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Preprint REVIEW | doi:10.20944/preprints201810.0235.v1

Bile Acid Signaling and Cardioprotection

Noorul Izzati Hanafi, Anis Syamimi Mohamed, Siti Hamimah Sheikh Abdul Kadir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heart; ursodeoxycholic acid; cardioprotection; signaling

Online: 11 October 2018 (08:35:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0131.v2

Use of Deep Learning to Detect the Maternal Heart Rate and False Signals on Fetal Heart Rate Recordings

Samuel Boudet, Agathe Houzé de l'Aulnoit, Laurent Peyrodie, Romain Demailly, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: fetal heart rate; maternal heart rate; cardiotocogram; gated recurrent unit; deep learning

Online: 22 July 2022 (03:08:59 CEST)

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We have developed deep learning models for automatic identification of the maternal heart rate (MHR) and, more generally, false signals (FSs) on fetal heart rate (FHR) recordings. The models can be used to preprocess FHR data prior to automated analysis or as a clinical alert system to assist the practitioner. Three models were developed and used to detect (i) FSs on the MHR channel (the FSMHR model), (ii) the MHR and FSs on the Doppler FHR sensor (the FSDop model), and (iii) FSs on the scalp ECG channel (the FSScalp model). The FSDop model was the most useful because FSs are far more frequent on the Doppler FHR channel. All three models were based on a multilayer, symmetric, GRU and were trained on data recorded during the first and second stages of delivery. The FSMHR and FSDop models were also trained on antepartum recordings. The training dataset contained 1030 expert-annotated periods (mean duration: 36 min) from 635 recordings. In an initial evaluation of routine clinical practice, 30 fully annotated recordings for each sensor type (mean duration: 5 h for MHR and Doppler sensors, and 3 h for the scalp ECG sensor) were analyzed. The sensitivity, positive predictive value (PPV) and accuracy were respectively 62.20%, 87.1% and 99.90% for the FSMHR model, 93.1%, 95.6% and 99.68% for the FSDop model, and 44.6%, 87.2% and 99.93% for the FSScalp model. We built a second test dataset with a more solid ground truth by selecting 45 periods (lasting 20 min, on average) on which the Doppler FHR and scalp ECG signals were recorded simultaneously. Using scalp ECG data, the experts estimated the true FHR value more reliably and thus annotated the Doppler FHR channel more precisely. The models achieved a sensitivity of 53.3%, a PPV of 62.4%, and an accuracy of 97.29%. In comparison, two experts (blinded to the scalp ECG data) respectively achieved a sensitivity of 15.7%, a PPV of 74.3%, and an accuracy of 96.91% and a sensitivity of 60.7%, a PPV of 83.5% and an accuracy of 98.24%. Hence, the models performed at expert level (better than one expert and worse than the other), although a well-trained expert with good knowledge of FSs could probably do better in some cases. The models and datasets have been included in the Fetal Heart Rate Morphological Analysis open-source MATLAB toolbox and can be used freely for research purposes.

Preprint ARTICLE | doi:10.20944/preprints201807.0374.v1

Coordination and Private Information Revelation: Failure of Information Unraveling

Debdatta Saha, Prabal Roy Chowdhury

Subject: Business, Economics And Management, Economics Keywords: private information revelation; coordination; strategic uncertainty

Online: 20 July 2018 (04:51:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0181.v1

Biomarkers of Response to Adjunctive Yoga-Based Interventions in Depression: A Scoping Review

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: major depressive disorder; yoga; adjunctive treatment; hypothalamic-pituitary-adrenal axis; heart rate variability; interleukin-6; brain-derived neurotrophic factor

Online: 4 March 2024 (15:54:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1122.v1

Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation

Sarah Mende, Syed Ahmed, Lise DeShea, Edgardo Szyld, Birju A. Shah

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: electrocardiogram; heart rate; neonatal resuscitation

Online: 17 April 2024 (08:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0396.v1

Cardiac Laterality: Surgical Results of Right Atrial Isomerism

Diego B. Ortega-Zhindón, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José A. García-Montes, Juan Calderón-Colmenero, Jorge L. Cervantes-Salazar

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: heterotaxy syndrome; atrial isomerism; heart surgery; congenital heart disease.

Online: 7 September 2023 (03:33:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1471.v2

Pivotal Role of Artificial Intelligence in Cardiovascular Health: Highlights from the Late Breaking Trials at the AHA Scientific Sessions 2023

Sashwath Srikanth, Avilash Mondal, Sanjana Aggarwal, Naga Ruthvika Alle, Olufemi Odugbemi, Rupak Desai

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: artificial intelligence; machine learning; coronary artery diease; heart failure; risk stratification; screening

Online: 26 March 2024 (10:23:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0466.v1

Prevalence and Intensity of Sarcocystis Infections in Alpine Chamois (Rupicapra r. rupicapra) in Germany

Steffen Rehbein, Martin Visser

Subject: Biology And Life Sciences, Parasitology Keywords: Sarcocystis; chamois; heart; diaphragm; Germany

Online: 9 October 2023 (07:36:37 CEST)

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Chamois are mountain ungulates (Subfamily Caprinae) which inhabit several medium and high altitude mountain ranges from southern Europe to the Near East. The first findings of Sarcocystis cysts in the musculature of chamois were reported in the 1970s. However, only limited work on the epidemiology of sarcocystosis and identification of the species of Sarcocystis in chamois has been done in the past. The present work was part of a comprehensive study on the parasites of chamois in Germany aiming to provide, for the first time, data on the prevalence and intensity of Sarcocystis infection in native Alpine chamois using histology examination of heart and/or diaphragm tissue samples collected from 216 chamois (40 kids and 176 chamois ranging of one up to 18 years of age). Sarcocysts were detected in either heart or diaphragm of 167/216 chamois (77.3%) with 131 of 183 heart samples and 127 of 215 diaphragm samples testing sarcocyst positive. Of the 181 chamois with both heart and diaphragm available (34 kids and animals up to 18 years of age), sarcocysts were detected in heart and/or diaphragm of 142 animals translating in an overall 78.5% prevalence of Sarcocystis infection (95%CI 72.5% - 84.4%). Sarcocysts were more frequently recorded in heart vs. diaphragm (72.4% vs. 56.4%; p=0.0021), and diaphragm positivity was associated with heart positivity (p=0.0001). Sarcocyst positivity (heart and/or diaphragm) was significantly (p<0.001) lower in kids than in the older chamois (27.1% vs. 88.6%, respectively) but prevalence did not differ between the sexes, regardless of the chamois’ age (p>0.3). Intensity of infection was generally low (<10 sarcocysts per cm² muscle cut) in both heart positive and diaphragm positive animals (94.7% and 93.7%, respectively) with heart yielding higher sarcocyst counts than diaphragm (p<0.001). Both heart and diaphragm sarcocyst counts were significantly (p<0.001) lower in kids than in the older chamois. Sarcocystis infection was demonstrated to be prevalent in chamois in Germany but intensity is apparently low. Further studies are desired to identify the species of Sarcocystis parasitizing the chamois using both phenotypic and molecular characteristics.

Preprint ARTICLE | doi:10.20944/preprints202402.1025.v1

Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study

Luana Nosetti, Marco Zaffanello, Carolina Lombardi, Alessandra Gerosa, Giorgio Piacentini, Abramo Michele, Massimo Agosti

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: children; congenital heart disease; Electrocardiogram; Infant; long QT syndrome; neonatal screening; sudden infant death syndrome.

Online: 19 February 2024 (08:22:38 CET)

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(1) Background: Sudden Infant Death Syndrome (SIDS) represents unexplained and sudden deaths during the sleep of infants under one year of age, despite thorough investigation. Screening for prolonged QTc or Long QT Syndrome (LQTS) should be conducted on all newborns to reduce the incidence of SIDS. Neonatal electrocardiogram (ECG) could identify congenital heart defects (CHD) early, especially those not detected at birth. Infants with prolonged QT intervals typically undergo genetic analysis for Long QT Syndrome; (2) Methods: The study involved infants aged 20-40 days, born clinically healthy, with initial ECG screening. Infants with prenatal diagnoses or signs/symptoms of CHD identified immediately after birth, as well as those who underwent ECG or echocardiogram for other clinical or historical indications, were excluded from the study. The data were analyzed using SPSS version 22.0; (3) Results: Of the 42,200 infants involved, 2,245 were enrolled, with 39.9% being males. Subsequently, 164 children (37.8% males) with prolonged QT intervals underwent further diagnostic investigations. Genetic mutations were identified in 11 out of 18 tested children. The most common mutations were LQT1 (54.5%), LQT2 (36.4%), and LQT3 (1 patient). Medications used included propranolol (39.8%), nadolol (22.2%), inderal (11.1%), metoprolol (11.1%), and no treatment (16.7%). The most common abnormalities were focal right bundle branch block (54.5%), left axis deviation (9.2%), and nonspecific ventricular repolarization abnormalities (7.1%). Multiple anomalies were found in 0.47% of children with focal right bundle branch block. Structural abnormalities were associated with specific features in 267 patients (11.9%), primarily isolated patent foramen ovale (PFO) at 61.4%; (4) Conclusions: The screening has proven effective in early diagnosing Long QT Syndrome and other cardiac rhythm anomalies, with additional benefits in detecting mutations and/or QTc prolongations in family members. Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening.

Preprint REVIEW | doi:10.20944/preprints202402.0456.v1

The Potential Use of Soluble TREM Like Transcript – 1, a Platelet-Specific Receptor, for Early Detection of Anthracyclines Induced Congestive Heart Failure (CHF) in Leukemia Patients

Siobhan Branfield, Susan LaGrand, Ian Cleary, Angelia Gibson, Anthony Valance Washington

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Keywords: keyword triggering receptor expressed in myeloid cells-like transcript (TLT-1); blood platelets; cardiovascular diseases; left ventricular ejection fraction (LVEF); biomarker; anthracyclines, Troponin I, cardiotoxicity, congestive heart failure (CHF)

Online: 7 February 2024 (17:08:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0895.v1

Ubiquitin Proteasome System Role in Diabetes-Induced Cardiomyopathy

Ortal Nahum-Ankonina, Efrat Kurtzwald-Josefson, Aaron Ciechanover, Maayan Waldman, Orna Schwartz Rohaker, Edith Hochhauser, Sam j Meyer, Dan Aravot, Moshe Philip, Yaron D. Barac

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: UPS; T2DM; Heart

Online: 11 August 2023 (08:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0700.v1

Numerical Analysis of TRC Shells – Force Interaction and Failure Types

Iurii Vakaliuk, Silke Scheerer, Manfred Curbach

Subject: Engineering, Civil Engineering Keywords: Textile-reinforced concrete; TRC; shell structures; material model; numerical analysis; lightweight concrete elements

Online: 11 December 2023 (12:51:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1018.v1

Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center

Marisa Domingues Santos, Vânia Magalhães, Luís Loureiro, Pedro Pina, Ana Castro, Paulina Aguiar, Ana Gomes, Diana Soares, Anabela Rocha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Keywords; Short bowel Syndrome; Chronic Intestinal failure; Home Parenteral Nutrition; Teduglutide; Complications of Parenteral Support

Online: 19 February 2024 (16:24:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0842.v1

Prognostic Value and Limits of Heart Rate and QT-Corrected in A Large Population

Paolo Giovanardi, Cecilia Vernia, Sara Roversi, Enrico Tincani, Giuseppe Spadafora, Federico Silipo, Claudio Giberti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: electrocardiogram; QT corrected; Bazett; heart rate; all-cause death; mortality

Online: 12 April 2024 (09:54:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0788.v1

The Lipid-Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-fat and High Linoleic Acid Consumption

Academic Editor: Mary T Newport, Fabian M Dayrit

Subject: Public Health And Healthcare, Health Policy And Services Keywords: lipid-heart hypothesis; Ancel Keys; saturated fat; trans-fat; polyunsaturated fat; cholesterol; heart disease; dietary guidelines

Online: 11 April 2024 (10:20:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0017.v1

Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left-Heart Syndrome, Ciliopathies and Neurodevelopmental Delays

Kalyani B Karunakaran, George C Gabriel, N Balakrishnan, Cecilia W Lo, Madhavi K Ganapathiraju

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein-protein interactions; interactome; congenital heart disease; developmental disorder; hypoplastic left heart syndrome; web application

Online: 1 February 2022 (16:00:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0113.v1

Software Failure Analysis and Mitigation Techniques: Featuring Complexity, Safety, Quality and Resilience

Bhanu Prakash

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Complexity Analysis & Mitigation; Software Architecture & Design, Safety; Quality; Fragility; Failure Obviation

Online: 6 January 2021 (11:45:48 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0027.v1

The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle

Igor Giarretta, Eleonora Gaetani, Paolo Tondi, Takayuki Asahara, Roberto Pola

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hedgehog; Ischemia; Heart; Brain; Skeletal muscle

Online: 1 August 2018 (16:31:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0364.v1

Weil's Disease - from Gut Dysbiosis to Immunopathogenesis and Multiple Organ Failure

Pavlo Petakh, Vitaliia Isevych, Valentyn Oksenych

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: leptospirosis; dysbiosis; Weil's disease

Online: 21 November 2022 (03:26:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0244.v1

Automatic Failure Mode and Effect Analysis of Electronic Fuel Injection Model

Dongwoo Lee, Dongmin Lee, Jongwhoa Na

Subject: Engineering, Automotive Engineering Keywords: failure mode and effect analysis (FMEA); model-based design; automatic generation tool; fault injection simulation

Online: 18 May 2022 (12:40:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0014.v2

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Bipradas Roy, Sadia Afrin Runa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; Diabetes; Neurological dysfunction; Cardiovascular complications; Pulmonary dysfunction; Renal dysfunction; bone loss; Eye disease; Gastrointestinal complications

Online: 23 May 2022 (11:00:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0350.v1

HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in Trauma

Zhangsheng Yang, Milomir O Simovic, Peter R Edsall, Bin Liu, Tomas S Cancio, Andriy I Batchinsky, Leopoldo C Cancio, Yansong Li

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HMGB1; trauma; hemorrhagic shock; inflammation; multiple organ failure

Online: 22 December 2021 (10:36:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0498.v1

An Essay on Railway Track Bed Failure Issues, Analysis and Remedy

S M Nazmuz Sakib

Subject: Engineering, Civil Engineering Keywords: Railway; Track bed; Track bed failure; Railway track; Track bed failure remedy

Online: 29 September 2021 (14:23:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1490.v1

Liver-Kidney-Heart Axis – A Clinical Challenge

Dina Fernandes Neto, Iago Blanco, María Melendo Viu, David Dobarro Perez, Andrés Iñiguez Romo

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type-5 cardio-renal syndrome; heart failure; cirrhosis; Liver-Kidney-Heart axis

Online: 19 January 2024 (13:11:37 CET)

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Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome. A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states. With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.

Preprint COMMUNICATION | doi:10.20944/preprints202309.1187.v1

Preliminary Study on the Immunohistochemical Expression of Galectin-3 in Hypertrophic Hearts

Cecilia Salzillo, Lorenzo Giovannico, Giuseppe Fischetti, Gerardo Cazzato, Mario Magistro, Grazia Nucci, Gabriella Serio, Andrea Marzullo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: galectin-3; cardiac hypertrophy; immunohistochemical expression; heart transplantation; heart disease; cardiorenal syndrome

Online: 19 September 2023 (03:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0099.v1

Failure assessment of steel/CFRP double strap joints

Hamid Reza Majidi, Seyed Mohammad Javad Razavi, Filippo Berto

Subject: Engineering, Mechanical Engineering Keywords: double strap joint; failure load prediction; finite element analysis; steel; stress-based failure criterion.

Online: 21 June 2017 (03:26:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0155.v1

Fracture Failure Mechanisms of Long Single PA6 Fibers

Huiling Ding, Yongzhen Zhang, Zhitao He

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: single fiber; cutting; fracture morphology; failure mechanism

Online: 22 May 2017 (05:29:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0378.v1

Factors Affecting Success and Failure in Higher Education Mathematics: Students and Teachers’ Perspectives

Mili Saha, Shobha Islam, Asma Akter Akhi, Goutam Saha

Subject: Computer Science And Mathematics, Mathematics Keywords: Mathematics; Factors; Success; Failure; Students; Teachers;

Online: 26 September 2022 (05:35:23 CEST)

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Background: Bangladeshi students from science, technology, engineering, and mathematics (STEM) often struggle with solving many mathematical problems in different pedagogic contexts. They mostly lack the considerable prior learning or strong basics required to cope with the teaching and learning materials used at the undergraduate levels, which leads many students to take readmissions every year. Objective: This research aims at investigating the factors affecting the success and deficit of university undergraduate mathematics students in Bangladesh. The mixed-method research incorporates quantitative and qualitative data analysis on the students' and teachers’ perspectives regarding the issues. The authors focus more on categorizing the reasons influencing effective mathematics pedagogies than on identifying new or unknown causes. Methodology: This study is outlined in three phases. The phases include i. Exploratory qualitative survey ii. Quantitative triangulation survey, iii. Explanatory semi-structured interviews. Findings: First, the qualitative survey exposes the important factors that highlight the student’s success and failure in mathematics. Next, the quantitative data confirm that there are some similarities and dissimilarities between students’ and teachers’ perceptions. Also, the coefficient correlation analysis shows male students lack consistency and passion for study resulting in poor performances. Conversely, female students emphasize the inability to connect mathematical theories to real-life usages, curriculum loads, and unavailable resources as the reasons for underperformance. Finally, the interview data demonstrate the students attribute their failure to inadequate practices, memorizing habits, poor teaching, low motivation, and external distractions. Also, students acknowledge the necessity of steady practice, clear understanding, regular study, and working strategies for successful mathematics education. Teachers emphasize students’ clear concepts, aptitude, motivation, and curiosity for successful learning. Conclusion: This conclusion proposes a fresh start with the local mathematics pedagogic practices by analyzing teacher-student feedback on the success and failure factors impacted by varied individual and contextual elements. The study offers inclusive feedback on the part of both stakeholders. However, an open discussion or interaction between students and teachers might be needed to enhance mutual trust and understanding between them.

Preprint REVIEW | doi:10.20944/preprints202010.0493.v1

Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications

Abdallah Fayssoil, Marie Charlotte De Carne De Carnavalet, Nicolas Mansencal, Frédéric Lofaso, Benjamin Davido

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Obesity; BMI; heart; lung; severity

Online: 23 October 2020 (13:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0353.v1

Experimental and Numerical Investigations into the Failure Mechanisms of TRIP700 Steel Sheets

Niloufar Habibi, Veera Sundararaghavan, Ulrich Prahl, Ali Ramazani

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: TRIP steel sheet; cross-die test; forming limit diagram; finite element analysis; failure mechanisms

Online: 16 October 2018 (11:12:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.2153.v1

Different Mechanisms in Doxorubicin-induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

Hien C. Nguyen, Jefferson C. Frisbee, Krishna K. Singh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BRCA2; BRCA1; doxorubicin; breast cancer; heart failure

Online: 28 December 2023 (05:10:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0087.v1

Difference between Serum BNP Admission Level and that Detected at Discharge in Patients with ADHF Predicts Six-Month Mortality in a More Reliable Manner with Respect to Isolated BNP Determination Taken on Admission

Renato De Vecchis, Carmelina Ariano, Cesare Baldi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: natriuretic peptides; heart failure; congestion; outcome

Online: 9 August 2016 (11:33:03 CEST)

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Background According to some authors, a single isolated measurement of serum BNP executed on hospital admission would not be a sufficiently accurate method to predict the outcome of patients with ADHF. Aims For verifying this assumption, a retrospective study was conducted on patients hospitalized for ADHF. Our main objective was to ascertain whether there was any difference in midterm mortality among patients with rising BNP at discharge as compared to those with decreasing BNP at discharge. Methods Medical records were examined so as to make a partition of the ADHF patient population into two groups, the former characterized by a rise in BNP during hospitalization, and the latter exhibiting a decrease in BNP in the measurement taken at hospital discharge. Results 177 patients were enrolled in a retrospective study. Among them, 53 patients (29.94%) had increased BNPs at the time of discharge, whereas 124 (70.06%) showed decreases in serum BNP during their hospital stay. The group with patients who exhibited BNP increases at the time of discharge had higher degree of congestion evident in the higher frequency of persistent jugular venous distention and persistent orthopnea at discharge. Moreover, patients with increased BNP at the time of discharge had a lower reduction in inferior vena cava maximum diameter [1.58 ± 2.2 mm vs. 6.32 ± 1.82 mm; p (one-way ANOVA)=0.001]. In contrast, there was no significant difference in weight loss when patients with increased BNP at discharge were compared to those with no such increase. A total of 14 patients (7.9%) died during the six-month follow-up period. Cox proportional hazard analysis revealed that BNP increase at the time of discharge was an independent predictor of six-month all-cause mortality after adjustment for age, sodium at discharge, creatinine at discharge and New York Heart Association (NYHA) class at discharge (hazard ratio 34.49; 95% confidence intervals: 4.55–261.06; P =0.001). Conclusions Among patients with history of ADHF, more elevated BNP levels at the time of discharge from the hospital compared to those detected at admission identify a patient subset with higher grade of congestion and higher six-month mortality.

Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0531.v1

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-ischemic Hypertensive Heart Disease

Nikolaos PE Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael Myrianthefs

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertensive heart disease; echocardiography; prognosis; speckle tracking

Online: 8 March 2024 (16:49:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0185.v1

Role of Chest Radiographs and Electrocardiograms in Predicting the Hemodynamics of Congenital Heart Disease

Romila Chimoriya, Gaurav Kumar, Kritika Rana, Ritesh Chimoriya, Reena Anand, Kulbhusan S. Dagar, Neeraj Awasthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; chest radiograph; electrocardiogram; echocardiography

Online: 14 September 2022 (02:55:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0020.v1

Tachycardia-Induced Cardiomyopathy in an Infant with Atrial Flutter and Prolonged Recovery of Cardiac Function

Tomohide Sakai, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka W Ozawa, Yukiko Hata, Shojiro Ichimata, Naoki Nishida, Keiichi Hirono

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: tachycardia-induced cardiomyopathy; atrial flutter; heart failure

Online: 1 May 2024 (04:30:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0039.v1

Fetal Heart Rate Signal Dataset for Training Morphological Analysis Methods and Evaluating them Against an Expert Consensus

Samuel Boudet, Agathe Houze de l'Aulnoit, Romain Demailly, Aline Delgranche, Laurent Peyrodie, Régis Beuscart, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Other Keywords: fetal heart rate, baseline, acceleration, deceleration, dataset

Online: 2 July 2019 (11:17:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0116.v1

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and EPAC : A Role for the Mitochondrial Permeability Transition Pore

Martin John Lewis, Igor Khaliulin, Katie Hall, M.Saadeh Suleiman

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Ischaemia/reperfusion injury; Development; Mitochondria; Immature Heart

Online: 10 January 2022 (13:38:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0185.v1

Extracorporeal Membrane Oxygenation for Respiratory Failure: A Narrative Review

John C. Grotberg, Daniel Reynolds, Bryan D Kraft

Subject: Pulmonary And Respiratory Medicine, Medicine And Pharmacology Keywords: extracorporeal membrane oxygenation; respiratory insufficiency; respiratory distress syndrome

Online: 3 May 2024 (09:44:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1985.v1

Role of Tolvaptan in Heart Failure: A Meta-Analysis

Avichal Dani, Kinjal Shah, Tanvi Sahni, Dev Desai

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Tolvaptan; ADHF; PRISMA; VRA

Online: 26 December 2023 (10:26:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0230.v1

Investigation of Failure Mechanism of Lungchok Landslide, Sikkim (India)

Neharika Rao Ganta, Neelima Satyam

Subject: Engineering, Civil Engineering Keywords: finite element method; earthquake induced landslide; static and dynamic analysis; deformation based failure

Online: 22 August 2019 (10:45:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0462.v1

Acoustic Emissions in Rock Deformation and Failure: New Insights from Q-Statistical Analysis

Sergio Vinciguerra, Annalisa Greco, Alessandro Pluchino, Andrea Rapisarda, Constantino Tsallis

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Acoustic emissions; q-statistics; rocks fractures

Online: 27 March 2023 (13:30:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0482.v1

Fuzzy-Based Failure Modes, Effects and Criticality Analysis Applied to Cyber-Power Grids

Andrés A. Zúñiga, João Filipe Pereira Fernandes, Paulo J. C. Branco

Subject: Engineering, Electrical And Electronic Engineering Keywords: FMECA; Fuzzy Inference Systems; fuzzy-based FMECA, Risk assessment, cyber-power grids

Online: 26 January 2023 (16:10:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0285.v1

Large Power Transformers: Time Now for Addressing Their Monitoring and Failure Investigation Techniques

Jonathan Velasco Costa, Diogo F.F. Silva, P.J. Costa Branco

Subject: Engineering, Electrical And Electronic Engineering Keywords: Large power transformer; condition monitoring; transformer fault diagnosis; diagnostic techniques; mechanical or electrical integrity of the core and windings

Online: 21 March 2022 (10:47:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1473.v1

Characterization of a Decellularized Sheep Pulmonary Heart Valves and Analysis of their Capability as a Xenograft Initial Matrix Material in Heart Valve Tissue Engineering

Müslüm Süleyman İNAL, Cihan DARCAN, Ali AKPEK

Subject: Engineering, Bioengineering Keywords: Decellularization; heart valve; tissue engineering; xenograft; biomaterial

Online: 22 May 2023 (08:26:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1198.v1

Pirfenidone Prevents the Onset of Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy

Tatiana Araújo Silva, Diane Thomas, Jair Lage Siqueira-Neto, Claudia Magalhaes Calvet

Subject: Biology And Life Sciences, Parasitology Keywords: Heart fibrosis; Chagas disease; Pirfenidone

Online: 20 November 2023 (07:34:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0800.v1

The Role of Right Ventriculo-Arterial Coupling in Symptoms Presentation of Patients With Hypertrophic Cardiomyopathy

Andreas Angelopoulos, Evangelos Oikonomou, Alexios S. Antonopoulos, Panagiotis Theofilis, Konstantinos Kalogeras, Paraskevi Papanikolaou, George Lazaros, Gerasimos Siasos, Dimitris Tousoulis, Konstantinos Tsioufis, Charalambos Vlachopoulos

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypertrophic cardiomyopathy; cardiomyopathies; heart failure

Online: 12 June 2023 (08:41:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0290.v2

A New Algorithm for Estimating Fast Variations in the Heart Rate

Enrico Maria Staderini, Harish Kambampati, Amith K. Ramakrishnaiah, Stefano Mugnaini, Andrea Magrini, Sandro Gentili

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability; signal analysis

Online: 6 February 2023 (04:45:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0040.v1

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Dae Yun Seo, Jeong Rim Ko, Jung Eun Jang, Tae Nyun Kim, Jae Boum Youm, Hyo-Bum Kwak, Jun Hyun Bae, Amy Hyein Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diabetes; exercise; cardiomyopathy; heart failure

Online: 3 October 2019 (13:59:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1262.v1

Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation

Aurelio Quesada, Javier Quesada-Ocete, Blanca Quesada-Ocete, Victor Del Moral-Ronda, Javier Jiménez-Bello, Ricardo Rubini-Costa, Carl J. Lavie, Daniel P. Morin, Fernando De la Guía-Galipienso, Ricardo Rubini-Puig, Fabian Sanchis-Gomar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; gender; electrical cardioversion; heart failure; mortality

Online: 17 August 2023 (07:15:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0174.v1

Strangers, Friends, and Lovers Show Specific Physiological Synchronies In Different Emotional Contexts

Andrea Bizzego, Atiqah Azhari, Nicola Campostrini, Anna Truzzi, Li Ying Ng, Giulio Gabrieli, Marc H. Bornstein, Peipei Setoh, Gianluca Esposito

Subject: Social Sciences, Behavior Sciences Keywords: heart rate variability; dyads; physiological synchrony; relationship; emotion

Online: 15 November 2019 (06:09:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0249.v1

Ultra-High Resolution Electrocardiography Enables Earlier Detection of Transmural and Subendocardial Myocardial Ischemia Compared to Conventional Electrocardiography

Kirill V. Zaichenko, Anna A. Kordyukova, Dmitry L. Sonin, Michael M. Galagudza

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart; ischemia; reperfusion; electrocardiography; ultra-high resolution electrocardiography; power spectral density; ischemic heart disease; subclinical atherosclerosis; sensitivity; risk stratification

Online: 3 August 2023 (05:17:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1254.v1

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca, Valeria de Cassia Gonçalves, Mario Augusto Izidoro, Antônio-Carlos G. de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Online: 16 June 2023 (14:16:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1922.v1

Statistical and Diagnostic Properties of pRR30, pRR3.25% and Asymmetrical Entropy Descriptors in Atrial Fibrillation Detection

Bartosz Biczuk, Szymon Buś, Sebastian Żurek, Jarosław Piskorski, Przemysław Guzik

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: atrial fibrillation; cardiac arrhythmia; electrocardiography; heart rate variability; entropy

Online: 26 January 2024 (13:50:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0508.v1

Is Continuous ECG Recording on Heart Rate Monitors the Most Expected Function by Endurance Athletes, Coaches, and Doctors?

Robert Gajda

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: heart rate monitor; ECG; portable/wearable monitoring system; heart rate variability; long-term assessment; arrhythmia; QARDIO MD VSI system

Online: 24 August 2020 (07:45:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0619.v1

Embodimetrics: A Principal Component Analysis of the Combined Assessment of Cardiac, Cognitive and Mobility Parameters

Andrea Chellini, Katia Salmaso, Michele Di Domenico, Nicola Gerbi, Marco Donati, Marco Iosa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: embodiment; heart rate variability; stroop task; motor control

Online: 12 February 2024 (13:19:53 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.1692.v1

One-Year Real-World Experience with Mavacamten and its Physiologic Effects on Obstructive Hypertrophic Cardiomyopathy

Daniel Kim, Emily Chu, Emily Keamy-Minor, Ishan Paranjpe, Wilson Tang, Jack O'Sullivan, Yaanik Desai, Michael Liu, Elise Munsey, Kimberly Hecker, Isabella Cuenco, Beth Kao, Ellen Bacolor, Colleen Bonnett, Andrea Linder, Kathleen Lacar, Nancy Robles, Cynthia Lamendola, Allysonne Smith, Joshua Knowles, Marco Perez, Masataka Kawana, Karim Sallam, Chad Weldy, Matthew Wheeler, Victoria Parikh, Heidi Salisbury, Euan Ashley

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mavacamten; cardiac myosin inhibitor; hypertrophic cardiomyopathy; heart failure

Online: 27 November 2023 (11:50:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0731.v1

The Effect of Drotaverine on Gastrointestinal Motility and Heart Rate Variability in Normal, Resting Horses

Alina Anton

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: antispasmodic; heart rate variability; intestinal function; parasympathetic activity

Online: 9 June 2023 (15:50:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0655.v1

ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

Mario Pavez-Giani, Pablo Sanchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Paula Giraldo, Silke Oberdorf-Maass, Kirsten Nijholt, Salva Yurista, Hendrik Milting, Joan Heller Brown, Peter Van Der Meer, Rudolf A. de Boer, Herman H.W. Silljé, B. Daan Westenbrink

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondria; Ca2+ handling; heart failure; CaMKII; cardiomyocyte hypertrophy

Online: 26 March 2021 (10:41:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0278.v1

Perinatal Cardiovascular Evaluation in Dorper Sheep: Echocardiographic Description and Behavior of the Heart Rate Variability on the Field

Amanda Sarita Cruz Aleixo, Mayra de Castro Ferreira Lima, Ana Luisa Holanda de Albuquerque, Raphael Tortorelli Teixeira, Renata Alves de Paula, Marina Cecília Grandi, Danilo Otávio Laurenti Ferreira, Lukas Garrido Albertino, Miriam Harumi Tsunemi, Simone Biagio Chiacchio, Maria Lucia G. Lourenço

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: sheep; gestation; hemodinamycs; heart rate variability; cardiac output

Online: 13 October 2020 (12:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0280.v1

Failure of Perforated Polymethyl Methacrylate Specimens Loaded by Inserted Pins

Adrian Gonzalez, Young W. Kwon

Subject: Engineering, Mechanical Engineering Keywords: pin loading; failure criteria; notch

Online: 5 May 2023 (03:05:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1030.v1

Impaired Mitochondrial Function and Marrow Failure in Patients Carrying a Variant on SRSF4 Gene

Maurizio Miano, Nadia Bertola, Alice Grossi, Gianluca Dell'Orso, Stefano Regis, Marta Rusmini, Paolo Uva, Diego Vozzi, Francesca Fioredda, Elena Palmisani, Michela Lupia, Marina Lanciotti, Federica Grilli, Fabio Corsolini, Luca Arcuri, Maria Carla Giarratana, Isabella Ceccherini, Carlo Dufour, Enrico Cappelli, Silvia Ravera

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Marrow failure; mitochondria; SRSF4; mTOR; CLUH; DRP1; OPA1

Online: 14 December 2023 (08:07:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0246.v1

Shearing with Infiltration Tests to Study Mechanical Behavior and Failure Mechanism of Shallow Slopes

Ali Murtaza Rasool, Jiro Kuwano

Subject: Engineering, Civil Engineering Keywords: shallow slopes; unsaturated soil; slope stability; deviatoric stress; pore-water pressure; water infiltration

Online: 21 October 2019 (15:22:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0540.v1

Neuromuscular Fatigue at Task Failure and During Immediate Recovery after Isometric Knee Extension Trials

Christian Froyd, Fernando G. Beltrami, Timothy D. Noakes

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: maximal voluntary contraction; peripheral fatigue; neuromuscular activation; femoral nerve electrical stimulation; critical peripheral fatigue threshold; electromyography

Online: 23 October 2018 (15:12:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0256.v1

Effects of Bisphenol A and 4-Tert-octylphenol on Embryo Implantation Failure in Mouse

Dinh Nam Tran, Eui-Man Jung, Changhwan Ahn, Jae-Hwan Lee, Yeong-Min Yoo, Eui-Bae Jeung

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Implantation failure; Bisphenol A; 4-tert-octylphenol; calcium channel

Online: 18 May 2018 (07:38:04 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0438.v1

Exercise-Induced Arrhythmia or Munchhausen Syndrome in a Marathon Runner?

Robert Gajda, Wojciech Drygas, Jacek Gajda, Pawel Kiper, Beat Knechtle, Magdalena Kwaśniewska, Maciej Sterliński, Elżbieta Katarzyna Biernacka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate monitor; endurance running; arrhythmia, tachycardia; artifacts; exertion rhythm disorders; Munchhausen syndrome; athlete's heart

Online: 7 July 2023 (07:41:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1283.v2

The Future of Stress Management: Integration Smartwatches and HRV Technology

Ravinder Jerath, Mohammad Syam, Shajia Ahmed

Subject: Biology And Life Sciences, Life Sciences Keywords: smartwatch; stress; wearable device; heart rate variability; comparative analysis

Online: 25 July 2023 (09:28:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0384.v1

Moderate Effect of Flavonoids on Vascular and Renal Function In Spontaneously Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemi Atucha, Francisco O’Valle, Julian Castillo, M. Clara Ortiz, Joaquin Garcia-Estañ

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Flavonoids, nitric oxide, heart, kidney, sodium balance, phenylephrine, acetylcholine

Online: 20 July 2018 (12:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1181.v1

Hemodialysis Efficiency Predictor in End Stage Kidney Disease Using Real-Time Heart Rate Variability

Sung Il Im, Ye Na Kim, Hyun Su Kim, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, YeonSoon Jung, Hark Rim, Sung Pil Cho, Jung Hwan Park, Ho Sik Shin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: predictors of hemodialysis; heart rate variability

Online: 16 January 2024 (13:55:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0346.v1

Heart in Patients Infected with 2019 Novel Coronavirus (COVID-19)

Abdallah Fayssoil, Benjamin Davido, Hazrije Mustafic, Aurélien Dinh, Nicolas Mansencal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronavirus; heart; prognosis; COVID-19; ICU

Online: 19 April 2020 (13:15:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0100.v1

Role of Cardiac Troponin I level in predicting in-hospital outcomes in patients with ST-segment elevation myocardial infarction in Erbil-Iraq

Salam Zangana, Abdulkareem Al-Othman, Namir Al-Tawil

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiac troponin I; Ischemic heart disease

Online: 9 August 2016 (14:31:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1697.v1

Interplay of Angiotensin Peptides, Vasopressin and Insulin in the Heart: Altered Interactions in Obesity and Diabetes Mellitus

Ewa Szczepańska-Sadowska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Angiotensin; diabetes mellitus; heart failure; hypertension; hypoxia; insulin; obesity; vasopressin

Online: 22 December 2023 (08:12:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0479.v2

Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects

Zubin Mehta, Marlin Touma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Posttranscriptional Modification; Alternative Splicing; Congenital Heart Defects; Transcriptome; Splicing Variants

Online: 27 December 2022 (10:54:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0867.v1

Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician

Ageliki A Karatza, Sotirios Fouzas, Despoina Gkentzi, Eirini Kostopoulou, Nikoleta Oikonomou, Gabriel Dimitriou, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; acquired heart disease; children; diagnostic errors; missed diagnosis; delayed diagnosis; primary care pediatrician

Online: 17 March 2024 (16:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.2247.v1

Experimental One Side Choppers Relating Neuro-Muscular Human Abilities to Heart Rates and Technological Evolution

Igor Parra, Maria Luisa Morales, Francisco Javier Mar, Eudald Carbonell

Subject: Arts And Humanities, Archaeology Keywords: hominins; chopper; human evolution; heart rate; piano playing; technome

Online: 30 June 2023 (11:47:16 CEST)

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Working Paper BRIEF REPORT

The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement

Peter Hotez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; SARS 2; coronavirus; Th17; eosinophils; heart disease

Online: 9 April 2020 (14:45:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0190.v1

NOX Inhibition Improves β Adrenergic-Stimulated Contractility and Intracellular Calcium Handling in the Aged Heart

Alvaro Valdés, Guillermo Barrios, Nikol Ponce, Raul A Dulce, Daniel R Gonzalez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: NADPH oxidases; apocynin; VAS2870; aged heart; cardiomyocytes; isoproterenol; TBARS

Online: 16 April 2018 (06:17:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0060.v1

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemí M. Atucha, Francisco O’Valle, Julián Castillo, M. Clara Ortiz, Joaquín García-Estañ

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine

Online: 8 March 2018 (03:31:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0656.v1

Simulation of the Damage and Failure Characteristics of Coal under True Triaxial Static-Dynamic Loads

Hu He, Siyuan Gong, Xuwei Li, Zonglong Mu

Subject: Engineering, Mining And Mineral Processing Keywords: rockburst; true triaxial; numerical simulation; static-dynamic loads; damage evolution

Online: 9 June 2023 (03:51:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0545.v1

Genetic and Protein Expression Profile of Conjunctival Bleb Hyperfibrosis in Early Failure of Glaucoma Surgery

Elena Millá, Néstor Ventura-Abreu, Cristina Vendrell, Mª Jesús Muniesa, Marta Pazos, Xavier Gasull, Núria Comes

Subject: Medicine And Pharmacology, Ophthalmology Keywords: conjunctival filtration bleb; glaucoma surgery failure; conjunctival fibrosis; gene expression; profibrotic genes; fibrosis biomarker

Online: 7 June 2023 (11:37:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0295.v1

Classical Failure Modes and Effects Analysis in the Context of Smart Grid Cyber-Physical Systems

Andrés A. Zúñiga, Alexandre Baleia, João Fernandes, Paulo Jose Da Costa Branco

Subject: Engineering, Electrical And Electronic Engineering Keywords: cyber-power network; distribution system reliability; FMEA; reliability assessment; risk priority number (RPN); Smart Grid

Online: 20 February 2020 (08:33:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0113.v1

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure

Yaniv Mordecai, Dov Dori

Subject: Engineering, Control And Systems Engineering Keywords: conceptual modeling; cyber-physical systems; cyber-physical gap; Object-Process Methodology; model-based systems engineering; Three Mile Island 2 Accident

Online: 26 June 2017 (04:59:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0660.v1

Debonding Failure Analysis of Reinforced Concrete Beams Strengthened with CFRP Plates

Rendy Thamrin, Zaidir Zaidir, Silvy Desharma

Subject: Engineering, Civil Engineering Keywords: Debonding load; CFRP plate; RC beams; flexural strengthening; simple statistical analysis; fiber element method

Online: 29 July 2021 (13:57:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0876.v1

Position of Transseptal Puncture for Left Atrial Access in Invasive Procedures – A Brief History, Potential Complications and Available Techniques

Piotr Denysiuk, Adrianna Denysiuk, Marcin Szczasny, Joanna Popiolek-Kalisz, Piotr Blaszczak, Andrzej Glowniak

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Transseptal puncture; TSP; left atrium catheterization; left heart catheterization

Online: 13 June 2023 (04:33:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0362.v1

Cardioprotective Potential of the Ethanol and Water Extracts of Four Psilocybin Mushrooms on Angiotensin II-Induced Hypertrophy and Oxidative Stress on H9C2 Cardiomyocytes

Sanah Malomile Nkadimeng, Christiaan Martin Steinmann, Jakobus Nicolaas Eloff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: reactive oxygen species; angiotensin II; hypertrophy; psilocybin mushrooms; heart failure

Online: 6 June 2023 (03:07:37 CEST)

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Psilocybin-containing mushrooms, commonly known as magic mushrooms have antidepressant effect, however, their safety in cardiovascular diseases such as heart failure is not fully known and needs to be investigated. Cardiac hypertrophy is an independent risk factor for heart failure morbidity and mortality. Angiotensin II (Ang-II) plays a major role in the pathogenesis of cardiac hypertrophy. We investigated the cardiovascular safety of extracts of Panaeolus cyanescens, Psilocybe natalensis, Psilocybe cubensis, and Psilocybe cubensis leucistic A+ strain mushrooms, well-known psilocybin-containing mushrooms in the Panaeolus and Psilocybe genus on Ang II-induced hypertrophy oxidative stress. The four mushrooms were grown, dried and extracted with 70% ethanol, cold and hot water. Extracts were tested for cytotoxicity on H9C2 cardiomyoblast cells. The cardiomyocytes were induced with (10 µM) AngII and treated with the three extracts of the four mushrooms over 48 hours. Control cells were serum starved but neither AngII induced nor treated while AngII cells were serum starved and stimulated with AngII but not treated. Losartan, an inhibitor of AngII type 1 receptor was used as positive control. Effects of the extracts on actin-filament labelling and cell surface area, mitochondrial activity, reactive oxygen species (ROS) and atrial natriuretic peptide levels were determined. Stimulation with AngII lowered cell viability, increased the cell width measurements and intracellular ROS levels significantly compared to control cells. The results indicated that the ethanol and water extracts of the four psilocybin mushrooms did not exacerbate the angiotensin II-induced hypertrophy conditions, but the extracts had cardio-protective activity against angiotensin II-induced oxidative stress. The phytochemical analysis of the extracts confirmed detections of known compounds with antioxidant and anti-inflammatory effects in the water and ethanol extracts of these four psilocybin mushrooms.

Preprint REVIEW | doi:10.20944/preprints202008.0557.v1

Dental Implant Failure Rate and Marginal Bone Loss in Transplanted Patients: A Systematic Review and Meta-Analysis

Marcela Paraizo, João Botelho, Vanessa Machado, José João Mendes, Ricardo Alves, Paulo Mascarenhas, José Maria Cardoso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: transplantation; dental implant; marginal bone loss; implant failure rate; systematic review; periodontitis; periodontal diseases; oral health

Online: 25 August 2020 (13:45:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0103.v1

Central and Peripheral Fatigue Related to the Type of Exercise

José Trinidad Quezada Chacón, Edson Francisco Estrada Meneses, Gustavo Sierra Muñiz, Arnulfo Ramos-Jimenez, Felipe Reynoso Sánchez, Janeth Miranda Mendoza, German Hernánez Cruz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: acute physical stress; sports performance; heart rate variability; physical exhaustion

Online: 5 November 2018 (10:35:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0346.v1

The Effects of Low-Dose Empagliflozin on Cardiac Function and Β-Adrenoceptor Responses in a Rat Model of Streptozotocin-Induced Diabetes

Zeynep Elif Yesilyurt, Irem Karaomerlioglu, Betul Rabia Erdogan, Gaye Ozturk, Martin C. Michel, Ebru Arioglu-Inan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: β-adrenoceptor; diabetes; empagliflozin; heart; pressure-volume loop analysis

Online: 25 May 2022 (09:59:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2222.v1

Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

Martina Belli, Lucy Barone, Susanna Longo, Francesca Romana Prandi, Dalgisio Lecis, Rocco Mollace, Davide Margonato, Saverio Muscoli, Domenico Sergi, Massimo Federici, Francesco Barillà

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Gut microbiota; Cardiovascular diseases; Trimethylamine N-Oxide; Heart failure; Atherosclerosis

Online: 30 June 2023 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1669.v1

Anticoagulation Status and Left Atrial Appendage Occlusion Indications in Hospitalized Cardiology Patients with Atrial Fibrillation: A Hellenic Cardiorenal Morbidity Snapshot (HECMOS) Sub-Study

Dimitris Tsiachris, Panteleimon E. Papakonstantinou, Ioannis Doundoulakis, Panagiotis Tsioufis, Michail Botis, Kyriakos Dimitriadis, Ioannis Leontsinis, Athanasios Kordalis, Christos-Konstantinos Antoniou, Emmanouil Mantzouranis, Panagiotis Iliakis, Panayotis Vlachakis, Konstantinos A Gatzoulis, Konstantinos Tsioufis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; heart failure; rhythm strategy; catheter ablation; snapshot

Online: 25 August 2023 (02:48:47 CEST)

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Background and Objectives: Proper use of oral anticoagulants is crucial in the management of non-valvular atrial fibrillation (AF) patients. Left atrial appendage closure (LAAC) may be considered for stroke prevention in patients with AF and contraindications for long-term anticoagulant treatment. We aimed to assess the anticoagulation status and LAAC indications in patients with AF from HECMOS (Hellenic Cardiorenal Morbidity Snapshot) survey. Materials and Methods: HECMOS was a nationwide snapshot survey of cardiorenal morbidity in hospitalized cardiology patients. HECMOS used an electronic platform to collect demographic and clinically relevant information from all patients hospitalized on March 3, 2022, in 55 different cardiology departments. In this substudy, we included patients with known AF without mechanical prosthetic valves and moderate to severe mitral valve stenosis. Patients with prior stroke, previous major bleeding, poor adherence to anticoagulants, and end-stage renal disease were considered candidates for LAAC. Results: Two hundred fifty-six patients (mean age 76.6±11.7, 148 males) were included in our analysis. Most of them (n=159; 62%) suffered from persistent AF. Mean CHA2DS2-VASc score was 4.28±1.7, while mean HAS-BLED score was 1.47±0.9. Three out of 3 patients with a CHA2DS2-VASc 0 or 1 (female) received improperly anticoagulants. Sixteen out of 18 patients with a CHA2DS2-VASc 1 or 2 (female) received anticoagulants. Thirty-three out of 235 patients with a CHA2DS2-VASc > 1 or 2 (for female) did not receive improperly anticoagulants. Among 221 under anticoagulant therapy, 191 (86.4%) received non-vitamin K antagonist oral anticoagulants (NOACs) and 30 (13.6%) received vitamin K antagonists. Relative indications for LAAC were present in 64 patients with NVAF (60 had only one risk factor and 2 had two concurrent risk factors). In detail, 36 had a prior stroke, 17 patients had a history of major bleeding, 15 patients reported poor or no adherence to the anticoagulant therapy and 5 had eGFR< 15 ml/min/1.73m2. Moreover, 33 had a HAS-BLED score ≥3. No LAAC treatment was recorded. Conclusions: Anticoagulation status was nearly optimal in a high thromboembolic risk population of cardiology patients, mainly treated with NOACs. One out of four AF patients should be screened for LAAC.

Preprint REVIEW | doi:10.20944/preprints202401.0237.v1

In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease

Francesco Nappi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart disease; first heart field; second heart field; whole exome sequencing; whole genome sequencing; loss-of-function variant; copy number variants; gene variants; deletion; de novo mutations

Online: 3 January 2024 (11:57:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1125.v1

Research of the Failure Mechanism and Preventive Strengthening of Prefabricated Small Box Girder under Car Explosion

Wenliang Hu, Fenghui Dong, Zinan Yu

Subject: Engineering, Civil Engineering Keywords: Failure mechanism; Preventive strengthening; Prefabricated small box girder; Car explosion

Online: 19 March 2024 (12:27:38 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202010.0151.v2

Numerical Investigation of the Collapse of the Steel Truss Roof and a Probable Reason of Failure

Mertol Tufekci, Ekrem Tüfekci, Adnan Dikicioğlu

Subject: Engineering, Automotive Engineering Keywords: Steel truss; roof structure; partial collapse; finite element analysis; lightning strike.

Online: 26 October 2020 (11:35:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0149.v1

Overburden Failure and Ground Pressure Behaviour of Longwall Top Coal Caving in Hard Multi-layered Roof

Zhijie Zhu, Hongwei Zhang, Jan Nemcik, Chen Cao, Jun Han

Subject: Engineering, Energy And Fuel Technology Keywords: multi-layer hard roof; failure of overlying strata; ground pressure behaviour; longwall top coal caving

Online: 11 April 2018 (12:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0395.v1

Understanding the Dynamics of Failure Development in Marginalized Areas: A Comprehensive Analysis

Mohammed Saaida, Ibraheem Saaidah

Subject: Social Sciences, Area Studies Keywords: Marginalized Areas; Failure Development; Socioeconomic Conditions; Community Engagement; Policy Recommendations; Sustainable Development

Online: 6 December 2023 (10:22:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0087.v1

Regenerating Damaged Myocardium: A Review of Stem-Cell Therapies for Heart Failure

Dihan Fan, Hanrong Wu, Huashan Peng, Kaichao Pan, Rongxue Wu

Subject: Biology And Life Sciences, Aging Keywords: iPSCs; ESC; differentiation; Cardiovascular disease, Myocardial repair

Online: 6 September 2021 (12:03:49 CEST)

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Working Paper ARTICLE

Effect of Loading Frequency Ratio on Multiaxial Fatigue Failure of 30CrMnSiA Steel

Tianqi Liu, Xinxin Qi, Xinhong Shi, Limin Gao, Tian Zhang, Jianyu Zhang

Subject: Engineering, Automotive Engineering Keywords: 30CrMnSiA steel; crack growth path; fatigue life prediction; asynchronous loading; frequency ratio

Online: 31 May 2021 (12:13:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0194.v1

Wealth Accumulation in Rotation Forestry – Failure of the Net Present Value Optimization?

Petri P. Kärenlampi

Subject: Biology And Life Sciences, Forestry Keywords: capital return; real estate; capitalization

Online: 21 January 2019 (07:28:01 CET)

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