Version 1
: Received: 28 March 2024 / Approved: 28 March 2024 / Online: 28 March 2024 (17:00:31 CET)
How to cite:
Balagobi, B.; Thangarajah, B.R.; Thuraisamy Sarma, S.I.; Sripandurangana, S.; Sivashankar, M.; Rajendra, S.; Vinojan, S.; Shathana, P. The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.. Preprints2024, 2024031788. https://doi.org/10.20944/preprints202403.1788.v1
Balagobi, B.; Thangarajah, B.R.; Thuraisamy Sarma, S.I.; Sripandurangana, S.; Sivashankar, M.; Rajendra, S.; Vinojan, S.; Shathana, P. The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.. Preprints 2024, 2024031788. https://doi.org/10.20944/preprints202403.1788.v1
Balagobi, B.; Thangarajah, B.R.; Thuraisamy Sarma, S.I.; Sripandurangana, S.; Sivashankar, M.; Rajendra, S.; Vinojan, S.; Shathana, P. The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.. Preprints2024, 2024031788. https://doi.org/10.20944/preprints202403.1788.v1
APA Style
Balagobi, B., Thangarajah, B.R., Thuraisamy Sarma, S.I., Sripandurangana, S., Sivashankar, M., Rajendra, S., Vinojan, S., & Shathana, P. (2024). The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre.. Preprints. https://doi.org/10.20944/preprints202403.1788.v1
Chicago/Turabian Style
Balagobi, B., Satchchithanantham Vinojan and Paramanathan Shathana. 2024 "The Spectrum the Disease and Metabolic Evaluation in Urolithiasis Patients: A Prospective Study in a Tertiary Urology Centre." Preprints. https://doi.org/10.20944/preprints202403.1788.v1
Abstract
Introduction
Urolithiasis, a prevalent urological condition (8-13% globally) exhibits regional variations, influenced by water quality, climate, health factors and diet. Sri Lanka with its tropical climate and dietary patterns is part of the "Stone Belt" of Asia. This study in Northern Sri Lanka examines urinary stone compositions and assesses the prevalence of metabolic disorders among urolithiasis patients.
Methods
This prospective cross-sectional study, conducted at tertiary urology centre from July 2022 to June 2023, focused on surgically treated urolithiasis patients. Institutional ethical clearance was obtained. Patient details and investigational findings were collected through questionnaires and data extraction forms. Stone analysis utilized Fourier transform infrared spectroscopy and detailed metabolic evaluation of 24 hour urine collection sample is carried out.
Results
This study followed 153 surgically treated urolithiasis patients, primarily male (64.3%), mean age 48.64. Ureteric colic (48.4%) was common, with kidney stones (45.8%) prevalent; 57.52% had recurrent stones. Diabetes mellitus (DM=23.5%) was the top comorbidity. Calcium oxalate monohydrate (COM) stones (78.4%) were most frequent, followed by uric acid (12.4%). COM predominated in 40-59 age group. No significant gender-stone type association. 86.9% had metabolic abnormalities, notably hypocitraturia (60.1%). 23% had both hypocitraturia and hypomagnesuria. Some metabolic disorders showed gender differences, with a marginal age-metabolic disorders association (p < 0.061). Urine oxalate levels were normal with higher variability in males.
Conclusion
Middle-aged males with urolithiasis commonly presented with ureteric colic and predominantly had calcium oxalate monohydrate stones. Recurrent stones were common, often accompanied by metabolic abnormalities such as hypocitraturia and hypomagnesuria, with diabetes mellitus as the primary comorbidity.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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