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Subject: Life Sciences, Biotechnology Keywords: genome-scale metabolic model; microbial community; optimization; design; engineering; computational methods; synthetic microbial consortia

Online: 23 September 2020 (09:52:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0496.v1

Exploring the Potential of β-Catenin O-GlcNAcylation by Using Fluorescence-Based Engineering and Imaging

Angelina Kasprowicz, Corentin Spriet, Christine Terryn, Matthew G. Alteen, Tony Lefebvre, Christophe Biot

Subject: Chemistry, Applied Chemistry Keywords: bioorthogonal chemistry; fluorescence; glycosylation; metabolic incorporation; GFP; beta-catenin

Online: 31 May 2020 (19:37:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0163.v1

Yarrowia lipolytica strains and their biotechnological applications: how natural biodiversity and metabolic engineering could contribute to cell factories improvement

Catherine Madzak

Subject: Biology, Other Keywords: white biotechnology; metabolic engineering; non-conventional yeast; oleaginous yeast; cell factory; heterologous expression; biodiversity; Yarrowia lipolytica; Yarrowia clade; GMO

Online: 7 June 2021 (10:50:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0079.v1

Glucose Starvation or Pyruvate Dehydrogenase Activation Induce A Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation

Abrar Ul Haq Khan, Hamideh Salehi, Catherine Alexia, José M. Valdivielso, Milica Bozic Stanojevic, Isabel Cristina López-Mejía, Lluis Fajas, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Delphine Gitenay, Martín Villalba

Subject: Life Sciences, Biochemistry Keywords: fatty acid oxidation; glycolysis; ERK5; metabolic flexibility; metabolic plasticity

Online: 8 April 2022 (11:04:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0381.v1

The Metabolic Flux Probe (MFP) - Secreted Protein as a Non-Disruptive Information Carrier for ¹³C-Based Metabolic Flux Analysis

Christian Dusny, Andreas Schmid

Subject: Life Sciences, Biochemistry Keywords: 13C-labeling; Metabolic flux analysis; Metabolic flux probe; Isotope mapping

Online: 16 July 2021 (14:49:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0461.v2

The Evolution of Cell Free Biomanufacturing

Michael Vilkhovoy, Abhinav Adhikari, Sandra Vadhin, Jeffrey Varner

Subject: Engineering, Biomedical & Chemical Engineering Keywords: cell free protein synthesis; cell free metabolic engineering; metabolic modeling

Online: 30 April 2020 (05:19:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0287.v1

1H NMR Metabolic Profiling and Meat Quality in Three Beef Cattle Breeds from Northeastern Thailand

Chirasak Phoemchalard, Suthipong Uriyapongson, Tanom Tathong, Pitukpol Pornanek

Subject: Biology, Animal Sciences & Zoology Keywords: metabolic profiling; meat quality; beef

Online: 19 October 2022 (13:10:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0280.v1

A Mechanistic Model for Genome-Scale Estimations of Metabolic Activity

Cankut Cubuk, Carlos Loucera, Marta Hidalgo, Alicia Amadoz, Jose Carbonell-Caballero, María Peña-Chilet, Joaquin Dopazo

Subject: Life Sciences, Biochemistry Keywords: metabolic pathways; mechanistic model; Transcriptomic

Online: 14 January 2021 (18:01:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0124.v1

Development of a Food-Based Index of Dietary Inflammatory Potential for Koreans and Its Relationship with Metabolic Syndrome

Woori Na, Tae Yang Yu, Cheongmin Sohn

Subject: Life Sciences, Other Keywords: metabolic syndrome; inflammation; index; Korea

Online: 10 April 2018 (09:50:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0143.v1

Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity

Babiker M. El-Haj, Samrein B.M. Ahmed, Mousa A. Qarawi, Heyam S. Ali

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: Aromatic hydroxy metabolites; arenolic drug metabolites; metabolic O-dealkylation; metabolic aromatic ring hydroxylation; primary and auxiliary pharmacophores; auxophores; metabolic modification of drug activity

Online: 9 July 2018 (13:28:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0225.v1

Positive or U-Shaped Association of Elevated Hemoglobin Concentration Levels with Metabolic Syndrome and Metabolic Components: Findings from Taiwan Biobank and UK Biobank

Vanessa Joy Timoteo, Kuang-Mao Chiang, Wen-Harn Pan

Subject: Life Sciences, Other Keywords: hemoglobin; iron nutrition status; metabolic syndrome; metabolic disorders; observational study; Taiwanese Han Chinese; European White

Online: 12 August 2022 (04:03:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0564.v1

Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases

Francesca Faggioli, Micheal Velarde, Christopher D. Wiley

Subject: Life Sciences, Other Keywords: cellular senescence; metastasis; metabolic adaptation; invasion

Online: 30 November 2022 (04:23:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0128.v1

Cut Points of the Conicity Index and Associated Factors in Brazilian Rural Workers

Camila Bruneli do Prado, Cleodice Alves Martins, Ana Clara Petersen Cremonini, Júlia Rabelo Santos Ferreira, Monica Cattafesta, Luciane Bresciani Salaroli

Subject: Medicine & Pharmacology, Nutrition Keywords: Rural Health; Obesity abdominal; Metabolic syndrome

Online: 10 October 2022 (13:59:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0554.v1

Metabolic Syndrome in Patients of a Psychosocial Care Center in Brazil: A Cross-Sectional Study

Dandara Almeida Reis da Almeida Reis da Silva, Ludmila Santana de Almeida, Livia Lugarinho Correa, Rodrigo Fernandes Weyll Pimentel, Antonio Marcos Tosoli Gomes, Ana Gabriela Travassos, Adriana Mattos Viana, Monique Monique Magnavita Borba da Fonseca Cerqueira, Marcio Costa de Souza, Anderson Reis de Sousa, Paulo José Bastos Barbosa, Julita Maria Freitas Coelho, Lucelia Batista Neves Cunha Magalhães, Argemiro D’Oliveira Júnior, Jorge Lopes Cavalcante Neto, Charles Souza Santos, Luiz Carlos Moraes França, Juliana de Lima Brandão, Livia Fajin de Mello dos Santos, Helena Ferraz Gomes, Ellen Marcia Peres, Thais Regis Aranha Rossi, Kairo Silvestre Meneses Damasceno, Magno Conceição das Merces

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Metabolic syndrome; Mental disorders; Obesity; Multimorbidity

Online: 30 November 2021 (10:38:08 CET)

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Working Paper ARTICLE

Simulating Metabolic Flexibility in Low Energy Expenditure Conditions using Genome-scale Metabolic Models

Andrea Cabbia, Peter A. J. Hilbers, Natal A. W. van Riel

Subject: Life Sciences, Biotechnology Keywords: metabolic flexibility, respiratory quotient, energy expenditure

Online: 24 May 2021 (13:48:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0005.v1

Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies

Oliwia Gawlik-Kotelnicka, Dominik Strzelecki

Subject: Medicine & Pharmacology, Allergology Keywords: depression; metabolic syndrome; microbiota; probiotics; obesity

Online: 1 April 2021 (10:07:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0272.v1

Metabolic Reprogramming, Meaning and Implications

Pierre Jacquet, Angélique Stéphanou

Subject: Life Sciences, Cell & Developmental Biology Keywords: Metabolic reprogramming; Warburg effect; Cancer metabolism

Online: 14 January 2021 (13:30:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0020.v1

Euglena Central Metabolic Pathways and Their Subcellular Locations

Sahutchai Inwongwan, Nicholas J. Kruger, R. George Ratcliffe, Ellis C. O'Neill

Subject: Biology, Plant Sciences Keywords: Euglena; central metabolic pathway; subcellular location

Online: 5 May 2019 (12:41:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0439.v1

Biosynthesis of Fatty Acid Derivatives by Recombinant Yarrowia Lipolytica Containing Msexd2 and Msexd3 Desaturase Genes from Manduca Sexta

Jaroslav Hambalko, Peter Gajdoš, Jean-Marc Nicaud, Rodrigo Ledesma-Amaro, Michal Tupec, Iva Pichová, Milan Čertík

Subject: Life Sciences, Biotechnology Keywords: Yarrowia; pheromone; desaturase; Manduca; conjugase; metabolic engineering

Online: 23 December 2022 (03:50:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0351.v1

ecBSU1: A Genome-scale Enzyme-constrained Model of Bacillus subtilis based on the ECMpy Workflow

Ke Wu, Zhitao Mao, Yufeng Mao, Jinhui Niu, Jingyi Cai, Qianqian Yuan, Lili Yun, Xiaoping Liao, Zhiwen Wang, Hongwu Ma

Subject: Biology, Other Keywords: enzyme-constrained model; Bacillus subtilis; metabolic engineering

Online: 18 November 2022 (07:09:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0019.v1

Construction and Analysis of an Enzyme‐constrained Metabolic Model of Corynebacterium glutamicum

Jinhui Niu, Zhitao Mao, Yufeng Mao, Ke Wu, Zhenkun Shi, Qianqian Yuan, Jingyi Cai, Hongwu Ma

Subject: Biology, Other Keywords: enzyme-constrained model; Corynebacterium glutamicum; metabolic engineering

Online: 1 September 2022 (09:54:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Medicine & Pharmacology, Nutrition Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0257.v1

13C-Metabolic Flux Analysis in Developing Flaxseed Embryos to Understand Storage Lipid Biosynthesis

Sebastien Acket, Anthony Degournay, Yannick Rossez, Stephane Mottelet, Pierre Villon, Adrian Troncoso-Ponce, Brigitte Thomasset

Subject: Biology, Plant Sciences Keywords: parallel labeling experiments; metabolic flux analysis; flaxseed

Online: 19 December 2019 (09:40:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0086.v1

Hyperglycemia: The Metabolic Syndrome Component That Aggravates Erectile Dysfunction in Mexican Patients

Alan Espinosa-Marrón, Christian A. Quiñones-Capistrán, Aquiles Rubio-Blancas, María del Pilar Milke-García, Ricardo A. Castillejos-Molina

Subject: Keywords: erectile dysfunction; metabolic syndrome; risk factors; hyperglycaemia

Online: 11 June 2019 (08:04:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0081.v1

Insulin Resistance Syndrome- the Sensitive IRS

Eleni Pellazgu

Subject: Medicine & Pharmacology, Nutrition Keywords: insulin resistance; diet; exercise; microbiome; metabolic disorders

Online: 9 January 2018 (10:05:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0474.v1

Identifying personalized metabolic signatures in breast cancer

Priyanka Baloni, Wikum Dinalankara, John C. Earls, Theo A. Knijnenburg, Donald Geman, Luigi Marchionni, Nathan D. Price

Subject: Life Sciences, Other Keywords: Breast cancer, genome-scale metabolic models, constraint-based analysis, divergence analysis, gene expression, metabolism, drug targets, personalized metabolic networks.

Online: 18 November 2020 (12:29:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0515.v2

The Double-edged Sword of Antioxidant Supplements on Metabolic Diseases, A Necessity for Quantification of Oxidative Status

Wei-Zheng Zhang

Subject: Medicine & Pharmacology, Other Keywords: antioxidant supplements; ROS; oxidative stress analysis; metabolic diseases

Online: 30 January 2023 (02:46:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0242.v1

Discovery of Boar Pheromones and their Functional Role in Reproduction of Mouse Deer (Moschiola Indica)

Vinod Kumar, Shivakumara Manu, Karunakaran Caroline, Anupama Sekhar, Sajwan-Khatri Mamta, Mushkam Sandeep, Wasimuddin Wasimuddin, Balasubramanian Senthilkumaran, Govindhaswamy Umapathy

Subject: Biology, Physiology Keywords: pheromones; androstenone; mouse deer; metabolic pathway; reproduction; hormones

Online: 18 October 2022 (02:44:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0062.v1

The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted

Grégorie Lebeau, Mathilde Hoareau, Daed El Safadi, Aurélie Paulo-Ramos, Philippe Desprès, Pascale Krejbich-Trotot, Florian Chouchou, Marjolaine Roche, Wildriss Viranaïcken

Subject: Life Sciences, Virology Keywords: antiviral response; ISGs; OXPHOS; mitochondrial respiration; metabolic reprogramming

Online: 5 September 2022 (13:13:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0507.v1

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Alicja Kołodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka

Subject: Medicine & Pharmacology, Pediatrics Keywords: vitamin D; osteopenia; prematurity; metabolic bone disease; rickets

Online: 26 August 2021 (11:54:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0189.v1

Simultaneous Recording of the Uptake and Conversion of Glucose and Choline in Tumors by Deuterium Metabolic Imaging (DMI)

Andor Veltien, Jack van Asten, Niveditha Ravichandran, Robin De Graaf, Henk De Feyter, Egbert Oosterwijk, Arend Heerschap

Subject: Medicine & Pharmacology, Allergology Keywords: MRI; deuterium metabolic imaging; tumor; 2H; glucose; choline

Online: 8 July 2021 (10:06:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0543.v1

The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity – PRO-DEMET Randomised Study Protocol

Oliwia Gawlik-Kotelnicka, Anna Skowrońska, Aleksandra Margulska, Karolina H. Czarnecka-Chrebelska, Igor Łoniewski, Karolina Skonieczna-Żydecka, Dominik Strzelecki

Subject: Medicine & Pharmacology, Allergology Keywords: depression; metabolic syndrome; probiotics; microbiota; inflammation; oxidative stress

Online: 24 February 2021 (11:20:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0583.v1

An Optimized Ustilago Chassis for Itaconic Acid Production at Theoretical Maximal Yield

J. Becker, H. Hosseinpour Tehrani, P. Ernst, L. M. Blank, N. Wierckx

Subject: Life Sciences, Biochemistry Keywords: Itaconic acid; U. maydis; Metabolic engineering; Fungi; Yeast

Online: 23 November 2020 (13:47:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0610.v1

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism

Caroline Geisler, Benjamin Renquist

Subject: Biology, Physiology Keywords: GPR109a; β-OH butyrate; niacin; metabolic homeostasis; liver

Online: 27 August 2020 (10:32:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0205.v1

Incorporating an Increase in Plant-Based Food Choices into a model of Culturally Responsive Care for Obesity in Hispanic/Latino Adults and Children

Pramil Singh, Jessica Steinbach, Anna Nelson, Wendy Shih, Mary D'Avila, Selene Castilla, Michael Jordan, William McCarthy, David Hayes Bautista, Hector Flores

Subject: Medicine & Pharmacology, Nutrition Keywords: diabetes; vegetarian; diet; nutrition; metabolic syndrome; disparity; child

Online: 17 October 2019 (15:24:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0315.v1

Prevalence of Metabolic Syndrome and Its Associated Factors among Vegetarians in Malaysia

Yuan Kei Ching, Yit Siew Chin, Mahenderan Appukutty, Wan Ying Gan, Vasudevan Ramanchadran, Yoke Mun Chan

Subject: Medicine & Pharmacology, Nutrition Keywords: metabolic syndrome; vegetarian; vegetarianism practices; overweight; lifestyle behaviors

Online: 20 June 2018 (08:49:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201803.0064.v2

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

Marit K. Zinöcker, Inge A. Lindseth

Subject: Medicine & Pharmacology, Nutrition Keywords: western diet; microbiome; food processing; inflammation; metabolic diasease

Online: 19 March 2018 (07:31:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201706.0121.v1

Molecular interactions of autophagy with the immune system and cancer

Yonggeun Hong, Yunho Jin, Yunkyung Hong, Chanyoung Park

Subject: Life Sciences, Immunology Keywords: autophagy； immune system； cancer；cell death；metabolic homeostasis

Online: 27 June 2017 (06:30:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0198.v1

Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes

Mansor Fazliana, Zubaidah Nor Hanipah

Subject: Medicine & Pharmacology, General Medical Research Keywords: diabetes; bariatric surgery; metabolic surgery; hormones; adipokines; microRNA; metabolomic

Online: 14 October 2022 (03:12:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0202.v1

SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome

Clayton Goddard, Karin Allenspach, Audrey Deflandre, Claudine Zemirline, Emilie Guillot, Jonathan P. Mochel

Subject: Medicine & Pharmacology, Other Keywords: Metabolic syndrome; SGLT2 inhibitors; Dapagliflozin; Empagliflozin; Canagliflozin; Translational modeling

Online: 21 April 2022 (10:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0463.v1

Examine the Association between Metabolic Syndrome and Frailty in an Older Asian Population

Hiep Huu Hoang Dao, Anh Trung Nguyen, Huyen Thi Thanh Vu, Tu Ngoc Nguyen

Subject: Medicine & Pharmacology, Cardiology Keywords: metabolic syndrome; diabetes; hypertension; obesity; frailty; older people; Asian

Online: 29 December 2021 (12:09:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0188.v1

Modifiable Lifestyle Factors and their Relationships with Metabolic Disorders among Adults in Burkina Faso: Findings from the First National Survey

Jeoffray Diendéré, Jean Kaboré, Augustin Nawidimbasba Zeba, William Kofi Bosu, Jérôme Winbetourefa Somé, Franck Garanet, Victor Pingdéwendé Ouédraogo, Abdoul Aziz Savadogo, Athanase Millogo

Subject: Medicine & Pharmacology, General Medical Research Keywords: Modifiable lifestyle factors; Metabolic disorders; Prevalence; Relationships; Burkina Faso

Online: 12 October 2021 (21:02:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0637.v1

The Association Between Vitamin C Deficiency and Metabolic Syndrome Among Patients Who Developed Kidney Disease

Ayenew Negesse, Beminet Moges, Tigest kebede, Abiy Kifle, Dagim Alemayehu, Yilkal Negesse, Sisay Tesfaye, Alemu Fite

Subject: Medicine & Pharmacology, Allergology Keywords: Metabolic syndrome; vitamin C deficiency; kidney disease; Albuminuria; USA

Online: 26 May 2021 (13:10:40 CEST)

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Introduction: Elevated albuminuria is an important outcome of diabetic complications and metabolic syndrome (MetS), the complex metabolic abnormalities manifested as glucose intolerance, hypertension, and dyslipidemia and enlarged waist circumference. These coexisting cardio-metabolic abnormalities are also associated with oxidative stress and low grade inflammation. Vitamin C (vitC) has long been recognized as hydrophilic antioxidant and blocker of oxidative stress which also has a protective role of MetS and kidney disease. Objective: The aim of this study was to identify the predictive effect of vitC deficiency on kidney disease among patients who developed metabolic syndrome. Method and procedures: To meet this objective, the National Health and Nutrition Examination Survey (NHANES) 2007-2008 data were used. NHANES represents the civilian, non-institutionalized US population data implemented for continuous system of monitoring health, nutritional status and well-being in the US. The predictive power of MetS on AU and vitC deficiency (vitC < 0.25 mg/dl) as effect modifier was assessed with binary logistic regression. Age, gender, race and BMI were used as covariates. Results: Among the respondents, 1.9% of the US population had risk of kidney damage, whereas 14.5 % of respondents had MetS. MetS was significantly positively correlated with AU (p < 0.01). Higher elevation of albuminuria creatinine ratio (ACR) was found in participants with VCD. The regression models developed in this study showed that the severity of kidney disease measured by ACR was increased among individuals who developed both VCD and MetS compared with individuals who developed MetS only (AOR=5.53; 95% CI: 2.73, 11.21). Increasing age and being African-American in race were independently associated with elevated AU. Conclusion: Specific considerations tailored to metabolic syndrome, vitamin C and kidney diseases measured by ACR screening and monitoring mechanisms at the community level is critical to tackle further medical complications. Moreover, the role of VitC fortified foods on prevention of kidney diseases among patients with MetS warrant further investigation.

Preprint ARTICLE | doi:10.20944/preprints202103.0023.v1

Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated with Maternal Undernutrition

Polyxeni-Maria Sarli, Antigoni Manousopoulou, Elias Efthymiou, Andreas Zouridis, Anastasios Potiris, Panagiota Pervanidou, Konstantinos Panoulis, Nikolaos Vlahos, Efthimios K. Deligeoroglou, Spiros D. Garbis, Makarios Eleftheriades

Subject: Medicine & Pharmacology, Allergology Keywords: FGR; fetal programming; food restriction; metabolic disorders; liver proteomics

Online: 1 March 2021 (13:54:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0516.v1

From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) – New Terminology in Pediatric Patients as a Step in Good Scientific Direction?

Marta Flisiak-Jackiewicz, Anna Bobrus-Chociej, Natalia Wasilewska, Dariusz Lebensztejn

Subject: Medicine & Pharmacology, Allergology Keywords: MAFLD; NAFLD; fatty liver; metabolic syndrome; obesity; children; nomenclature

Online: 25 January 2021 (15:36:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0399.v1

The Association between Vitamin C Deficiency and Metabolic Syndrome among Patients who Developed Kidney Disease

Ayenew Negesse, Beminet Moges, Tigest Kebede, Abiy Kifle, Dagim Alemayehu, Yilkal Negesse, Sisay Tesfaye, Alemu Fite

Subject: Medicine & Pharmacology, Allergology Keywords: metabolic syndrome; vitamin C deficiency; kidney disease; Albuminuria; USA

Online: 16 December 2020 (09:43:21 CET)

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Introduction: Elevated albuminuria is an important outcome of diabetic complications and metabolic syndrome (MetS), the complex metabolic abnormalities manifested as glucose intolerance, hypertension, and dyslipidemia and enlarged waist circumference. These coexisting cardio-metabolic abnormalities are also associated with oxidative stress and low grade inflammation. Vitamin C (vitC) has long been recognized as hydrophilic antioxidant and blocker of oxidative stress which also has a protective role of MetS and kidney disease. Objective: The aim of this study was to identify the predictive effect of vitC deficiency on kidney disease among patients who developed metabolic syndrome. Method and procedures: To meet this objective, the National Health and Nutrition Examination Survey (NHANES) 2007-2008 data were used. NHANES represents the civilian, non-institutionalized US population data implemented for continuous system of monitoring health, nutritional status and well-being in the US. The predictive power of MetS on AU and vitC deficiency (vitC < 0.25 mg/dl) as effect modifier was assessed with binary logistic regression. Age, gender, race and BMI were used as covariates. Results: Among the respondents, 1.9% of the US population had risk of kidney damage, whereas 14.5 % of respondents had MetS. MetS was significantly positively correlated with AU (p < 0.01). Higher elevation of albuminuria creatinine ratio (ACR) was found in participants with VCD. The regression models developed in this study showed that the severity of kidney disease measured by ACR was increased among individuals who developed both VCD and MetS compared with individuals who developed MetS only (AOR=5.53; 95% CI: 2.73, 11.21). Increasing age and being African-American in race were independently associated with elevated AU. Conclusion: Specific considerations tailored to metabolic syndrome, vitamin C and kidney diseases measured by ACR screening and monitoring mechanisms at the community level is critical to tackle further medical complications. Moreover, the role of VitC fortified foods on prevention of kidney diseases among patients with MetS warrant further investigation.

Preprint ARTICLE | doi:10.20944/preprints202006.0283.v1

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Kamila Bonifacio, Michael Maes, Carine de Farias, Andressa Matsumoto, Crisieli Tomereli, Danilo Pereira da Silva, Edilson Cyrino, Suzana Nixdorf, Danielle Venturini, Decio Barbosa

Subject: Medicine & Pharmacology, General Medical Research Keywords: Metabolic Syndrome; Obesity; inflammation; Oxidative Stress; nitrosative stress; biomarkers

Online: 23 June 2020 (11:35:38 CEST)

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Working Paper ARTICLE

Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High Fat Diet Fed Mice

Zibusiso Mkandla, Tinashe Mutize, Phiwayinkosi V. Dludla, Bongani B. Nkambule

Subject: Medicine & Pharmacology, Nutrition Keywords: high fat diet; metabolic dysregulation; platelets; monocytes; hypercoagulation; inflammation

Online: 27 October 2019 (03:13:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0015.v1

Beneficial Effects of Multicomponent Functional Foods in Patients with Metabolic Syndrome

Simona Dragan, Georgiana Damian, Dana Velimirovici, Maria Rada, Delia Berceanu, Mircea Iurciuc, Marius Badalica-Petrescu, Mihaela Valcovici, Carmen Socaciu, Ruxandra Christodorescu

Subject: Medicine & Pharmacology, Nutrition Keywords: metabolic syndrome; multicomponent functional foods; antioxidant bioactive ingredients; polyphenols

Online: 2 November 2018 (05:06:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0274.v1

Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene-Bran Metabolite Relationships

Iman Zarei, Emily Luna, Jan E. Leach, Anna McClung, Samuel Vilchez, Ousmane Koita, Elizabeth P. Ryan

Subject: Chemistry, Food Chemistry Keywords: rice bran; rice genes; rice cultivars; metabolic pathway; metabolomics

Online: 15 September 2018 (19:34:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0210.v1

Intestinal Microbial and Metabolite Profiling of Mice Fed with Dietary Glucose and Fructose

João C. P. Silva, Marta Mota, Fátima O. Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S. Barros, John G. Jones, Ana M. Gil

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: fructose; intestinal microbiota; short-chain fatty acids; metabolic profiling

Online: 23 January 2018 (05:31:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine & Pharmacology, Nutrition Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0467.v1

Genetic Diversity of Cytochrome P450s CYP6M2 and CYP6P4 Associated with Pyrethroid Resistance in the Major Malaria Vectors Anopheles coluzzii and Anopheles gambiae from Yaoundé, Cameroon

Yvan Gaetan Fotso-Toguem, Billy Tene-Fossog, Leon M.J. Mugenzi, Murielle J. Wondji, Flobert Njiokou, Hilary Ranson, Charles S. Wondji

Subject: Biology, Entomology Keywords: CYP6M2; CYP6P4; polymorphism; metabolic resistance; pyrethroid; Anopheles coluzzii; Anopheles gambiae

Online: 25 November 2022 (05:51:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0026.v1

Tracking Obesity Phenotypes in Korean Adults Based on KNHANES (2015-2019)

Jieun Shin, Okhyun Kim, Myoungsook Lee

Subject: Medicine & Pharmacology, Nutrition Keywords: obesity phenotypes, obesogenic environments, metabolic syndrome, K-score, food pattern

Online: 1 November 2022 (09:36:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0239.v1

Bioengineering of Escherichia coli Nissle 1917 for Overproduction and Excretion of Spermidine, a Key Metabolite in Human Health

Clement Caffaratti, Caroline Plazy, Valérie Cunin, Bertrand Toussaint, Audrey Le Gouellec

Subject: Life Sciences, Biotechnology Keywords: Microbiota; Immunity; Spermidine; Metabolic engineering; Probiotics; Live Biotherapeutic Product; Metabolomics

Online: 17 October 2022 (12:09:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0355.v1

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates

Surbhi Jain, Utkarsha Sahu, Awanish Kumar, Prashant Khare

Subject: Life Sciences, Other Keywords: Leishmania; Human Pathogen; Targeting Metabolic Pathways; Repurposed Drugs; New Antileishmanials.

Online: 27 June 2022 (08:47:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0014.v1

Microbial Degradation of Pharmaceuticals

Swathi Kandhasamy, Sudha Balraj, Suganya Kanagaraj, Sumathi Sundaravadivelu

Subject: Life Sciences, Other Keywords: pharmaceutical toxicants; recalcitrant pollutants; co-metabolic pathways; biostimulation; bioaug-mentation

Online: 1 June 2022 (10:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0071.v1

Macronutrient Intake in Adults Diagnosed with Metabolic Syndrome: using the Health Examinee (HEXA) Cohort

Hyerim Park, Anthony Kityo, Yeon-Jin Kim, Sang-Ah Lee

Subject: Medicine & Pharmacology, Nutrition Keywords: Macronutrient intake; Metabolic syndrome; the Korean Health Examinee (HEXA) stud

Online: 3 November 2021 (09:07:55 CET)

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Working Paper ARTICLE

Associations between Dietary Pattern, Bioactive Algal Nutrients Supplementation and Metabolic Risk Markers in Japanese Women: The NAMI Pilot Study

Ngatu Roger Nlandu, Tomohiro Hirao, Mitsunori Ikeda

Subject: Medicine & Pharmacology, Allergology Keywords: Adiponectin; Adiponectin modulation inducer; C-reactive protein; Metabolic marker; Sujiaonori.

Online: 20 July 2021 (14:46:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0415.v1

Associations between Bioactive Algal Biomaterial Supplementation, Dietary Pattern and Metabolic Risk Markers in Japanese Women

Nlandu Roger Ngatu, Tomohiro Hirao, Mitsunori Ikeda

Subject: Medicine & Pharmacology, General Medical Research Keywords: Adiponectin; Adiponectin modulation inducer; C-reactive protein; Metabolic marker; Sujiaonori.

Online: 19 July 2021 (14:28:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0202.v1

The Metabolic Bone Disease X-Linked Hypophosphatemia: Case Presentation, Pathophysiology and Pharmacology

Jon Vincze, Brian W Skinner, Katherine A Tucker, Jonathan W Lowery, Julia M Hum

Subject: Medicine & Pharmacology, General Medical Research Keywords: metabolic bone disease; burosumab; KRN23; x-linked hypophosphatemia; crysvita; xlh

Online: 10 May 2021 (14:37:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0209.v1

Utilizing the Food-Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach

Snehal R. Jadhav, Rohan M. Shah, Avinash V. Karpe, Robert Barlow, Kate McMillan, Michelle L. Colgrave, David J. Beale

Subject: Chemistry, Analytical Chemistry Keywords: leafy greens; spinach; metabolomics; metabolic profiling; food pathogens; biomarker discovery

Online: 12 January 2021 (08:20:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0338.v1

Treatment Strategies and Metabolic Pathway Regulation in Urothelial Cell Carcinoma: A Comprehensive Review

Huang-Yu Yang, Chao-Yi Wu, Jia-Jin Chen, Tao-Ha Lee

Subject: Medicine & Pharmacology, Allergology Keywords: Urothelial carcinoma; immune checkpoint inhibitors; immunotherapy; tumor microenvironment; metabolic pathway

Online: 16 October 2020 (08:00:41 CEST)

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Working Paper REVIEW

Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19

Ersilia Nigro, Rita Polito, Andreina Alfieri, Annamaria Mancini, Esther Imperlini, Ausilia Elce, Peter Krustrup, Stefania Orrù, Pasqualina Buono, Aurora Daniele

Subject: Keywords: Physical Activity; COVID-19; healthy lifestyle; metabolic disorders; immune system

Online: 7 June 2020 (11:31:17 CEST)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine & Pharmacology, Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0132.v1

Geography of Food Consumption Patterns between South and North China

Fangfang Song, Mi Sook Cho

Subject: Medicine & Pharmacology, Nutrition Keywords: Chinese adults; north region; south region; dietary pattern; metabolic syndrome

Online: 31 October 2016 (02:51:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0300.v1

Profiling of G-protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research

Saeed Al Mahri, Meshail Okla, Mamoon Rashid, Shuja Shafi Malik, Jahangir Iqbal, Maria Al Ibrahim, Ghida Dairi, Amer Mahmood, Manikandan Muthurangan, Ahmed Yaqinuddin, Sameer Mohammad

Subject: Biology, Physiology Keywords: adipose tissue; adipogenesis; G-protein-coupled receptors; thermogenesis; obesity; metabolic syndrome

Online: 16 November 2022 (08:52:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0230.v1

Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers

Olatunbosun Arowolo, J. Richard Pilsner, Oleg Sergeyev, Alexander Suvorov

Subject: Life Sciences, Molecular Biology Keywords: PBDE; dose-response relationships; mTOR signaling; steroidogenesis; metabolic disruption; sperm epigenome

Online: 17 October 2022 (05:37:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0146.v1

Basal Metabolism, Body Composition and Physical Activity with Central Obesity in Adults: A Systematic Review

Génesis Chen, Claudia Lora, Diana Rodríguez, Victoria Valdés, Fabiana Pirán, Alex Brito, Israel Ríos-Castillo

Subject: Life Sciences, Other Keywords: central obesity; waist circumference; physical activity; basal metabolic rate; body composition

Online: 12 September 2022 (11:36:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0082.v1

Purinergic Receptors Are a Key Bottleneck in Tumor Metabolic Reprogramming: The Prime Suspect in Cancer Therapeutic Resistance

Hamid Aria, Marzieh Rezaei, Shima Nazem, Abdolreza Daraei, Ghasem Nikfar, Behnam Mansoori, Maryam Bahmanyar, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

Subject: Biology, Other Keywords: therapy resistance; tumor microenvironment; metabolic reprogramming; purinergic receptor; cancer metabolism; immunometabolism

Online: 3 August 2022 (10:35:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0306.v1

Usefulness of Novel Atherogenic Lipid Indices for The Evaluation of Metabolic Status Leading to Coronary Heart Disease in A Real-World Survey of The Japanese Population

Isamu Matsunaga, Miyuki Ando, Yuki Tsubakimoto, Miyuki Nagasawa, Yoshimasa Kurumi

Subject: Medicine & Pharmacology, Other Keywords: Atherogenesis; metabolic status; lipid index; coronary heart disease; medical check-up

Online: 23 March 2022 (03:34:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0294.v1

Meal Timing, Meal Frequency and Metabolic Syndrome

Fatema Alkhulaifi, Charles Darkoh

Subject: Life Sciences, Virology Keywords: meal timing; meal frequency; skipping meals; fasting; obesity; metabolic syndrome; diabetes

Online: 22 March 2022 (04:20:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0382.v1

Employing Statistical Machine Reading for Inferring Key Concepts of a Research Field From a Body of Abstracts and Blog Posts

Wenfa Ng

Subject: Mathematics & Computer Science, Artificial Intelligence & Robotics Keywords: statistical machine reading; metabolic engineering; concepts; terms and phrases; computational complexity

Online: 26 October 2021 (12:27:54 CEST)

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The world of science is drowned in a wealth of information. How to make sense of this wealth of published articles, blog posts and abstracts has become an important challenge given the importance of science to different aspects of societal function. At the crux of the issue lies the increasing trend where scientific discovery informs decision making at the societal level. One example, is the elucidation of the ozone hole to the promulgation of the Montreal Protocol in 1987, and documenting increasing atmospheric carbon dioxide concentration led to climate action and signing of the Paris Agreement in 2015. Hence, understanding a research field becomes an important need for many decision makers across different sectors of society. But, the scientific literature is cryptic and esoteric, and presents a significant barrier to comprehension. One approach to ameliorate the problem is statistical machine reading, which provides the critical capability of identifying key concepts that underpins a research field. Such important concepts help provide an incision point to gain further understanding of the field and initiating further conversation about the field. This work sought to validate the concept of whether applying statistical machine reading to a body of literature comprising short blog posts and abstracts of published articles help in understanding the field of metabolic engineering. One important angle pursued in this research is whether the tabulated list of terms and phrases identified by statistical machine reading could be creatively analyzed to gain a deeper understanding of the research field. For example, the most frequently occurring terms and phrases could describe key concepts of the research field. Moving down in frequency occurrence would be terms and phrases that describe methodologies and approaches of the field. Finally, less frequently occurring terms and phrases may be tools and resources used in the research field. Results validated the utility of statistical machine reading in identifying important terms and phrases associated with the research field. But the small dataset of blog posts and abstracts used in this study severely hampered the identification of most of the key concepts of metabolic engineering, which is a fairly broad field of research. Overall, statistical machine reading shows utility in identifying terms and phrases that could describe a field. However, the level of understanding is closely tied in to the breadth and depth of reading material available, which meant that the methodology is data intensive in nature. Future use of supercomputing or quantum computing could help alleviate constraints of computational capacity, and help tackle the exponential rise in computational complexity as the size of the reading material for machine reading expands.

Preprint ARTICLE | doi:10.20944/preprints202110.0035.v1

Distinguishing Between Isobaric Ions Using Microdroplet Hydrogen-Deuterium Exchange Mass Spectrometry

Xiaowei Song, Jia Li, Mohammad Mofidfar, Richard N. Zare

Subject: Chemistry, Analytical Chemistry Keywords: hydrogen-deuterium exchange; mass spectrometry; isobaric ions; ambient ionization; metabolic profiling

Online: 4 October 2021 (09:21:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0123.v1

Effects of Caffeinated and Decaffeinated Coffee Consumption on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials

Nur Nadiah Syuhada Ramli, Areej A Alkhaldy, Abbe Maleyki Mhd Jalil

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: metabolic syndrome; caffeinated coffee; decaffeinated coffee; green coffee extract; chlorogenic acid

Online: 4 August 2021 (22:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0434.v1

Going beyond Soil Conservation with the Use of Cover Crops in Mediterranean Sloping Olive Orchards

Luis F. Arias-Giraldo, Gema Guzmán Díaz, Miguel Montes-Borrego, David Gramaje, José A. Gómez, Blanca B. Landa

Subject: Life Sciences, Biochemistry Keywords: bacterial community composition; metabolic activity; microbial diversity; soil erosion; soil quality

Online: 16 June 2021 (10:23:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0342.v1

Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis

Ifan Ali Wafa, Nando Reza Pratama, Nurizzah Farahiyah Sofia, Elsha Stephanie Anastasia, Tiffany Konstantin, Maharani Ayuputeri Wijaya, M. Rifqi Wiyono, Lilik Djuari, Hermina Novida

Subject: Medicine & Pharmacology, Allergology Keywords: COVID-19 lockdown; diabetes mellitus; meta-analysis; metabolic control; systematic review

Online: 14 June 2021 (09:44:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0730.v1

The Role of Cellular Stress in Intrauterine Growth Restriction and Postnatal Dysmetabolism

Shelby L Oke, Daniel Barry Hardy

Subject: Life Sciences, Biochemistry Keywords: intrauterine growth restriction (IUGR); metabolism; cell stress; cell death; metabolic syndrome

Online: 31 May 2021 (10:19:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0358.v1

Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery

Consuelo Ripoll, Pilar Herrero-Foncubierta, Virginia Puente-Muñoz, M. Carmen Gonzalez-Garcia, Delia Miguel, Sandra Resa, Jose M. Paredes, Maria J. Ruedas-Rama, Emilio Garcia-Fernandez, Miguel Martin, Mar Roldan, Susana Rocha, Herlinde De Keersmaecker, Johan Hofkens, Juan M. Cuerva, Angel Orte

Subject: Chemistry, Analytical Chemistry Keywords: Antitumor agents; Fluorescence lifetime imaging; Medicinal chemistry; Metabolic drug; Mitochondrial carrier

Online: 15 December 2020 (08:35:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0301.v1

The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals

Natalie Wallis, Eleanor Raffan

Subject: Life Sciences, Genetics Keywords: Obesity; Genetics; Companion Animals; Metabolic Disease; Comparative Genomics; Dogs; Cats; Horses

Online: 14 October 2020 (10:51:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Working Paper REVIEW

Corrective Metabolism: An Appreciation

Dan Fraenkel

Subject: Life Sciences, Microbiology Keywords: metabolism; metabolic by products; overflow; damage; toxicity; repair; geneticist-induced stress

Online: 20 June 2019 (10:10:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0094.v1

Irreversibility as Thermodynamic Time

Charles C. Hwang

Subject: Physical Sciences, Other Keywords: time; availability; irreversibility; time dilation; biological clock; metabolic efficiency; telomere; mitochondria

Online: 8 May 2019 (11:21:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0078.v1

Factors Influencing the Production of Different Types of Fatty Acid and Staphyloxanthin in the Staphylococcus aureus Membrane

Kiran Tiwari, Craig Gatto, Brian J. Wilkinson

Subject: Life Sciences, Microbiology Keywords: membrane fatty acids composition; Staphylococcus aureus; staphyloxanthin; membrane fluidity; metabolic regulation

Online: 6 April 2018 (11:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0194.v1

Adipose Tissue Caveolin-1 Upregulation in Obesity Involves TNF-α/NFκB Mediated Signaling.

Ashraf Al Madhoun, Shihab Kochumon, Dania Haddad, Reeby Thomas, Rasheeba Nizam, Lavina Miranda, Sardar Sindhu, Milad S. Bitar, Rasheed Ahmad, Fahd Al-Mulla

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: Caveolin 1; Obesity; Adipose tissue; Metabolic inflammation; Cytokines; TNF-α; NF-κB

Online: 12 December 2022 (06:02:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0320.v1

A Time-series Metabolomic Analysis of SARS-CoV-2 Infection in a Ferret Model

Avinash V. Karpe, Thao V. Nguyen, Rohan Shah, Gough G. Au, Alexander J. McAuley, Glenn A. Marsh, Sarah Riddell, Seshadri S. Vasan, David J. Beale

Subject: Life Sciences, Biochemistry Keywords: COVID19; SARS-CoV-2; metabolomics; omics; animal models; ferret; host metabolic responses

Online: 21 October 2022 (03:55:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0059.v1

The Staphylococcus Epidermidis RP62A Metabolic Network: Validation and Intervention Strategies

Francisco Guil, Guillermo Sánchez-Cid, José Manuel García

Subject: Biology, Other Keywords: Staphylococcus epidermidis; metabolic network validation; minimal cut sets; knock-outs; systems biology

Online: 2 August 2022 (09:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0212.v1

Comparison of Different Label-free Techniques for the Semi-absolute Quantification of Protein Abundance

Aarón Millán-Oropeza, Mélisande Blein-Nicolas, Véronique Monnet, Michel Zivy, Céline Henry

Subject: Life Sciences, Biochemistry Keywords: label free; metabolic models; Saccharomyces; semi-absolute quantification; quantitative proteomics; TPA; UPS2.

Online: 13 December 2021 (16:04:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0124.v2

Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome

Anca Maria Amzolini, Fortofoiu Mircea-Catalin, Anca Barău Al-Hija, Ionela Mihaela Vladu, Diana Clenciu, Adina Mitrea, Maria Fortofoiu, Daniela Matei, Magdalena Diaconu, Marinela Sinziana Tudor, Elena Simona Micu

Subject: Medicine & Pharmacology, Gastroenterology Keywords: nonalcoholic liver disease; triglyceride and glucose index; metabolic syndrome; liver biopsy; obesity

Online: 8 October 2021 (13:34:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0280.v1

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase

Colbie Reed, Geoffrey Hutinet, Valérie de Crécy-Lagard

Subject: Life Sciences, Biochemistry Keywords: comparative genomics; metabolic reconstruction; bioinformatics; conserved unknowns; function prediction; functional annotation; orthology

Online: 13 July 2021 (08:58:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0457.v1

Body Mass Index and Birth Weight Improve Polygenic Risk Score for Type 2 Diabetes

Avigail Moldovan, Yedael Y. Waldman, Nadav Brandes, Michal Linial

Subject: Medicine & Pharmacology, Allergology Keywords: Body weight; Genetic variations; GWAS; Metabolic disease; Obesity; Sex difference; UK-Biobank

Online: 20 May 2021 (08:55:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0487.v1

Increased Nitro-Oxidative Toxicity in Association With Metabolic Syndrome, Atherogenicity and Insulin Resistance in Patients With Affective Disorders

Nayara Morelli, Michael Maes, Kamila Bonifacio, Heber Vargas, Sandra Nunes, Decio Barbosa

Subject: Medicine & Pharmacology, Allergology Keywords: Major depression; Bipolar disorder; Metabolic syndrome; oxidative and nitrosative stress, antioxidants; biomarkers.

Online: 18 March 2021 (15:56:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0822.v1

Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease – The Union of Two Culprits

Saad Emhmed Ali, Mindie H. Nguyen

Subject: Medicine & Pharmacology, Gastroenterology Keywords: Sarcopenia; Non-alcoholic Fatty Liver Disease; Obesity, Insulin Resistance; Prevalence; Metabolic Diseases

Online: 31 December 2020 (15:34:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0069.v1

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms using Computational Systems Biology Approaches

Sahar Aghakhani, Naouel Zerrouk, Anna Niarakis

Subject: Biology, Other Keywords: Fibroblasts; Rheumatoid Arthritis; Cancer; Metabolic Reprogramming; Glycolytic Switch; Systems Biology; Computational Modelling

Online: 2 November 2020 (19:28:02 CET)

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Working Paper ARTICLE

Body Shape Index and Body Roundness Index: Two New Body Indices for Prediction of Multiple Metabolic Risk Factors in Southern China Adults

Jinjian Xu, Qiong Wu, Yaohan Zhou, Ziqi Jin, Yimin Zhu

Subject: Life Sciences, Molecular Biology Keywords: body shape index; body roundness index; metabolic risk factors; Southern China adults

Online: 24 May 2020 (16:44:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0169.v1

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Liudmyla Lazarenko, O. Melnikova, Lidiia Babenko, Rostyslav Bubnov, Tetiana Beregova, Tetiana Falalyeyeva, Mykola Spivak

Subject: Medicine & Pharmacology, Nutrition Keywords: metabolic syndrome; diabetes mellitus; obesity, lactobacilli; bifidobacteria; glucose; macrophages; inflammation; mouse model

Online: 8 August 2018 (14:27:20 CEST)

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