Version 1
: Received: 7 August 2023 / Approved: 7 August 2023 / Online: 7 August 2023 (10:46:46 CEST)
How to cite:
Gupta, S.; Gupta, R.K.; Mishra, V.; Prakash, H. Serum Specific Immunoglubulin E: Major Determinant for Accessing Sensitivity for Various Pediatric Allergies in North India. Preprints2023, 2023080536. https://doi.org/10.20944/preprints202308.0536.v1
Gupta, S.; Gupta, R.K.; Mishra, V.; Prakash, H. Serum Specific Immunoglubulin E: Major Determinant for Accessing Sensitivity for Various Pediatric Allergies in North India. Preprints 2023, 2023080536. https://doi.org/10.20944/preprints202308.0536.v1
Gupta, S.; Gupta, R.K.; Mishra, V.; Prakash, H. Serum Specific Immunoglubulin E: Major Determinant for Accessing Sensitivity for Various Pediatric Allergies in North India. Preprints2023, 2023080536. https://doi.org/10.20944/preprints202308.0536.v1
APA Style
Gupta, S., Gupta, R.K., Mishra, V., & Prakash, H. (2023). Serum Specific Immunoglubulin E: Major Determinant for Accessing Sensitivity for Various Pediatric Allergies in North India. Preprints. https://doi.org/10.20944/preprints202308.0536.v1
Chicago/Turabian Style
Gupta, S., Vigyan Mishra and Hridayesh Prakash. 2023 "Serum Specific Immunoglubulin E: Major Determinant for Accessing Sensitivity for Various Pediatric Allergies in North India" Preprints. https://doi.org/10.20944/preprints202308.0536.v1
Abstract
High prevalence of allergic disorders in Indian pediatric patients demands early diagnosis of allergens so that appropriate allergen avoidance methods, pharmacotherapy or immunotherapy can be provided in time to avoid the worsening of symptoms due to triggers. In this context, identification of the most prevalent aeroallergens in a given area is critical for diagnosis and treatment of various allergic reactions especially in case of rhino-conjunctivitis and asthma. The specific diagnosis of IgE mediated allergy is usually based on the correlation between the clinical history and signs and symptoms endorsed by the diagnostic tests. Skin prick tests are the gold standard however has some limitation. In view of this, the aim of this study was to assess the significance of ImmunoCAP assay for assessing serum specific IgE levels, available in India, against skin prick test by standardized allergens, for the diagnosis of allergic sensitization. A single-center observational study was conducted at tertiary care corporate hospitals in North India from 2017-2020. Patients with self-reported allergic symptoms or whose symptoms were suspected for allergies were tested for the type of sensitization using skin prick test (SPT) after their consents followed by ImmunoCAP based quantification of serum specific IgE levels. A total of 256 (95.9%) pediatric patients were analyzed in the study and were analysed. The patients were most commonly (30% patients) sensitized to D. farinae (173 [67.6%]), D. pteronyssinus (174 [68.0%]), Acarus siro (93 [36.3%]), Lepidoglyphus destructor (96 [37.5%]), Plantago lanceolata (Engl.). The ROC curve of Bermuda grass shows that the AUC of serum-specific IgE is larger than that of SPT (1.000 / 0.881). The receiver operating characteristic (ROC) analysis of serum-specific IgE reference method resulted in the largest AUC of all the allergens taken into consideration (0.711 / 1.000) compared to those of SPT (0.589 / 1.000). These results revealed that serum-specific IgE is more reliable method over prick test for accessing the sensitivity of patient for various allergens. This study may be helpful in performing early diagnosis of allergies as well as in taking appropriate preventive measures for managing life threatening allergic reactions
Keywords
Pediatric Allergy. Specific IgE; Skin prick test; allergens
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
