Version 1
: Received: 29 April 2023 / Approved: 29 April 2023 / Online: 29 April 2023 (07:44:53 CEST)
How to cite:
Singh, R.B.; Tarnava, A.; Fedacko, J.; Fatima, G.; Rupee, S.; Sumbalová, Z.; Moshiri, A. Effects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases. Preprints2023, 2023041223. https://doi.org/10.20944/preprints202304.1223.v1
Singh, R.B.; Tarnava, A.; Fedacko, J.; Fatima, G.; Rupee, S.; Sumbalová, Z.; Moshiri, A. Effects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases. Preprints 2023, 2023041223. https://doi.org/10.20944/preprints202304.1223.v1
Singh, R.B.; Tarnava, A.; Fedacko, J.; Fatima, G.; Rupee, S.; Sumbalová, Z.; Moshiri, A. Effects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases. Preprints2023, 2023041223. https://doi.org/10.20944/preprints202304.1223.v1
APA Style
Singh, R.B., Tarnava, A., Fedacko, J., Fatima, G., Rupee, S., Sumbalová, Z., & Moshiri, A. (2023). Effects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases. Preprints. https://doi.org/10.20944/preprints202304.1223.v1
Chicago/Turabian Style
Singh, R.B., Zuzana Sumbalová and Arsha Moshiri. 2023 "Effects of Molecular Hydrogen in the Pathophysiology and Management of Metabolic and Non-communicable Diseases" Preprints. https://doi.org/10.20944/preprints202304.1223.v1
Abstract
The sustainable development goals(SDG) of the UNO would be difficult to achieve without prevention of metabolic diseases and other non-communicable diseases (NCDs). Western diet and lifestyle, which are major risk factors of NCDs, are known to cause oxidative stress and decrease in production of molecular hydrogen in the intestines which leads to a decline in endogenous antioxidant status in the body, leading to increase in systemic inflammation. Many experts consider molecular hydrogen as a potential nutrient, which may be administered as gas in the body. There are gaps in the knowledge about the role molecular hydrogen plays, in the treatment of metabolic diseases and other NCDs This review aims to discuss the role of hydrogen in the pathogenesis and prevention of NCDs. Molecular hydrogen (H2) has been studied extensively as a therapeutic gas, with an estimated 2000 publications to date, exploring its potential therapeutic use in 170 disease models across every organ in the mammalian body. Hydrogen therapy can be administered through several methods, such as H2 inhalation, dissolving H2 gas in water to make hydrogen-rich water (HRW) for oral consumption or topical application, or hydrogen-rich saline. The exact mechanism of action of molecular hydrogen is not known but it is in itself a potential antioxidant that can also inhibit hydroxyl and nitrosyl radicals in the cells and tissues. Hydrogen is known to cause a marked decline in oxidative stress, and inflammation that are crucial in the pathogenesis of NCDs. Hydrogen therapy has been found protective against NCDs, including, metabolic diseases, cardiovascular diseases (CVDs), neurodegenerative diseases, chronic kidney disease, cancer and chronic lung diseases.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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