Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cell Type Specific Extracellular Vesicles and Their Impact on Health and Disease

Sohil Amin
ORCID logo ,
Hamed Massoumi
,
Deepshikha Tewari
,
Arnab Karmaker Roy
,
Madhurima Chaudhuri
ORCID logo ,
Cedra Jazayerli
,
Abhi Krishan
,
Mannat Singh
,
Mohammad Soleimani
,
Esra Karaca
,
Arash Mirzaei
,
Victor H Guaiquil
,
Mark I Rosenblatt
,
Ali R Djalilian
* ,
Elmira Jalilian
Version 1 : Received: 7 February 2024 / Approved: 8 February 2024 / Online: 8 February 2024 (09:18:13 CET)

A peer-reviewed article of this Preprint also exists.

Amin, S.; Massoumi, H.; Tewari, D.; Roy, A.; Chaudhuri, M.; Jazayerli, C.; Krishan, A.; Singh, M.; Soleimani, M.; Karaca, E.E.; Mirzaei, A.; Guaiquil, V.H.; Rosenblatt, M.I.; Djalilian, A.R.; Jalilian, E. Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease. Int. J. Mol. Sci. 2024, 25, 2730. Amin, S.; Massoumi, H.; Tewari, D.; Roy, A.; Chaudhuri, M.; Jazayerli, C.; Krishan, A.; Singh, M.; Soleimani, M.; Karaca, E.E.; Mirzaei, A.; Guaiquil, V.H.; Rosenblatt, M.I.; Djalilian, A.R.; Jalilian, E. Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease. Int. J. Mol. Sci. 2024, 25, 2730.

Abstract

Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal in mediating intercellular communication due to their ability to selectively transfer biomolecules to specific cell types. EVs, composed of proteins, nucleic acids, and lipids, are taken up by cells to affect a variety of signaling cascades. Research in the field has primarily focused on stem-cell derived EVs, with a particular focus on mesenchymal stem cells, for their potential therapeutic benefits. Recently, tissue specific EVs or cell type specific extracellular vesicles (CTS-EVs), have garnered attention for their unique biogenesis and molecular composition because they enable highly targeted cell-specific communication. Various studies have outlined the roles that CTS-EVs play in signaling for physiological function and maintenance of homeostasis, including immune modulation, tissue regeneration, and organ development. These properties are also exploited for disease propagation, such as in cancer, neurological disorders, infectious diseases, autoimmune conditions, and more. The insights gained from analyzing CTS-EVs in different biological roles not only enhance our understanding of intercellular signaling and disease pathogenesis, but also open new avenues for innovative diagnostic biomarkers and therapeutic targets for a wide spectrum of medical conditions. This review comprehensively outlines current understanding of CTS-EV origins, function within normal physiology, and implications in diseased states.

Keywords

cell type specific extracellular vesicles; extracellular vesicles; exosomes; intercellular communication; diagnostic biomarkers; disease pathogensis

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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