Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-Flair Hyperintensity Volume, and Anti-myelin Antibodies 7 Years Apart

Marina Khodanovich
* ORCID logo ,
Mikhail Svetlik
,
Anna Naumova
ORCID logo ,
Daria Kamaeva
ORCID logo ,
Anna Usova
,
Marina Kudabaeva
,
Tatyana Anan’ina
,
Irina Wasserlauf
,
Valentina Pashkevich
ORCID logo ,
Marina Moshkina
,
Victoria Obukhovskaya
,
Nadezhda Kataeva
,
Anastasia Levina
,
Yana Tumentceva
,
Vasily Yarnykh
Version 1 : Received: 7 November 2023 / Approved: 8 November 2023 / Online: 8 November 2023 (07:41:37 CET)

A peer-reviewed article of this Preprint also exists.

Khodanovich, M.; Svetlik, M.; Naumova, A.; Kamaeva, D.; Usova, A.; Kudabaeva, M.; Anan’ina, T.; Wasserlauf, I.; Pashkevich, V.; Moshkina, M.; Obukhovskaya, V.; Kataeva, N.; Levina, A.; Tumentceva, Y.; Yarnykh, V. Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart. Biomedicines 2024, 12, 61. Khodanovich, M.; Svetlik, M.; Naumova, A.; Kamaeva, D.; Usova, A.; Kudabaeva, M.; Anan’ina, T.; Wasserlauf, I.; Pashkevich, V.; Moshkina, M.; Obukhovskaya, V.; Kataeva, N.; Levina, A.; Tumentceva, Y.; Yarnykh, V. Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart. Biomedicines 2024, 12, 61.

Abstract

Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using the fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33–60 years in the first study) were scanned twice, 7 years apart. An age-related decrease in MPF was found in global WM, GM, and mixed WM-GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2-5%), genu of the corpus callosum (CC) (4.0%) and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM-GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. MPF mapping showed high sensitivity to age-related changes in brain myelination, providing the feasibility of this method in clinics.

Keywords

normal aging; myelin; quantitative MRI; neuroimaging; macromolecular fraction mapping; magnetization transfer; MPF; white matter; FLAIR hyperintensities; demyelination; myelin-specific autoantibodies; myelin basic protein, proteolipid protein

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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