Lebeau, G.; El Safadi, D.; Paulo-Ramos, A.; Hoareau, M.; Desprès, P.; Krejbich-Trotot, P.; Chouchou, F.; Roche, M.; Viranaicken, W. The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted. Pathogens2022, 11, 1168.
Lebeau, G.; El Safadi, D.; Paulo-Ramos, A.; Hoareau, M.; Desprès, P.; Krejbich-Trotot, P.; Chouchou, F.; Roche, M.; Viranaicken, W. The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted. Pathogens 2022, 11, 1168.
Lebeau, G.; El Safadi, D.; Paulo-Ramos, A.; Hoareau, M.; Desprès, P.; Krejbich-Trotot, P.; Chouchou, F.; Roche, M.; Viranaicken, W. The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted. Pathogens2022, 11, 1168.
Lebeau, G.; El Safadi, D.; Paulo-Ramos, A.; Hoareau, M.; Desprès, P.; Krejbich-Trotot, P.; Chouchou, F.; Roche, M.; Viranaicken, W. The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted. Pathogens 2022, 11, 1168.
Abstract
When exposed to a viral infection, the attacked cells promptly set up defence mechanisms. Part of antiviral responses, the innate immune interferon pathway and associated interferon stimulated genes are notably allowing the production of proteins bearing an antiviral activity. Numerous viruses are able to evade the interferon response, highlighting the importance of controlling this pathway to ensure their efficient replication. Several viruses are also known to manipulate the metabolism of infected cells to optimize the availability of amino acids, nucleotides and lipids. They then benefit from a reprogramming of the metabolism that favours glycolysis instead of mitochondrial respiration. Given the increasingly discussed crosstalk between metabolism and innate immunity, we wondered whether this switch from glycolysis to mitochondrial respiration would be beneficial or deleterious for an efficient antiviral response. We used a cell based model of metabolic reprogramming. Interestingly, we showed that increased mitochondrial respiration was associated with an enhanced interferon response following poly:IC stimulation. This suggests that during viral infection, the metabolic reprogramming towards glycolysis is also part of the virus' strategies to inhibit the antiviral response.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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