Review
Version 1
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Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
Version 1
: Received: 12 October 2022 / Approved: 14 October 2022 / Online: 14 October 2022 (03:12:00 CEST)
A peer-reviewed article of this Preprint also exists.
Fazliana, M.; Nor Hanipah, Z. Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes. Metabolites 2022, 12, 1134. Fazliana, M.; Nor Hanipah, Z. Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes. Metabolites 2022, 12, 1134.
Abstract
This review aimed at synthesizing the mechanisms and outcomes of metabolic surgery on hormones, adipokines, metabolomics, and at the molecular level. We reviewed the endocrine, microRNA, and metabolomics changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. PubMed, Science Direct, Scopus, and Google Scholar databases were searched up to February 2022. The most relevant studies in the area over the past 17 years have been considered for this review. In most cases, metabolic procedures especially those that include intestinal bypass components, showed remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity, and secretion. The miRNAs’ dysregulated expressions have essential roles in metabolic processes. Metabolic surgery is a potentially sustainable treatment that can modify a patient’s physiology and glucose regulation mechanism. The feasibility and role of miRNA are important for potential targeted genetic pathways in future obesity with type 2 diabetes management.
Keywords
diabetes; bariatric surgery; metabolic surgery; hormones; adipokines; microRNA; metabolomic
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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