Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications

Version 1 : Received: 22 October 2020 / Approved: 23 October 2020 / Online: 23 October 2020 (13:28:04 CEST)

How to cite: Fayssoil, A.; De Carne De Carnavalet, M.C.; Mansencal, N.; Lofaso, F.; Davido, B. Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications. Preprints 2020, 2020100493 (doi: 10.20944/preprints202010.0493.v1). Fayssoil, A.; De Carne De Carnavalet, M.C.; Mansencal, N.; Lofaso, F.; Davido, B. Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications. Preprints 2020, 2020100493 (doi: 10.20944/preprints202010.0493.v1).

Abstract

Obesity is a significant public health concern with higher morbidity. Obesity patients are at risk of severe COVID-19 infection and obesity is a higher risk factor for intensive Care Unit admission in COVID-19 infection. Obesity status affects lung volumes, cardiac structure and hemodynamics. Obesity is associated with a low inflammation state, endothelial dysfunction, hyperinsulinaemia and metabolic disorders. The authors review cardio-respiratory pathophysiological aspects involved in obesity and propose clinical management in obese patients infected by COVD-19.

Subject Areas

COVID-19; Obesity; BMI; heart; lung; severity

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