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Preprint REVIEW | doi:10.20944/preprints202404.1239.v1

Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches

Carlo Domenico Maida, Rosario Luca Norrito, Salvatore Rizzica, Marco Mazzola, Antonino Tuttolomondo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Stroke; Ischemic; hemorrhagic; pathophysiology; Long non-coding RNAs; MicroRNAs; Stroke therapeutics

Online: 18 April 2024 (14:00:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1246.v1

Reduction in Hippocampal Aβ Content During Gly-Pro-Glu Co-Administration Is Associated with Changes in Inflammation and IGF-I Signaling

Laura M. Frago, Emma Burgos-Ramos, María Rodríguez-Pérez, Sandra Canelles, Eduardo Arilla-Ferreiro, Jesús Argente, Manuela. G. Lopez, Vicente Barrios

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer´s disease; cytokines; Gly-Pro-Glu; IGF-I signaling; inflammation

Online: 18 April 2024 (10:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1172.v1

Sound-Evoked Neural Activity in Normal Hearing Tinnitus: The Effect of Frequency and Simulation Side

Shahin Safazadeh, Remco A Renken, Marc Thioux, Pim van Dijk

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Tinnitus; Hyperacusis; Tonotopy; Auditory cortices; Parahippocampal gyrus

Online: 17 April 2024 (14:50:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1090.v1

Efficacy and Tolerability of Radiosurgery in Treating Benign Meningioma: A Dose Comparison Study from a Single-Center Analysis

Hyun Jeong Cho, Jong Min Lee, Sung Ho Park, Jun Bum Park, Na Young Jung

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dose; edema; meningioma; stereotactic radiosurgery; toxicity

Online: 17 April 2024 (14:40:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1171.v1

Therapeutic Hypothermia for Severe Traumatic Brain Injury: an Overviews of Reviews and Future Prospects

Hitoshi Kobata

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: clinical trials; evacuated hematoma; meta-analysis; therapeutic hypothermia; traumatic brain in-jury

Online: 17 April 2024 (14:32:27 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1145.v1

Real-World Case Series of Efgartigimod for Generalized Myasthenia Gravis：Well-Tailored Treatment Cycle Intervals Contribute to Sustained Symptom Control

Shingo Konno, Takafumi Uchi, Hideo Kihara, HIdeki Sugimoto

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: myasthnia gravis; efgartigimod; individualized treatment; real-world; cycle interval

Online: 17 April 2024 (13:34:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1130.v1

Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry

Masaru Tanaka, Simone Battaglia, Lydia Giménez-Llort, Chong Chen, Piril Hepsomali, Alessio Avenanti, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ageing; Alzheimer’ s disease; Parkinson’ s disease; spinal injuries; stem cells; depression; stroke; deep brain stimulation; machine learning; dysmenorrhea

Online: 17 April 2024 (08:43:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0907.v1

Emerging Roles of Exosomes in Stroke Therapy

Anthony Larson, Dilmareth N. Rodriguez, Andrew Crane, Dana Larocca, Walter C. Low, Andrew W. Grande, Jieun Lee

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; exosomes; stem cells; stroke therapy

Online: 15 April 2024 (09:46:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0822.v1

Synovial Sarcoma of the Ethmoid Sinus with Extension to the Cavernous Sinus: A Case Report and Literature Review

Haneen Hisham Sharabati, Laila Riyad Innab, Saja Shawki Hussein, Ayman Ahmad Salman, Anis Munir Naser, Izzeddin Abdulsamee' Bakri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ethmoid sinus; Synovial sarcoma; Stroke; Cavernous sinus; Surgery

Online: 12 April 2024 (04:54:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0698.v1

Is it Possible for Patients with Early Distal Junctional Kyphosis following Adult Cervical Deformity Corrective Surgery to Achieve Similar Outcomes to their Unaffected Counterparts: an Analysis of Recovery Kinetics

Oluwatobi O Onafowokan, Bailey Imbo, Tyler Williamson, Ankita Das, Jamshaid M Mir, Matthew Galetta, Nathan Lorentz, Peter G Passias

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cervical deformity; aliggnment; distal junctional kyphosis; recovery kinetics

Online: 10 April 2024 (13:13:00 CEST)

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BACKGROUND: Distal junctional kyphosis (DJK) remains a primary concern for surgeons performing cervical deformity (CD) surgery. Many times post-operative complications from CD surgeries render patients with worse recovery profiles than their peers. It is important to understand DJK recovery profiles following CD surgery patients. PURPOSE: To identify if DJK patients successfully recover from treatment/reoperation STUDY DESIGN/SETTING: Retrospective review of prospectively collected database PATIENT SAMPLE: 113 CD patients OUTCOME MEASURES: CD, HRQL, DJK, Recovery kinetics METHODS: CD patients with available BL and 2Y follow-up data. DJK angle (DJKA) was defined as >10° change in kyphosis between LIV and LIV-2, and a >10° index angle. Patients were stratified into two groups: 1) those who developed DJK by 3M and 2) those that did not develop DJK. Patients who developed DJK beyond 3M were excluded from the study. Means comparison tests analyzed differences in demographic, surgical, radiographic, and health related quality of life (HRQL) scores. Normalized HRQL scores at 3M and follow-up intervals (6M, 1Y, 2Y) were generated. Regression analysis assessed patient reported outcomes adjusting for baseline and surgical characteristics. RESULTS: 113 patients were included (17 DJK, 96 no DJK). Age (60.3 vs 62.2), gender (F: 71.0% vs 61.0%), BMI (27.0 vs 28.3), CCI (0.77 vs 0.98), OpTime (484.0 vs 556.5min), EBL (1028.3 vs 843.9mL), and presenting neurologic symptoms (70.6% vs 76.0%) were similar between groups (P > .05). DJK patients were more sagittally-malaligned preop (cervical sagittal vertical axis {cSVA}: 59.0 vs 43.9); had more osteotomies (76.5% vs 49.0%), and underwent more combined approaches (64.7% vs 26.0%), all p < .05. Posterior approaches, decompressions, and levels fused were similar between groups (p > .05). Following surgery, rate of complications and neurologic symptoms were similar between groups, except DJK patients experienced more dysphagia (17.7% vs 4.2%; p=0.034). DJK patients remained more malaligned in cSVA through 2-yr follow-up (p < .05). DJK patients exhibited worse reported outcomes from 3M to 1Y (p < .05), but these differences subsided when following patients through to 2Y: worse NDI (65.3 vs 35.3) and EQ5D (0.68 vs 0.79) scores at 1Y (both P

Preprint ARTICLE | doi:10.20944/preprints202404.0703.v1

Urine 5-Hydroxyindoleacetic Acid Negatively Correlates with Migraine Occurrence and Characteristics in the Interictal Phase of Episodic Migraine

Michal Fila, Jan Chojnacki, Marcin Derwich, Cezary Chojnacki, Elzbieta Pawlowska, Janusz Blasiak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; tryptophan metabolism; serotonin; 5-hydroxyindoleacetic acid; migraine-related anxiety

Online: 10 April 2024 (10:34:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0678.v1

Neurosurgical Management and Modifiable Risk Factors of Neurocognitive Decline

Ali Ahmed Mohamed, Garrett Flynn, Christopher Haff, Edwin Mouhawasse, Steven Faragalla, Brandon Luke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain computer interface; encapsulated cell biodelivery; focused ultrasound; radiofrequency; radiosurgery; transcranial direct current stimulation; transranial magnetic stimulation; electroconvulsive therapy; Deep Brain Stimulation

Online: 10 April 2024 (07:18:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0326.v2

Modulation of Corticospinal Excitability during Action Observation in Patients with Consciousness-Related Disturbances

Mauro Mancuso, Lucia Mencarelli, Laura Abbruzzese, Benedetta Basagni, Pierluigi Zoccolotti, Cristiano Scarselli, Simone Capitani, Francesco Neri, Emiliano Santarnecchi, Simone Rossi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Disorders of consciousness; minimally consciousness state; vegetative state/unresponsiveness wakefulness syndrome; transcranial magnetic stimulation; action observation

Online: 9 April 2024 (16:50:02 CEST)

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Brain imaging studies have recently provided some evidence in favour of covert cognitive processes ongoing in patients with disorders of consciousness (DoC) (e.g., minimally consciousness states, vegetative state/unresponsive wakefulness syndrome) engaged in passive sensory stimulation or active tasks such as motor imagery. In this exploratory study, we used transcranial magnetic stimulation (TMS) of the motor cortex to assess modulations of corticospinal excitability induced by action observation in eleven patients with DoC. Action observation is known to facilitate corticospinal excitability in healthy subjects, unveiling how the observer’s motor system maps others’ actions onto her/his motor repertoire. Additional stimuli were non-biological motion and acoustic startle stimuli, provided that sudden and loud acoustic stimulation is known to lower corticospinal excitability in healthy subjects. Results indicate that some form of motor resonance is spared in a subset of patients with DoC with some significant difference between biological and non-biological motion stimuli. However, there was no covariation between corticospinal excitability and the type of DoC diagnosis (i.e., whether VS/UWS or MCS). Similarly, no covariation was detected with clinical changes between admission and discharge in clinical outcome measures. Both motor resonance and biological/non-biological motion discrimination correlated with the amplitude of the N20 somatosensory evoked potentials following the stimulation of the median nerve at the wrist (i.e., the temporal marker signalling the activation of the contralateral primary somatosensory cortex). Moreover, the startle-evoking stimulus produced an anomalous increase in corticospinal excitability, suggesting a functional dissociation between cortical and subcortical circuits in patients with DoC. Further work is needed to better comprehend the conditions in which corticospinal facilitation occurs and whether and how they may relate to individual clinical parameters.

Preprint REVIEW | doi:10.20944/preprints202404.0670.v1

Benign Paroxysmal Torticollis

Elisabetta Tozzi, Luca Olivieri, Pamela Silva

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Torticollis; children periodic syndrome; migraine genetics

Online: 9 April 2024 (11:58:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0468.v1

Neuromodulation and Habituation: A Literature Review and Conceptional Analysis of Sustaining Therapeutic Efficacy and Mitigating Habituation

Anand S. Patil, Brittni Levasseur, Mayank Gupta

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal cord stimulator; neuromodulation; explant; chronic pain; waveform; habituation

Online: 7 April 2024 (10:09:58 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0401.v1

Rare and Riveting: A Case Report on Artery of Percheron Occlusion

Simoni Shah, Heer Shah, Mudassir Ahmed, Vismit Gami, Dev Desai

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Artery of Percheron Infract; Ischemic stroke; Thalamus; Midbrain

Online: 5 April 2024 (15:53:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0347.v1

High PGC-1α Expression as a Poor Prognostic Indicator in Intracranial Glioma

Yu-Wen Cheng, Jia-Hau Lee, Chih-Hui Chang, Tzu-Ting Tseng, Chee-Yin Chai, Ann-Shung Lieu, Aij-Lie Kwan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: glioma; PGC-1α; prognosis

Online: 4 April 2024 (17:26:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0366.v1

MicroRNAs (miRNAs) as Biomarkers for Diagnosis, Prognosis, or as Therapeutics Molecules in Neurodegenerative Diseases

Zahraa Alkhazaali, Sajad Sahab-Negah, Amir Reza Boroumand, Jalil Tavakol Afshari

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Microglia cell; neurodegenerative disease; ; miRNA; protein accumulation

Online: 4 April 2024 (10:12:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0360.v1

Functional Characterization of a Spectrum of Genetic Variants in a Family With Succinic Semialdehyde Dehydrogenase Deficiency

Miroslava Didiasova, Samuele Cesaro, Simon Feldhoff, Ilaria Bettin, Nana Tiegel, Vera Füssgen, Mariarita Bertoldi, Ritva Tikkanen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurotransmitter diseases; GABA; mitochondria; protein folding; chaperones; aldehyde dehydrogenases

Online: 4 April 2024 (09:12:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0337.v1

The Role of Tnf and Soluble Tnf Receptors (TNFR1/2) as Therapeutic Targets for Inflammation Secondary to Intracerebral Stroke and Hemorrhage

Rakan Alshaibi, Kanishka Ekanayake, Emily Barlow, Ali Ahmed Mohamed, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebroprotection; ischemia; tumor necrosis factor

Online: 4 April 2024 (06:04:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0301.v1

Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantation in Patients with ALS by Investigating Patient's Specific MicroRNAs as Novel Biomarkers: A Retrospective Study

Zahraa Alkhazaali, Sajad Sahab-Negah, Amir Reza Boroumand, Najmeh Kaffash Farkhad, Mohammad Ali Khodadoust, Rashin Ganjali, Jalil Tavakol-Afshari

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: bone marrow-derived mesenchymal stem cells; ALS; microRNA; Mir206; Mir338-3p; RT -PCR.

Online: 3 April 2024 (14:25:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0277.v1

The Role of CyberKnife Stereotactic Radiosurgery in Recurrent Cranial Medulloblastomas across Pediatric and Adult Populations

Kelly H Yoo, Neelan J Marianayagam, David J Park, Aroosa Zamarud, Xuejun Gu, Erqi L Pollom, Scott G Soltys, Antonio Meola, Steven D Chang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Stereotactic radiosurgery; CyberKnife Radiosurgery; Medulloblastoma

Online: 3 April 2024 (14:12:48 CEST)

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Background and Objectives: Medulloblastoma is the most common malignant brain tumor in children. In recent decades, the therapeutic landscape has undergone significant changes, with stereotactic radiosurgery (SRS) emerging as a promising treatment for recurrent cases. Our study provides a comprehensive analysis of the long-term efficacy and safety of SRS in recurrent medulloblastomas across both pediatric and adult patients at a single institution. Methods: We retrospectively reviewed the clinical and radiological records of patients who underwent CyberKnife SRS for recurrent cranial medulloblastomas at our institution between 1998 and 2023. Follow-up data were available for 15 medulloblastomas in 10 patients. The cohort comprised 8 pediatric patients (ages 3-18) and 2 adult patients (ages 19-75). Median age at the time of SRS was 13 years, median tumor volume accounted for 1.9 cc, median biologically equivalent dose (BED) was 126 Gy, and single-fraction equivalent dose (SFED) was 18 Gy. The SRS was administered at 75% of the median isodose line. Results: Following a median follow-up of 39 months (range: 6-78), 53.3% of the medulloblastomas progressed, 13.3% regressed, and 33.3% remained stable. The 3-year local tumor control (LTC) rate for all medulloblastomas was 65%, with lower rates observed in the adult cohort (50%) and higher rates in pediatric patients (67%). The 3-year overall survival (OS) rate was 70%, with significantly higher rates in pediatric patients (75%) compared to adult patients (50%). The 3-year progression-free survival (PFS) rate was 58.3%, with higher rates in pediatric patients (60%) compared to adult patients (50%). Two pediatric patients developed radiation-induced edema, while two adult patients experienced radiation necrosis at the latest follow-up, with both adult patients passing away. Conclusion: Our study provides a complex perspective on the efficacy and safety of CyberKnife SRS in treating recurrent cranial medulloblastomas across pediatric and adult populations. The rarity of adverse radiation events (ARE) underscores the safety profile of SRS, reinforcing its role in enhancing treatment outcomes. The intricacies of symptomatic outcomes, intertwined with factors such as age, tumor location, and prior surgeries, emphasize the need for personalized treatment approaches. Our findings underscore the imperative for ongoing research and the development of more refined treatment strategies for recurrent medulloblastomas. Given the observed disparities in treatment outcomes, a more meticulous tailoring of treatment approaches becomes crucial.

Preprint ARTICLE | doi:10.20944/preprints202404.0247.v1

Use of Psychoactive Substances among Biological and Health Sciences Students from Bahia/Brazil

Gustavo Sampaio, Michell Silva, Suzana Souza, Denis Soares

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Psychoactive substances; university students; profile of consumption; anonymous questionnaire

Online: 3 April 2024 (11:06:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0872.v2

Beneficial versus Detrimental Effects of Complement-Microglial Interactions in Alzheimer’s Disease

Gunel Ayyubova, Nadeem Fazal

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: complement proteins, cognitive decline, synapse loss, microglia, neurodegeneration

Online: 2 April 2024 (15:22:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0223.v1

The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity

James Richard Hall, Melissa Petersen, Sid E. O’Bryant

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuropsychological tests; Alzheimer’ s disease; plasma biomarkers; ethnicity

Online: 2 April 2024 (15:15:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0216.v1

Reduced Acute Ischemic Stroke-Induced Neural Inflammation Using Neural Stem Cell-Derived Extracellular Vesicles (AB126)

Samantha Spellicy, Emily Baker, Kelly Arscott, Sean Savitz, Steven L. Stice

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neural stem cell-derived extracellular vesicles, stroke, ; neuroinflammation

Online: 2 April 2024 (14:29:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0202.v1

Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the Substantia Nigra, Jejunum, and Colon, in a Model of O3 Pollution in Rats

Marlen Valdés-Fuentes, Erika Rodríguez-Martínez, Selva Rivas-Arancibia

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ozone pollution; neurodegeneration; Alpha-synuclein; inflammation; NFκB; Th17; substantia nigra; gut

Online: 2 April 2024 (12:16:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0188.v1

Neuromodulation and the Gut-Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders

Baha’ Aljeradat, Danisha Kumar, Suliman Abdulmuizz, Mrinmoy Kundu, Yasser F. Almealawy, Dima Ratib Batarseh, Oday Atallah, Michelle Ennabe, Muath Alsarafandi, Albert Alan, Martin Weinand

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Gut-Brain-Axsis; Neuromodulation; Deep Brain stimulation; Vagus nerve Stimulation; Irritable Bowel Syndrome; Inflammatory Bowel Disease.

Online: 2 April 2024 (10:40:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0135.v1

Molecular Links between Inflammatory Bowel Disease and Mild Cognitive Impairment- a Narrative Review

Oliviu Florentiu Sarb, Adriana Daniela Porca, Maria Iacobescu, Irina-Maria Vlad, Mircea Vasile Milaciu, Lorena Ciumarnean, Vitalie Vacaras, Alina-Ioana Tantau

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: IBD; neurodegeneration; mild cognitive impairment; serum biomarker; systemic inflammation; gut-brain axis

Online: 2 April 2024 (07:35:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0024.v1

The Critical Issues for Patients and Caregivers in Neuro-Oncology During Covid-19 Pandemic: What We Have Learnt by an Observational Study.

Elena Anghileri, Irene Tramacere, Sara Morlino, Catia Leuzzi, Lorena Pereja Gutierrez, Saba Motta, Antonio Silvani, Francesca Romana Berrini

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Anxiety; Caregivers; Caregiver Burden; Communication; COVID-19; (Brain) Neoplasms; Pandemics; Perception; Psycho-Oncology; Quality of Life

Online: 1 April 2024 (10:08:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1844.v1

Normalized Clinical Severity Scores Reveal a Correlation between X Chromosome Inactivation and Disease Severity in Rett Syndrome

Jonathan K. Merritt, Xiaolan Fang, Raymond C. Caylor, Steven A. Skinner, Michael J. Friez, Alan K. Percy, Jeffrey L. Neul

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Rett Syndrome, X Chromosome Inactivation, longitudinal modeling

Online: 29 March 2024 (10:27:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1799.v1

Motor-Control Notions in Health and Disease (What Controls Motor Control?)

Payam Dibaj, Uwe Windhorst

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Motor control; kinematics and kinetics; motoneuron; central pattern generators; reflex; internal models; neural networks; sensory-motor learning; cerebellum; neurological diseases; movement disorders

Online: 29 March 2024 (09:16:41 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.1738.v1

A Comparison of Laminectomy and Hemilaminectomy Approaches for Resection of Spinal Schwannomas and Meningiomas

Serena Vittoria Lisi, Fabiola Cappella, Denis Aiudi, Alessandro Di Rienzo, Elena Bianchi, Mario Chiapponi, Andrea Mattioli, Mauro Dobran

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal schwannomas; spinal meningiomas; laminectomy; hemilaminectomy; spinal intradural extramedullary tumors

Online: 29 March 2024 (05:23:24 CET)

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Background: Spinal schwannomas and meningiomas are the most common spinal cord benign tumors in adults and total excision is the goal of the treatment. The traditional surgical approach is performed by total laminectomy, but recently unilateral hemilaminectomy has been recognized as a valuable surgical alternative. We report the clinical results of patients affected by spinal schwannoma and meningioma in whom total laminectomy or unilateral hemilaminectomy were performed. Material and Methods: A retrospective study of patients who underwent resection of spinal meningioma or schwannoma by laminectomy or unilateral hemilaminectomy approaches in our Institute from January 2013 to January 2023 was made. The baseline data of these patients, operative approach and postoperative outcome were compared. Results: The study was performed on 41 patients with mean age of 62.5 ±14.6 years. Our series included 24 (59%) cases of schwannomas and 17 (41%) cases of meningiomas, with a prevalent location in the thoracic spine. The average schwannomas volume was 3,6 ±2,7 cm3, whereas the average meningiomas volume was 1.1 ±0.5 cm3. Total excision was achieved in all cases. Operative time of schwannomas was longer (p=0.001) respect to meningiomas with higher intra-operative blood loss (p=0.000). Total laminectomy approach was performed in 24 out of 41 patients (59%) and unilateral hemilaminectomy approach in 17 out of 41 (41%) patients. Unilateral hemilaminectomy was associated with shorter postoperative bed rest (p=0.003), shorter hospitalization (p=0.028) and lower postoperative pain (p=0.02) respect to total laminectomy. Conclusions: Both spinal schwannomas and spinal meningiomas in various size can be safely and effectively treated with unilateral hemilaminectomy approach. This approach grants more advantages compared with standard total laminectomy, including shorter postoperative bed rest, shorter hospitalization and reduced postoperative pain.

Preprint REVIEW | doi:10.20944/preprints202403.1692.v1

The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

Adonis Sfera, Hassan Imran, Dan O Sfera, Jacob J Anton, Zisis Kozlakidis, Sabine Hazan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: aryl hydrocarbon receptor; dopamine; antipsychotic drugs; naturally occurring antipsychotics; senotherapeutics

Online: 28 March 2024 (12:24:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1689.v1

Benefits of Badminton for Preventing Cognitive Decline and Dementia

Ayame Oishi, Takao Yamasaki

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: badminton; physical activity; open-skill sport; cognitive function

Online: 27 March 2024 (14:14:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1643.v1

Electroencephalogram Criticality in Cognitive Impairment: A Monitoring Biomarker?

Vasilis-Spyridon Tseriotis, Magdalini Tsolaki, George Vavougios, Martha Spilioti, Efstratios Kosmidis

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: EEG; criticality; Alzheimer’ s; mild cognitive impairment; cognitive training; disease monitoring; biomarker

Online: 27 March 2024 (06:39:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1564.v1

Individual progression of S100 calcium-binding protein beta as a surrogate for epilepsy risk: rationale and design of a meta-analysis project

Jianxun He, Beilei Li, Chuhan Miao

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: S100B; Epilepsy; Biomarker; Diagnostic marker; Prognostic value

Online: 27 March 2024 (01:45:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1581.v1

Safety, Tolerability and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist), in a Randomized Clinical Trial in a Subgroup of Patients with ASD

Baltazar Gomez-Mancilla, Craig Erickson, Ernest V Pedapati, Eric Painbeni, Gregory Bonfils, Lauren M Schmitt, Hannah Sachs, Meredith Will, Lisa Destefano, Grace Westerkamp, Adriano De Souza, Oliver Pohl, Offir Laufer, Gil Issachar, Jean-Marc Hyvelin, Lynn A Durham

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ASD-Phen1; STP1; ibudilast; bumetanide; phase 1b; EGG; NIH-TCB; SRS-2; ABC-C

Online: 26 March 2024 (10:20:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1389.v1

Dystonia, Tremor, and Dystonic Tremor

Aasef G. Shaikh, Alfonso Fasano, Sanjay Pandey, Rick Helmich, Alberto Albanese, Marie Vidailhet, Rodger Elble, Victor Fung, Marina Tijssen, Boemsuk Joen, Mark Hallett, Hyder Jinnah

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dystonia, tremor, dystonic tremor, movement disorder, oscillations

Online: 22 March 2024 (14:30:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1071.v1

Microcurrent Therapy Mitigates Neuronal Damage and Cognitive Decline in an Alzheimer's Disease Mouse Model: Insights into Mechanisms and Therapeutic Potential

Eun Ho Kim, Won Seok Lee, Dong Rak Kwon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Microcurrent therapy; Alzheimer’ s disease; β -amyloid; neuronal damage

Online: 19 March 2024 (08:09:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1052.v1

Optimization, Characterization, and Comparison of Two Luciferase-Expressing Mouse Glioblastoma Models

Louis T Rodgers, Julia A Schulz Pauly, Bryan J Maloney, Anika MS Hartz, Björn Bauer

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: blood-brain barrier; glioblastoma; luciferase; bioluminescence imaging; preclinical; GL261 Red-FLuc; TRP-mCherry-FLuc; AI

Online: 19 March 2024 (06:54:14 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1073.v1

Improved Brain Function with Deep Spectrum Biotherapeutics

Iain Strickland, David S Oakley, Anna Parievsky

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Electroencephalogram (EEG); Event Related Potential (ERP); Advanced &; Deep Biotherapeutics; Photobiomodulation (PBM); Mild Cognitive Impairment (MCI)

Online: 19 March 2024 (05:13:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0872.v1

Beneficial versus Detrimental Effects of Complement-Microglial Interactions in Alzheimer’s Disease

Gunel Ayyubova, Nadeem Fazal

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: complement proteins, cognitive decline, synapse loss, microglia, neurodegeneration

Online: 15 March 2024 (11:21:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0851.v1

Rare Pathogenic Variants in Pooled Whole-Exome Sequencing Data Suggest Ciliary Defects and Hyperammoniemia as Possible Causes of Dementia Not Classified as Alzheimer’s Disease or Frontomteporal Dementia

Sena Karachanak-Yankova, Dimitar Serbezov, Mikaela Stancheva, Savina Hadjidekova, Draga Toncheva, Diana Belezhanska, Mariya Petrova, Shima Mehrabian, Latchezar Traykov

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dementia; whole exome sequencing; rare pathogenic variants; ciliary defects; argininosuccinate synthase deficiency

Online: 14 March 2024 (15:18:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0684.v1

How Rapid-Eye-Movement Dreams May Facilitate Learning and Creativity

Nicolas Deperrois, Mihai A. Petrovici, Jakob Jordan, Lukas S. Huber, Walter Senn

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: rapid-eye-movement; sleep; learning

Online: 12 March 2024 (10:20:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0515.v2

Efficacy and Safety of Pulse Intravenous Methylprednisolone in Pediatric Epileptic Encephalopathies: Timing and Networks Consideration

Angelo Russo, Serena Mazzone, Laura Landolina, Roberta Colucci, Flavia Baccari, Anna Fetta, Antonella Boni, Duccio Maria Cordelli

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Methylprednisolone; Pulse therapy; childhood epilepsy; epileptic encephalopathy

Online: 11 March 2024 (13:15:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0625.v1

No Evidence Of Sensory Neuropathy In A Traditional Mouse Model Of Idiopathic Parkinson’s Disease

Mahvish Faisal, Anna Rusetskaya, Liis Vali, Pille Taba, Ave Minajeva, Miriam A Hickey

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Heat sensation; cold sensation; touch sensation; sample size; repeated testing; unbiased stereology; motor coordination

Online: 11 March 2024 (11:31:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0576.v1

Medicine Non-adherence: A New Viewpoint on Adherence Arising From Research in Sub-Saharan Africa

Peter Michael Ward

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: medicine; adherence; sub-Saharan Africa

Online: 11 March 2024 (05:38:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0515.v1

Efficacy and Safety of Pulse Intravenous Methylprednisolone in Pediatric Epileptic Encephalopathies: Timing and Networks Consideration

Angelo Russo, Serena Mazzone, Laura Landolina, Roberta Colucci, Flavia Baccari, Anna Fetta, Antonella Boni, Duccio Maria Cordelli

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Methylprednisolone; Pulse therapy; childhood epilepsy; epileptic encephalopathy

Online: 8 March 2024 (10:02:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0422.v1

Site-Dependency of Anodal tDCS on Reaction Time and Transfer of Learning during a Sequential Visual Isometric Pinch Task

Fahimeh Hashemirad, Maryam Zoghi, Paul B Fitzgerald, Masoumeh Hashemirad, Shapour Jaberzadeh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: anodal transcranial direct current stimulation; a-tDCS; Reaction time; transfer learning; primary motor cortex; dorsolateral prefrontal cortex; posterior parietal cortex

Online: 8 March 2024 (01:55:26 CET)

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Noninvasive brain stimulation technique can be used for modulation of motor behaviors such as reaction time (RT). The main aim of this study was to investigate whether RT during a sequential visual isometric pinch task (SVIPT) can be affected by anodal transcranial direct current stimulation (a-tDCS) over three different stimulation sites such as dorsolateral prefrontal cortex (DLPFC), primary motor cortex (M1) or posterior parietal cortex (PPC). We also aimed to assess if stimulation of these cortical sites affect the transfer of learning during SVIPT. A total of 48 right-handed healthy participants were randomly assigned to one of the four a-tDCS groups: 1) left M1, 2) left DLPFC, 3) left PPC and 4) sham. A-tDCS was applied concurrent with SVIPT in which the participants were precisely controlled their forces to reach seven different target forces from 10 to 40% of maximum voluntary contraction (MVC) presenting on a computer screen with right dominant hand. Four test blocks were randomly performed at baseline and 15 min after the intervention including sequence and random blocks with either hand. Our results showed significant differences between a-tDCS groups on ratio RT in the sequence blocks of both the right trained (P = .041) and left untrained hands (P = .023) for target forces of 15% and 30 % of MVC, respectively. In sequence blocks, M1 showed significant elongation in ratio RT for the target force of 15% and 30 % MVC compared to PPC and Sham groups in the right hand. In sequence blocks with left hand, this negative effect were found between M1-DLPFC and M1-Sham groups. In random blocks, no significant differences were found among four groups at each target forces for the left hand while there were significant differences for 15% (P =. 04) and 40% MVC (P =. 035) in the right hand. Our findings suggest that three different stimulation sites (DLPFC, M1 or PPC) were differentially affected by a single session of a-tDCS at some target forces during SVIPT. The effects of a-tDCS on ratio RT were transferred in the left untrained hand for sequence blocks but not random blocks. Further research is needed to understand fundamental aspects of these main areas of the brain on temporal processing in a precision control task such as SVIPT.

Preprint ARTICLE | doi:10.20944/preprints202403.0326.v1

Modulation of corticospinal excitability during action observation in patients with consciousness-related disturbances

Mauro Mancuso, Marco Emanuele, Lucia Mencarelli, Laura Abbruzzese, Benedetta Basagni, Pierluigi Zoccolotti, Simone Capitani, Francesco Neri, Emiliano Santarnecchi, Luciano Fadiga, Simone Rossi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Disorders of consciousness; minimally consciousness state; vegetative state/unresponsiveness wakefulness syndrome; transcranial magnetic stimulation; action observation

Online: 6 March 2024 (10:50:21 CET)

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Brain imaging studies have recently provided some evidence in favour of covert cognitive processes ongoing in patients with disorders of consciousness (DoC) (e.g., minimally consciousness states, vegetative state/unresponsive wakefulness syndrome) engaged in passive sensory stimulation or active tasks such as motor imagery. In this exploratory study, we used transcranial magnetic stimulation (TMS) of the motor cortex to assess modulations of corticospinal excitability induced by action observation in eleven patients with DoC. Action observation is known to facilitate corticospinal excitability in healthy subjects, unveiling how the observer’s motor system maps others’ actions onto her/his motor repertoire. Additional stimuli were non-biological motion and acoustic startle stimuli, provided that sudden and loud acoustic stimulation is known to lower corticospinal excitability in healthy subjects. Results indicate that some form of motor resonance is spared in a subset of patients with DoC with some significant difference between biological and non-biological motion stimuli. However, there was no covariation between corticospinal excitability and the type of DoC diagnosis (i.e., whether VS/UWS or MCS). Similarly, no covariation was detected with clinical changes between admission and discharge in clinical outcome measures. Both motor resonance and biological/non-biological motion discrimination correlated with the amplitude of the N20 somatosensory evoked potentials following the stimulation of the median nerve at the wrist (i.e., the temporal marker signalling the activation of the contralateral primary somatosensory cortex). Moreover, the startle-evoking stimulus produced an anomalous increase in corticospinal excitability, suggesting a functional dissociation between cortical and subcortical circuits in patients with DoC. Further work is needed to better comprehend the conditions in which corticospinal facilitation occurs and whether and how they may relate to individual clinical parameters.

Preprint REVIEW | doi:10.20944/preprints202403.0247.v1

Biomarkers for Managing Neurodegenerative Diseases

Lara Cheslow, Adam E. Snook, Scott A. Waldman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; biomarkers

Online: 5 March 2024 (10:35:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0112.v1

Role of Epigenetics in Drug-Induced Autism Spectrum Disorder

Antonei B Csoka, Nacer El Kouhen, Samia Bennani, Bruk Getachew, Michael Aschner, Yousef Tizabi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Autism Spectrum Disorder; Epigenetics; Teratogen; Valproic Acid; Propionic Acid; Acetaminophen; Gliosis; Glial Cells; Neuroinflammation

Online: 4 March 2024 (05:53:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0059.v1

Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Mariaconsiglia Santantonio, Carmela Riso, Simona Gaudino, Alessio Simonetti, Giuseppe Varcasia, Francesco Schimperna, Bruno Sergi, Eugenio De Corso, Marco Rossi, Jacopo Galli, Marco De Spirito, Giuseppe Maulucci, Giulio Cesare Passali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: olfactory rehabilitation; chronic pain; fMRI

Online: 1 March 2024 (18:18:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0058.v1

The Impact of Anxiety on Athletic Performance

Meaghan Mulvey

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Sports Performance, Athletic Performance, Neuroanatomy, Neuropsychology, Anxiety, Mental Fatigue, Mental Strength, Sports Psychology, Sports Anxiety, Muscular Control, Neuronal Control, Hormone Effects, Physiology, Anatomy, Psychology, Performance, Team Dynamics, Coping Mechanisms

Online: 1 March 2024 (13:59:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1762.v1

Increased Vulnerability against Ferroptosis in FUS‐ ALS

Muhammad Ismail, Dajana Großmann, Andreas Hermann

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: amyotrophic lateral sclerosis; oxidative damage; mitochondria; cell death

Online: 29 February 2024 (20:02:00 CET)

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Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxide accumulation, plays a pivotal role in various pathological conditions, including neurodegenerative diseases. While reasonable evidence for ferroptosis exist e.g. in Parkinson’s disease or Alzheimer’s disease, there are only few reports on amyotrophic lateral sclerosis (ALS), a fast progressive and incurable neurodegenerative disorder characterized by progressive motor neuron degeneration. Initial studies, however, highlight that ferroptosis might be significantly involved in ALS. Key features of ferroptosis include oxidative stress, glutathione depletion, mitochondrial and dysfunction alterations in mitochondrial morphology, mediated by proteins such as GPX4, xCT, ACSL4 FSP1, Nrf2 and TfR1. Induction of ferroptosis involves small molecule compounds like erastin and RSL3, which disrupt system Xc- and GPX4 activity, respectively, yielding in lipid peroxidation and cellular demise. Mutations in Fused in Sarcoma (FUS) are associated with familial ALS. Pathophysiological hallmarks of FUS-ALS involve mitochondrial dysfunction and oxidative damage, implicating ferroptosis as putative cell death pathway in motor neuron demise. However, mechanistic understanding of ferroptosis in ALS, particularly FUS-ALS, remains limited. Here, we investigated ferroptosis vulnerability in a FUS-ALS cell model, revealing mitochondrial disturbance and increased susceptibility for ferroptosis in cells harboring the mutant FUS variant. This was accompanied by altered expression of ferroptosis-associated proteins, particularly by dramatic reduction of xCT expression, leading to cellular imbalance of the redox system and increased lipid peroxidation. Iron chelation with deferoxamine as well as inhibition of the mitochondrial calcium uniporter (MCU) significantly alleviated ferroptotic cell death and lipid peroxidation. These findings suggest a link between ferroptosis and FUS-ALS, offering potential therapeutic targets.

Preprint ARTICLE | doi:10.20944/preprints202402.1734.v1

Synergistic Approaches in Neurodegenerative Therapeutics: Multi-Target Drug Innovative Interventions for Alzheimer’s Disease

Sarfaraz K. Niazi, Matthias Magoola, Zamara Mariam

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurodegenerative diseases; Alzheimer’s disease; mRNA vaccine; antibody targeting; chemical targeting; blood-brain barrier; nanobodies.

Online: 29 February 2024 (12:55:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1685.v1

Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of consciousness:A Retrospective Cohort Study

Yan-Gang Wang, Zhongzhen Li, Yu-Zhang Wu, Guang-Rui Zhao, Yifeng Cheng, Keke Feng, Shao-Ya Yin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: prolonged disorder of consciousness; consciousness-regaining therapy; recovery; factors; efficacy

Online: 29 February 2024 (09:59:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1525.v1

Advances in Understanding and Managing Movement Disorders: A Comprehensive Review

Eduardo R. Santos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: movement disorders; neurological conditions; hyperkinetic disorders; hypokinetic disorders; Parkinson's disease; tremors; dystonia; chorea; myoclonus; treatment strategies

Online: 27 February 2024 (10:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1461.v1

Handedness Fifty Years Later. A Neurological and Methodological Update

Anna Rita Giovagnoli, Alessandra Parisi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Handedness; hand, foot and eye laterality; hemispheric lateralization; immune-mediated diseases; Edinburg Handedness Inventory; literature overview.

Online: 26 February 2024 (13:23:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1406.v1

Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study

Malik Galijasevic, Ruth Steiger, Stephanie Alice Treichl, Wing Man Ho, Stephanie Mangesius, Valentin Ladenhauf, Johannes Deeg, Leonhard Gruber, Miar Ouaret, Milovan Regodic, Lukas Lenhart, Bettina Pfausler, Astrid Ellen Grams, Ondra Petr, Claudius Thomé, Elke Ruth Gizewski

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: subarachnoidal hemorrhage, brain aneurysm, phosphorous spectroscopy, vasospasm, delayed ischemia

Online: 26 February 2024 (09:42:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1303.v1

A Pilot Phase 2 Randomized Trial to Evaluate the Safety and Potential Efficacy of Etravirine in Friedreich Ataxia Patients

Gabriella Paparella, Cristina Stragà, Nicola Pesenti, Valentina Dal Molin, Gian Antonio Martorel, Vasco Merotto, Cristina Genova, Arianna Piazza, Giuseppe Piccoli, Elena Panzeri, Alessandra Rufini, Roberto Testi, Andrea Martinuzzi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Friedreich ataxia; etravirine; treatment; safety; efficacy

Online: 23 February 2024 (08:29:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1245.v1

GLP-1 Receptor Agonists: A New Challenge in Parkinson’s Disease Treatment

Kallirhoe Kalinderi, Vasileios Papaliagkas, Liana Fidani

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’ s disease; type 2 diabetes mellitus; GLP1-R agonists; GLP-1; exendin-4; liraglutide; lixisenatide; semaglutide; clinical trials; neurodegeneration

Online: 22 February 2024 (12:38:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0963.v1

Current and Emerging Treatment Options in Pediatric Onset Multiple Sclerosis

Artemis Mavridi, Maria Eleni Bompou, Aine Margaret Redmond, Paraschos Archontakis-Barakakis, George D. Vavougios, DIMOS-DIMITRIOS MITSIKOSTAS, Theodoros Mavridis

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: POMS; Pediatric Onset Multiple Sclerosis; Disease-modifying therapies; DMT; Pediatric MS; Interferons; Finglolimod; Teriflunomide; Cyclophosphamide; Rituximab; Ocrelizumab; Daclizumab; Alemtuzumab; Natalizumab; Ofatumumab; Siponimod; Vitamin D; TCR vaccine; Stem cell therapy; Glatiramer acetate; Azathioprine; Dimethyl fumarate; Mitoxantrone

Online: 19 February 2024 (14:52:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0892.v1

Blood Biomarkers Show Neural Consequences of LongCOVID-19

Norina Tang, Tatsuo Kido, Jian Shi, Erin McCafferty, Judith M. Ford, Kaitlyn Dal Bon, Lynn Pulliam

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: LongCOVID-19; biomarkers; neuronal extracellular vesicles; BDNF; cortisol; cognition

Online: 16 February 2024 (07:02:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0810.v1

Artificial Intelligence as A Complementary Tool for Clinic Decision-Making in Stroke and Epilepsy

Smit P Shah, John D Heiss

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Artificial; Intelligence; Neurology; Stroke; Epilepsy; Neuroimaging

Online: 15 February 2024 (02:11:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0812.v1

Formulating Treatment to Cure Alzheimer’s Dementia

Jeffrey Fessel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's dementia; cure; causal elements; individualize therapy; treat elements applicable to individual

Online: 14 February 2024 (13:44:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0800.v1

Innovative developments in Deep Brain Stimulation devices

Attilio Della Torre, Domenico La Torre, Giusy Guzzi, Erica Lo Turco, Angelo Lavano

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: deep brain stimulation; directional leads; neuromodulation.

Online: 14 February 2024 (11:27:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0779.v1

Determining the algorithm of rehabilitation procedures in patients with brachial plexus injuries based on the prospective clinical neurophysiology studies

Kinga Lewczuk, Agnieszka Wiertel-Krawczuk, Juliusz Huber

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brachial plexus injury; clinical neurophysiology; motor evoked potential; electroneurography, rehabilitation algorithm

Online: 14 February 2024 (05:50:09 CET)

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The clinical neurophysiological tests allow determine the type, extent, and nature of brachial plexus damage. They are crucial in decision-making regarding surgical procedures or conservative treatment. This report aimed to present an algorithm for rehabilitation procedures in patients with brachial plexus injury of various origins based on the results of neurophysiology findings for the selection of procedures supporting the process of nerve and muscle regeneration. The research group consisted of patients whose medical documentation was analyzed concerning the reason, level, and localization of damage to the brachial plexus structures, surgical and or rehabilitative treatment as well as the MRI results. Among the group of ten patients, the clinical studies showed the greatest incidence of brachial plexus injuries of the mixed (both pre- and postganglionic), all trunks, and cervical root injuries, respectively. Results of the motor evoked potentials (MEP) and electroneurography (ENG) recordings induced at levels of spinal roots and Erb's point showed a decrease of more than 40% in amplitudes on the symptomatic side in comparison to the asymptomatic side. This difference was recorded for the axillary and radial innervation and the C5, C6, and C7 root domains, ranging from 56% to 71%; the lowest decrease was recorded following electrical stimulation at Erb's point for the ulnar nerve (41.5%). The latency prolongation on the symptomatic side in CMAP and MEP tests ranged from 0.2 to 1.9 ms, the most following magnetic stimulation of the C5 cervical root for the axillary innervation. All results indicated the axonotmesis and neuropraxia type of injury in motor fibers (40%) confirmed by EMG results. The sensory conduction studies (SNCS) in distal nerve branches did not confirm the severe advancement of the brachial plexus injury (22%). The proposed algorithm of the physiotherapeutic procedures should be mainly targeted for recovery of motor dysfunction as the consequence of brachial plexus injury. Rehabilitation should incorporate the treatment supporting nerve regeneration, muscle strengthening, and maintaining functional ranges of motion of the injured extremities. The rehabilitation treatment for patients with brachial plexus injuries is an individualized process, and the selection of procedures and the effectiveness of the treatment undertaken should be confronted with results of neurophysiological tests verifying the motor neural transmission from the level of the cervical motor center to the effector, peripheral nerve function, and muscle’s motor unit activity.

Preprint ARTICLE | doi:10.20944/preprints202402.0753.v1

Focal Traumatic Brain Injury Impairs Integrity of Basement Membrane of Hindlimb Muscle Fibers Revealed by Extracellular Matrix Immunoreactivity

Mette Albæk Kristensen, Karen Kalhøj Rich, Tobias Christian Mogensen, Åsa Fex Svenningsen, Mengliang Zhang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; hindlimb postural asymmetry; motor deficits; extracellular matrix; laminin; collagen type IV

Online: 13 February 2024 (15:29:10 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202310.2100.v2

The Role of Furin on the Pathogenesis of COVID-19 Associated Neurological Disorders

Gunel Ayyubova, Sergiy G. Gychka, Sofia I. Nikolaienko, Fada Alghenaim, Tadahisa Teramoto, Nataliia V. Shults, Yuichiro J. Suzuki

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’ s disease; Angiotensin II; Angiotensin-converting enzyme 2; COVID-19; Brain; Dementia; Furin; Neurological disorders; SARS-CoV-2; Spike protein

Online: 12 February 2024 (15:48:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0694.v1

Caregivers’ burden experience: a comparison between Parkinson's Disease, Multiple System Atrophy and Amyotrophic Lateral Sclerosis

Luna Carpinelli, Giulia Savarese, Claudio Russo, Giovanna Stornaiuolo, Ettore Luisi, Francesca Pellegrino, Monica Mollo, Antonella Toriello, Paolo Barone, Maria Teresa Pellecchia

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Caregivers’ burden; Quality of Life; Neurological diseases; Parkinson’ s Disease; Multiple System Atrophy; Amyotrophic Lateral Sclerosis

Online: 12 February 2024 (13:28:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0679.v1

Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative Diseases

Allison Carles, Aline Freyssin, Florent Perin-Dureau, Gilles Rubinstenn, Tangui Maurice

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: N-methyl-D-aspartate receptor; Alzheimer's disease; post-traumatic stress disorder; Fluoroethylnormemantine (FENM)

Online: 12 February 2024 (13:20:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0661.v1

The P2X7 Hypothesis of Central Post-Stroke Pain: Modulations of P2X7 Receptors Influence Central Post-Stroke Pain Regarding Behaviors, Electrophysiological Activity, and Molecular Expression in Mice

Andrew Chih-Wei Huang, Hsi Chien Shih, Bai Chuang Shyu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: CPSP; P2X7 receptor; the P2X7 hypothesis of central post-stroke pain; stroke hemorrhage; mice

Online: 12 February 2024 (13:11:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0573.v1

Landscape of Intrinsically Disordered Proteins in Mental Disorder Diseases

Xinwu Zhang, Yaqing Yang, Guangchun Hu, Ruotong Liu, Na Zhou, Xixi Song, Sankar Chandra Basu, Ming Jing, Qingzhen Hou

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: mental disorder; intrinsically disordered protein; neural signaling; Neurological development

Online: 12 February 2024 (12:01:31 CET)

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Intrinsically Disordered Proteins (IDPs) play crucial roles in signal transduction, cell differentiation, and transcriptional regulation. Many disrupted genes associated with mental disorders are identified as IDPs, and emerging evidence suggests the functional role of IDPs in neuropsychiatric disorders. However, few studies comprehensively explore the functional association between protein disorder properties and different mental diseases. To address this gap, we collected disrupted gene sets for seven mental diseases (MDD, SCZ, BP, ID, AD, ADHD, ASD) and a control gene set from normal brains using DisGeNET and GeneCards databases. The state-of-the-art predictor IUPred2A was then utilized to calculate the disorder properties , followed by a thorough comparison between the disordered proteins in mental diseases and healthy controls. Functional enrichment analysis and protein-protein interaction networks were conducted to investigate the IDPs’ functional roles in psychiatric diseases. Additionally, we demonstrated the role of IDPs in protein binding formations through a case study of alpha-synuclein using protein docking. Our findings reveal that differentially expressed proteins in mental disorders, especially in ASD and ADHD, exhibit more IDPs than those in healthy controls. IDPs in psychiatric disorders are significantly enriched in neurodevelopmental pathways and play an important role in in gene expression regulation. Our results indicate distinct functional patterns of disorder proteins among mental diseases and healthy controls. When comparing the IDPs between ASD and ADHD, we observed that IDPs in ADHD are more likely linked to the synaptic signaling and regulation, while IDPs in ASD are more tendentiously related to diverse and complex biological processes. Our work offers valuable insights into the important functions of IDPs in psychiatric disorders, enhancing our understanding of the molecular mechanisms involved in psychiatric disorders.

Preprint SHORT NOTE | doi:10.20944/preprints202312.0622.v2

Safeguarding Lives: SUDEP Awareness and Empathetic Discussions in Epilepsy Management

Anisa Isufi, Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Epilepsy; Awareness; Prevention; SUDEP

Online: 12 February 2024 (11:09:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0544.v1

Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study

Valentina Cenacchi, Giovanni Furlanis, Alina Menichelli, Alberta Lunardelli, Valentina Pesavento, Paolo Manganotti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Long-COVID; neuro-long-COVID; SARS-CoV-2; Cognitive impairment; Co-ultraPEALut

Online: 9 February 2024 (10:52:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0450.v1

Performance Assessment of Presurgical Tests in Temporal Lobe Epileptic Patients

Jesús Pastor, Lorena Vega-Zelaya, Rafael G. Sola, Paloma Pulido

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: electroencephalography; Engel’s grade, magnetic resonance imaging; multiple binary logistic model; single photon emission computed tomography; video-electroencephalography.

Online: 7 February 2024 (13:51:24 CET)

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The performance of the presurgical test (preSurg) for temporal lobe epilepsy (TLE) was evaluated via video-electroencephalography (VEEG), electroencephalography (EEG), 99mTc-HmPAO single-photon emission tomography (SPECT) and 1.5 T magnetic resonance imaging (MRI) in a group of 112 men (37.0 ± 1.1 years) and 106 women (39.7 ± 1.1 years) operated on for TLE. The epileptic zone (EZ) was adequately identified to determine whether the patient reached an Engel I grade (EI) at least one year postop. Accuracy was evaluated by the coefficient α, ranging from 3 (when result = EZ) to 2 (result in the same hemisphere as the EZ), 1 (noninformative result) or 0 (EZ in the contralateral hemisphere). The simplicity of diagnosis was defined as the number of preSurg surgeries needed to identify the EZ. EI was obtained in 85.8% of patients even though 42.2% of patients had noninformative MRI results. For preSurg α was (mean ± SEM) = VEEG (2.83 ± 0.04) > MRI (2.14 ± 0.08) > EEG (1.87 ± 0.09) > SPECT (1.71 ± 0.09). The accuracy (combination of sensitivity and specificity) was calculated as follows: VEEG (0.797) > MRI (0.518) > EEG (0.446) > SPECT (0.360). The likelihood positive ratio was greater, and the likelihood negative ratio was lower for VEEG. The most relevant factor for the regression model was VEEG (3.106) > MRI (2.558) > EEG (1.905), and the factors were not significantly related to SPECT. EZs in EI patients with low simplicity were identified mainly by VEEG. A very good postoperative outcome can be obtained even in TLE patients with no lesions on MRI. The VEEG is the most reliable preSurg test and may be the only reliable test for patients with very low simplicity (i.e., difficult).single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.

Preprint REVIEW | doi:10.20944/preprints202402.0303.v1

Molecular Process Of Trigeminal Neuralgia, its Pharmacologic, and Comparison of Surgical Treatment Options with Outcomes

Siddharth Shah, Jibran Ikram, Malik Waleed Zeb Khan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Trigeminal Neuralgia; Treatment of TN; Neurosurgery; Radiosurgery; Facial pain

Online: 5 February 2024 (16:29:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0108.v1

Early Improvement of Affective, Fatigue and Allodynic Symptoms in a Cohort of Resistant Migraineurs Treated with Anti-CGRP/R Antibodies

Alessandra Della Vecchia, Ciro De Luca, Lucrezia Becattini, Letizia Curto, Elena Ferrari, Gabriele Siciliano, Sara Gori, Filippo Baldacci

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; depression; anxiety; fatigue; comorbidities; monoclonal antibodies anti-CGRP/R

Online: 2 February 2024 (04:54:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0050.v1

Enhancing Upper Limb Functionality, Gross and Fine Motor Skills, Autonomy, and Quality of Life in Acute Stroke Patients: A Mirror Therapy, Cognitive Therapeutic Exercise, and Task-Oriented Training

Jessica Fernández-Solana, Rodrigo Vélez-Santamaría, Adrián Moreno-Villanueva, Sergio Álvarez-Pardo, Jerónimo J. González-Bernal, Mirian Santamaría-Peláez, Josefa González-Santos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: mirror therapy; cognitive therapeutic exercise; task-oriented training; upper limb; gross notor; fine motor; autonomy; quality of life; acute stroke

Online: 1 February 2024 (13:50:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0070.v1

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

Jamir Pitton Rissardo, Ana Leticia Fornari Caprara

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: drug-induced; drug-induced parkinsonism; parkinsonism; dystonia; drug-induced side-effects; tardive syndrome; basal ganglia; dyskinesia; secondary; movement disorder

Online: 1 February 2024 (10:30:01 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.2077.v1

Impact of Various Non-contrast Enhanced MRA Techniques on Lumen Visibility in Vascular Flow Models with Surpass Evolve Flow Diverter

Yigit Ozpeynirci, Margarita Gorodezky, Augusto Fava Sanches, Ana Beatriz Solana, Thomas Liebig

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: silent MRA; deep learning; flow diverter; intracranial aneurysm

Online: 31 January 2024 (01:46:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1958.v1

Neuromuscular Electrical Stimulation Does Not Influence Spinal Excitability in Multiple Sclerosis Patients

Martina Scalia, Riccardo Borzuola, Martina Parrella, Giovanna Borriello, Francesco Sica, Fabrizia Monteleone, Elisabetta Maida, Andrea Macaluso

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: electric stimulation; H-reflex; spinal excitability; multiple sclerosis; soleus; GABA; presynaptic inhibition; rehabilitation

Online: 29 January 2024 (03:59:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1832.v1

Induction of Neuroinflammation and Brain Oxidative Stress by Brain-derived Extracellular Vesicles from Hypertensive Rats

Xinqian Chen, Xin Yan, Leah Gingerich, Qing-Hui Chen, Lanrong Bi, Zhiying Shan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuroinflammation; oxidative stress; extracellular vesicles; hypertension; reactive oxygen species (ROS)

Online: 26 January 2024 (02:05:18 CET)

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Neuroinflammation and brain oxidative stress are recognized as significant contributors to hypertension including salt sensitive hypertension. Extracellular vesicles (EVs) play an essential role in intercellular communication in various situations, including physiological and pathological ones. Based on this evidence, we hypothesized that EVs derived from the brains of hypertensive rats with salt sensitivity could trigger neuroinflammation and oxidative stress during hypertension development. To test this hypothesis, we compared the impact of EVs isolated from the brains of hypertensive Dahl Salt Sensitive rats (DSS) and normotensive Sprague Dawley (SD) rats on inflammatory factors and mitochondrial reactive oxygen species (mtROS) production in primary neuronal cultures and brain cardiovascular relevant regions, including the hypothalamic paraventricular nucleus (PVN) and lamina terminalis (LT). We found that brain-derived DSS-EVs significantly increased mRNA levels of proinflammatory cytokines (PICs) and chemokines, including TNFα, IL1β, CCL2, CCL5, and CCL12, as well as the transcriptional factor NF-κB in neuronal cultures. DSS-EVs also induced oxidative stress in neuronal cultures, as evidenced by elevated NADPH oxidase subunit CYBA coding gene mRNA levels and persistent mtROS elevation. When DSS-EVs were injected into the brains of normal SD rats, mRNA levels of PICs, chemokines, and the chronic neuronal activity marker FOSL1 were significantly increased in the PVN and LT. Furthermore, DSS-EVs caused mtROS elevation in brain PVN and LT, particularly in neurons. Our study reveals a novel role for brain-derived EVs from hypertensive rats in triggering neuroinflammation, upregulating chemokine expression, and inducing excessive ROS production. These findings provide insight into the complex interactions between EVs and hypertension-associated processes, offering potential therapeutic targets for hypertension-linked neurological complications.

Preprint ARTICLE | doi:10.20944/preprints202401.1793.v1

Progressive Age-Associated Blood Brain Barrier Leak/Dysfunction- Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New targets for Future Treatments

Charles Joseph

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Blood brain barrier; Microvascular pathology; Neurodegenerative Inflammatory changes; ASL MRI; DCE MRI; Serologic markers

Online: 25 January 2024 (15:51:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1837.v1

The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome

Ann-Charlotte E Granholm, Eric D. Hamlett

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Down syndrome (DS); Alzheimer’s disease (AD); neurofibrillary tangles (NFTs); seeding competent p-Tau; neuropathology.

Online: 25 January 2024 (12:11:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1610.v1

Focal Dystonia – an Update of Genetic Background and Novel Treatment

Jan Koptielow, Emilia Szyłak, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Jan Kochanowicz, Alina Kułakowska, Monika Chorąży

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: focal dystonia; blepharospasm; cervical dystonia; oromandibular dystonia; spasmodic dysphonia

Online: 23 January 2024 (03:52:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1530.v1

Cenobamate Plasma Levels in Patients with Epilepsy: Correlation with Efficacy and Tolerability

Bernhard J. Steinhoff, Dimitra Georgiou, Daniel Dietmann, Tassanai Intravooth

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: epilepsy; cenobamate; plasma levels; therapeutic drug monitoring; effectiveness; correlation

Online: 22 January 2024 (04:30:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1443.v1

In Silico Methods to Assess CNS Penetration of Small Molecules

Mayuri Gupta, Jun Feng, Govinda Bhisetti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: The Blood-Brain Barrier (BBB); CNS drug discovery; passive diffusion; active transport; Efflux transporters; Influx Transporters; P-glycoproteins (P-gp); breast cancer resistance protein (BCRP); in silico models

Online: 19 January 2024 (09:32:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1455.v1

Master Regulators of Vigilance and Stress Response: The Intricate Involvement of Orexin/Hypocretin Neuropeptides in Physiology and Behavior

Miklós Jászberényi, Balázs Thurzó, Zsolt Bagosi, László Vécsei, And Masaru Tanaka

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: orexins; neuropeptides; neurotransmitters; stress; appetite: body temperature regulation; fear; anxiety; learning; sleep wake disorders

Online: 19 January 2024 (06:57:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1301.v1

Neurocutaneous Diseases: Diagnosis, Management, and Treatment

Ivelina Kioutchoukova, Devon Foster, Rajvi Thakkar, Christopher Ciesla, Jake Salvatore Cabassa, Jacob Strouse, Hayley Kurz, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurocutaneous disorders; cutaneous; neurologic; phakomatoses; genetic advances; precision medicine

Online: 17 January 2024 (09:45:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1216.v1

Differential Dysferlin Expression in Rat Muscle

Marija Meznaric, Corrado Angelini

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Dysferlin; Western blotting; PAGE; myosin heavy chain isoforms; skeletal muscle; rat; EDL; soleus

Online: 16 January 2024 (09:05:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1185.v1

Deferoxamine in Spontaneous Intracranial Hemorrhage: A Pilot Study on Neurological and Radiological Outcomes

Mohammad Shirani, Ali Meshkini, Seyed Mohammad Mahdi Hashemi, Farhad Mirzaei, Ali Salami, Fatemeh Jafari, Ebrahim Rafiei, Masoud SohrabiAsl, Arad Iranmehr

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Deferoxamine; Spontaneous Intracranial Hemorrhage; Intracranial hemorrhage (ICH); Randomized Clinical Trial; Neurosurgery

Online: 16 January 2024 (06:36:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1168.v1

Connecting the Dots: AfrAbia's Environmental Challenges and Parkinson's Disease

Wael Mohamed Yousef Mohamed

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: AfrAbia; Parkinson’ s Disease; Global warming; Malathion; Air pollution; Heavy metals

Online: 16 January 2024 (06:29:16 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1175.v1

The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics

Laynie Dratch, Tanya M Bardakjian, Kelsey Johnson, Nareen Babaian, Pedro Gonzalez-Alegre, Lauren Elman, Colin Quinn, Michael H Guo, Steven S Scherer, Defne A Amado

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurogenetics; genetic testing; genetic counseling; neuromuscular

Online: 16 January 2024 (06:25:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1010.v1

Sensory Nutrition and Polyphenols; Regulation of Homeostasis through Chemosensory Receptor Interaction with Bitter or Astringent Taste

Naomi Osakabe, Takafumi Shimizu, Yasuyuki Fujii, Taiki Fushimi, Vittorio Calabrese

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Polyphenol; sensory nutrition; bitter; astringency; central nervous system

Online: 12 January 2024 (11:27:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0810.v1

Leveraging Mobile Health for Rehabilitation of Long-COVID Patients: A Scoping Review

Kim Daniels, Joanna Mourad, Bruno Bonnechère

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: telerehabilitation; COVID-19; digital healthcare; post-COVID care; health-related consequence; rehabilitation; COVID-19 sequelae

Online: 10 January 2024 (09:24:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0702.v1

iPSCs and Organoids in Advancing Neuropathology Research and Therapies

Douglas Bottega Pazzin, Thales Previato, João Ismael Budelon Gonçalves, Gabriele Zanirati, Fernando Costa Xavier, Jaderson C Da Costa, Daniel Rodrigo Marinowic

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: iPSCs; Organoids; Alzheimer's disease; epilepsy; Parkinson's disease; spinal cord injury.

Online: 9 January 2024 (07:03:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0682.v1

Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS), Antioxidants, and Cerebral Vascular Tone

Michele SALVAGNO, Elda Diletta STERCHELE, Mario ZACCARELLI, Simona MRAKIC-SPOSTA, Ian WELSBY, Costantino BALESTRA, Fabio Silvio TACCONE

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Oxidants; Reactive Oxygen Species; Reactive Nitrogen Species; antioxidants; cerebrovascular tone

Online: 9 January 2024 (04:44:03 CET)

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Medicine and Pharmacology