Version 1
: Received: 18 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (16:24:26 CET)
How to cite:
Santos, M.D.; Magalhães, V.; Loureiro, L.; Pina, P.; Castro, A.; Aguiar, P.; Gomes, A.; Soares, D.; Rocha, A. Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center. Preprints2024, 2024021018. https://doi.org/10.20944/preprints202402.1018.v1
Santos, M.D.; Magalhães, V.; Loureiro, L.; Pina, P.; Castro, A.; Aguiar, P.; Gomes, A.; Soares, D.; Rocha, A. Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center. Preprints 2024, 2024021018. https://doi.org/10.20944/preprints202402.1018.v1
Santos, M.D.; Magalhães, V.; Loureiro, L.; Pina, P.; Castro, A.; Aguiar, P.; Gomes, A.; Soares, D.; Rocha, A. Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center. Preprints2024, 2024021018. https://doi.org/10.20944/preprints202402.1018.v1
APA Style
Santos, M.D., Magalhães, V., Loureiro, L., Pina, P., Castro, A., Aguiar, P., Gomes, A., Soares, D., & Rocha, A. (2024). Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center. Preprints. https://doi.org/10.20944/preprints202402.1018.v1
Chicago/Turabian Style
Santos, M.D., Diana Soares and Anabela Rocha. 2024 "Management of Short Bowel Syndrome/Chronic Intestinal Failure – the Experience of a Single Portuguese Center" Preprints. https://doi.org/10.20944/preprints202402.1018.v1
Abstract
Aim: To analyze a single center's experience with Short Bowel Syndrome/ Chronic Intestinal Failure (SBS/CIF) in adult patients treated with Home Parenteral Nutrition (HPN).
Materials and methods: In the last thirty years, 13 patients with SBS/CIF were included in an HPN program.
Results: Between 1992 and 2023, 13 patients were included in an HPN program. The primary underlying pathology was acute mesenteric ischemia. The median age of the starting HPN was 44 years old. Most are submitted to several surgeries of extensive intestinal resection with posterior intestinal reconstruction. Five of the 13 patients have died while on HPN for a median of 42 months. The causes of death HPN-related were catheter sepsis, endocarditis with cardiac failure, or hepatic failure. One patient died due to underlying pathology: pelvic abscesses and bleeding related to radiotherapy. Eight patients remain alive with a median time of HPN of 173 months. During the HPN support, the most frequent complications were venous catheter infection and venous territory thrombosis. None of the eight patients alive have hepatic failure. Two patients recently started teduglutide, with good tolerance, and need reduction of HPN support. All these eight patients have a satisfactory quality of life (parenteral support needs range between five to two nutrition bags per week).
Conclusion: HPN remains the gold standard of SBS/CIF treatment, although Teduglutide may reduce HPN needs and HPN complications and provide a better quality of life. An HPN multidisciplinary healthcare group support is essential to ensure these patients' survival and quality of life.
Keywords
Short bowel Syndrome, Chronic Intestinal failure, Home Parenteral Nutrition, Teduglutide, Complications of Parenteral Support.
Keywords
Keywords; Short bowel Syndrome; Chronic Intestinal failure; Home Parenteral Nutrition; Teduglutide; Complications of Parenteral Support
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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