Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association of Metabolic Syndrome Components with Kidney Cancer in Young Adult Population : A Nationwide Population-Based Cohort Study in Korea

Version 1 : Received: 8 May 2023 / Approved: 10 May 2023 / Online: 10 May 2023 (04:38:19 CEST)

A peer-reviewed article of this Preprint also exists.

Lee, H.Y.; Han, K.-D.; Woo, I.S.; Kwon, H.-S. Association of Metabolic Syndrome Components and Nutritional Status with Kidney Cancer in Young Adult Population: A Nationwide Population-Based Cohort Study in Korea. Biomedicines 2023, 11, 1425. Lee, H.Y.; Han, K.-D.; Woo, I.S.; Kwon, H.-S. Association of Metabolic Syndrome Components and Nutritional Status with Kidney Cancer in Young Adult Population: A Nationwide Population-Based Cohort Study in Korea. Biomedicines 2023, 11, 1425.

Abstract

The aim of this study was to determine the association of metabolic syndrome (MetS) with kidney cancer and the impact of age and gender on such association. Using Korean National Health Insurance Service database, 9,932,670 subjects who had check-up in 2009 were followed up until the diagnosis of kidney cancer or death or until 2019. Kidney cancer was significantly associated with MetS (HR 1.56). This association was higher in the younger age group (HR: 1.82, 1.5, and 1.37 in 20-39 years, 40-64 years, and ≥65 years, respectively). In terms of the association of kidney cancer with obesity and central obesity, young-aged males showed higher HR for kidney cancer than old-aged ones (HR of obesity: 1.96, 1.52, and 1.25; HR of central obesity: 1.94, 1.53, and 1.3 in 20-39 years, 40-64 years, ≥65 years, respectively), while young-aged females showed lower HR. Kidney cancer was associated with obesity and MetS. The association was higher in younger aged population than in older ones. Regarding gender, MetS, obesity, and central obesity showed higher associations with kidney cancer in younger aged male population, while there was no significant difference in such association according to age in females.

Keywords

Kidney cancer; Metabolic syndrome; Age; Young adults

Subject

Biology and Life Sciences, Endocrinology and Metabolism

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