Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies

Version 1 : Received: 31 March 2021 / Approved: 1 April 2021 / Online: 1 April 2021 (10:07:32 CEST)

A peer-reviewed article of this Preprint also exists.

Gawlik-Kotelnicka, O.; Strzelecki, D. Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies. Pharmaceuticals 2021, 14, 384. Gawlik-Kotelnicka, O.; Strzelecki, D. Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies. Pharmaceuticals 2021, 14, 384.

Journal reference: Pharmaceuticals 2021, 14, 384
DOI: 10.3390/ph14040384

Abstract

Depression and metabolic diseases often coexist having several features in common, e.g., chronic low-grade inflammation and intestinal dysbiosis. Different microbiota interventions have been proposed to be used as a treatment for these disorders. In the paper we review the efficacy of probiotics in depressive disorders, obesity, metabolic syndrome and its liver equivalent based on the published experimental studies, clinical trials and meta-analyses. Probiotics seem to be effective in reducing depressive symptoms when administered in addition to antidepressants. Additionally, probiotics intake may ameliorate some of the clinical components of metabolic diseases. However, standardized methodology regarding probiotics clinical trials has not been established yet. In this narrative review we discuss current knowledge on the recently used methodology with its strengths and limitations and propose criteria that may be implemented to create a new study of the effectiveness of probiotics in depressive disorders comorbid with metabolic abnormalities. We put across our choice on type of study population, probiotics genus, strains, dosages and formulations, intervention period, as well as primary and secondary outcome measures.

Keywords

depression; metabolic syndrome; microbiota; probiotics; obesity

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