Preprint Hypothesis Version 1 This version is not peer-reviewed

Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank

Wei Li * ORCID logo
Version 1 : Received: 13 January 2020 / Approved: 15 January 2020 / Online: 15 January 2020 (07:53:46 CET)

How to cite: Li, W. Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank. Preprints 2020, 2020010147 (doi: 10.20944/preprints202001.0147.v1). Li, W. Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank. Preprints 2020, 2020010147 (doi: 10.20944/preprints202001.0147.v1).

Abstract

As of today, there is not any direct report yet of the degree to which missing residues exist for experimentally determined membrane protein (MP) structures, which constitute more than half of current drug targets. With a chain- and position-specific visualisation and a statistical analysis of all MP structures inside PDB (as of September 25, 2019), this article argues that the experimentally uncharted territories (EUTs, i.e., consisting of missing residues) within PDB are pluggable and should be plugged with an experimental data-driven hybrid approach, and calls for continued development of MP structural determination with less and less EUTs, in light of MPs' crucial role in biological and biomedical research, both fundamental and pharmaceutical.

Subject Areas

position-specific visualization; experimentally uncharted territories; membrane protein structure; protein data bank

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.