Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Version 1 : Received: 1 May 2022 / Approved: 4 May 2022 / Online: 4 May 2022 (14:17:42 CEST)
Version 2 : Received: 21 May 2022 / Approved: 23 May 2022 / Online: 23 May 2022 (11:00:06 CEST)

How to cite: Roy, B.; Runa, S.A. SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints 2022, 2022050014 (doi: 10.20944/preprints202205.0014.v2). Roy, B.; Runa, S.A. SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure. Preprints 2022, 2022050014 (doi: 10.20944/preprints202205.0014.v2).

Abstract

Since the discovery of the Coronavirus disease 2019 (COVID-19) outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ dysfunction, while the co-existence of these two culprits can accelerate the pathophysiology and magnify the severity of the diseases. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases of multiple organs, including the lungs, heart, kidney, brain, eyes, gastrointestinal system, and bones, and subsequent manifestation of multi-system organ failure.

Keywords

COVID-19; SARS-CoV-2; Diabetes; Neurological dysfunction; Cardiovascular complications; Pulmonary dysfunction; Renal dysfunction; bone loss; Eye disease; Gastrointestinal complications

Subject

LIFE SCIENCES, Molecular Biology

Comments (1)

Comment 1
Received: 23 May 2022
Commenter: Bipradas Roy
Commenter's Conflict of Interests: Author
Comment: The title and the abstract have been changed.
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