Version 1
: Received: 13 January 2020 / Approved: 15 January 2020 / Online: 15 January 2020 (07:53:46 CET)
How to cite:
Li, W. Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank. Preprints2020, 2020010147. https://doi.org/10.20944/preprints202001.0147.v1
Li, W. Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank. Preprints 2020, 2020010147. https://doi.org/10.20944/preprints202001.0147.v1
Li, W. Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank. Preprints2020, 2020010147. https://doi.org/10.20944/preprints202001.0147.v1
APA Style
Li, W. (2020). Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank. Preprints. https://doi.org/10.20944/preprints202001.0147.v1
Chicago/Turabian Style
Li, W. 2020 "Visualising the Experimentally Uncharted Territories of Membrane Protein Structures inside Protein Data Bank" Preprints. https://doi.org/10.20944/preprints202001.0147.v1
Abstract
As of today, there is not any direct report yet of the degree to which missing residues exist for experimentally determined membrane protein (MP) structures, which constitute more than half of current drug targets. With a chain- and position-specific visualisation and a statistical analysis of all MP structures inside PDB (as of September 25, 2019), this article argues that the experimentally uncharted territories (EUTs, i.e., consisting of missing residues) within PDB are pluggable and should be plugged with an experimental data-driven hybrid approach, and calls for continued development of MP structural determination with less and less EUTs, in light of MPs' crucial role in biological and biomedical research, both fundamental and pharmaceutical.
Keywords
position-specific visualization; experimentally uncharted territories; membrane protein structure; protein data bank
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
