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Preprint ARTICLE | doi:10.20944/preprints202109.0335.v1

Personalization of a Human Body Model Using Subject-Specific Clothing Industry Dimensions

Luděk Hynčík, Hana Čechová, Tomasz Bońkowski, Gabriela Kavalířová, Petra Špottová, Viola Hampejsová, Hong Meng

Subject: Engineering, Other Keywords: human body; anthropometric dimensions; personalization; subject-specific model; biofidelity

Online: 20 September 2021 (14:15:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0380.v2

Considerations and Challenges for Sex-Aware Drug Repurposing

Jennifer Fisher, Emma Jones, Victoria Flanary, Avery Williams, Elizabeth Ramsey, Brittany Lasseigne

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: sex differences; drug repurposing; sex-bias; sex-aware; review; therapeutics; pharmaceuticals; computational drug repurposing

Online: 8 March 2022 (10:34:42 CET)

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Sex differences are essential factors in disease etiology and manifestation in many diseases such as cardiovascular disease, cancer, and neurodegeneration (1). The biological influence of sex differences (including genomic, epigenetic, hormonal, immunological, and metabolic differences between males and females) and the lack of biomedical studies considering sex differences in their study design has led to several policies. For example, the National Institute of Health’s (NIH) sex as a biological variable (SABV) and Sex and Gender Equity in Research (SAGER)) policies to motivate researchers to consider sex differences (2). However, drug repurposing, a promising alternative to traditional drug discovery by identifying novel uses for FDA-approved drugs, lacks sex-aware methods that can improve the identification of drugs that have sex-specific responses (1,3–5). Sex-aware drug repurposing methods either select drug candidates that are more efficacious in one sex or deprioritize drug candidates based on if they are predicted to cause a sex-bias adverse event (SBAE), unintended therapeutic effects that are more likely to occur in one sex. Computational drug repurposing methods are encouraging approaches to develop for sex-aware drug repurposing because they can prioritize sex-specific drug candidates or SBAEs at lower cost and time than traditional drug discovery. Sex-aware methods currently exist for clinical, genomic, and transcriptomic information (3,6,7). They have not expanded to other data types, such as DNA variation, which has been beneficial in other drug repurposing methods that do not consider sex (8). Additionally, some sex-aware methods suffer from poorer performance because a disproportionate number of male and female samples are available to train computational methods (3). However, there is development potential for several different categories (i.e., data mining, ligand binding predictions, molecular associations, and networks). Low-dimensional representations of molecular association and network approaches are also especially promising candidates for future sex-aware drug repurposing methodologies because they reduce the multiple hypothesis testing burden and capture sex-specific variation better than the other methods (9,10). Here we review how sex influences drug response, the current state of drug repurposing including with respect to sex-bias drug response, and how model organism study design choices influence drug repurposing validation.

Preprint ARTICLE | doi:10.20944/preprints201911.0168.v1

Fine Motor Precision Tasks: Sex Differences in Performance with and without Visual Guidance across Different Age Groups

Liudmila Liutsko, Ruben Muinos, Josep Maria Tous Ral, María José Contreras

Subject: Social Sciences, Cognitive Science Keywords: fine motor precision; vision; proprioception; sex differences; individual differences; personality

Online: 15 November 2019 (03:46:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0169.v1

Girls Outperform Boys in Early Syntactic Development? Negative Evidence from Mandarin-Speaking Preschoolers

Nga Yui Tong, Hui Li

Subject: Social Sciences, Language And Linguistics Keywords: sex differences; syntactic development; Mandarin-speaking children

Online: 14 February 2022 (09:19:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0243.v1

Action and Entropy in Heat Engines: An Action Revision of the Carnot Cycle

Ivan Robert Kennedy, Migdat Hodzic

Subject: Physical Sciences, Quantum Science And Technology Keywords: Carnot cycle; Caloric; specific heat; entropy; Gibbs potential; vortical entropy; reversible cycle; working fluid, quantum field, relative action, heat engine

Online: 11 May 2021 (11:18:39 CEST)

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Despite the remarkable success of Carnot’s heat engine cycle in founding the discipline of thermodynamics two centuries ago, false viewpoints of his use of the caloric theory in the cycle still linger, limiting his legacy. An action revision of the Carnot cycle can correct this, showing that the heat flow powering external mechanical work is compensated internally with configurational changes in the thermodynamic or Gibbs potential of the working fluid, differing in each stage of the cycle quantified by Carnot as caloric. Action (@) is a property of state having the same physical dimensions as angular momentum (mrv=mr2ω). However, this property is scalar rather than vectorial, including a dimensionless phase angle (@=mr2ωδφ). We have recently confirmed with atmospheric gases that their entropy is a logarithmic function of the relative vibrational, rotational and translational action ratios with Planck’s quantum of action ħ. The Carnot principle shows that the maximum rate of work (puissance motrice) possible from the reversible cycle is controlled by the difference in temperature of the hot source and the cold sink, the colder the better. This temperature difference between the source and the sink also controls the isothermal variations of the Gibbs potential of the working fluid, that Carnot identified as reversible temperature-dependent but unequal exchanges in caloric. Importantly, the engine’s inertia ensures that heat from work performed adiabatically in the expansion phase is all restored to the working fluid during the adiabatic recompression, less the net work performed. This allows both the energy and the thermodynamic potential to return to the same values at the beginning of each cycle, a point strongly emphasized by Carnot. Our action revision equates Carnot’s calorique, or the non-sensible heat later described by Clausius as ‘work-heat’ exclusively to negative Gibbs energy (-G) or quantum field energy. This action field complements the sensible energy or vis-viva heat as molecular kinetic motion and its recognition should have significance for designing more efficient heat engines or better understanding of the heat engine powering the Earth’s climates.

Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0369.v1

Domain-Specific Languages for Workflows.A Systematic Literature Review

Akif Quddus Khan

Subject: Computer Science And Mathematics, Information Systems Keywords: WorkflowDSL, DSL, Domain-Specific Language, Workflow.

Online: 19 November 2021 (15:08:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0213.v1

Independent Evolution of Sex Chromosomes in Eublepharid Geckos, a Lineage with Environmental and Genotypic Sex Determination

Eleonora Pensabene, Lukáš Kratochvíl, Michail Rovatsos

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Gekkota; reptiles; DNA-seq; sex chromosomes; sex determination; qPCR

Online: 5 November 2020 (14:14:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0649.v1

The Origin and Immune Recognition of Tumor-Specific Antigens

Anca Apavaloaei, Marie-Pierre Hardy, Pierre Thibault, Claude Perreault

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: antigen processing and presentation; cancer immunotherapy; cross-priming; immunogenicity; major histocompatibility complex; T lymphocyte; tumor-infiltrating lymphocytes, tumor microenvironment; tumor-specific antigen

Online: 30 August 2020 (10:30:50 CEST)

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Working Paper ARTICLE

Comparative Transcriptomics of Non-Embryogenic and Embryogenic Callus in Semi-Recalcitrant and Non-Recalcitrant Upland Cotton Lines

Sonika Kumar, Ashleigh Ruggles, Sam Logan, Alora Mazarakis, Tyson Thomas, Matthew Bates, Dave Reed, Clayton Grosse, Zhigang Li, Jane Grimwood, Jeremy Schmutz, Christopher A Saski

Subject: Biology And Life Sciences, Plant Sciences Keywords: callus; genotype-specific recalcitrance; reprogramming; somatic embryogenesis; transcriptomics; upland cotton

Online: 20 July 2021 (15:30:47 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202001.0147.v1

Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank

Wei Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: position-specific visualization; experimentally uncharted territories; membrane protein structure; protein data bank

Online: 15 January 2020 (07:53:46 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202007.0073.v2

Sexual Dimorphism in the Multielemental Stoichiometric Phenotypes and Stoichiometric Niches of Spiders

Łukasz Sobczyk, Michał Filipiak, Marcin Czarnoleski

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: ecological stoichiometry; predator; spider; sex; nutrition; nutritional ecology; arthropod; nutrient cycling; trophic link; food web

Online: 29 July 2020 (09:40:28 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201810.0491.v1

CMV-Specific Immune Reconstitution after Allogenic Stem Cell Transplantation: Central Role of Specific IgG in Immunodefense Against CMV Reactivation as a Leading Parameter during Profound and Long-Lasting Immune Deficiency

Przemyslaw Zdziarski

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cytomegalovirus (CMV); infection, reactivation, epidemiology, host-virus interaction, CMV-specific IgG; protective IgG level, avidity, adoptive/acquired immune response, hematopoietic stem cell transplantation (HSCT); secondary immunodeficiency, Quantiferon, pentamer, β2-microglobulin/beta 2-Microglobulin

Online: 22 October 2018 (11:53:47 CEST)

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Working Paper ARTICLE

Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-analysis and Meta-regression

Elke van Westering-Kroon, Maurice J Huizing, Eduardo Villamor-Martínez, Eduardo Villamor

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: preterm birth; oxidative stress; sex differences; male disadvantage; female advantage; bronchopulmonary dysplasia; retinopathy of prematurity; necrotizing enterocolitis; intraventricular hemorrhage; periventricular leukomalacia; mortality.

Online: 3 September 2021 (11:08:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0154.v1

Computational Fluid Dynamic Modelling and Optimisation of Wastewater Treatment Plant Bioreactor Mixer

Andrew Elshaw, N. M. S. Hassan, M. M. K. Khan

Subject: Engineering, Mechanical Engineering Keywords: wastewater treatment; computational fluid dynamics; hydrodynamic performance; specific power dissipation; anoxic zone

Online: 7 November 2018 (09:23:28 CET)

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Working Paper ARTICLE

Functional Analysis of the Acinetobacter baumannii XerC and XerD Site-Specific Recombinases: Potential Role in Dissemination of Resistance Genes

David L. Lin, German M. Traglia, Rachel Baker, David J. Sherratt, Maria S. Ramirez, Marcelo E. Tolmasky

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: site-specific recombination; carbapenemase; ESKAPE; Acinetobacter; plasmid; Xer; dif; pdif; Re27; gene transfer; gene dissemination; horizontal transfer; horizontal dissemination

Online: 10 July 2020 (02:10:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0549.v1

Topology Optimization of Microstructures to Reduce Structural Oscillations

Georgios Stylianos Zymvragakis, Panagiotis Koutsianitis, Georgios E. Stavroulakis

Subject: Engineering, Automotive Engineering Keywords: vibration suppression; topology optimization; band gaps; Bloch theory; finite element analysis (List three to ten pertinent keywords specific to the article; yet reasonably common within the subject discipline.)

Online: 20 November 2020 (16:35:21 CET)

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Working Paper ARTICLE

Comparison of BSGI and MRI as Approaches to Evaluating Residual Tumor Status After Neoadjuvant Chemotherapy in Chinese Women With Breast Cancer

Hongbiao Liu, Hongwei Zhan, Ying Zhang, Gangqiang He, Hui Wang, Qiaoxia Zhang, Lili Zheng

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: breast-specific gamma imaging (BSGI); neoadjuvant chemotherapy (NAC); breast cancer; Magnetic resonance imaging (MRI); residual tumor size

Online: 6 July 2021 (12:40:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0131.v1

Adhesion Hysteresis due to Chemical Heterogeneity

Valentin L. Popov

Subject: Engineering, Mechanical Engineering Keywords: adhesion; hysteresis; energy dissipation; JKR theory; MDR; specific surface energy; hetero-geneity

Online: 8 March 2020 (04:31:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0401.v1

Assessing Loss of Regulatory Divergence, Genome–Transcriptome Incongruence, and Preferential Expression Switching in Abaca/ Banana Backcrosses

Nelzo C. Ereful, Antonio G. Lalusin, Antonio C. Laurena

Subject: Biology And Life Sciences, Plant Sciences Keywords: abaca (Musa textilis); allelic imbalance; regulatory divergence; banana (M. balbisiana); allele-specific expression

Online: 29 June 2022 (09:34:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1200.v1

Antioxidant Defense and Ionic Homeostasis Govern Stage-Specific Response of Salinity Stress in Contrasting Rice Varieties

Vikash Kumar, Ashish Kumar Srivastava, Deepak Sharma, Shailaja P Pandey, Manish Pandey, Ayushi Dudwadkar, Harshala J Parab, Penna Suprasanna, Bikram Kishore Das

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rice; Salt Stress; Stage-specific salinity; Antioxidant defense; Ionic homeostasis; Salt tolerance

Online: 16 January 2024 (06:55:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0234.v1

Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses

Larry Rodriguez, Dean Kirson, Sarah A. Wolfe, Reesha R. Patel, Florence P. Varodayan, Angela E. Snyder, Pauravi J. Gandhi, Sophia Khom, Roman Vlkolinksy, Michal Bajo, Marisa Roberto

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: corticotropin releasing factor (CRF); patch-clamp electrophysiology; sex difference; alcohol use disorder (AUD); Gamma-Aminobutyric Acid (GABA); central amygdala (CeA); spontaneous inhibitory post synaptic currents (sIPSCs)

Online: 16 June 2022 (08:41:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Working Paper ARTICLE

Domain-Specific Stimulation of Executive Functioning in Low-Preforming Students with a Roma Background: Cognitive Potential Of Mathematics

Iveta Kovalčíková, Jochanan Veerbeek, Bart Vogelaar, Alena Prídavková, Ján Ferjenčík, Edita Šimčíková, Blanka Tomková

Subject: Business, Economics And Management, Accounting And Taxation Keywords: executive functioning; domain-specific cognitive stimulation; math; low-performing student; Roma ethnic group.

Online: 13 May 2021 (13:06:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0347.v1

Strain, Sex, and Time Dependent Antidepressant-like Effects of Cannabidiol

Gabriela Pandini Silote, Michelle C. Gatto, Amanda Eskelund, Francisco S. Guimarães, Gregers Wegener, Sâmia R. L. Joca

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cannabidiol; S-Ketamine; Sex; Mice strain; Flinders Sensitive Line rats; Tail suspension test; Forced Swim Test.

Online: 25 October 2021 (12:32:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0146.v1

Differences between Women and Men in terms of Safety Measures to Prevent COVID-19 Pandemic in the Hotel Sector

Alexandra Lenis Escobar, Ramón Rueda López, Antonio Menor Campos, Teresa López-Felipe

Subject: Business, Economics And Management, Economics Keywords: Covid-19; tourism; security measures; sex differences; ANOVA; hotel sector

Online: 6 August 2020 (10:08:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0528.v1

Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers’ Health Study

Zypher Jude G. Regencia, Godofreda V. Dalmacion, Antonio D. Ligsay, Emmanuel S. Baja

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: black carbon; systolic blood pressure; diastolic blood pressure; sex; obesity; traffic enforcers

Online: 30 September 2021 (16:08:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0591.v1

Sex Differences in Exercise Induced Bronchoconstriction in Athletes: A Systematic Review and Meta-Analysis

Daniel Rodriguez Bauza, Patricia Silveyra

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: inflammation; atopy; exercise induced asthma; exercise induced bronchoconstriction; sex differences

Online: 27 August 2020 (05:31:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0168.v1

The sex Differences in Blood Pressure and Cardiac Autonomic Modulation during the Menopause Transition at Rest and after Aerobic Exercise Training

Maycon Jr Ferreira, Rodrigo D. Esposti, Aline O. Jarrete, Carlos H. G. Sponton, Angelina Zanesco

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: sex differences; blood pressure; redox state; perimenopausal women; nitric oxide

Online: 12 December 2019 (09:43:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0187.v1

The Impact of Water Loss by Evaporation and Calcite Precipitation on the Sodium Adsorption Ratio (SAR) and an Alternative Method of Estimating the SAR of Irrigation Drainage Water

Qiyu Zhou, William Bleam, Douglas Soldat

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: sodium adsorption ratio; SAR; CROSS, electrical conductivity; specific conductivity; salinity; irrigation; groundwater; water quality

Online: 9 October 2020 (08:45:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0286.v1

Classical-Relativistic Variability of Inertia of Photon Displacement Mass in the Matter and the Specific Vacuum Temperature

Daniel Souza Cardoso, José Rafael Bordin

Subject: Physical Sciences, Optics And Photonics Keywords: photon inertia; inertia momenta; photon inertia variability; photon inertia momenta variability; specific vacuum temperature; Abraham momenta; Minkowski momenta; relativistic energy wave; translational inertia; rotational inertia; photon displacement mass

Online: 21 March 2022 (11:21:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0288.v1

Sex Differences in the Associations of Nutrient Patterns with Total and Regional Adiposity: A Study of Middle-Aged Black South African Men and Women

Tshifhiwa Ratshikombo, Julia H. Goedecke, Melikhaya Soboyisi, Clement Kufe, Maphoko Masemola, Lisa K Micklesfield, Tinashe Chikowore

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Nutrient patterns; Obesity; Sex differences; Total and regional adiposity; South Africa

Online: 20 October 2021 (10:17:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0038.v1

Changes in DNA Methylation in Response to 6-Benzylaminopurine Affect Allele-Specific Gene Expression in Populus tomentosa

Anran Xuan, Yuepeng Song, Chenhao Bu, Panfei Chen, Yousry A. El-Kassaby, Deqiang Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: allele specific expression; 6-BA; DNA methylation; long noncoding RNA; siRNA; poplar

Online: 4 February 2020 (05:22:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0178.v1

A Genome-Wide Association Study Reveals New Genes in a Molecular Network Associated With Alcohol Dependence and Related Clinical Measures

Anastasia Levchenko, Sergey Malov, Alexey Antonik, Anastasia Protsvetkina, Kseniya V. Rybakova, Alexander Kanapin, Alexey N. Yakovlev, Anna Y. Nenasteva, Anton E. Nikolishin, Nikolay Cherkasov, Natalia A. Chuprova, Anna S. Blagonravova, Angelica V. Sergeeva, Tatyana V. Zhilyaeva, Maria K. Denisenko, Raul R. Gainetdinov, Alexander O. Kibitov, And Evgeny M. Krupitsky

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol dependence; comorbidity; gene network; genome-wide association study; sex differences

Online: 9 August 2022 (10:35:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0372.v1

Cell Compartment-specific Folding of Ty1 Long Terminal Repeat Retrotransposon RNA Genome

Małgorzata Zawadzka, Angelika Andrzejewska-Romanowska, Julita Gumna, David J. Garfinkel, Katarzyna Pachulska-Wieczorek

Subject: Biology And Life Sciences, Virology Keywords: RNA genome; RNA structure; Cell compartment-specific folding; LTR-retrotransposon; gRNA dimerization; gRNA cyclization; tRNA annealing; Ty1; Gag.

Online: 25 July 2022 (10:07:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0426.v1

Predicting the Cross-Coordinated Immune Response Dynamics in Sars-Cov-2 Infection: Implications for Disease Pathogenesis

Dmitry Grebennikov, Antonina Karsonova, Marina Loginova, Valentina Casella, Andreas Meyerhans, Gennady Bocharov

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: SARS-CoV-2 infection; innate immune response; antigen-specific immune response; kinetic coordination; mathematical model; pathogenesis, long COVID-19

Online: 27 July 2022 (15:11:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0285.v1

Usefulness of a Concept Called Autonomous Selection

Idan S. Solon

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: extended evolutionary synthesis; inheritance of acquired characters; stress-induced mutagenesis; fitness-dependent sex; horizontal gene transfer

Online: 25 July 2019 (08:24:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0237.v1

Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients

Wei Huang, Ming Tang, Yun-Liang Chen, Tao-Lan Zhang, Tao Hong, Jing Li, Guo-Hua Lv, Yiguo Yan, Zhi-Hua Ouyang, Mingxiang Zou

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Colorectal cancer; Cerebrovascular-specific mortality; Cerebrovascular-specific diseases; Incidence; Risk factors

Online: 12 November 2021 (16:47:45 CET)

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Working Paper ARTICLE

Artiﬁcial Neural Network for Uncertainty Quantiﬁcation in RF Radiation Modeling with High-Dimensional Data

Xi Cheng, Clement Henry, Francesco Andriulli, Christian Person, Joe Wiart

Subject: Computer Science And Mathematics, Mathematics Keywords: artificial neural networks; uncertainty quantification; specific absorption rate

Online: 6 March 2020 (02:57:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0281.v1

Software-Defined Networks for Optical Networks using Flexible Orchestration : Advances, Challenges and Opportunities

Kenneth Nsafoa-Yeboah, Eric Tchao, Bright Yeboah-Akowuah, Benjamin Kommey, Andrew Selasi Agbemenu, Eliel Keelson, Mohammad Monirujjaman Khan

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Optical networks; software-defined networks; fifth-generation wireless network(5G); network service orchestrators; customer- specific requirements; Quality of service, flexibility.

Online: 19 July 2022 (07:44:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1267.v1

A Female-Specific Treatment Group for ADHD – Description of the Programme and Qualitative Analysis of First Experiences

Maxime de Jong, Dora S.R.M. Wynchank, Marieke Michielsen, Aartjan T.F. Beekman, Sandra J.J. Kooij

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: attention deficit/hyperactivity disorder (ADHD); women; menstrual cycle; non-pharmacological treatment; group treatment; sex hormones; premenstrual; female specific therapy; self-awareness; self-acceptance

Online: 21 March 2024 (11:26:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0633.v1

Exploring the Therapeutic Potential of Natural Products on Polycystic Ovarian Syndrome (PCOS): A Mini Review of Lipid Profile, Blood Glucose, and Ovarian Histological Improvements

Syawany Wahid, Muhammad Danial Che Ramli, Ezza Fazleen Mohd Fathil, Muhammad Naim Rosli, Mohd Helmy Mokhtar

Subject: Medicine And Pharmacology, Reproductive Medicine Keywords: natural products; polycystic ovarian syndrome; lipid profile; sex hormone; blood glucose

Online: 11 July 2023 (05:19:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0159.v1

The Impact of Sex on Changes in Plasma Corticosterone and Cotinine Levels Induced by Nicotine in C57BL/6J Mice

Khoa Nguyen, Keiko Kanamori, Abdul Hamid, Kabirullah Lutfy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Nicotine; Cotinine; Corticosterone; LCMS; Sex; C57BL/6J mouse; CYP2A5; Plasma Levels; Subcutaneous Injection

Online: 7 September 2020 (08:08:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0130.v1

Sex Differences in Visceral Pain and Comorbidities: Clinical Outcomes, Preclinical Models, and Cellular and Molecular Mechanisms

Namrata Tiwari, Liya Y Qiao

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: pain; visceral; sex; clinical; preclinical; molecule

Online: 3 January 2024 (07:41:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0489.v1

Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy

Hyun-mi Lee, SiWon Lee, Min-Kyung Park, You Jung Han, Moon Young Kim, Hye Yeon Boo, Jin Hoon Chung

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Velamentous cord insertion; Twin; Perinatal outcomes; Pregnancy outcomes; Chorionicity; Twin specific complications

Online: 21 December 2020 (10:14:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0074.v1

Isochoric Specific Heat in the Dual Model of Liquids

Fabio Peluso

Subject: Physical Sciences, Condensed Matter Physics Keywords: Liquid model; Phonons in liquids; Instantaneous Normal Modes; Mesoscopic model of liquids; Phonon – particle interaction; Specific heat

Online: 3 November 2021 (09:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0167.v1

Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

Ekaterina Pashkina, Veronika Evseenko, Natalya Dumchenko, Maxim Zelikman, Alina Aktanova, Maria Bykova, Mikhail Khvostov, Aleksandr Dushkin, Vladimir Kozlov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: drug delivery; allergen; glycyrrhizic acid; allergen-specific immunotherapy

Online: 10 December 2021 (08:50:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0050.v2

Enthalpies of Adduct Formation between Boron Trifluoride and Selected Organic Bases in Solution: Toward an Accurate Theoretical Entry to Lewis Basicity

Jean-François Gal, Pierre-Charles Maria, Manuel Yáñez, Otilia Mó

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: BF3 enthalpies; Lewis basicity; Specific solvation; High-level ab initio calculations; Dichloromethane; Boron trifluoride.

Online: 2 November 2021 (10:38:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0135.v1

Implementation of Environment, Social, and Governance (ESG): Case of Korean Global Firms

Diane So-Hyun Park, Taewon Lee, Hee Kyung Kim, Shawn Seung-Chul Kim

Subject: Business, Economics And Management, Business And Management Keywords: ESG Integration; Korean Multinationals; Sustainability’ Industry-Specific Strategies; Corporate Governance

Online: 3 January 2024 (10:05:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0125.v1

A Fish of Multiple Faces, which Show us Enigmatic and Incredible Phenomena in Nature: Biology and Cytogenetics of the Genus Carassius

Martin Knytl, Adrian Forsythe, Lukáš Kalous

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hybridization; sexuality; asexuality; biotype; species; sex determination; ploidy level; Carassius auratus complex

Online: 7 July 2022 (09:56:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0436.v1

DNA Environment of Centromeres and Non-homologous Chromosomes Interactions in Mouse

Victor Spangenberg, Losev Michail, Volkhin Ilya, Svetlana Smirnova, Nikitin Pavel, Oxana Kolomiets

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Prophase I of meiosis; chromatin; synaptonemal complex; chromosome; satellite DNA; chromocenter; nuclear architecture; MSCI; sex chromosomes; interactions of non-homologous chromosomes; chromatin silencing

Online: 23 November 2021 (15:58:17 CET)

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Pericentromeric regions of chromosomes enriched in tandemly repeated satellite DNA although representing a significant part of eukaryotic genomes are still understudied mainly due to interdisciplinary knowledge gaps. Recent studies suggest their important role in genome regulation, karyotype stability and evolution. Thus, the idea of satellite DNA as a junk part of the genome was refuted. Integration of data about molecular composition, chromosome behaviour and details of in situ organization of pericentromeric regions is of great interest. The objective of this work was a cytogenetic analysis of the interactions of pericentromeric regions non-homologous chromosomes in mouse spermatocytes using immuno-FISH. We analysed two events: the associations between cerntomeric regions of X chromosome and autosomes, and associations between centromeric regions of autosomal bivalents forming chromocenters. We conclude that X chromosome form temporary synaptic associations with different autosomes in early meiotic prophase I which normally can be found at pachytene-diplotene without signs of pachytene arrest. These associations are formed between the satellite DNA-enriched centomeric regions of X chromosome and different autosomes but not involve the satellite-poor centromeric region of Y-chromosome. We suggest the mechanism of X chromosome competitive replacement from such associations during synaptic correction. We showed that centromeric region of the X chromosome remains free of γH2Ax-dependent chromatin inactivation, while Y chromosome is completely inactivated. This findings highlights the predominant role of associations between satellite DNA-enriched regions of different chromosomes including X. We assume that X-autosome temporary associations is a manifestation of an additional synaptic disorders checkpoint. These associations are normally corrected before the late diplotene. We revealed that the intense spreading conditions applied to the spermatocytes I nuclei did not lead to destruction of stretched chromatin fibers i.e. elongated chromocenters enriched in satellite DNA. Revealed by us tight associations between pericentromeric regions of different autosomal bivalents and X chromosome may represent the basis for repeat stability maintenance in autosomes an X chromosome. The consequences of our findings are discussed. We obtained the preparations of mouse spermatocytes nuclei in the meiotic prophase I using two approaches: standard and extremely intense surface spread techniques. Using immuno-FISH we visualized tandemly repeated mouse Major and Minor satellite DNA located in the pericentromeric regions of chromosomes and performed a morphological comparison of the standard- and intensely spreaded meiotic nuclei. Based on our results, we assume the remarkable strength of the chromocenter-mediated associations, “chromatin “bridges”, between different bivalents at the pachytene and diplotene stages. We have demonstrated that the chromocenter “bridges” between the centromeric ends of meiotic bivalents are enriched in both tandemly repeated Major and Minor satellite DNA. Association of centromeric regions of autosomal bivalents and X-chromosome but not with Y-chromosome correlates with the absence of Major and Minor satellites on Y-chromosome. We suggest that revealed tight associations between pericentromeric regions of bivalents may represent the network-like system providing dynamic stability of chromosomal territories, as well as add new data for the hypothesis of ectopic recombination in these regions which supports sequence homogeneity between non-homologous chromosomes and does not contradict the meiotic restrictions imposed by the crossing-over interference near centromeres. We conclude that nuclear architecture in meio-sis may play an essential role in contacts between the non-homologous chromosomes providing the specific characteristics of pericentromeric DNA.

Preprint REVIEW | doi:10.20944/preprints202306.0833.v1

The Price of Human Evolution: Cancer-Testis-Antigens, the Decline in Male Fertility and the Increase in Cancer

Jekaterina Erenpreisa, Ninel M Vainshelbaum, Marija Lazovska, Roberts Karklins, Kristine Salmina, Pawel Zayakin, Felikss Rumnieks, Inna Inashkina, Dace Pjanova, Juris Erenpreiss

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer-testis-antigens; parthenogenetic; polyploid giant cancer cells; PGCCs; genome fragility; phylostratigraphic analysis; innate immunity-placentation; endogenous retroviruses; sex determination; male infertility; endocrine disruption; environmental pollution

Online: 12 June 2023 (12:59:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0075.v1

Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

Efstathios S. Giotis, Emine Cil, Greg N. Brooke

Subject: Biology And Life Sciences, Virology Keywords: coronavirus; TMPRSS2; ACE2; SARS-CoV-2; androgens; sex hormones; antiandrogens

Online: 3 November 2022 (09:21:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0403.v1

Are Men Better at Recognizing Emojis than Facial Expressions?

Linda Dalle Nogare, Alice Cerri, Alice Mado Proverbio

Subject: Social Sciences, Cognitive Science Keywords: visual perception; emotion; emoji; emoticon; sex differences; anger; fear; emotional communication; texting

Online: 23 January 2023 (08:43:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0761.v1

A Narrative Review on a Deep Understanding of the Dominant Physiological Energy Systems in Basketball and the Importance of Specificity and Uniqueness in Measuring Basketball Players

Asaf Shalom, Roni Gottlieb, Pedro E. Alcaraz, Julio Calleja-González

Subject: Biology And Life Sciences, Life Sciences Keywords: physiology; basketball; testing; explosive; unique; specific movements

Online: 12 October 2023 (05:32:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0536.v1

Serum Specific Immunoglubulin E: Major Determinant for Accessing Sensitivity for Various Pediatric Allergies in North India

Swati Gupta, Rajiv Kumar Gupta, Vigyan Mishra, Hridayesh Prakash

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pediatric Allergy. Specific IgE; Skin prick test; allergens

Online: 7 August 2023 (10:46:46 CEST)

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High prevalence of allergic disorders in Indian pediatric patients demands early diagnosis of allergens so that appropriate allergen avoidance methods, pharmacotherapy or immunotherapy can be provided in time to avoid the worsening of symptoms due to triggers. In this context, identification of the most prevalent aeroallergens in a given area is critical for diagnosis and treatment of various allergic reactions especially in case of rhino-conjunctivitis and asthma. The specific diagnosis of IgE mediated allergy is usually based on the correlation between the clinical history and signs and symptoms endorsed by the diagnostic tests. Skin prick tests are the gold standard however has some limitation. In view of this, the aim of this study was to assess the significance of ImmunoCAP assay for assessing serum specific IgE levels, available in India, against skin prick test by standardized allergens, for the diagnosis of allergic sensitization. A single-center observational study was conducted at tertiary care corporate hospitals in North India from 2017-2020. Patients with self-reported allergic symptoms or whose symptoms were suspected for allergies were tested for the type of sensitization using skin prick test (SPT) after their consents followed by ImmunoCAP based quantification of serum specific IgE levels. A total of 256 (95.9%) pediatric patients were analyzed in the study and were analysed. The patients were most commonly (30% patients) sensitized to D. farinae (173 [67.6%]), D. pteronyssinus (174 [68.0%]), Acarus siro (93 [36.3%]), Lepidoglyphus destructor (96 [37.5%]), Plantago lanceolata (Engl.). The ROC curve of Bermuda grass shows that the AUC of serum-specific IgE is larger than that of SPT (1.000 / 0.881). The receiver operating characteristic (ROC) analysis of serum-specific IgE reference method resulted in the largest AUC of all the allergens taken into consideration (0.711 / 1.000) compared to those of SPT (0.589 / 1.000). These results revealed that serum-specific IgE is more reliable method over prick test for accessing the sensitivity of patient for various allergens. This study may be helpful in performing early diagnosis of allergies as well as in taking appropriate preventive measures for managing life threatening allergic reactions

Preprint ARTICLE | doi:10.20944/preprints202112.0075.v1

Dynamic Patterns of Sex Chromosome Evolution in Neognath Birds: Many Independent Barriers to Recombination at the ATP5F1A Locus

Rebecca T. Kimball, Edward L. Braun

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Sex chromosomes; Hill-Robertson interference; male-driven molecular evolution; pseudoautosomal region; pseudogenes; purifying selection; protein structure; Psittaciformes

Online: 6 December 2021 (13:21:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0185.v1

De Novo Assembly and Annotation of 11 Diverse Shrub Willow (Salix) Genomes Reveals Novel Gene Organization in Sex-Linked Regions

Brennan Hyden, Kai Feng, Timothy B Yates, Sara Jawdy, Chelsea Cereghino, Lawrence B Smart, Wellington Muchero

Subject: Biology And Life Sciences, Plant Sciences Keywords: Salix; shrub willow; genome assembly; sex determination

Online: 12 December 2022 (01:46:15 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202212.0219.v1

SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies

Maria Noel Badano, Matias Pereson, Florencia Sabbione, Irene Keitelman, Natalia Aloisi, Roberto Chuit, Maria Marta Elizalde de Bracco, Susana Fink, Patricia Bare

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2 breakthrough infections; vaccines; anti-spike antibody levels; humoral response; IgG specific salivary antibodies

Online: 13 December 2022 (02:28:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0487.v2

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Wolfgang Poller, Bettina Heidecker, Enrico Ammirati, Andreas W Kuss, Ana Tzvetkova, Wolfram C Poller, Carsten Skurk, Arash Haghikia

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Immunology; innate immunity; immunogenetics; noncoding genome; tRNA biology; evolutionary genetics (list 3-10 specific to the article yet reasonably common within the subject discipline)

Online: 1 November 2022 (09:55:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0516.v1

The Confound of Hemodynamic Response Function Variability in Resting-State Functional MRI Studies

D Rangaprakash, Robert Barry, Gopikrishna Deshpande

Subject: Biology And Life Sciences, Biophysics Keywords: BOLD fMRI; HRF; resting state connectivity; aging; sex differences; confound

Online: 28 February 2023 (09:32:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1752.v2

Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Setting an Organotypic Brain Slice Culture Investigating Tool

Eugenia Vivi, Lea R Seeholzer, Anastasia Nagumanova, Barbara Di Benedetto

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: organotypic brain slice culture; astrocyte; synaptic phagocytosis; critical period; sex differences

Online: 29 November 2023 (09:43:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0810.v1

Risk Factors and Prognostic Nomogram for Early-onset Endometrial Cancer: A SEER-Based Analysis

Yunfeng Zheng, Peng Jiang, Qingyu Shen, Yuan Tu, Yuzhen Huang, Jinyu Wang, Chenfan Tian, Shikai Gou, Rui Yuan

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: early-onset endometrial cancer; prognostic nomogram; overall survival; cancer-specific survival; SEER

Online: 13 October 2023 (03:02:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0377.v1

Calibrating A Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness

Peter Bröde, Maren Claus, Patrick D. Gajewski, Stephan Getzmann, Klaus Golka, Jan G. Hengstler, Edmund Wascher, Carsten Watzl

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; immunosenescence; physical fitness; physical activity; obesity; sex

Online: 26 September 2022 (05:00:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1568.v1

Gender: a Postmodern idea Developed in Association with the Modern Concept of Sex; Implications for Evolving Sexuality

Carol Nash

Subject: Social Sciences, Gender And Sexuality Studies Keywords: gender; modern thought; sex; capitalism; standardization; eugenics; postmodern thought; sexuality

Online: 23 May 2023 (04:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0420.v1

Normative scores for CrossFit® Open Workouts: 2011 - 2022

Gerald T. Mangine, Nina Grundlingh, Yuri Feito

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fitness assessment; sport-specific; athlete classification; high-intensity functional training; sex differences

Online: 22 December 2022 (06:34:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0989.v1

An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease

Mara Schvarzstein, Fatema Alam, Muhammad Toure, Judith L Yanowitz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Whole genome duplication; tetraploidy; polyploidy; aneuploidy; Caenorhabditis; WGD model (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)

Online: 26 April 2023 (12:43:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1276.v1

Understanding Transcription Factors and How They Affect Metabolic Processes in Cucumber Sex Determination

Szymon Turek, Aparna Aparna, Agnieszka Skarzyńska, Wojciech Pląder, Magdalena Pawełkowicz

Subject: Biology And Life Sciences, Plant Sciences Keywords: transcription factors; interactome network; sex development; sex determination; Cucumber (Cucumis sativus); metabolomic processes

Online: 1 May 2023 (00:01:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0457.v1

Lateral Flow Biosensor for microRNA Detection Based on Peptide Nucleic Acid Probes

Aodi Liu, Qingjie Xia, Yang Huang, Haoheng Liu, Jin Tian, Kezhou Li

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Peptide nucleic acid; microRNA detection; duplex specific nuclease; Early diagnosis of pancreatic cancer; Lateral flow biosensor

Online: 18 April 2023 (02:48:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0023.v1

PSI-mediated Vacuolar Sorting is not Disrupted in Arabidopsis leb-2 Mutant

Tatiana Cardoso, Miguel Sampaio, João Neves, Sofia Oliveira, Inês Moura, Ana Séneca, José Pissarra, Susana Pereira, Cláudia Pereira

Subject: Biology And Life Sciences, Plant Sciences Keywords: Arabidopsis; ER-bodies; aspartic proteinases; Plant Specific Insert; Vacuolar sorting; Endomembranes

Online: 3 April 2023 (10:36:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0646.v1

Pacing Strategy of 800-Meter and 1500-Meter Freestyle Swimming Finals in the World Championships According to the Performance in Males and Females of Different Age Groups

Sabrina Demarie, Jean Renaud Pycke, Alessia Pizzuti, Veronique Billat

Subject: Biology And Life Sciences, Other Keywords: energy cost; endurance; training; technique; tactic; fatigue; performance; time series; mathematical modelling; sex difference

Online: 11 September 2023 (14:45:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0200.v1

SARS-CoV-2-Specific Immune Responses in Vaccination and Infection during the Pandemic in 2020–2022

Wakana Inoue, Yuta Kimura, Shion Okamoto, Takuto Nogimori, Akane Sakaguchi-Mikami, Takuya Yamamoto, Yasuko Tsunetsugu-Yokota

Subject: Medicine And Pharmacology, Other Keywords: SARS-CoV-2; COVID-19; infection and vaccination; serum and saliva; RBD and N-specific; IgG and IgA; T-cell responses

Online: 5 February 2024 (03:43:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0587.v1

Development of Clause Complexity in Children with Specific Language Impairment/Language Development Disorder. A Longitudinal Study

Claudia Araya, Carmen Julia Coloma, Camilo Quezada, Paula Benavente

Subject: Social Sciences, Language And Linguistics Keywords: Grammar; clause complexity; longitudinal study; Specific Language Impairment (SLI); Developmental Language Disorder (DLD).

Online: 8 June 2023 (04:41:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1348.v1

A Cancer-Specific Monoclonal Antibody against Podocalyxin Exerted Antitumor Activities in Pancreatic Cancer Xenografts

Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: podocalyxin; PODXL; cancer-specific monoclonal antibody; defucosylated antibody; pancreatic cancer

Online: 20 October 2023 (11:46:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0117.v2

Brain Stars Take the Lead during Critical Periods of Early Postnatal Brain Development: Relevance of Astrocytes in Health and Mental Disorders

Eugenia Vivi, Barbara Di Benedetto

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: astrocytes; critical period; synapse phagocytosis; sex differences; neuropsychiatric and neurodevelopmental disorders

Online: 13 March 2024 (07:22:10 CET)

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In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to the onset of severe pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology, molecular makeup and astrocyte-dependent processes in different affected brain regions in neurodevelopmental (ND) and neuropsychiatric (NP) disorders. Astrocytes proliferate, differentiate and mature during the critical period of early postnatal brain development, a time window of elevated glia-dependent regulation of a proper balance between synapse formation/elimination, which is pivotal in refining synaptic connectivity. Therefore, any intrinsic and/or extrinsic factors altering these processes during the critical period may result in an aberrant synaptic remodelling and onset of mental disorders. The peculiar bridging position of astrocytes between synaptic and vascular compartments further allows them to “compute” the brain state and consequently secrete factors in the bloodstream, which may serve as diagnostic biomarkers of distinct healthy or disease conditions.Here, we collect recent advancements regarding astrogenesis and astrocyte-mediated regulation of neuronal network remodelling during early postnatal critical periods of brain development, focusing on synapse elimination. We then propose alternative hypotheses for an involvement of aberrancies in these processes in the onset of ND and NP disorders. In light of the well-known differential prevalence of certain brain disorders between males and females, we also discuss putative sex-dependent influences on these neurodevelopmental events.From a translational perspective, understanding age- and sex-dependent astrocyte-specific molecular and functional changes may help to identify biomarkers of distinct cellular (dys)functions in health and disease, favouring the development of diagnostic tools or the selection of tailored treatment options for male/female patients.

Preprint REVIEW | doi:10.20944/preprints202305.0031.v1

Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, Igor Buchwalow, Markus Tiemann, Mami Noda

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: molecular hydrogen; reactive oxygen intermediates; mast cells; secretome; specific mast cell proteases; local tissue microenvironment; inflammation

Online: 1 May 2023 (11:54:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.2099.v1

Epidemiological and Clinical Characteristics of Mpox in Cisgender and Transgender Women and Non-Binary Individuals Assigned to Female Sex at Birth: A Comprehensive, Critical Global Perspective

Nicola Luigi Bragazzi, Woldegebriel Assefa Woldegerima, Jianhong Wu, Manlio Converti, Lukasz Szarpak, Andrea Crapanzano, Marwan Odeh, Raymond Farah, Rola Khamisy-Farah

Subject: Biology And Life Sciences, Life Sciences Keywords: Mpox; cisgender; transgender women; and non-binary individuals assigned to female sex at birth; gender-specific differences; gender medicine ;

Online: 30 January 2024 (13:04:15 CET)

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The 2022-2023 Mpox multi-country outbreak, identified in over 110 WHO Member States, revealed a predominant impact on cisgender men, particularly those engaging in sex with men, while less frequently affecting women. This disparity prompted a focused investigation into the gender-specific characteristics of Mpox infections, particularly among women, to address a notable knowledge gap. This review systematically gathers and analyzes scientific literature and case reports concerning Mpox infections in women, covering a broad geographical spectrum including regions such as Buenos Aires, Brazil, Northern California, Colombia, Nigeria, Europe, Vietnam, Spain, Switzerland, and the United States. The analysis delves into various aspects of Mpox in women, including clinical features, epidemiology, psychological impacts, preparedness strategies, and case studies, with particular attention to pregnant women and those with underlying health conditions. Empirical data from multiple studies underscore the unique epidemiological and clinical patterns of Mpox in women. In the United States, a small percentage of Mpox cases were reported among cisgender women, with a notable portion involving non-Hispanic Black or African American, non-Hispanic White, and Hispanic or Latino ethnicities. The primary transmission route was identified as sexual or close intimate contact, with the virus predominantly manifesting on the legs, arms, and genital areas. Further, a study in Spain highlighted significant disparities in diagnosis delays, transmission modes, and clinical manifestations between genders, indicating a different risk profile and disease progression in women. Additionally, a case from Vietnam linked to a new Mpox sublineage in women emphasizes the role of women in the transmission dynamics and the importance of genomic monitoring. This review emphasizes the necessity for inclusive surveillance and research to fully understand Mpox dynamics across diverse population groups, including women. Highlighting gender and sexual orientation in public health responses is crucial for an effective approach to managing the spread and impact of the disease. The findings advocate for a gender-diverse assessment in health services and further research to explore the nuances of Mpox transmission, behavior, and progression among different groups, thereby enhancing the global response to Mpox and similar public health challenges.

Preprint ARTICLE | doi:10.20944/preprints202310.0683.v2

Perception Of Pre-Marital Sex, Courtship among Osun State University Undergraduates, Osogbo, Osun State

Abdulazeez A. Olayiwola, Adeyemi O. Omoge, Abayomi Olarinmoye, Grace Benzard, Halima U. Yahaya, Odunayo G. Aborisade, Jennifer Osolase

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Pre-Marital Sex; courtship; influences; university; undergraduates

Online: 17 October 2023 (03:38:54 CEST)

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BACKGROUND: Pre-marital sex is a sexual interest practiced by people who are yet to get married and has ended up being accepted specifically in western countries. Sex before marriage is sexual behavior engaged in by single people. In the past, having sex before getting married is seen as a moral dilemma that many cultures forbade and that many people regarded to be sin in many religions, although it has gained wider acceptance across the board. OBJECTIVES: This study was carried out to determine the perception, practices, and factors associated with pre-marital sex, courtship, and its influences among Osun State University Undergraduates, Osogbo, Osun State. METHODOLOGY: The study was a descriptive study, and respondents were selected using multi-stage sampling technique. Students of Osun State University, Osogbo main campus form the population of the study and its sample size was calculated using Leslie Kish’s formula. A total of 387 responses were validated from the survey. The instrument for data collection was a self-administered semi-structured questionnaire consisting of four sections. The data obtained were collated, examined for completion, coded, imputed, and analyzed using SPSS v21. RESULTS: The mean age of the respondents was between 19.19±2.17, and the majority were between 18 – 24 years. About 52% of the respondents show a positive perception of premarital sex and courtship. Also, in the practice of courtship majority (88.3%) of the respondents think those that go around together are courting and from the responses obtained and analyzed from the factors leading to pre-marital sex, the findings revealed that peer pressure (90.4%), Internet (86.7%), pornography (83.9%) and drugs (82.9%) are the leading factors which contribute to pre-marital sex among undergraduates. CONCLUSION: The study hereby recommends that Parents should as a matter of responsibility monitor and pays regular visits to their children in the universities and provide them with materials that will make them stay comfortable for them not to fall victim to peer pressure.Pre-marital sex is a practice that should be avoided by undergraduate students, though most students consider courtship as a normal practice, it is still used as a normal factor that leads them to practice pre-marital sex.

Preprint ARTICLE | doi:10.20944/preprints202311.0496.v1

Marina Khodanovich, Mikhail Svetlik, Anna Naumova, Daria Kamaeva, Anna Usova, Marina Kudabaeva, Tatyana Anan’ina, Irina Wasserlauf, Valentina Pashkevich, Marina Moshkina, Victoria Obukhovskaya, Nadezhda Kataeva, Anastasia Levina, Yana Tumentceva, Vasily Yarnykh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: normal aging; myelin; quantitative MRI; neuroimaging; macromolecular fraction mapping; magnetization transfer; MPF; white matter; FLAIR hyperintensities; demyelination; myelin-specific autoantibodies; myelin basic protein, proteolipid protein

Online: 8 November 2023 (07:41:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1435.v1

A-DSCNN: Depthwise Separable Convolutional Neural Network Inference Chip Design using an Approximate Multiplier

Jin-Jia Shang, Nicholas Phipps, I-Chyn Wey, Tee Hui Teo

Subject: Engineering, Electrical And Electronic Engineering Keywords: Application-Specific Integrated Circuits; Approximate Multiplier; CMOS; Convolutional Neural Network; Depthwise Separable Convolution; Processing Element

Online: 21 June 2023 (03:49:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0371.v1

Nuclei on the Rise: When Nuclei-Based Methods Meet Next-Generation Sequencing

Tamer Butto, Kanak Mungikar, Peter Baumann, Jennifer Winter, Beat Lutz, Susanne Gerber

Subject: Medicine And Pharmacology, Hematology Keywords: Nuclei isolation; Next-generation sequencing; Cell-type specific isolation; Epigenetics; Transcriptomics; Single cell sequencing; Single nucleus sequencing

Online: 21 March 2023 (06:40:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0211.v1

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Xinming Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: klotho; estrogen; hippocampus; chronic stress; sex difference; stress resilience

Online: 13 December 2022 (01:09:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0845.v1

The Genetic Basis Underpinning Sexually Selected Traits across Different Animal Lineages: Are the Genetic Mechanisms in Common?

Ji Hyoun Kang

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: co-option; evolutionary novelty; male ornament; male-specific trait; sexual selection

Online: 10 January 2024 (14:43:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0605.v1

Synthesis and Evaluation of 99mTc-labeled PSMA-targeted Tracers Based on the Lys-urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography

Kelly Lu, Chengcheng Zhang, Zhengxing Zhang, Hsiou-Ting Kuo, Nadine Colpo, François Bénard, Kuo-Shyan Lin

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: prostate-specific membrane antigen (PSMA); technetium-99m; single photon emission computed tomography (SPECT); molecular imaging; HYNIC

Online: 8 June 2023 (08:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0355.v1

Risk Assessment of Transgender People: Development of Rodent Models Mimicking Gender-Affirming Hormone Therapies and Identification of Sex-Dimorphic Liver Genes as Novel Biomarkers of Sex Transition

Roberta Tassinari, Alessia Tammaro, Gabriele Lori, Sabrina Tait, Andrea Martinelli, Luigia Cangemi, Paolo Frassanito, Francesca Maranghi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: testosterone; estrogen; cyprotenone acetate; masculinizing; feminizing; cytochrome P450; sex-specific genes

Online: 18 November 2022 (10:10:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0275.v1

Unveiling Racial and Ethnic Disparities in MPOX Virus Vaccine Distribution and Demographic Patterns in the United States

Alex Siu Wing Chan

Subject: Arts And Humanities, Other Keywords: MPOX; health care intervention; Men who have sex with men; public health strategies; vaccine

Online: 6 November 2023 (13:38:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0262.v1

Synthesis, ¹²³I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with Tributylstannyl Prosthetic Group in Their Structures

Lutfi A. Hasnowo, Maria S. Larkina, Evgenii V. Plotnikov, Vitalina Bodenko, Feruza Yuldasheva, Elena Stasyuk, Stanislav A. Petrov, Nikolai Y. Zyk, Aleksei E. Machulkin, Nikolay I. Vorozhtsov, Elena K. Beloglazkina, Valentine G. Nenajdenko, Vladimir Tolmachev, Anna Orlova, Alexander G. Majouga, Mekhman S. Yusubov

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: DCL ligand; iodine radioisotopes; radiolabeled pharmaceuticals; targeted delivery; prostatic specific membrane antigen; prostate cancer

Online: 5 July 2023 (04:43:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0049.v1

Dietary and Sexual Correlates of Gut Microbiota in the Japa-Nese Gecko, Gekko japonicus (Schlegel, 1836)

Xin-Ru Jiang, Ying-Yu Dai, Yu-Rong Wang, Kun Guo, Yu Du, Jian-Fang Gao, Long-Hui Lin, Peng Li, Hong Li, Xiang Ji, Yan-Fu Qu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: ASVs; diet habit; Gekko japonicus; gut microbiota; sex

Online: 3 March 2023 (01:31:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0496.v1

Cell Type Specific Extracellular Vesicles and Their Impact on Health and Disease

Sohil Amin, Hamed Massoumi, Deepshikha Tewari, Arnab Karmaker Roy, Madhurima Chaudhuri, Cedra Jazayerli, Abhi Krishan, Mannat Singh, Mohammad Soleimani, Esra Karaca, Arash Mirzaei, Victor H Guaiquil, Mark I Rosenblatt, Ali R Djalilian, Elmira Jalilian

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell type specific extracellular vesicles; extracellular vesicles; exosomes; intercellular communication; diagnostic biomarkers; disease pathogensis

Online: 8 February 2024 (09:18:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0711.v1

Young Women’s Attitudes and Concerns on Pornography and Their Sexual Experiences: A Qualitative Approach

Mónica Fernández-Ruiz, Olga María López-Entrambasaguas, Jose Manuel Martínez-Linares, José Granero-Molina

Subject: Public Health And Healthcare, Primary Health Care Keywords: pornography; qualitative research; sexual behavior; sex education; sexual health; young women

Online: 9 August 2023 (09:05:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0575.v1

Di(2-Ethylhexyl) Phthalate Induces Osteoblast Cytotoxicity through Alterations in the Oxidant-Antioxidant System

Gautham Chengizkhan, Manju Mohan, Shabana Thabassum Mohammed Rafi, Sridhar Muthusami, Satish Ramalingam, Lurdes Queimado, R. Ileng Kumaran, Srinivasan Narasimhan, Ilangovan Ramachandran

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Di(2-ethylhexyl) phthalate (DEHP); Endocrine disrupting compound (EDC); sex steroid receptor; Runt-related transcription factor 2 (Runx2); oxidant-antioxidant system; osteoblastic cells; bone

Online: 8 January 2024 (07:14:11 CET)

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Humans are often exposed to various environmental contaminants, among which phthalates are prevalent due to their extensive use as plasticizers in various consumer goods. Di(2-ethylhexyl) phthalate (DEHP), a widely used phthalate, is recognized as an endocrine disruptor chemical (EDC). DEHP is reported to affect various organs. Few studies have addressed the effects of phthalates on bone. However, the effects of DEHP on the bone forming cells (osteoblasts) are obscure. The present study was peformed to determine the cytotoxic effects of DEHP on human osteoblasts in vitro and to delineate the mechansims. In this study, we exposed the human osteo-blastic cell line MG-63 to various concentrations of DEHP (1, 25, 50 and 100 µM) for 24, 48 and 72 h. Cell viability was assessed by MTT assay. Total RNA and protein were collected after 48 h treatment with 1 and 100 µM DEHP and determined for the mRNA and/or protein expression of alkaline phosphatase (ALP), sex steroid receptors (androgen and estrogen receptors), receptor activator of nuclear factor kappa-Β ligand (RANKL), runt-related transcription factor 2 (RUNX2) and peroxisome proliferator-activated receptor alpha (PPARα). The mRNA expression was stud-ied by real-time RT-PCR analysis and the protein expression was determined by western blot analysis. Statistical analyses were done by one-way analysis of variance (ANOVA) followed by the Students–Newman–Keuls (SNK) test. The exposure of MG-63 cells to DEHP caused a signifi-cant decrease in osteoblast viability in all the treatment groups and at all the time points stud-ied. Interestingly, DEHP exposure decreased the mRNA expression of ALP, a bone formation marker. DEHP had differential effects on estrogen receptor alpha (ERα) mRNA and protein ex-pression. However, DEHP treatment downregulated the mRNA and protein expression of ERβ, and androgen receptor (AR). Surprisingly, DEHP downregulated the RANKL mRNA expression. DEHP decreased the protein expression of RUNX2, the key transcription factor and master regu-lator of bone formation. Furthermore, DEHP increased the PPARα protein expression in the os-teoblasts. Importantly, DEHP increased the reactive oxygen species (ROS) molecules and thus oxidative stress in osteoblasts, as observed by increased hydrogen peroxide, hydroxyl radical levels and lipid peroxidation. On the other hand, it decreased the enzymatic and non-enzymatic antioxidant levels namely catalase, superoxide dismutase, glutathione peroxidase activity and reduced glutathione. Our study demonstrated that in vitro exposure to DEHP reduces the osteo-blast viability possibly through alterations in the oxidant-antioxidant system and modulation of the key genes involved in bone formation, highlighting the cytotoxic effects of DEHP on bone forming cells.

Preprint REVIEW | doi:10.20944/preprints202402.1401.v1

3-D structure of Novel Liver Cancer Biomarker LC-SPIK and its Performance in Clinical Diagnosis of HCC

Xuanyong Lu, Felix Lu, Connor Ott, Prabha Bista

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Biomarker; HCC (Hepatocellular Carcinoma); LC-SPIK (Liver Cancer specific Serine Protease Inhibitor Kazal); AFP (Alpha-Fetoprotein); NAFLD (nonalcoholic fatty liver disease)

Online: 26 February 2024 (12:01:59 CET)

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LC-SPIK is a liver cancer-specific isoform of Serine Protease Inhibitor Kazal and has been proposed as a new biomarker for the detection of HCC given its unique 3-D structure which differs from normal pancreatic SPIK. An ELISA technology based on its unique structure was developed to use LC-SPIK as an effective biomarker for the clinical diagnosis of HCC. AFP, the most widely used biomarker for HCC surveillance currently, suffers from poor clinical performance, especially in the detection of early-stage HCC. In one case-control study, which included 164 HCC patients and 324 controls, LC-SPIK had an AUC of 0.87 compared to only 0.70 for AFP in distinguishing HCC from liver disease controls (cirrhosis, HBV/HCV). LC-SPIK also performed significantly better than AFP for the 81 patients with early-stage HCC (BCLC stage 0 and A), with an AUC of 0.85 compared to only 0.61 for AFP. Cirrhosis is the major risk factor for HCC, about 80% of patients with newly diagnosed HCC have preexisting cirrhosis. LC-SPIK’s clinical performance was also studied in HCC patients with viral and non-viral cirrhosis including cirrhosis caused by nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). In a total of 163 viral cirrhosis patients with 93 HCC patients (50 early-stage), LC-SPIK had an AUC of 0.85, while AFP had an AUC of 0.70. For patients with early-stage HCC, LC-SPIK had a similar AUC of 0.83, while AFP had an AUC of only 0.60. For 120 patients with nonviral cirrhosis, including 62 HCC (23 early-stage) patients, LC-SPIK had an AUC of 0.84 while AFP had an AUC of only 0.72. For the 23 patients with early-stage HCC, LC-SPIK had a similar AUC of 0.83, while the AUC for AFP decreased to 0.65. All these results suggest that LC-SPIK has significantly better performance in the detection of HCC than AFP in all etiologies of liver diseases. In addition, LC-SPIK accurately detected the presence of HCC in 71%-91% of HCC patients with false-negative AFP test results in viral associated HCC and non-viral associated HCC.

Preprint REVIEW | doi:10.20944/preprints202401.0124.v1

Phage Display for Early Diagnosis of Prostate Cancer

VALERY A Petrenko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Phage display; landscape phage; molecular evolution; affinity selection; recombinant antibodies, PC; prostate specific antigen (PSA); prostate-specific matrix antigen (PSMA); Enzyme-linked immunosorbent assay (ELISA); phage ELISA; phage capture assay; electrochemical biosensor; total prostate-specific antigen (t-PSA); free prostate-specific antigen (F-PSA); electrochemical impedance spectroscopy; label-free immunosensor

Online: 3 January 2024 (10:36:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1632.v1

A Cross-Sectional, Multicenter, Disease-Specific, Health-Related Quality of Life study in Greek Transfusion Dependent Thalassemia Patients

Philippos Klonizakis, Noémi Roy, Ioanna Papatsouma, Maria Mainou, Ioanna Christodoulou, Despina Pantelidou, Smaro Kokkota, Michael Diamantidis, Alexandra Kourakli, Vasilios Lazaris, Dimitrios Andriopoulos, Apostolos Tsapas, Robert J. Klaassen, Efthymia Vlachaki

Subject: Biology And Life Sciences, Life Sciences Keywords: Transfusion-Dependent Thalassemia; Health-Related Quality of Life; Patient Reported Outcomes; disease-specific TranQol questionnaire; Healthcare policy; Thalassemia Unfastructure

Online: 21 December 2023 (13:41:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0307.v1

Testing and Evaluation of Cervical Joint in Young Males and Females: Strength, Range of Motion and Musculoskeletal Pains

Christos Batatolis, Konstantina Karatrantou, Vaggelis Gymnopoulos, Dr. Vassilis Gerodimos

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: neck; isometric assessment; hand‐held dynamometer; functional capacity; cervical flexion/extension ratio; injury prevention; strength asymmetries; rehabilitation; sex effect

Online: 6 September 2023 (04:27:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1142.v1

Editing Metabolism, Sex, and Microbiome: How can we Help Poplar Resist Pathogens?

Maxim A. Kovalev, Natalya S. Gladysh, Alina S. Bogdanova, Nadezhda L. Bolsheva, Mikhail I. Popchenko, Anna V. Kudryavtseva

Subject: Biology And Life Sciences, Plant Sciences Keywords: Populus; plant pathogens; plant immunity; plant microbiome; plant sex

Online: 15 December 2023 (08:50:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0978.v1

Long-Chain Acyl Coenzyme a Dehydrogenase, a Key Player in Metabolic Rewiring/Invasiveness in Experimental Tumors and Human Mesothelioma Cell Lines

Daniel L. Pouliquen, Giacomo Ortone, Letizia Rumiano, Alice Boissard, Cécile Henry, Stéphanie Blandin, Catherine Guette, Chiara Riganti, Joanna Kopecka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: malignant mesothelioma; metabolism; mitochondria; long-chain specific acyl-CoA dehydrogenase; fatty acid β-oxidation, biomarker

Online: 15 May 2023 (05:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1870.v1

Exploring the Effects of Rearing Densities on Epigenetic Modifications in the Zebrafish Gonads

Alejandro Valdivieso, Marta Caballero-Huertas, Javier Moraleda-Prados, Francesc Piferrer, Laia Ribas

Subject: Biology And Life Sciences, Aquatic Science Keywords: stress; gonad; sex; methylation; masculinization; rearing

Online: 27 September 2023 (10:46:16 CEST)

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