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Preprint REVIEW | doi:10.20944/preprints202404.0312.v1

The Aftermath of COVID-19: Exploring Long-Term Effects on the Organ Systems

Maryam Golzardi, Altijana Hromić-Jahjefendić, Jasmin Šutković, Orkun Aydin, Pinar Aydin, Tea Bećirević, Elrashy M. Redwan, Alberto Rubio-Casillas, Vladimir N. Uversky

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV-2; long-COVID; organ systems

Online: 3 April 2024 (17:00:10 CEST)

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Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) is a complicated disease that affects millions of people all over the world. Previous studies have shown that PASC impacts 10% of SARS-CoV-2 infected patients of which 50-70% are hospitalized. It has also been shown that 10-12% of those vaccinated against COVID-19 were affected with PASC and its complications. The severity and the later development of PASC symptoms is positively associated with the early intensity of the infection. Results: The generated health complications caused by PASC involve a vast variety of organ systems. Patients affected by PASC have been diagnosed with neuropsychiatric and neurological symptoms. Cardiovascular system also has been involved and several diseases such as myocarditis, pericarditis, and coronary artery diseases were reported. Chronic hematological problems such as thrombotic endothelialitis and hypercoagulability were described as a condition that could increase the risk of clotting disorders and coagulopathy in PASC patients. Chest pain, breathlessness, and cough in PASC patients were associated with respiratory system in long COVID-19 causing respiratory distress syndrome. The observed immune complications were notable, involving several diseases. Renal system also was impacted and result in raising the risk of diseases such as thrombotic issues, fibrosis, and sepsis. Endocrine gland malfunction can lead to diabetes, thyroiditis, and male infertility. Symptoms such as diarrhea, nausea, loss of appetite and taste were also among reported observations due to several gastrointestinal disorders. Skin abnormalities might be an indication of infection and long-term implications such as persistent cutaneous complaints were linked to PASC. Conclusions: Long COVID is a multidimensional syndrome with considerable public health implications, affecting several physiological systems and demanding thorough medical therapy as well as more study to address its underlying causes and long-term effects.

Preprint ARTICLE | doi:10.20944/preprints202403.1834.v1

Genome-Wide Methylation Analysis in Two Wild-Type Non-small Cell Lung Cancer Subgroups with Low and High PD-L1 Expression Levels

Georg Hutarew, Beate Alinger-Scharinger, Karl Sotlar, Theo F.J. Kraus

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Lung cancer; Epigenetic profiling; Methylome; Methylation analysis; Programmed cell death ligand 1; Precision medicine

Online: 29 March 2024 (10:53:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1762.v1

CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis

Dariusz Szukiewicz

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chemokine CX3CL1; fractalkine; CX3CR1; fractalkine receptor; CX3CL1/CX3CR1 axis; angiogenesis; tumorigenesis; inflammation; inflammation-induced angiogenesis.

Online: 28 March 2024 (11:27:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1312.v1

Will Liquid Biopsy Deliver the Expected Breakthrough in Clinical Oncology? Contribution of Mass Spectrometry-Based Proteomics

Pietro Traldi, Marco Agostini, Mahmoud Hamdan

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Liquid biopsy; clinical oncology; mass spectrometry-based proteomics body fluids; circulating biomarkers; Protein post translational modifications

Online: 26 March 2024 (03:14:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0996.v1

p53 Immunohistochemistry Defines a Subset of Human Papillomavirus-Independent Penile Squamous Cell Carcinomas with Adverse Prognosis

Isabel Trias, Ferran Algaba, Inés De Torres, Adela Saco, Lorena Marimon, Núria Peñuelas, Laia Diez-Ahijado, Lia Sisuashvili, Katarzyna Darecka, Alba Morató, Marta Del Pino, Carla Ferrandiz-Pulido, Maria J. Ribal, Tarek Ajami, Juan Manuel Corral Molina, Josep M. Gaya, Oscar Reig, Oriol Ordi, Inmaculada Ribera-Cortada, Adriana García-Herrera, Natalia Rakislova

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: penile cancer; penile squamous cell carcinoma; HPV; p53; prognosis; disease-specific survival

Online: 18 March 2024 (09:42:24 CET)

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Background: Penile squamous cell carcinoma (PSCC) is classified into two prognostically distinct types: human papillomavirus (HPV)-associated and HPV-independent. Conversely, the impact of p53 status on prognosis remains controversial. We correlated HPV and p53 status with prognosis in a large series of PSCC patients. p53 was analysed according to a recently described immunohistochemical (IHC) pattern-based framework that includes two normal (scattered, mid-epithelial) and four abnormal patterns (diffuse, basal overexpression, cytoplasmic and null) and closely correlates with TP53 mutational status. Methods: A total of 122 patients with surgically treated PSCC in three hospitals in Barcelona, Spain, were included. Based on HPV in situ hybridization and p16 and p53 IHC expression, the tumors were classified into three molecular types: HPV-associated, HPV-independent/p53 normal, and HPV-independent/p53 abnormal. All patients were followed for at least 22 months (median 56.9 months), and disease-specific survival (DSS) was analysed. Results: Thirty-six tumors (29%) were HPV-associated, 35 (29%) were HPV-independent/p53 normal, and 51 (42%) were HPV-independent/p53 abnormal. Disease-related deaths were observed in 3/36 (8%), 0/35 (0%) and 14/51 (27%) of the patients, respectively (p<0.001). A total of 7/14 deaths in the latter group were patients with tumors showing p53 patterns not recognized in the classical p53 IHC interpretation (basal, null, cytoplasmic). According to our multivariate analysis, HPV-independent/p53 abnormal tumors and advanced stage were associated with impaired DSS (hazard ratio=23.4, 95% confidence interval [CI]= 2.7-3095.3; p=0.001 and 16.3, 95% CI=1.8-2151.5; p=0.008, respectively). CONCLUSION: Compared with patients with HPV-associated and HPV-independent/p53-normal PSCC, patients with HPV-independent/p53 abnormal PSCC have worse clinical outcomes. p53 IHC results define two prognostic categories in HPV-independent PSCC: HPV-independent/p53-normal tumors as low-risk tumors, whereas HPV-independent/p53-abnormal tumors as aggressive neoplasms.

Preprint REVIEW | doi:10.20944/preprints202403.0947.v1

Tumid Lupus Erythematosus (TLE): a review of a rare variant of chronic Cutaneous Lupus Erythematosus (cCLE) with emphasis on differential diagnosis

Maged Daruish, Francesca Ambrogio, Caterina Foti, Alessandra Filosa, Gerardo Cazzato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Tumid Lupus Erythematosus; Systemic Lupus Erythematosus; cCLE; inflammatory dermatopathology

Online: 18 March 2024 (08:19:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0856.v1

Comprehensive Investigation of Angiogenesis, PASS Score and Immunohistochemical Factors in Risk Assessment of Malignancy for Paraganglioma and Pheochromocytoma

Marija Milinkovic, Ivan Soldatovic, Vladan Zivaljevic, Vesna Bozic, Maja Zivotic, Svetislav Tatic, Dusko Dundjerovic

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Angiogenesis; Pheochomocytoma; Paraganglioma; CD105; ERG; PASS; Ki67; S100, SDHB

Online: 14 March 2024 (13:01:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0340.v1

Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition: Comprehensive Analysis Using Immunohistochemistry, Proteomics, and a Literature Review

Shojiro Ichimata, Yukiko Hata, Tsuneaki Yoshinaga, Nagaaki Katoh, Fuyuki Kametani, Masahide Yazaki, Yoshiki Sekijima, Naoki Nishida

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Amyloid; beta-2 micro-globulin; corpora amylacea; functional amyloids; lactoferrin; lysosome; macrophage; pulmonary surfactant protein

Online: 6 March 2024 (14:06:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1693.v1

The Enigma of Cancer Polyploidy as Deciphered by Evolutionary Cancer Cell Biology (ECCB)

Vladimir Niculescu, Eugenia Niculescu

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cancer; hepatocytes; cardiomyocytes; Entamoeba; cysts; germline; polyploidy

Online: 29 February 2024 (10:06:59 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.1700.v1

Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions

Mitsuhiro Tachibana, Hideki Hamayasu, Akihiko Yokota, Masahiro Matsushita

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: hyperplastic nodule; polypoid lesion; colitis nucleomigrans; colorectal mucosa; tumor-like lesion

Online: 29 February 2024 (08:24:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1596.v1

Advances in Target Therapy Research in Osteosarcoma

Caterina Chiappetta, Carlo Della Rocca, Claudio Di Cristofano

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Osteosarcoma; Next Generation Sequencing; Tumor targeted therapy; Immunotherapy

Online: 28 February 2024 (08:01:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1534.v1

Unraveling the Complexity of Helicobacter pylori Pathogenicity: Insights into Outer Membrane Proteins, Virulence Factors, and Treatment Strategies

Zahra Sedarat, Andrew W. Taylor-Robinson

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Helicobacter pylori; outer membrane protein; virulence factor; gastric cancer; gastric disease

Online: 27 February 2024 (12:11:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0235.v2

Spontaneous Lesions of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis douglasi, Archer 1979) with Emphasis in Reproductive Pathology

Viviana Gonzalez-Astudillo, Andrea Schaffer-White, Lawrence Noble, Patricia O'Hara, Peter Murray, Tamsin S. Barnes, Rachel Allavena

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; captive breeding; Dasyuridae; lymphoma; marsupial; senescence; reproductive pathology; Sminthopsis douglasi; Australian wildlife

Online: 22 February 2024 (12:33:40 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202402.1096.v1

Delayed Fatal Pulmonary Hemorrhage Following COVID-19 Vaccination: Case Report, Batch Analysis, And Proposed Autopsy Checklist

Nicolas Hulscher, Peter A. McCullough

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19 vaccination; Death; Autopsy; Pulmonary hemorrhage; Adverse events; Spike protein; Batch; Thrombosis; Safety

Online: 20 February 2024 (06:33:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1022.v1

The Value of Autopsy in the Modern Age: Discrepancy between Clinical and Autopsy Diagnoses

Cecilia Salzillo, Roberta Basile, Gerardo Cazzato, Giuseppe Ingravallo, Andrea Marzullo

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: hospital autopsy; modern age; clinical diagnosis; autopsy diagnosis; Public Health

Online: 19 February 2024 (08:22:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0905.v1

The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Function and Activity in Diabetes Mellitus

Shengyuan Xu, Anders Larsson, Lars Lind, Cecilia Lindskog, Johan Ärnlöv, Per Venge

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: nephropathy; biomarker; podocyte

Online: 16 February 2024 (11:34:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0792.v1

Poroid Neoplasms: A Clinicopathological Study of 13 Cases

Boubacar Efared, Idrissa Boubacar, Kadre Alio Ousmane Kadre, Aichatou Balaraba Abani Bako, Hamadou Halidou Koura, Habiba Salifou Boureima, Idrissa Seriba Coulibaly, Soumaila Amadou, Hassan Nouhou

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Poroid neoplasms; Eccrine poroma; Sweat glands; Apocrine differentiation; Histopathology

Online: 14 February 2024 (10:59:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0714.v1

Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus

Doinița Temelie-Olinici, Ionuț Cătălin Botezatu, Mihaela Perțea, Laura Stoica, Pavel Onofrei, Ana Emanuela Botez, Vasile Bogdan Grecu, Petronela Bărgăoanu, Carmen Elena Cotrutz

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: streptozotocin diabetes; ultrastructural diagnosis; insulin resistance

Online: 13 February 2024 (09:18:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0681.v1

Cancer-associated Systemic Abnormality: A Novel Marker Panel for Early-stage Breast Cancer Characterization

Stefan Schreier, Prapaphan Budchart, Suparerk Borwornpinyo, Lakkana Adireklarpwong, Prakasit Chirappapha, Wannapong Triampo, Panuwat Lertsithichai

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: early-stage breast cancer; circulating tumor cells; rare cells, liquid biopsy; systemic cancer; cytomorphology

Online: 12 February 2024 (11:37:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2187.v1

Assessment of Cervicovaginal Smear and HPV DNA Cotest for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies

Neslihan Kaya Terzi, Ozden Yulek

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cervical cancer screening; colposcopy; conventional smear; liquid-based cytology; HPV

Online: 31 January 2024 (12:56:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2110.v1

Staunch the Age Related Decline into Depression, Dementia, Diabetes, Obesity, Cancer, Long Covid, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Patrick Chambers

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tumor microenvironment (TME); indoleamine 2,3 dioxygenase (IDO); kynurenine; short chain fatty acid (SCFA)

Online: 30 January 2024 (14:26:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1873.v1

Subtype Transdifferenziation in Human Cancer: The Power of Tissue Plasticity in Tumor Progression

Monica Fedele, Laura Cerchia, Sabrina Battista

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: luminal to basal-like transition; neuroendocrine differentiation; proneural to mesenchymal transition; tissue trans-differentiation; breast cancer; prostate cancer; glioblastoma; pancreatic adenocarcinoma

Online: 26 January 2024 (10:47:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1689.v1

Vaccination-Associated Pathogenesis

Chih-Peng Chang, Chia Yu Chi, Chih-Chiang Yang, Shiou-Chih Hsu

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: vaccine; pathogenesis; viruses; evolution; adjuvant; precision medicine

Online: 23 January 2024 (11:13:33 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1400.v1

Alveolar Soft Part Sarcoma of Nasal Cavity showing Unusual Histologic Feature: A Case Report

Kyungbin Kim, Suji Lee, Soon Wook Kwon, Yuri Lee, Seoyoung Park, Chang Hun Lee, Ahrong Kim, Gi Young Huh, Kyu-Sup Cho, Kyung Un Choi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: alveolar soft part sarcoma; nasal cavity; pathology; TFE3

Online: 18 January 2024 (11:08:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1304.v1

Tissue-Based Biomarkers in Aggressive Variant Prostate Cancer: A Narrative Review

Olga Kouroukli, Vasiliki Bravou, Konstantinos Giannitsas, Vasiliki Tzelepi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: AVPC; biomarkers; NEPC; transdifferentiation; ADT; tumor suppressors; DDR; epigenetic regulation

Online: 17 January 2024 (11:29:27 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.0934.v1

Breast Cancer Molecular Subtyping in Practice: A Real-World Study of the APIS Breast Cancer Subtyping Assay in a Consecutive Series of Breast Core Biopsies

Silvana Di Palma, Panagiotis Koliou, Alex Simonovic, Daniela Costa, Catherine Faulkes, Brenda Kobutungi, Felicity Paterson, Jonathan David Horsnell, Farrokh Pakzad, Tracey Irvine, Polly Partlett, Elizabeth Clayton, Nadine Collins

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Breast Cancer; Immunohistochemistry; ER; PR; HER-2; Ki-67; APIS; mRNA Expression Testing

Online: 12 January 2024 (02:38:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0361.v1

Spatial Computational Hepatic Molecular Biomarker Reveals LSECs Role in Mid Lobular Liver Zonation Fibrosis in DILI and NASH Induced Liver Injury

Munish Puri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: DILI; NASH; liver zonation marker; bridging fibrosis; spatial transcriptomics; liver injury; computational biomarker; LSEC

Online: 4 January 2024 (07:10:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0235.v1

Spontaneous Pathology of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis douglasi, Archer 1979) with Emphasis in Reproductive Pathology

Viviana Gonzalez-Astudillo, Andrea Schaffer-White, Lawrence Noble, Patricia O'Hara, Peter Murray, Tamsin S. Barnes, Rachel Allavena

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; captive breeding; Dasyuridae; lymphoma; marsupial; senescence; reproductive pathology; Sminthopsis douglasi; Australian wildlife

Online: 4 January 2024 (03:26:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2181.v1

The Cyst Epithelium in Polycystic Kidney Disease Patients Displays Normal Apical-Basolateral Cell Polarity

Samuel Loft Sandegaard, Andreas Riishede, Henrik Birn, Helle Hasager Damkier, Jeppe Praetorius

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: polycystic kidney disease; cell polarity; crumbs complex; par complex; scribble complex; cadherin

Online: 29 December 2023 (03:14:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1981.v1

Exploring SVA Insertion Polymorphisms in Shaping Differential Gene Expression in the Central Nervous System

Lauren S Hughes, Alexander Fröhlich, Abigail L Pfaff, Vivien J Bubb, John P Quinn, Sulev Kõks

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SINE-VNTR-Alu; transposable elements; whole genome sequencing; RNA-seq; quantitative trait loci; Amyotrophic Lateral Sclerosis; HLA; MAPT

Online: 26 December 2023 (11:27:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1149.v1

Artificial Intelligence in MALDI-TOF MS: Microbial Identification, Strain Typing, and Antimicrobial Resistance Detection

Hsin-Yao Wang, Chia-Ru Chung, Wan-Ying Lin, Sriram Kalpana, Jorng-Tzong Horng, Tzong-Yi Lee, Jang-Jih Lu

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: artificial intelligence; antimicrobial susceptibility testing; antimicrobial typing; MALDI-TOF

Online: 15 December 2023 (08:57:01 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202312.0774.v1

Challenging Standard Protocols: A New Perspective on MMR Deficiency from a Longitudinal Regional Study

Eric Y Zhang, Min Yan, Victoria LS Owens, Yan Xia

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: DNA mismatch repair; MMR immunohistochemistry; colon cancer; endometrial carcinoma; microsatellite instability; MSI-H; MLH1/PMS2

Online: 12 December 2023 (05:05:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0734.v1

miRNA-221 and miRNA-483-3p Dysregulation Correlated with Poor Survival in Esophageal Adenocarcinoma

Isotta Bozzarelli, Federica Isidori, Arianna Orsini, Luca Mastracci, Deborah Malvi, Marialuisa Lugaresi, Silvia Fittipaldi, Henna Soderstrom, Jari Räsänen, Antonietta D'Errico, Anna Tomezzoli, Riccardo Rosati, Roberto Fiocca, Marco Seri, Kausilia Krishnawatie Krishnadath, Elena Bonora, Sandro Mattioli

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Esophageal adenocarcinoma; microRNA; miR-221; miR-483-3p

Online: 11 December 2023 (16:18:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0648.v1

Immunohistochemical Expression of the ANGPT1, Casr and PTK2 Proteins in Uterine Fibroids

Anna Markowska, Mateusz De Mezer, Paweł Kurzawa, Wiesława Bednarek, Anna Gryboś, Monika Krzyżaniak, Janina Markowska, Marian Gryboś, Jakub Żurawski

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: uterine myoma; Angiopoietin 1; Calcium sensing receptor; Focal Adhesion Kinase

Online: 11 December 2023 (06:03:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1636.v1

Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

Nikolaos S. Lotsios, Chrysi Keskinidou, Ioanna Dimopoulou, Αnastasia Kotanidou, Stylianos E. Orfanos, Alice G. Vassiliou

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aquaporin; sepsis; ARDS; SNP; lnRNA; miRNA

Online: 27 November 2023 (04:12:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1488.v1

Fluvastatin Converts Human Macrophages into Pro-inflammatory Foam Cells with Therapeutic Potential in Tuberculosis

M.Teresa Montero-Vega, Joaquin Matilla, Eulalia Bazán, Diana Reimers, Ana De Andrés-Martín, Rafael Gonzalo-Gobernado, Carlos Correa, Francisco Urbano, Diego Gómez-Coronado

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; statins; host-directed therapy; foam cells; granulomas; NLRP3 inflammasome; mevalonate-kinase deficiencies

Online: 23 November 2023 (08:23:48 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.0760.v1

Comparative Characterisation of Proliferation and Apoptosis of Colonic Epithelium after Electron Irradiation with 2 GY and 25 GY

Grigory Demyashkin, Elza Karakaeva, Susanna Saakian, Natalia Tarusova, Amina Guseinova, Anita Vays, Konstantin Gotovtsev, Dmitri Atiakshin, Peter Shegay, Andrey D. Kaprin

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: radiotherapy; electrons; irradiation; colon; caspase-3; Ki-67

Online: 13 November 2023 (10:19:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0508.v1

The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Megakaryocites Up-Regulation in the Microthrombosis Mechanism

Giuseppe Prof Pannone, Maria Carmela Pedicillo, Ilenia Sara De Stefano, Raffaele Barile, Mario Meccariello, Alessio Agostinone, Chiara Pannone, Giuliana Villani, CRISTINA PIZZULLI, Francesco Miele, Maria Antonietta Ramunno, Maurizio Municinò, Gaetano Serviddio, Andrea Ronchi, Federica Zito Marino, Renato Franco, Tommaso Colangelo, Rosanna Zamparese

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: TRLs; TRL-2; SARS-CoV-2; lethal COVID-19; lung disease; ARDS; CD61; micro-thrombosis; megakaryocites

Online: 8 November 2023 (16:01:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1135.v1

Multidisciplinary Aproach: A Goal For The Management Of Complications In Systemic Scleroderma. Literature Review And Case Scenario

Dariana-Elena Pătrîntașu, Hédi Katalin Sárközi, Eugeniu Lupușor, Irina Elena Vlangăr, Gheorghe-Marian Rotariu, Ionuț-Alexandru Rența, Anda-Nicoleta Nan, Corina Eugenia Budin

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: systemic sclerosis; interstitial lung disease; lung diseases; Raynaud’s syndrome

Online: 18 October 2023 (17:05:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1796.v2

Rapid Remote Online Evaluation in Endoscopic Diagnostics: An Analysis of Biopsy-Proven Respiratory Cytopathology

Hatice Elmas, Binnur Onal, Stefan Steurer, Birgit Hantzsch-Kuhn, Martin Claussen, Elnur MEHDİ, Umit Ince, Klaus F. Rabe, Guido Sauter, Lutz Welker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: telecytology; ROSE, telepathology; EBUS; lung cytology; endoscopic diagnostics; whole-slide imaging; diagnostic accuracy; cytopathology

Online: 18 October 2023 (04:23:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0947.v1

Calpain and Cardiometabolic Diseases

Takuro Miyazaki

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: alternative mRNA splicing; amino acids; inflammation; dyslipidemia; macrophages; NAFLD; NASH; regulatory T cells; vascular endothelial cells

Online: 17 October 2023 (03:30:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0207.v1

Unpredictable Metastasis in the Head and Neck Region: a Diagnostic Immunohistochemical Challenge

Raluca-Maria Closca, Adrian Nicoara, Marina Rakitovan, Ion Cristian Mot, Flavia Baderca

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Head and neck, unusual metastases, immunohistochemistry, renal clear cell carcinoma, hepatocellular carcinoma

Online: 4 October 2023 (07:56:35 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202310.0004.v1

A Simple Cyst of the Testis was Found Incidentally during Castration for Prostatic Cancer

Mitsuhiro Tachibana, Hideki Hamayasu, Hiromichi Nakagawa, Hayato Nozawa, Shigeki Fukuzawa

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: simple cyst of the testis; mesothelium; ectopic rete testis; prostatic cancer; castration; case report

Online: 1 October 2023 (10:16:18 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202310.0023.v1

When Mast Cells Run Amok: A Comprehensive Review and Case Study on Severe Neonatal Diffuse Cutaneous Mastocytosis

Gheorghe Emilian Olteanu, Mihaela Bataneant, Maria Puiu, Adela Chirita-Emandi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Neonatal diffuse cutaneous mastocytosis; KIT gene; case report; systemic mastocytosis; review

Online: 1 October 2023 (08:44:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1796.v1

Rapid Remote Online Evaluation in Endoscopic Diagnostics: An Analysis of Biopsy-Proven Respiratory Cytopathology

Hatice Elmas, Binnur Onal, Stefan Steurer, Birgit Hantzsch-Kuhn, Martin Claussen, Elnur MEHDİ, Umit Ince, Klaus F. Rabe, Guido Sauter, Lutz Welker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: telecytology; ROSE, telepathology; EBUS; lung cytology; endoscopic diagnostics; whole-slide imaging; diagnostic accuracy; cytopathology

Online: 27 September 2023 (02:52:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1347.v1

Validation of a Gene-Expression Approach for the Cytological Diagnosis of Epithelioid and Biphasic Pleural Mesothelioma on a Consecutive Series

Rossella Bruno, Anello Marcello Poma, Greta Alì, Agnese Proietti, Alessandro Ribechini, Antonio Chella, Gabriella Fontanini

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: pleural mesothelioma; mesothelial hyperplasia; pleural effusions; subtyping; gene expression

Online: 20 September 2023 (04:42:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1034.v1

Developing Models to Predict BRAFV600E and RAS Mutational Status in Papillary Thyroid Carcinoma

Agnes Stephanie Harahap, Imam Subekti, Sonar Soni Panigoro, Asmarinah Asmarinah, Lisnawati Lisnawati, Retno Asti Werdhani, Hasrayati Agustina, Dina Khoirunnisa, Mutiah Mutmainnah, Fajar Lamhot Gultom, Abdillah Hasbi Assadyk, Maria Francisca Ham

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: papillary thyroid carcinoma; BRAF-like; RAS-like; BRAFV600E; RAS mutation; prediction model

Online: 15 September 2023 (10:54:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0866.v1

Validation of the Histological Diagnosis of Hydatidiform Moles with p57KIP2 Immunophenotyping at the University Teaching Hospitals of Kigali and Butare (CHUK, CHUB)

Habanabakize Thomas, Ntirushwa David, Manirakiza Felix, Uwineza Annette, Rugwizangoga Belson

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: hydatidiform mole; histology; p57KIP2 immunohistochemistry; histomorphology; Rwanda

Online: 13 September 2023 (09:39:07 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202309.0462.v1

Colloid Carcinoma Arising in an Intestinal-Type Intraductal Papillary Mucinous Neoplasm with High-Grade Dysplasia Appearing as Signet-Ring Cells of the Pancreas by Serial Pancreatic Juice Aspiration Cytology: A Case Report

Mitsuhiro Tachibana, Takayoshi Hirota, Hideki Hamayasu, Yu Takeuchi, Kei Tsukamoto, Masahiro Matsushita

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: claudin-18; cytopathology; colloid carcinoma (CC) of the pancreas; intraductal papillary mucinous neoplasm with high-grade dysplasia (IPMNHGD) of the pancreas; signet-ring cell; serial pancreatic juice aspiration cytological examination (SPACE)

Online: 7 September 2023 (10:45:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0355.v1

Article Molecular Profile of Liver Tumors in the Setting of Fontan-Associated Liver Disease

Paola Francalanci, Isabella Giovannoni, Chantal Tancredi, Maria Giulia Gagliardi, Rosalinda Palmieri, Gianluca Brancaccio, Marco Spada, Giuseppe Maggiore, Andrea Pietrobattista, Lidia Monti, Aurora Castellano, Maria Cristina Giustiniani, Andrea Onetti Muda, Rita Alaggio

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: FALD; hepatocellular carcinoma; cholangiocarcinoma; NGS; FGFRs genes; GNAS and TMB

Online: 6 September 2023 (10:13:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0257.v1

Clinical and Histopathologic Predictors of Survival among Children with Retinoblastoma from Two Tertiary Health Facilities in Uganda

Raymond Atwine, Damaris Laffita, Abraham Birungi, Ritah Kiconco, Keith Waddell

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: clinical features; histopathologic features; retinoblastoma; survival; children

Online: 5 September 2023 (11:25:46 CEST)

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BACKGROUND: Retinoblastoma is a malignant tumour that develops from the immature cells of the retina. It is the most frequent type of paediatric intraocular cancer and is curable. Clinical and histological findings after enucleation of the affected eye dictate not only the patient's secondary care but also their prognosis. We assessed the clinical and histopathologic predictors of survival among children with retinoblastoma from two tertiary health facilities in Uganda. METHODS: This retrospective research utilized archived formalin fixed & paraffin embedded blocks of eye specimens enucleated between 2014 to 2016 at Mbarara University, pathology department and Ruharo Eye Centre. The specimens were then processed and stained with haematoxylin and eosin. The confirmation of retinoblastoma was made to include histologic stage and features of the tumor. Biographic data of the patients and the clinical features such as leukocoria, proptosis, phthisis, staphyloma, buphthalmos were retrieved from the records.RESULTS: Males (55.1%) dominated the study population (N=78). The median age was 31 months. The commonest clinical sign was leukocoria (69.2%) and the most abundant histopathological stage was stage 1 (41%). Optic nerve invasion 39.5%, choroidal invasion 29.5%, scleral invasion 7.7% and orbital extension 16.7% were seen. Flexner-Wintersteiner rosettes were seen in 24.6%. Necrosis was a prominent feature (71.2%). The two-year survival was estimated to be 62%. Leukocoria (RR 1.1), female gender (RR 1.4), intralaminar optic nerve invasion (RR 7.6) and a lack of orbital extension (RR- 7) were significant predictors of survival.CONCLUSION: Leukocoria and proptosis are noticeable clinical signs of retinoblastoma. Most patients present while in stage one although stage four presentation is also common. Leukocoria, optic nerve invasion, orbital extension, and gender are significant factors predictive of survival in patients with retinoblastoma.

Preprint ARTICLE | doi:10.20944/preprints202309.0255.v1

Combined Biomarker System Predicts Prognosis in Patients with Metastatic Oral Squamous Cell Carcinoma

Tatjana Khromov, Lucas Fischer, Andreas Leha, Felix Bremmer, Andreas Fischer, Henning Schliephake, Michal A. Rahat, Phillipp Brockmeyer

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: oral squamous cell carcinoma; prognosis; overall survival; disease free survival; connexin 43; EMMPRIN; E-cadherin; vimentin; metastasis; epithelial-to-mesenchymal transition

Online: 5 September 2023 (07:54:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0117.v1

Exploring p53 Protein Expression and Its Link to TP53 Mutation in Myelodysplasia-Related Malignancies - Interpretive Challenges and Potential Field of Applications

Judit Bedekovics, Kristóf Madarász, Attila Mokánszki, Sarolta Molnár, Ágnes Mester, Zsófia Miltényi, Gábor Méhes

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: p53 expression; TP53 mutation; myelodysplasia; myeloblast; bone marrow

Online: 4 September 2023 (07:23:19 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202308.2023.v1

Brain Metastases from Breast Cancer Histologically Exhibit Solid Growth-Pattern with at Least Focal Comedonecrosis: A Histopathologic Study on a Monocentric Series of 30 Cases

Jessica Farina, Giuseppe Angelico, Giada Maria Vecchio, Lucia Salvatorelli, Gaetano Magro, Lidia Puzzo, Andrea Palicelli, Magda Zanelli, Roberto Altieri, Francesco Certo, Saveria Spadola, Maurizio Zizzo, Giuseppe Maria Vincenzo Barbagallo, Rosario Caltabiano, Giuseppe Broggi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: brain metastasis; breast cancer; diagnosis; comedonecrosis; solid growth pattern

Online: 30 August 2023 (04:44:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1990.v1

Chat GPT in Diagnostic Human Pathology: Will It Really Be Useful to the Pathologist?

Gerardo Cazzato, Marialessandra Capuzzolo, Paola Parente, Francesca Arezzo, Vera Loizzi, Andrea Marzullo, Gennaro Cormio, Giuseppe Ingravallo

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: ChatGPT; chatbot; Artificial Intelligence; AI; Pathology; Histology

Online: 29 August 2023 (13:15:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0879.v1

Enhanced risk stratification in early-stage endometrial cancer: Integrating Molucular-L1CAM Classification and Simplified L1CAM/p53 Categorization

Seungyeon Joe, Miseon Lee, Jun Kang, Joori Kim, Sook-Hee Hong, Sung Jong Lee, Keun Ho Lee, Ahwon Lee

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: early-stage endometrial cancer; molecular classification; L1CAM; risk stratification; prognosis

Online: 11 August 2023 (08:38:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0720.v1

The Practice of Teaching and Scientific Research on Cadaveric Material Remains Crucial for Medical Education: Finally, in Italy Too, a Comprehensive Legislation Has Been Introduced

Giorgio Bolino, Vittorio Fineschi, Camilla Cecannecchia, Gianpiero D’Antonio, And Paola Frati

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: autopsy; body donation; surgical training; scientific research; law dissemination; Italian law no. 10/2020.

Online: 9 August 2023 (08:07:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0452.v1

Endocrine Mucin-Producing Sweat Gland Carcinoma: Case Presentation with a Comprehensive Review of the Literature

Gerardo Cazzato, Emilio Bellitti, Irma Trilli, Anna Colagrande, Nicoletta Sgarro, Vincenza Sara Scarcella, Teresa Lettini, Giuseppe Ingravallo, Domenico Piscitelli, Leonardo Resta, Lucia Lospalluti

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: EMPSGC; Skin neoplasm; Mucinous carcinoma; rare neoplasms

Online: 7 August 2023 (10:06:48 CEST)

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(1) Background: Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) is a rare low-grade, neuroendocrine-differentiated, cutaneous adnexal tumour, officially recognized by the World Health Organization (WHO) Skin Tumours Classification in 2018 as a separate entity and homologue of endocrine ductal carcinoma in situ (eDCIS)/solid papillary carcinoma of the breast. Although it is more frequent in the female sex, between the sixth and seventh decade, in the peri-orbital region, EMPSGC has also been described in the male sex, in subjects under 60 and over 80, and in extra-eyelid localizations (cheek, temple, scalp), but also in extra-facial localizations (chest and scrotum). (2) Methods: We present the clinical case of a 71-year-old woman with an undated lesion of the scalp, which presented as a nodule, skin-coloured, 2.5 cm in maximum diameter. We also conduct a comprehensive literature review from 1997 to the end of 2022, consulting PubMed, Scopus and Web of Science (WoS), using the following keywords: "Endocrine mucin-producing sweat gland carcinoma" and/or "EMPSGC" and/or "skin" AND "cutaneous neoplasms", and following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 248 patients were recorded with the majority, 146 females (58,8%) and 102 males (41,1%). The vast majority of the lesions were in the elides (peri-ocular region) and only a minority of cases involved the cheeks, supra-auricular, retro-auricular and occipital region, with very rare cases in the scalp, to which the present is also added (4) Conclusions: The morphological and immunophenotypical features are essential both for the correct diagnosis and to be able to classify this lesion among the corresponding eDCIS/solid papillary carcinoma of the breast, with neuroendocrine differentiation. Recent papers have attempted to shed light on the molecular features of EMPSGC and much remains to be done in the attempt to subtype the molecular profiles of these entities. Future studies with large case series, and especially with molecular biology techniques, will be needed to further add information about EMPSGC and its relationship in the PCMC spectrum.

Preprint ARTICLE | doi:10.20944/preprints202308.0382.v1

New Immunohistochemical Markers for Pleural Mesothelioma Subtyping

Iosè Di Stefano, Greta Alì, Anello Marcello Poma, Rossella Bruno, Agnese Proietti, Cristina Niccoli, Carmelina Cristina Zirafa, Franca Melfi, Maria Giovanna Mastromarino, Marco Lucchi, Gabriella Fontanini

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: pleural mesothelioma; subtypes; immunohistochemistry; Mesothelin; Claudin-15; Complement Factor B (CFB); Plasminogen Activator Inhibitor 1 (PAI1); p21-activated kinase 4 (PAK4).

Online: 4 August 2023 (12:34:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0323.v1

Diagnostic Roles of Immunohistochemical Markers, CK20, CD44, AMACR, and p53 in Urothelial Carcinoma In Situ: A Meta-Analysis and Diagnostic Test Accuracy Review

Daeseon Yoo, Kyueng-Whan Min, Jung-Soo Pyo, Nae Yu Kim

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: urothelial carcinoma in situ; immunohistochemistry; meta-analysis; diagnostic test accuracy review

Online: 3 August 2023 (10:03:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1254.v1

Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma

Daeseon Yoo, Kyueng-Whan Min, Jung-Soo Pyo, Nae Yu Kim

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: urothelial carcinoma; GATA3; immunohistochemistry; overall survival; meta-analysis

Online: 19 July 2023 (12:44:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1099.v1

Brown Tumour in Chronic Kidney Disease: Revisiting an Old Disease with a New Perspective

Djoko Santoso, Mochammad Thata, Maulana A. Empitu, Ika Nindya Kadariswantiningsih, Satriyo Dwi Suryantoro, Mutiara Rizki Haryati, Desca Medika Hertanto, Dana Pramudya, S. Ugroseno Yudho Bintoro, N. Nasronudin, Mochamad Yusuf Alsagaff, Hendri Susilo, Citrawati Dyah Kencono Wungu, Nicolaas C. Budhiparama, Pancras C.W. Hogendoorn

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Bone Tumour; hyperparathyroidism; giant cell; osteoclast

Online: 17 July 2023 (10:20:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1026.v1

The Paradigm of the EMT Process. Tissue-Specific Factors as a Potential Treatment Tool for Prostate Cancer Patients

Martyna Ewa Parol-Kulczyk, Dariusz Grzanka

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: epithelial-mesenchymal transition; prostate cancer; tissue biomarkers; microRNA; EMT-related proteins; metastasis

Online: 14 July 2023 (16:12:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0828.v1

ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer

Irene Fernández De Los Reyes, Marisa Gómez-Dorronsoro, Iñaki Monreal-Santesteban, Agustin F Fernandez, Mario Fraga, Pablo Azcue, Laura Alonso, Beatriz Fernandez-Marlasca, Javier Suárez-Alecha, Alicia Córdoba-Iturriagagoitia, David Guerrero-Setas

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: methylation; prognosis; colon cancer; biomarkers

Online: 12 July 2023 (11:09:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0572.v1

Case Report and Mini-Review: Sarcina ventriculi in the Stomach of an 80-Year-Old Female

Andrea Kirmaier, Jeffrey Kubiak, Lily Mahler, Xia Qian, Leo Wu, Yuho Ono, Stefan Riedel, Alexandra Medline, Xiao Yang, Sami Elamin, Nezam Afdhal, Ramy Arnaout

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: sarcina; bundles; tetrads; Micrococcus; Zymosarcina; Clostridia

Online: 10 July 2023 (09:59:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2059.v1

Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus

Doinița Temelie-Olinici, Ionuț-Cătălin Botezatu, Mihaela Perțea, Laura Stoica, Pavel Onofrei, Ana-Emanuela Botez, Vasile-Bogdan Grecu, Raluca Maria Haba, Petronela Bărgăoanu, Carmen Elena Cotrutz

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: streptozotocin diabetes; ultrastructural diagnosis; insulin resistance.

Online: 28 June 2023 (20:40:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1905.v1

Assessment of the Tumor-Stroma Ratio and Tumor Infiltrating Lymphocytes in Colorectal Cancer: Inter-Observer Agreement Evaluation

Azar Kazemi, Masoumeh Gharib, Nema Mohammadian Roshan, Shirin Traz Jamshid, Fabian Stögbauer, Saeid Eslami, Peter Schüffler

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tumor-infiltrating lymphocytes; tumor-stroma ratio; colorectal cancer; inter-observer

Online: 27 June 2023 (12:36:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1670.v1

Low and Ultra-low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes

Mariausilia Franchina, Cristina Pizzimenti, Vincenzo Fiorentino, Maurizio Martini, Giuseppina Rosaria Rita Ricciardi, Nicola Silvestris, Antonio Ieni, Giovanni Tuccari

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HER2 expression; Breast cancer; Neoadjuvant treatment; HER2-low carcinomas; HER2 ultra-low carcinomas

Online: 23 June 2023 (11:55:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1487.v1

Circular and Circulating DNA in IBD: from Pathogenesis to Potential Molecular Therapies

Federica Di Vincenzo, Ylenia Yadid, Valentina Petito, Valeria Emoli, Letizia Masi, Daniela Gerovska, Marcos Jesus Araúzo-Bravo, Antonio Gasbarrini, Birgitte Regenberg, Franco Scaldaferri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cell-free nucleic acids; cell-free DNA; circular DNA; microvescicles; inflammatory bowel disease; cGAS-STING; TLR9; oligonucleotides; bioinformatics; molecular therapies.

Online: 21 June 2023 (08:55:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1217.v1

Primary Pulmonary Carcinomas With Spindle And/or Giant Cell Features: A Review With Emphasis in Classification and Pitfalls in Diagnosis

Cesar A. Moran

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: lung; giant cells; sarcomatoid; pleomorphic; carcinoma

Online: 16 June 2023 (10:27:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1113.v1

Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational and Transformational Risks from Exogenous Free Hemoglobin Alpha Chain: A By-product of Extravasated Erythrocyte Macrophage Erythrophagocytosis

Maya A Bragg, William A Breaux, Amosy E M'Koma

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Inflammatory bowel disease; Colitis-associated colorectal cancer; exogenous frees hemoglobin alpha chain; Fenton reaction; DNA damage; haptoglobin; deferoxamine; flavonoids; hydrogen peroxide; hygiene; iron; nanomedicine; oxidative stress; polyphenol; pharmaceutical therapy

Online: 16 June 2023 (07:11:38 CEST)

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The aggregate aftermath of persistent inflammation in patients with inflammatory bowel disease (IBD) places them at increased risk for the advancement to colitis-associated colorectal cancer (CACRC). CACRC is preceded by IBD, the highly heterogenous, pharmacologically incurable, pertinacious, reverting/worsening, and immune-mediated inflammatory pathologies of the colon and rectum. The molecular and immunological basis of CACRC is highly correlated with the length/duration and stringency/severity of colon inflammation predisposed by the exogenous/free hemoglobin alpha chain (HbαC) the byproduct of infiltrating immune cells, extravasated erythrocytes, and macrophage erythrophagocytosis. The exogenous free HbαC prompts oxygen-free radical-arbitrated DNA damage (DNAD) through increased cellular reactive oxygen species (ROS) exacerbated by decreased tissue antioxidant defenses. Mitigation of Fenton reaction via pharmaceutical therapy would attenuate the ROS, promote apoptosis, DNAD repair, and subsequent prevent the incidence of CACRC. Three pharmaceutical options that attenuate hemoglobin toxicity include haptoglobin, deferoxamine, and flavonoids (vitamins C/E). Haptoglobin’s clearance rare from plasma is inversely correlated with its size; the smaller the size, the faster the clearance. Thus, the administration of Hp1-1 may prove to be beneficial. Furthermore, deferoxamine’s hydrophilic structure limits its ability to cross cell membranes. Thus, it may be beneficial if administered intracellularly to avoid the higher plasma concentrations and longer incubation periods associated with extracellular administration. Finally, the effectiveness of flavonoids and natural herb antioxidants is associated with high reactivity of hydroxyl substituents. Multiple analyses are currently underway to assess the clinical context of CACRC and outline the molecular basis of HbαC-induced ROS pathogenesis by exposing colonocytes and/or colonoids to HbαC. These cells are then treated with haptoglobin, deferoxamine (DFO), and flavonoids in order to separate free HbαC and measure their impact on hydroxyl radical formation therapies. The molecular pathogenesis of sporadic colorectal cancer (SCRC) i.e., “inflammation-dysplasia-carcinoma” progression sequence is well described, but the immunopathogenesis of CACRC herein reviewed is broadly still in prodromal stage/phase to be validated and understood. Therefore this timely review outlines the molecular and immunological basis of disease pathogenesis and the pharmaceutical intervention as a protective measure for CACRC.

Preprint ARTICLE | doi:10.20944/preprints202306.1178.v1

Implementing an On-Slide Molecular Classification of Gastric Cancer: A Tissue Microarray Study

Simona Costache, Rebecca De Havilland, Sofia Diaz McLynn, Maria Sajin, Sarah Wedden, Corrado D'Arrigo

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: gastric cancer; molecular classification; EBER; MMR; E-cadherin; beta-catenin; p53; Her2; PD-L1; Claudin18.2

Online: 16 June 2023 (05:46:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1101.v1

Identification of Diagnostic Metabolic Signatures in Thyroid Tumors using Mass Spectrometry Imaging

Xinxin Mao, Luojiao Huang, Tiegang Li, Abliz Zeper, Jiuming He, Jie Chen

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: thyroid follicular adenoma; thyroid follicular carcinoma; mass spectrometry; tumor; diagnose; marker

Online: 15 June 2023 (08:13:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0975.v1

N-Glycomic Profiling of Microsatellite Unstable Colorectal Cancer

Iiris Ukkola, Pirjo Nummela, Annamari Heiskanen, Matilda Holm, Sadia Zafar, Mia Kero, Caj Haglund, Tero Satomaa, Soili Kytölä, Ari Ristimäki

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: BRAFV600E; colorectal cancer; microsatellite instability; mass spectrometry; N-glycosylation

Online: 14 June 2023 (04:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0480.v1

Characterization of the Immune Landscapes of Malignant Pleural Effusions and Their Corresponding Primary Tumors from Patients with Breast Carcinoma or Lung Adenocarcinoma

Caddie Laberiano-Fernandez, Qiong Gan, Sophia Mei Wang, Auriole Tamegnon, Ignacio Wistuba, Esther Yoon, Sinchita Roy-Chowdhuri, Edwin Roger Parra

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Breast; lung; cancer; microenvironment; pleural effusion; immunofluorescence

Online: 7 June 2023 (03:49:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0039.v1

Cystic Clear Cell Renal Cell Carcinoma: A Morphological and Molecular Reappraisal

Giacomo Maria Pini, Roberta Lucianò, Maurizio Colecchia

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Renal cell carcinoma; Cystic renal neoplasm; differential diagnosis

Online: 1 June 2023 (07:03:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2187.v1

Effects of diabetes mellitus related dysglycemia on the functions of blood-brain barrier and the risk of dementia

Mateusz Wątroba, Anna D. Grabowska, Dariusz Szukiewicz

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: diabetes mellitus; blood-brain barrier disruption; dysglycemia; hyperglycemia; insulin resistance; neurodegenerative disease; diabetic complications; dementia, diabetic encephalopathy

Online: 31 May 2023 (10:05:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2189.v1

IL-23/IL-17 axis in the Chronic Hepatitis C and Nonalcoholic Steatohepatitis – New Insight Into Immunohepatotoxicity of Different Chronic Liver Diseases

Ankica Vujovic, Andjelka M Isakovic, Sonja Misirlic-Dencic, Jovan Juloski, Milan Mirkovic, Marina Djelic, Ivana Milošević

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic hepatitis C; nonalcoholic steatohepatitis; IL-23/IL-17 axis; immunohepatotoxicity

Online: 31 May 2023 (07:46:51 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.1900.v1

Perforating Gout: Expanding the Differential for Transepidermal Elimination

Michal Bohdanowicz, Scott H Bradshaw

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Gout; Tophus; Perforating Dermatosis; Transepidermal Elimination; Pseudoepitheliomatous Hyperplasia; Granulomatous Dermatitis

Online: 26 May 2023 (09:36:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1344.v1

Gray-Zone Lymphoma: A Still Open Issue

Stefano Pileri, Valentina Tabanelli, Chiarle Roberto, Angelica Calleri, Federica Melle, Giovanna Motta, Maria Rosaria Sapienza, Elena Sabattini, Pier Luigi Zinzani, Enrico Derenzini

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: mediastinal gray-zone lymphoma; classical Hodgkin lymphoma; primary mediastinal B-cell lymphoma; diffuse large B-cell lymphoma; NOS; EBV-positive diffuse large B-cell lymphoma; NOS; morphology; phenotype; gene expression profile; mutational landscape

Online: 18 May 2023 (12:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0526.v1

Immuno-Contexture and Immune Checkpoint Molecule Expression in Microsatellite Stable/Mismatch Repair Proficient Colorectal Carcinoma

Mauro Giacomelli, Matilde Monti, Diego Cesare Pezzola, Silvia Lonardi, Mattia Bugatti, Francesco Missale, Rossella Cioncada, Laura Melocchi, Viviana Giustini, Vincenzo Villanacci, Carla Baronchelli, Stefania Manenti, Luisa Imberti, Emanuele Giurisato, William Vermi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Colorectal cancer; mismatch repair; microsatellite instability; immune checkpoint; double negative T cells; tumor microenvironment; T-cell exhaustion; interferon-γ; PD-L1

Online: 8 May 2023 (10:53:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0879.v1

The Utility of Mitochondria Detection Methods Applied as an Additional Tool for the Differentiation of Renal Cell Tumours

Gorana Nikolic, Maja Zivotic, Sanja Cirovic, Sanja Despotovic, Sanja Radojevic Skodric

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: renal cell tumours; renal cell carcinomas; immunohistochemistry; immunofluorescence; mito-chondria; electron microscopy

Online: 25 April 2023 (03:58:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0694.v1

Medical Applications of Molecular Biotechnologies in the Context of the Hashimoto’s Thyroiditis

Maria Trovato, Andrea Valenti

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Hashimoto’s thyroiditis; molecular biotechnologies; clinical trials studies; hygiene hypothesis; parvoviruses

Online: 21 April 2023 (08:48:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202303.0225.v1

The Importance of Context in Inert Gas Asphyxiation Deaths: An Autopsy Case Report

Tyla Gelman, Andrew Sulaiman, Christine James, Diane Peterson

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Inert Gas Asphyxiation; Autopsy Case Report

Online: 13 March 2023 (09:44:40 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202303.0181.v1

Establishment of a Novel Anti-Human CCR6 Monoclonal Antibody C₆Mab-19 with the High Binding Affinity in Flow Cytometry

Tomohiro Tanaka, Kaishi Kitamura, Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: CCR6; monoclonal antibody; peptide immunization; flow cytometry; immunohistochemistry

Online: 9 March 2023 (13:45:12 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202303.0179.v1

Fatal Hemopericardium due to Rupture of the Ascending Aortic Artery in a Patient with Turner Syndrome: A Case Report with Autopsy Findings

Andrew Sulaiman, Tyla Gelman, Christine James, Diane Peterson

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Turner Syndrome; Autopsy Case Report

Online: 9 March 2023 (13:02:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0126.v1

Sarcoidosis, Mycobacterium paratuberculosis and Noncaseating Granulomas: Who Moved My Cheese

Coad Thomas Dow, Nancy W. Lin, Edward D. Chan

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: sarcoidosis; Mycobacterium avium ss. paratuberculosis; MAP; non-caseating granuloma; caseating granuloma; Blau syndrome; early onset sarcoidosis; Crohn’s disease; cell wall deficient (CWD); L-form; Mycobacterium tuberculosis; acid-fast bacilli; SLC11a1 (NRAMP1); NOD2 (CARD15)

Online: 7 March 2023 (03:46:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0091.v1

Unlocking the Therapeutic Potential of Irisin: Harnessing its Function in Degenerative Disorders and Tissue Regeneration

Yuwei Zhang, Lizhen Wang, Hongyan Kang, Chia-ying Lin, Yu-Bo Fan

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: FNDC5; Irisin; Degenerative disease; Regeneration; Tissue repair.

Online: 6 March 2023 (06:06:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0061.v1

A Landscape on Disorders Following Different COVID-19 Vaccination: A Systematic Review of Iranian Case Reports

Mona Sadat Larijani, Delaram Doroud, Mohammad Banifazl, Afsaneh Karami, Anahita Bavand, Fatemeh Ashrafian, Amitis Ramezani

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; Vaccination; Adverse event; Case report; Iran

Online: 3 March 2023 (08:30:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0178.v2

Performance of a 7-Type HPV mRNA Test in Triage of HPV DNA Primary Screen Positive Women Compared to Liquid-Based Cytology

Sveinung Wergeland Sørbye, Bente Marie Falang, Mona Antonsen

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HPV-DNA; primary screening; HPV-mRNA; biomarker; triage; liquid-based cytology; colposcopy; CIN2+

Online: 28 February 2023 (01:50:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0437.v1

Development of a Novel Anti-CD44 Variant 7/8 Monoclonal Antibody C44Mab-34 for Multiple Applications against Oral Carcinomas

Hiroyuki Suzuki, Kazuki Ozawa, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: CD44; CD44 variant 7/8; monoclonal antibody; flow cytometry; immunohistochemistry

Online: 27 February 2023 (04:13:02 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202302.0260.v1

COVID-19 and Vasa Vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings

Julia Makarova, Sofia Malachova, Tatiana Novitskaya, Valeria Shapkina, Leonid Churilov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-CoV-2; atherosclerosis

Online: 16 February 2023 (02:18:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0207.v1

Mild Chronic Kidney Disease Associated with Low Bone Formation and Decrease in Phosphate Transporters and Signaling Pathways Gene Expression

Evdokia Bogdanova, Airat Sadykov, Galina Ivanova, Irina Zubina, Olga Beresneva, Natalia Semenova, Olga Galkina, Marina Parastaeva, Vladimir Sharoyko, Vladimir Dobronravov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic kidney disease; bone remodeling; static bone histomorphometry; inorganic phosphate transporters; intracellular signaling

Online: 13 February 2023 (08:46:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0177.v1

The Role of Inflammation in the Cellular and Molecular Mechanisms of Cardiopulmonary Complications of Sickle Cell Disease

Oluwabukola T Gbotosho, Jahnavi Gollamudi, Hyacinth I Hyacinth

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Sickle cell disease; cardiopulmonary complications; inflammation; acute chest syndrome; cardiac hypertrophy; cardiac fibrosis; diastolic dysfunction; pulmonary hypertension

Online: 10 February 2023 (03:13:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0148.v1

Activation of Mast Cells by Neuropeptides: The Role of Pro-inflammatory and Anti-Inflammatory Cytokines

Dorina Lauritano, Filiberto Mastrangelo, Cristian D’Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Neuropeptide; Inflammation; Immunity; Mast cell: Pro-inflammatory cytokines; Anti-inflammatory cytokines

Online: 8 February 2023 (11:33:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0115.v1

Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease

Melvin R. Hayden

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Endothelial dysfunction; Exosomes; Hyperinsulinemia; Hyperglycemia; Hyperlipidemia; Hypertension; Insulin Resistance; Leptin Resistance; Metainflammation; miRNAs

Online: 7 February 2023 (03:07:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0583.v2

Cellular FXIII in Human Macrophage Derived Foam Cells

Laura Somodi, Emőke Horváth, Helga Bárdos, Barbara Baráth, Dávid Pethő, Éva Katona, József Balla, Nicola J Mutch, László Muszbek

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: factor XIII; foam cells; macrophages; vascular smooth muscle cells; oxidized LDL; enzyme-modified LDL; transglutaminase; atherosclerotic plaque; cross-linking

Online: 2 February 2023 (11:52:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0033.v1

Long-term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects

Anixa Muiños-Bühl, Karen K Ling, Roman Rombo, Eleonora Zilio, Frank Rigo, C. Frank Bennett, Brunhilde Wirth

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Neuromuscular disorder; NCALD; SMA; SMN2; Antisense oligonucleotide; Genetic modifier; Therapy; hiPSCs

Online: 2 February 2023 (07:54:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0583.v1

Cellular FXIII in Human Macrophage Derived Foam Cells

Laura Somodi, Emőke Horváth, Helga Bárdos, Barbara Baráth, Dávid Pethő, Éva Katona, József Balla, Nicola J Mutch, László Muszbek

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: factor XIII, foam cells, macrophages, vascular smooth muscle cells, oxidized LDL, enzyme-modified LDL, transglutaminase, atherosclerotic plaque, cross-linking

Online: 31 January 2023 (10:23:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0178.v1

Performance of a 7-type HPV mRNA Test in Triage of HPV DNA Primary Screen Positive Women Compared to Liquid-based Cytology

Sveinung Wergeland Sørbye, Bente Marie Falang, Mona Antonsen

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HPV-DNA; primary screening; HPV-mRNA; biomarker; triage; liquid-based cytology; colposcopy; CIN2+

Online: 10 January 2023 (07:13:00 CET)

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Medicine and Pharmacology