Preprint Review Version 1 This version is not peer-reviewed

The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle

Version 1 : Received: 1 August 2018 / Approved: 1 August 2018 / Online: 1 August 2018 (16:31:01 CEST)

How to cite: Giarretta, I.; Gaetani, E.; Tondi, P.; Asahara, T.; Pola, R. The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle. Preprints 2018, 2018080027 (doi: 10.20944/preprints201808.0027.v1). Giarretta, I.; Gaetani, E.; Tondi, P.; Asahara, T.; Pola, R. The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle. Preprints 2018, 2018080027 (doi: 10.20944/preprints201808.0027.v1).

Abstract

Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in ischemic condition is also presented.

Subject Areas

Hedgehog; Ischemia; Heart; Brain; Skeletal muscle

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