Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction

Sandra da Silva Silveira
* ,
Veridiana Mota Moreira
* ORCID logo ,
Maria Natália Chimirri Peres
,
Lucas Paulo Jacinto Saavedra
ORCID logo ,
Laize Peron Tófolo
,
Flávio Andrade Andrade
,
Tatiane Aparecida Ribeiro Domingos
,
Claudinéia Conationi Da Silva Franco
,
Christian Moreira Mendes
,
Ananda Malta
ORCID logo ,
Douglas Lopes Almeida
ORCID logo ,
Paulo Cezar de Freitas Mathias
Version 1 : Received: 14 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (10:58:52 CEST)

How to cite: Silveira, S.D.S.; Moreira, V.M.; Peres, M.N.C.; Saavedra, L.P.J.; Tófolo, L.P.; Andrade, F.A.; Ribeiro Domingos, T.A.; Da Silva Franco, C.C.; Mendes, C.M.; Malta, A.; Almeida, D.L.; Mathias, P.C.D.F. Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction. Preprints 2023, 2023071077. https://doi.org/10.20944/preprints202307.1077.v1 Silveira, S.D.S.; Moreira, V.M.; Peres, M.N.C.; Saavedra, L.P.J.; Tófolo, L.P.; Andrade, F.A.; Ribeiro Domingos, T.A.; Da Silva Franco, C.C.; Mendes, C.M.; Malta, A.; Almeida, D.L.; Mathias, P.C.D.F. Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction. Preprints 2023, 2023071077. https://doi.org/10.20944/preprints202307.1077.v1

Abstract

The purpose of this study was to examine the impact of fructose consumption during the peri-pubertal period on the later onset of metabolic syndrome in rats. Additionally, the study sought to explore the potential of moderate-intensity physical training as a non-pharmacological approach to mitigate the fructose effects. Male rats, 30 days old, received 10% fructose, and were submitted to concomitant moderate-intensity training until 60 days old. They were divided into 4 groups: sedentary control (SC), sedentary fructose (SF), trained control (TC), and trained fructose (TF). Fructose consumption mainly affected adult animals, resulting in glucose intolerance, increased periepididymal fat, and increased total cholesterol, triglycerides, and insulin levels. Furthermore, these rats exhibited reduced sympathetic nerve activity. The moderate running led to a decrease in periepididymal and retroperitoneal adipose tissue, as well as a reduction in total cholesterol and improved glucose tolerance. Peri-pubertal rats that received combination treatments exhibited lower levels of glucose and insulin during an intraperitoneal glucose tolerance test. The results indicate that 10% fructose supplementation during peripuberty predisposes to metabolic syndrome in adulthood. However, simultaneous moderate-intensity exercise training attenuates these effects and induces positive changes in glycemic homeostasis, lipid metabolism, and autonomic nervous system activity.

Keywords

aerobic exercise training; metabolic programming; DOHaD; adolescence

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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