Version 1
: Received: 1 May 2022 / Approved: 4 May 2022 / Online: 4 May 2022 (14:17:42 CEST)
Version 2
: Received: 21 May 2022 / Approved: 23 May 2022 / Online: 23 May 2022 (11:00:06 CEST)
How to cite:
Roy, B.; Runa, S.A. SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints2022, 2022050014. https://doi.org/10.20944/preprints202205.0014.v2
Roy, B.; Runa, S.A. SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints 2022, 2022050014. https://doi.org/10.20944/preprints202205.0014.v2
Roy, B.; Runa, S.A. SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints2022, 2022050014. https://doi.org/10.20944/preprints202205.0014.v2
APA Style
Roy, B., & Runa, S.A. (2022). SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints. https://doi.org/10.20944/preprints202205.0014.v2
Chicago/Turabian Style
Roy, B. and Sadia Afrin Runa. 2022 "SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure" Preprints. https://doi.org/10.20944/preprints202205.0014.v2
Abstract
Since the discovery of the Coronavirus disease 2019 (COVID-19) outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ dysfunction, while the co-existence of these two culprits can accelerate the pathophysiology and magnify the severity of the diseases. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases of multiple organs, including the lungs, heart, kidney, brain, eyes, gastrointestinal system, and bones, and subsequent manifestation of multi-system organ failure.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Bipradas Roy
Commenter's Conflict of Interests: Author