole-alginate-chitosan Nanocomposite Formulations using Full Factorial Designs. Preprints. https://doi.org/10.20944/preprints202001.0234.v1
Chicago/Turabian Style
Sabbagh, H., Rami Ayoub and Suha Abudoleh. 2020 "A Statistical Study on the Development of Metronidazole-alginate-chitosan Nanocomposite Formulations using Full Factorial Designs" Preprints. https://doi.org/10.20944/preprints202001.0234.v1
Abstract
The purpose of this study was to investigate the effect of chitosan (CS) and Alginate (Alg) polymers concentrations and CaCl2 concentration on metronidazole (MET) drug loading (LE), size particles and zeta potential. Nanocomposites were prepared by ionotropic pregelation method. A (21 *31 *21) *3= 36 full factorial design (FFD) was used to predict statistical equation and responses. The MET-CS-AlgNPs nanocomposites were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscope and in vitro drug release studies. All data indicated the presence of drug into MET-CS-AlgNPs nanocomposites. The release profile of MET-CS-AlgNPs nanocomposites was found to be sustained
Keywords
Full Factorial Design; Optimization; metronidazole; nanocomposites; sodium alginate; Chitosan
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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