Version 1
: Received: 1 March 2023 / Approved: 2 March 2023 / Online: 2 March 2023 (09:44:53 CET)
How to cite:
Quan, Q.; Yoon, K.; Lee, J.S.; Kim, E.J.; Lee, D.H. The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications. Preprints2023, 2023030039. https://doi.org/10.20944/preprints202303.0039.v1
Quan, Q.; Yoon, K.; Lee, J.S.; Kim, E.J.; Lee, D.H. The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications. Preprints 2023, 2023030039. https://doi.org/10.20944/preprints202303.0039.v1
Quan, Q.; Yoon, K.; Lee, J.S.; Kim, E.J.; Lee, D.H. The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications. Preprints2023, 2023030039. https://doi.org/10.20944/preprints202303.0039.v1
APA Style
Quan, Q., Yoon, K., Lee, J.S., Kim, E.J., & Lee, D.H. (2023). The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications. Preprints. https://doi.org/10.20944/preprints202303.0039.v1
Chicago/Turabian Style
Quan, Q., Eun Ju Kim and Dong Hun Lee. 2023 "The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications" Preprints. https://doi.org/10.20944/preprints202303.0039.v1
Abstract
Ultraviolet (UV) radiation has both harmful and beneficial effects on human health. It can cause skin damage and cancer, but also provides the primary source of vitamin D. Additionally, UV radiation affects energy metabolism in mice with metabolic diseases and has protective effects on hypertension and cardiovascular diseases.Metabolic Syndrome is a collection of metabolic dysfunctions such as dyslipidemia, hypertension, hyperglycemia, abdominal/central obesity, and insulin resistance. Chronic UVR exposure suppressed obesity and type 2 diabetes in high-fat diet-fed mice, while vitamin D supplementation did not replicate these effects. On the other hand, topical application of nitric oxide (NO) donors replicated UV effects on mice, and NO scavengers prevented the positive impact of UV. UVR may prevent the development of obesity and metabolic syndrome through mechanisms that depend on UVR-induced NO, not vitamin D. Exposure to sunshine has a protective impact on blood pressure and cardiovascular disease. Although lower vitamin D concentration is linked to increased hypertension and the incidence of CVD, oral vitamin D supplementation does not decrease blood pressure or the risk of CVD, indicating that vitamin D may not mediate the beneficial effects of sun exposure. Instead, NO plays a crucial role as an endogenous vasodilator, produced by the vascular endothelium. Solar UVA may release nitrogen oxides from skin storage into the bloodstream, lowering blood pressure and cardiovascular mortality.In conclusion, UVR exposure could be a promising non-pharmacological intervention for metabolic syndrome, hypertension, and CVD prevention, and NO may play a crucial role in mediating these effects. Further research is needed to explore the precise mechanisms and identify the optimal doses and exposure times of UVR.
Keywords
metabolic disorders; nitric oxide; obesity; ultraviolet; vitamin D
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
